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[Quantification of Ki-67 in PitNET (pituitary neuroendocrine tumors)/adenomas]. [PitNET（垂体神经内分泌肿瘤）/腺瘤中 Ki-67 的定量]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-07-11 DOI: 10.1007/s00292-024-01319-4
Judith Klein, Kai Saeger, Wolfgang Saeger
{"title":"[Quantification of Ki-67 in PitNET (pituitary neuroendocrine tumors)/adenomas].","authors":"Judith Klein, Kai Saeger, Wolfgang Saeger","doi":"10.1007/s00292-024-01319-4","DOIUrl":"10.1007/s00292-024-01319-4","url":null,"abstract":"<p><p>This study is the first to compare the determination of the Ki-67 index in pituitary neuroendocrine tumors (PitNET)/pituitary adenomas by pathologists with a computerized method (Cognition MasterSuite from VMScope, Berlin, Germany). PitNET/pituitary adenomas often show a low proliferation index. Observer variability is high, especially when estimating in this low percentage range. A more reliable determination would be possible using the four-eyes principle, but this cannot be realized continuously; thus, digital image analysis is a promising solution. In the study, there was clear agreement between the Ki-67 estimate by two experienced pathologists and the determination with the aid of digital image analysis. The digital image analysis system is excellent for determining the proliferation rate of PitNET/pituitary adenomas and can therefore be used to determine the \"third\" and \"fourth eye\".</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"339-343"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11343892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mesothelioma-30 years after the asbestos ban in Germany]. [德国禁止使用石棉 30 年后的间皮瘤]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-07-31 DOI: 10.1007/s00292-024-01350-5
T Kraus, D Jonigk
{"title":"[Mesothelioma-30 years after the asbestos ban in Germany].","authors":"T Kraus, D Jonigk","doi":"10.1007/s00292-024-01350-5","DOIUrl":"10.1007/s00292-024-01350-5","url":null,"abstract":"<p><p>In 1993, a total asbestos ban was introduced in Germany. Thirty years later, mesothelioma is still one of the most frequent occupational diseases. Recent data on incidence, mortality, recognized occupational diseases, early detection, and assessment are presented in this article.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"305-308"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mesotheliomas-current status in etiology, diagnostics, and molecular pathology]. [间皮瘤--病因学、诊断学和分子病理学现状]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-08-23 DOI: 10.1007/s00292-024-01348-z
Andrea Tannapfel, Iris Tischoff
{"title":"[Mesotheliomas-current status in etiology, diagnostics, and molecular pathology].","authors":"Andrea Tannapfel, Iris Tischoff","doi":"10.1007/s00292-024-01348-z","DOIUrl":"https://doi.org/10.1007/s00292-024-01348-z","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":"45 5","pages":"303-304"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Benign mesothelial tumors]. [良性间皮瘤]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-05-02 DOI: 10.1007/s00292-024-01333-6
Iris Tischoff, Anja Theile
{"title":"[Benign mesothelial tumors].","authors":"Iris Tischoff, Anja Theile","doi":"10.1007/s00292-024-01333-6","DOIUrl":"10.1007/s00292-024-01333-6","url":null,"abstract":"<p><p>Benign mesothelial tumors are rarer than malignant mesotheliomas and are often found in the peritoneum as incidental findings in women. They include the adenomatoid tumor (AT), the well-differentiated mesothelial tumor (WDPMT), the mesothelioma in situ (MIS), and the solid papillary mesothelial tumor (SPMT). ATs are always benign and predominantly manifest in the genital tract. WDPMTs can develop multifocally and are prone to recurrence, particularly in the case of incomplete resection. Only MISs are considered a confirmed precursor lesion of malignant mesothelioma according to the currently valid World Health Organization (WHO) classifications. As with malignant mesothelioma, alterations of BAP1, MTAP, and p16 are detectable for MIS in contrast to the other three tumors. SPMTs cannot be clearly assigned to the other mesothelial tumors and have so far only been described in the peritoneum in women with a benign course.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"324-332"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesothelioma: molecular pathology and biomarkers. 间皮瘤：分子病理学和生物标志物。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-08-07 DOI: 10.1007/s00292-024-01344-3
Yin P Hung
{"title":"Mesothelioma: molecular pathology and biomarkers.","authors":"Yin P Hung","doi":"10.1007/s00292-024-01344-3","DOIUrl":"10.1007/s00292-024-01344-3","url":null,"abstract":"<p><p>Diffuse mesotheliomas are characterized by recurrent genomic alterations involving tumor suppressors and epigenetic regulators such as BAP1, CDKN2A, MTAP, and NF2. Depending on the differential diagnosis as informed by histologic assessment, one can apply the appropriate immunohistochemical and/or molecular panels to reach the correct pathologic diagnosis, sometimes even in cases with limited tissues. Biomarkers aid in the diagnosis of mesothelioma in the following scenarios: 1) For a tumor that is overtly malignant, how can one distinguish mesothelioma from other tumors? 2) For a mesothelial proliferation, how can one distinguish mesothelioma from a reactive process? To distinguish mesotheliomas from carcinomas, at least two positive and two negative markers are currently recommended. To distinguish sarcomatoid mesothelioma from pleomorphic carcinoma, even more markers-and sometimes molecular testing-are needed. To distinguish mesothelioma from reactive mesothelial conditions, useful immunohistochemical biomarkers include BAP1, MTAP, and merlin, which serve as surrogates for the corresponding gene mutation status. In patients with unusual clinical history, for tumors with a peculiar microscopic appearance, and/or in cases with an equivocal immunophenotypic profile, molecular testing can help to exclude mimics and to confirm the pathologic diagnosis.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"316-323"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[HSVN - hepatic small vessel neoplasm]. [HSVN - 肝小血管肿瘤]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-08-14 DOI: 10.1007/s00292-024-01349-y
Su Ir Lyu, Jörn Meinel, Uta Drebber
{"title":"[HSVN - hepatic small vessel neoplasm].","authors":"Su Ir Lyu, Jörn Meinel, Uta Drebber","doi":"10.1007/s00292-024-01349-y","DOIUrl":"https://doi.org/10.1007/s00292-024-01349-y","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cystic granulomatous lymphadenitis]. [囊性肉芽肿性淋巴结炎]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-07-01 Epub Date: 2024-03-08 DOI: 10.1007/s00292-024-01316-7
Michaela Seyfarth, Ivan De la Peña Thevenet, Birgit Bassaly, Martin A Schneider, Stefan Gattenlöhner
{"title":"[Cystic granulomatous lymphadenitis].","authors":"Michaela Seyfarth, Ivan De la Peña Thevenet, Birgit Bassaly, Martin A Schneider, Stefan Gattenlöhner","doi":"10.1007/s00292-024-01316-7","DOIUrl":"10.1007/s00292-024-01316-7","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"237-238"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Renal pathology]. [肾脏病理学］
Pathologie (Heidelberg, Germany) Pub Date : 2024-07-01 Epub Date: 2024-06-25 DOI: 10.1007/s00292-024-01337-2
Kerstin Amann
{"title":"[Renal pathology].","authors":"Kerstin Amann","doi":"10.1007/s00292-024-01337-2","DOIUrl":"https://doi.org/10.1007/s00292-024-01337-2","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":"45 4","pages":"239-240"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Renal involvement in systemic diseases]. [全身性疾病中的肾脏受累]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.1007/s00292-024-01338-1
Renate Kain
{"title":"[Renal involvement in systemic diseases].","authors":"Renate Kain","doi":"10.1007/s00292-024-01338-1","DOIUrl":"10.1007/s00292-024-01338-1","url":null,"abstract":"<p><strong>Background: </strong>Diseases of the nonneoplastic renal parenchyma occur in the context of a number of disorders that affect the organism systemically and can thus represent a differential diagnosis for autoimmunological kidney diseases.</p><p><strong>Purpose: </strong>Two common autoimmunologic diseases of the kidney, namely antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and systemic lupus erythematosus (SLE), are presented and put into context of the broader field of renal diseases. Novel diagnostic and therapeutic approaches are discussed.</p><p><strong>Materials and methods: </strong>A review of the recent literature and an overview of the disease presentation are provided.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"261-268"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Lynch syndrome]. [林奇综合征］
Pathologie (Heidelberg, Germany) Pub Date : 2024-07-01 Epub Date: 2024-06-12 DOI: 10.1007/s00292-024-01339-0
Verena Steinke-Lange, Elke Holinski-Feder
{"title":"[Lynch syndrome].","authors":"Verena Steinke-Lange, Elke Holinski-Feder","doi":"10.1007/s00292-024-01339-0","DOIUrl":"10.1007/s00292-024-01339-0","url":null,"abstract":"<p><p>Patients with Lynch syndrome, one of the most common hereditary tumor predisposition syndromes, harbor an increased risk for a broad spectrum of especially gastrointestinal and gynecological tumors. Causative for the syndrome are variants in DNA mismatch repair genes, which are passed on to the offspring at a 50% chance (autosomal dominant inheritance). The tumor tissue of these patients usually shows microsatellite instability, which is of increasing relevance regarding prognosis and therapeutic decisions. The detection of a causative genetic variant in a patient enables predictive testing of family members to provide relief to noncarriers and provide carriers with intensified risk-adapted surveillance. In addition, chemoprevention with aspirin (acetylsalicylic acid) has been proven useful for chemoprevention in studies. Therefore, the diagnosis of Lynch syndrome is important for patients and their relatives.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"290-299"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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