Radiologie (Heidelberg, Germany)最新文献

Immunomodulatory impacts of thermal and pulsed field ablation therapy on hepatocellular carcinoma associated with viral hepatitis. 热和脉冲场消融治疗对病毒性肝炎相关肝细胞癌的免疫调节作用。

Radiologie (Heidelberg, Germany) Pub Date : 2025-07-10 DOI: 10.1007/s00117-025-01476-4

Yi Xiao, Jingyan Yu, Qiang Huang, Wenbo Xiao

{"title":"Immunomodulatory impacts of thermal and pulsed field ablation therapy on hepatocellular carcinoma associated with viral hepatitis.","authors":"Yi Xiao, Jingyan Yu, Qiang Huang, Wenbo Xiao","doi":"10.1007/s00117-025-01476-4","DOIUrl":"https://doi.org/10.1007/s00117-025-01476-4","url":null,"abstract":"Ablation therapy for liver cancer has become one of the most important tools for the radical treatment of early-stage liver cancer and the palliative treatment of middle- and late-stage liver cancer. Ablation not only kills liver cancer cells directly, but also activates the antitumor immune response of the body. However, the activated antitumor immune response is not enough to inhibit the recurrence or stop the progression of liver cancer. Immunotherapy offers new hope in this context, but its efficacy is still unsatisfactory. Understanding the role and mechanism of different ablation therapies in activating antitumor immune responses is the basis for the development of ablation-specific immunotherapy protocols. In particular, pulsed field ablation, as a nonthermal ablation technique, can make up for the shortcomings of thermal ablation. However, as pulsed field ablation is still an emerging technology, the mechanism of activation of antitumor immune responses by ablation remains unclear. Therefore, comparing the similarities and differences between thermal ablation and pulsed field ablation in activating antitumor immunity can provide theoretical support for the development of immunotherapy after thermal ablation and pulsed field ablation for liver cancer.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Magnetic resonance imaging of the pediatric chest]. [小儿胸部磁共振成像]。

Radiologie (Heidelberg, Germany) Pub Date : 2025-07-09 DOI: 10.1007/s00117-025-01486-2

Daniel Gräfe, Franz Wolfgang Hirsch

{"title":"[Magnetic resonance imaging of the pediatric chest].","authors":"Daniel Gräfe, Franz Wolfgang Hirsch","doi":"10.1007/s00117-025-01486-2","DOIUrl":"https://doi.org/10.1007/s00117-025-01486-2","url":null,"abstract":"Background: Magnetic resonance imagining (MRI) has become a well-established radiation-free alternative to computed tomography (CT) in pediatric imaging but is still rarely used for lung evaluation due to technical limitations such as low proton density and motion artifacts.Objective: To demonstrate how pediatric lung MRI can be performed reliably despite its known limitations and how recent technical innovations enhance its diagnostic potential.Materials and methods: Based on clinical experience from a university pediatric radiology center, a standardized thoracic MRI protocol for children is presented. It includes respiratory-triggered T2-weighted sequences and, when available, ultra-short TE (UTE) sequences. Emerging techniques such as ventilation-perfusion MRI and real-time MRI are also discussed.Results: Most clinical questions can be addressed using respiratory-triggered T2-weighted sequences. UTE sequences improve visualization of aerated lung parenchyma and low-proton lesions. Real-time MRI significantly reduces motion artifacts and enables functional assessment, especially in unsedated infants and toddlers. Total exam time is 15-20 min.Conclusion: Pediatric lung MRI is a reliable, radiation-free alternative to CT in many cases. New sequence techniques like UTE and real-time MRI considerably expand its diagnostic range. Wider adoption could meaningfully reduce radiation exposure in children with chronic lung disease.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Anatomy of the petrous portion of the temporal bone]. [颞骨岩部的解剖学]。

Radiologie (Heidelberg, Germany) Pub Date : 2025-07-09 DOI: 10.1007/s00117-025-01483-5

Umut Yilmaz

引用次数: 0

[Osteomyelitis, septic arthritis, nonbacterial osteomyelitis, SAPHO syndrome in children : What clinicians want to know from the radiologist?] 儿童骨髓炎、脓毒性关节炎、非细菌性骨髓炎、SAPHO综合征：临床医生想从放射科医生那里了解什么？］

Radiologie (Heidelberg, Germany) Pub Date : 2025-07-03 DOI: 10.1007/s00117-025-01470-w

Johannes-Peter Haas

引用次数: 0

[Primary imaging diagnostics of lymphomas]. [淋巴瘤的初步影像学诊断]。

Radiologie (Heidelberg, Germany) Pub Date : 2025-07-01 Epub Date: 2025-04-28 DOI: 10.1007/s00117-025-01447-9

Michael Winkelmann, Matthias Kassube, Johannes Rübenthaler, Gabriel T Sheikh, Wolfgang G Kunz

{"title":"[Primary imaging diagnostics of lymphomas].","authors":"Michael Winkelmann, Matthias Kassube, Johannes Rübenthaler, Gabriel T Sheikh, Wolfgang G Kunz","doi":"10.1007/s00117-025-01447-9","DOIUrl":"10.1007/s00117-025-01447-9","url":null,"abstract":"Clinical/methodological issue: Imaging procedures are an integral component of the diagnostics and treatment of lymphomas for the initial diagnosis, staging and assessment of the efficacy of treatment. The different lymphoma entities show differences in metabolic activity and therefore require different examination modalities.Standard radiological methods: This review article focuses on the primary imaging diagnostics of lymphomas using computed tomography (CT), positron emission tomography (PET)/CT and magnetic resonance imaging (MRI). It also discusses the special imaging features of the various subtypes.Methodological innovations: The potential of whole-body (WB) MRI, PET/MRI and other PET tracers are discussed.Performance: In addition, the most important classifications for the diagnosis of spread and diagnostic scores based on imaging are explained and important pitfalls in initial imaging are discussed.Assessment: Besides these most frequently used modalities, WB MRI and PET/MRI offer alternatives for special patient groups (e.g., children and pregnant women).Practical recommendations: Imaging in the initial diagnosis of lymphomas should generally include an examination of the neck, thorax, abdomen, pelvis and inguinal region. Depending on the lymphoma entity, imaging is often performed using PET/CT or CT. Standardized staging classifications are used for many lymphoma entities but there are adapted criteria for several subtypes that should be taken into consideration.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":"500-507"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Subarachnoid hemorrhage, part 2 : Treatment, complications and long-term sequelae]. [蛛网膜下腔出血，第2部分：治疗、并发症和长期后遗症]。

Radiologie (Heidelberg, Germany) Pub Date : 2025-07-01 Epub Date: 2025-06-17 DOI: 10.1007/s00117-025-01474-6

Umut Yilmaz, Malvina Garner, Wolfgang Reith

引用次数: 0

[Staging and treatment response assessment with radiological and nuclear medicine approaches for non-Hodgkin lymphomas]. [用放射学和核医学方法评估非霍奇金淋巴瘤的分期和治疗反应]。

Radiologie (Heidelberg, Germany) Pub Date : 2025-07-01 Epub Date: 2025-05-28 DOI: 10.1007/s00117-025-01459-5

Christian Neelsen, Ahmad Mohammad, Heinz-Peter Schlemmer, Antonia Dimitrakopoulou-Strauss, Christos Sachpekidis

{"title":"[Staging and treatment response assessment with radiological and nuclear medicine approaches for non-Hodgkin lymphomas].","authors":"Christian Neelsen, Ahmad Mohammad, Heinz-Peter Schlemmer, Antonia Dimitrakopoulou-Strauss, Christos Sachpekidis","doi":"10.1007/s00117-025-01459-5","DOIUrl":"10.1007/s00117-025-01459-5","url":null,"abstract":"Clinical/methodical issue: Non-Hodgkin lymphomas (NHL) represent a heterogeneous group of malignant diseases in which the choice of imaging modality and response criteria strongly depends on histology and clinical context. Selecting the appropriate method is essential for individualized treatment planning.Standard radiological methods: According to the Lugano classification, 18F‑fluorodeoxyglucose positron emission tomography/computed tomography (18F‑FDG PET/CT) is the reference standard for staging and response assessment in 18F-FDG-avid NHL. For other lymphoma subtypes with low or variable 18F-FDG avidity, or in cases where reimbursement by statutory health insurance (GKV) is lacking, contrast-enhanced CT is typically used.Methodological innovations: This article discusses the new classification systems Lymphoma Response to Immunomodulatory Therapy Criteria (LYRIC) and Response Evaluation Criteria in Lymphoma (RECIL), as well as specific features of certain lymphoma subtypes and novel imaging approaches such as whole-body MRI and innovative PET tracers.Performance: This narrative review does not include a systematic evaluation of sensitivity or specificity data.Achievements: In 18F-FDG-avid lymphomas 18F‑FDG PET/CT remains the gold standard for precise staging and response assessment.Practical recommendations: Imaging is essential for tailored therapy planning and monitoring in NHL. As most NHL subtypes are 18FDG-avid, PET/CT is the reference standard. However, contrast-enhanced CT continues to play a significant role, particularly in Germany. New PET tracers and whole-body MRI offer promising approaches but require further studies and standardization.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":"508-517"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Malignant non-Hodgkin's lymphoma : Current classification and biopsy diagnostics]. [恶性非霍奇金淋巴瘤：目前的分类和活检诊断]。

Radiologie (Heidelberg, Germany) Pub Date : 2025-07-01 Epub Date: 2025-05-05 DOI: 10.1007/s00117-025-01449-7

M Andrulis

{"title":"[Malignant non-Hodgkin's lymphoma : Current classification and biopsy diagnostics].","authors":"M Andrulis","doi":"10.1007/s00117-025-01449-7","DOIUrl":"10.1007/s00117-025-01449-7","url":null,"abstract":"Clinical/methodological issue: Imaging plays a central role in the staging and biopsy-based diagnosis of malignant lymphomas. The diagnostic approach using core needle biopsy requires an interdisciplinary strategy that integrates clinical, histopathological and molecular characteristics of non-Hodgkin's lymphomas (NHL).Standard radiological methods: Ultrasound and/or computed tomography (CT)-guided biopsy.Methodological innovations: The current WHO classification defines over 40 non-Hodgkin's lymphoma entities, taking the genomic heterogeneity into account.Performance/achievements: This review focuses on non-Hodgkin's lymphomas with imaging-based diagnostic relevance, including indolent and aggressive B‑NHL as well as systemic T/NK-NHL. It also discusses technical aspects of core needle biopsy and treatment-related effects that can impact the biopsy quality. Special attention is paid to the role of imaging and biopsy techniques in detecting high-grade transformation of indolent B‑NHL, which is associated with rapid progression and diagnostic challenges.Practical recommendations: Ultrasound-guided and CT-guided core needle biopsies are well-established standard procedures with a high sensitivity. Close interdisciplinary collaboration between radiology and pathology, along with structured communication of clinical information are essential to ensure high diagnostic accuracy.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":"483-489"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Modern systemic treatment-bispecific antibodies and CAR-T cell therapy : Clinical management, mechanisms of action, outcomes]. [现代全身治疗-双特异性抗体和CAR-T细胞治疗：临床管理，作用机制，结果]。

Radiologie (Heidelberg, Germany) Pub Date : 2025-07-01 Epub Date: 2025-06-13 DOI: 10.1007/s00117-025-01472-8

Henriette Huber, Elke Leupolt, Lukas Kündgen, Martin Bentz

{"title":"[Modern systemic treatment-bispecific antibodies and CAR-T cell therapy : Clinical management, mechanisms of action, outcomes].","authors":"Henriette Huber, Elke Leupolt, Lukas Kündgen, Martin Bentz","doi":"10.1007/s00117-025-01472-8","DOIUrl":"10.1007/s00117-025-01472-8","url":null,"abstract":"Background: Despite chemoimmunotherapy and autologous stem cell transplants, 30-40% of all patients with aggressive B‑cell non-Hodgkin lymphoma relapse.Objective: The use of targeted therapies is necessary to optimize the survival of these patients.Results: Chimeric antigen receptor (CAR) T‑cell therapies directed against CD19 are increasingly changing the therapeutic landscape for patients with diffuse large B‑cell lymphoma (DLBCL) and other B‑cell non-Hodgkin lymphomas. Follow-up data show that 30-40% of patients with relapsed or refractory aggressive lymphomas remain disease-free and can be cured in the long term after CAR-T cell therapy. Increasingly improved management of side effects, e.g., cytokine release syndrome (CRS) and neurotoxicity (immune effector cell-associated neurotoxicity syndrome, ICANS), by trained teams improves treatment safety. Bispecific antibodies are also targeted therapies that bind and activate CD3 effector T‑cells and assemble them into B‑cell antigens in the sense of an immunological synapse, resulting in cell-dependent cytotoxicity. Some of these drugs are also approved for aggressive and some for indolent B‑cell non-Hodgkin lymphoma; they are available off the shelf and can also be used in particular for older and less fit patients.Conclusion: Both treatment options have significantly improved the prognosis of patients with lymphoma and generally have lower toxicities.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":"490-499"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Radiotherapy of non-Hodgkin lymphoma-discussion of modern treatment concepts and innovations]. 【非霍奇金淋巴瘤的放疗——现代治疗理念与创新探讨】。

Radiologie (Heidelberg, Germany) Pub Date : 2025-07-01 DOI: 10.1007/s00117-025-01477-3

Michael Oertel, Hans Theodor Eich

{"title":"[Radiotherapy of non-Hodgkin lymphoma-discussion of modern treatment concepts and innovations].","authors":"Michael Oertel, Hans Theodor Eich","doi":"10.1007/s00117-025-01477-3","DOIUrl":"10.1007/s00117-025-01477-3","url":null,"abstract":"Background: Radiotherapy is an established treatment modality for malignant non-Hodgkin lymphoma. However, the complexity of the treatment situations demands precise treatment indication and execution. The following review presents modern radiooncological treatment strategies.Materials and methods: A selective literature search addressing radiotherapy of malignant non-Hodgkin lymphoma was conducted, focusing on diffuse large B‑cell lymphoma, marginal zone lymphoma, and follicular lymphoma. Relevant studies as well as the German national S3 guidelines were identified and discussed.Results: Indolent lymphoma in early stages can be treated with radiotherapy in curative intent. In carefully selected cases, dose de-escalation may be possible, although it is not recommended by the German S3 guideline. In the case of aggressive non-Hodgkin lymphoma, consolidation radiotherapy is conducted after systemic therapy, addressing regions with an increased risk of recurrence. Particularly patients with positron-emission tomography (PET)-positive residuals should be irradiated. Innovations like the application of radiotherapy before or after chimeric antigen receptor T‑cell therapy and the emerging implementation of online adaptive radiotherapy will enrich the therapeutic landscape in the future.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":"518-524"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0