Pathologie (Heidelberg, Germany)最新文献_第10页

Dank an die Gutachter*innen von Die Pathologie. 感谢《病理学》杂志的审稿人。

Pathologie (Heidelberg, Germany) Pub Date : 2024-01-03 DOI: 10.1007/s00292-023-01293-3

引用次数: 0

[Lethal lymphocytic myocarditis-an underestimated diagnosis in infancy and childhood?] 致死性淋巴细胞性心肌炎——婴儿期和儿童期被低估的诊断?］

Pathologie (Heidelberg, Germany) Pub Date : 2023-12-01 Epub Date: 2023-11-21 DOI: 10.1007/s00292-023-01279-1

R Dettmeyer

{"title":"[Lethal lymphocytic myocarditis-an underestimated diagnosis in infancy and childhood?]","authors":"R Dettmeyer","doi":"10.1007/s00292-023-01279-1","DOIUrl":"10.1007/s00292-023-01279-1","url":null,"abstract":"In the past, histological diagnosis of (post-)viral myocarditis was based on the so-called Dallas criteria, which have been criticized because of high interobserver variability and sampling error. Immunohistochemical qualification and quantification of interstitial intramyocardial leucocytes was established and standard values concerning adults were published. Fatal casualties due to a viral myocarditis are rare as far as babies and children are concerned (sudden unexpected death in infancy; SUDI). Cases of sudden unexpected death in the first year of life are frequently regarded as sudden infant death syndrome (SIDS). To diagnose myocarditis when there are only single focal lymphocytic infiltrates in the myocardium, the number of samples taken by autopsy is relevant. But even in babies, immunohistochemical qualification and quantification of interstitial lymphocytes and macrophages can lead to standard values allowing diagnosis of myocarditis. Depending on the course of a viral infection, molecular pathological detection of viral genome in the myocardium is possible to support the diagnosis. Using the mentioned methods gradually, there are more cases of suspected SIDS, which are in fact cases of virus-induced myocarditis as cause of death. Primary enteroviruses (coxsackie viruses) and adenoviruses were found but also Epstein-Barr virus and PVB-19.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"198-203"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138178193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Report of the Gynecological and Breast Pathology Working Group of the German Society for Pathology]. [德国病理学会妇科和乳腺病理工作组报告]。

Pathologie (Heidelberg, Germany) Pub Date : 2023-12-01 Epub Date: 2023-11-22 DOI: 10.1007/s00292-023-01255-9

Eike Burandt, Ramona Erber

引用次数: 0

[Zoonoses in endemic, free-ranging mammals]. [在地方性的、自由放养的哺乳动物中的人畜共患病]。

Pathologie (Heidelberg, Germany) Pub Date : 2023-12-01 Epub Date: 2023-11-21 DOI: 10.1007/s00292-023-01270-w

Reiner Ulrich

{"title":"[Zoonoses in endemic, free-ranging mammals].","authors":"Reiner Ulrich","doi":"10.1007/s00292-023-01270-w","DOIUrl":"10.1007/s00292-023-01270-w","url":null,"abstract":"Background: Zoonoses are diseases and infections that can be transmitted naturally between animals and humans. Direct and indirect contact of humans with wildlife occur during hunting activities, when diseased wildlife is found and treated, and in shared fields, forests, parks, gardens, and homes. Zoonoses can only be understood and controlled when ecosystems, animals, and humans are considered holistically.Objective: This paper presents important zoonotic pathogens that are currently present in wild mammals as reservoirs in Germany.Material and methods: The literature was searched to determine the prevalence of zoonotic pathogens currently occurring in wild mammals.Results: Viral zoonotic agents currently present in free-ranging, mammalian animals in Germany as reservoirs of natural origin are bornaviruses, lyssaviruses, hepatitis E virus genotype 3, and Puumala orthohantavirus. Bacterial zoonotic agents beyond typical wound and foodborne pathogens include Brucella suis Biovar 2, Francisella tularensis ssp. holarctica, Leptospira interrogans sensu latu, Mycobacterium caprae, and Yersinia pseudotuberculosis. In particular, parasitic zoonotic agents common in wildlife are Alaria alata, Baylisascaris procyonis, Echinococcus multilocularis, Sacoptes scabei, and Trichinella spp.Conclusion: The presence of zoonotic infectious agents of risk groups 2 and 3 has to be regularly expected in numerous endemic wildlife species, especially canines, small bears, rodents, insectivores, and bats. Animal caretakers, hunters, veterinarians, and human health professionals should be aware of this risk and take protective measures appropriate to the situation.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"208-214"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138178208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[William A. Meier-Ruge : 28 July 1930-09 April 2020]. 【William A.Meier Ruge：1937月28日至2020年4月9日】。

Pathologie (Heidelberg, Germany) Pub Date : 2023-12-01 Epub Date: 2023-09-22 DOI: 10.1007/s00292-023-01217-1

Michael Mihatsch

引用次数: 0

[Report of the Uropathology Working Group of the German Society for Pathology]. [德国病理学学会泌尿病理学工作组的报告]。

Pathologie (Heidelberg, Germany) Pub Date : 2023-12-01 Epub Date: 2023-11-07 DOI: 10.1007/s00292-023-01244-y

Felix Bremmer, Henning Reis

引用次数: 0

Using proteomics for stratification and risk prediction in patients with solid tumors. 利用蛋白质组学对实体瘤患者进行分层和风险预测。

Pathologie (Heidelberg, Germany) Pub Date : 2023-12-01 Epub Date: 2023-11-24 DOI: 10.1007/s00292-023-01261-x

Tilman Werner, Matthias Fahrner, Oliver Schilling

{"title":"Using proteomics for stratification and risk prediction in patients with solid tumors.","authors":"Tilman Werner, Matthias Fahrner, Oliver Schilling","doi":"10.1007/s00292-023-01261-x","DOIUrl":"10.1007/s00292-023-01261-x","url":null,"abstract":"Proteomics, the study of proteins and their functions, has greatly evolved due to advances in analytical chemistry and computational biology. Unlike genomics or transcriptomics, proteomics captures the dynamic and diverse nature of proteins, which play crucial roles in cellular processes. This is exemplified in cancer, where genomic and transcriptomic information often falls short in reflecting actual protein expression and interactions. Liquid chromatography-mass spectrometry (LC-MS) is pivotal in proteomic data generation, enabling high-throughput analysis of protein samples. The MS-based workflow involves protein digestion, chromatographic separation, ionization, and fragmentation, leading to peptide identification and quantification. Computational biostatistics, particularly using tools in R (R Foundation for Statistical Computing, Vienna, Austria; www.R-project.org ), aid in data analysis, revealing protein expression patterns and correlations with clinical variables. Proteomic studies can be explorative, aiming to characterize entire proteomes, or targeted, focusing on specific proteins of interest. The integration of proteomics with genomics addresses database limitations and enhances peptide identification. Case studies in intrahepatic cholangiocarcinoma, glioblastoma multiforme, and pancreatic ductal adenocarcinoma highlight proteomics' clinical applications, from subtyping cancers to identifying diagnostic markers. Moreover, proteomic data augment molecular tumor boards by providing deeper insights into pathway activities and genomic mutations, supporting personalized treatment decisions. Overall, proteomics contributes significantly to advancing our understanding of cellular biology and improving clinical care.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"176-182"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138300727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wilko Weichert : 22.09.1970–10.07.2023. Wilko Weichert : 22.09.1970-10.07.2023.

Pathologie (Heidelberg, Germany) Pub Date : 2023-12-01 Epub Date: 2023-11-21 DOI: 10.1007/s00292-023-01263-9

Manfred Dietel, Peter Schirmacher, Carolin Mogler

引用次数: 0

[Review of the 106th annual meeting of the DGP]. [总干事第 106 次年会回顾]。

Pathologie (Heidelberg, Germany) Pub Date : 2023-12-01 Epub Date: 2023-12-21 DOI: 10.1007/s00292-023-01273-7

Beatrix Zeller

引用次数: 0

[Report of the Hematopathology Working Group of the German Society for Pathology]. [德国病理学会血液病工作组报告]。

Pathologie (Heidelberg, Germany) Pub Date : 2023-12-01 Epub Date: 2023-10-24 DOI: 10.1007/s00292-023-01243-z

German Ott

引用次数: 0