Pathologie (Heidelberg, Germany)最新文献_第10页

[Challenges of cytopathological pancreas diagnostics]. [胰腺细胞病理学诊断的挑战]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2023-12-05 DOI: 10.1007/s00292-023-01277-3

Martin Schramm, Christina Neppl

{"title":"[Challenges of cytopathological pancreas diagnostics].","authors":"Martin Schramm, Christina Neppl","doi":"10.1007/s00292-023-01277-3","DOIUrl":"10.1007/s00292-023-01277-3","url":null,"abstract":"The cytologic diagnostics of solid and cystic pancreatic lesions with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is an integral part of the clinical workup and the decision of a surgical versus a conservative approach. Cystic lesions are increasingly being diagnosed due to improved imaging and represent numerous neoplastic as well as non-neoplastic epithelial and non-epithelial entities, which differ in biological behavior and prognosis. In particular, the differentiation of mucinous and non-mucinous cysts is significant for further clinical management. Regressive cellular changes, gastrointestinal contaminants, and overlapping morphologic changes of reactively altered ductal epithelial cells and cells of well-differentiated neoplasms and preneoplasms are special challenges of cytological diagnostics. For a uniform cytological classification of findings, an internationally developed seven-level classification system has been published and co-published by the World Health Organization (WHO). This classification system takes into account both morphological findings and further procedures on cytological material such as next-generation sequencing and immunocytochemistry and is based on the WHO classification for pancreatic tumors. Against this background, important cytologic diagnostic criteria of various solid and cystic lesions relevant in clinical practice are presented in this article, considering diagnostic possibilities and pitfalls as well as differential diagnoses.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"19-27"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138489299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Awards in pathology-a man's world?] 【悲情奖——男人的世界？】

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2023-10-20 DOI: 10.1007/s00292-023-01239-9

Elisa Malik, Thorsten Halling, Annegret Dreher, Chantal Marazia, Irene Esposito, Adrian Loerbroks, Nils Hansson

{"title":"[Awards in pathology-a man's world?]","authors":"Elisa Malik, Thorsten Halling, Annegret Dreher, Chantal Marazia, Irene Esposito, Adrian Loerbroks, Nils Hansson","doi":"10.1007/s00292-023-01239-9","DOIUrl":"10.1007/s00292-023-01239-9","url":null,"abstract":"Background: Awards provide their recipients with fame and recognition, and subsequently facilitate publications and acquisition of external funding through increased visibility. We hypothesize that despite increasing representation in pathology, women are underrepresented as awardees in the German Society of Pathology and consequently there is an associated imbalance between genders.Material and methods: Published data from the German Society of Pathology on female awardees during the period from 2000 to 2022 were examined. Only awards specifically dedicated to the field of pathology were considered. In addition, the publicly available data of the German Medical Association on gender and age distribution of pathologists in Germany were considered as reference material.Results: A total of six different awards were included in the analysis. Among the 143 awardees across 150 individual awards in the period from 2000 to 2022, 55 (38.4%) of the awardees were female compared to an average percentage of 31% of women working in the field of pathology in the 23-year period under consideration. Consequently, female awardees in pathology were not underrepresented when compared to the national figures on the proportion of women in the field of pathology. However, the distribution of female awardees across individual awards suggests that women were increasingly represented in less prestigious research and doctoral awards, while men made up a large proportion of awardees of honorary awards (0% women) and prestigious awards (17% women).","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10827953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Multiple neuroendocrine tumors of the pancreas]. [胰腺多发性神经内分泌肿瘤]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2024-01-05 DOI: 10.1007/s00292-023-01289-z

Bence Sipos

引用次数: 0

[Practical application of immunohistochemistry in pancreatic neuroendocrine neoplasms : Tips and pitfalls]. [免疫组化在胰腺神经内分泌肿瘤中的实际应用：技巧与陷阱]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2024-01-04 DOI: 10.1007/s00292-023-01276-4

Konstantin Bräutigam, Aziz Chouchane, Björn Konukiewitz, Aurel Perren

{"title":"[Practical application of immunohistochemistry in pancreatic neuroendocrine neoplasms : Tips and pitfalls].","authors":"Konstantin Bräutigam, Aziz Chouchane, Björn Konukiewitz, Aurel Perren","doi":"10.1007/s00292-023-01276-4","DOIUrl":"10.1007/s00292-023-01276-4","url":null,"abstract":"Pancreatic neuroendocrine neoplasms (PanNEN) are rather rare entities. Morphology, combined with immunohistochemistry, allows typing and grading, thereby leading therapeutic decisions. Depending on tumor stage and differential diagnosis, a broad diagnostic panel may be required. The present work summarizes the minimal diagnostic, prognostic, and predictive markers in PanNEN.Markers of choice for defining a neuroendocrine phenotype are synaptophysin, chromogranin A, and INSM1. The proliferation fraction Ki67 is indispensable for grading, while p53 and Rb1 can help in the differentiation from neuroendocrine carcinoma (NEC). Transcription factors, such as cdx2, TTF‑1, and Islet‑1, can indicate the site of a primary tumor in the setting of a cancer of unknown primary (CUP). DAXX/ATRX immunohistochemistry has mainly prognostic value. Molecular pathology studies currently have little practical value in the diagnosis of PanNEN.An important pitfall in routine diagnostics is the wide spectrum of differential diagnoses mimicking neuroendocrine neoplasms. An expanded immunohistochemical panel is strongly recommended in case of doubt.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"35-41"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10827836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitteilungen der Österreichischen Gesellschaft für Klinische Pathologie und Molekularpathologie. Mitteilungen der Österreichischen Gesellschaft für Klinische Pathologie und Molekularpathologie.

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 DOI: 10.1007/s00292-023-01292-4

引用次数: 0

[Sharply defined ulcerations of the colon excluding the terminal ileum]. [明确定义的结肠溃疡，不包括末端回肠]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2023-10-20 DOI: 10.1007/s00292-023-01240-2

Mirjam Forberger, Lena Seidemann, Henning Trawinski, Hendrik Bläker, Maximilian von Laffert

引用次数: 0

Dank an die Gutachter*innen von Die Pathologie. 感谢《病理学》杂志的审稿人。

Pathologie (Heidelberg, Germany) Pub Date : 2024-01-03 DOI: 10.1007/s00292-023-01293-3

引用次数: 0

[Lethal lymphocytic myocarditis-an underestimated diagnosis in infancy and childhood?] 致死性淋巴细胞性心肌炎——婴儿期和儿童期被低估的诊断?］

Pathologie (Heidelberg, Germany) Pub Date : 2023-12-01 Epub Date: 2023-11-21 DOI: 10.1007/s00292-023-01279-1

R Dettmeyer

{"title":"[Lethal lymphocytic myocarditis-an underestimated diagnosis in infancy and childhood?]","authors":"R Dettmeyer","doi":"10.1007/s00292-023-01279-1","DOIUrl":"10.1007/s00292-023-01279-1","url":null,"abstract":"In the past, histological diagnosis of (post-)viral myocarditis was based on the so-called Dallas criteria, which have been criticized because of high interobserver variability and sampling error. Immunohistochemical qualification and quantification of interstitial intramyocardial leucocytes was established and standard values concerning adults were published. Fatal casualties due to a viral myocarditis are rare as far as babies and children are concerned (sudden unexpected death in infancy; SUDI). Cases of sudden unexpected death in the first year of life are frequently regarded as sudden infant death syndrome (SIDS). To diagnose myocarditis when there are only single focal lymphocytic infiltrates in the myocardium, the number of samples taken by autopsy is relevant. But even in babies, immunohistochemical qualification and quantification of interstitial lymphocytes and macrophages can lead to standard values allowing diagnosis of myocarditis. Depending on the course of a viral infection, molecular pathological detection of viral genome in the myocardium is possible to support the diagnosis. Using the mentioned methods gradually, there are more cases of suspected SIDS, which are in fact cases of virus-induced myocarditis as cause of death. Primary enteroviruses (coxsackie viruses) and adenoviruses were found but also Epstein-Barr virus and PVB-19.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"198-203"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138178193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Report of the Gynecological and Breast Pathology Working Group of the German Society for Pathology]. [德国病理学会妇科和乳腺病理工作组报告]。

Pathologie (Heidelberg, Germany) Pub Date : 2023-12-01 Epub Date: 2023-11-22 DOI: 10.1007/s00292-023-01255-9

Eike Burandt, Ramona Erber

引用次数: 0

[Zoonoses in endemic, free-ranging mammals]. [在地方性的、自由放养的哺乳动物中的人畜共患病]。

Pathologie (Heidelberg, Germany) Pub Date : 2023-12-01 Epub Date: 2023-11-21 DOI: 10.1007/s00292-023-01270-w

Reiner Ulrich

{"title":"[Zoonoses in endemic, free-ranging mammals].","authors":"Reiner Ulrich","doi":"10.1007/s00292-023-01270-w","DOIUrl":"10.1007/s00292-023-01270-w","url":null,"abstract":"Background: Zoonoses are diseases and infections that can be transmitted naturally between animals and humans. Direct and indirect contact of humans with wildlife occur during hunting activities, when diseased wildlife is found and treated, and in shared fields, forests, parks, gardens, and homes. Zoonoses can only be understood and controlled when ecosystems, animals, and humans are considered holistically.Objective: This paper presents important zoonotic pathogens that are currently present in wild mammals as reservoirs in Germany.Material and methods: The literature was searched to determine the prevalence of zoonotic pathogens currently occurring in wild mammals.Results: Viral zoonotic agents currently present in free-ranging, mammalian animals in Germany as reservoirs of natural origin are bornaviruses, lyssaviruses, hepatitis E virus genotype 3, and Puumala orthohantavirus. Bacterial zoonotic agents beyond typical wound and foodborne pathogens include Brucella suis Biovar 2, Francisella tularensis ssp. holarctica, Leptospira interrogans sensu latu, Mycobacterium caprae, and Yersinia pseudotuberculosis. In particular, parasitic zoonotic agents common in wildlife are Alaria alata, Baylisascaris procyonis, Echinococcus multilocularis, Sacoptes scabei, and Trichinella spp.Conclusion: The presence of zoonotic infectious agents of risk groups 2 and 3 has to be regularly expected in numerous endemic wildlife species, especially canines, small bears, rodents, insectivores, and bats. Animal caretakers, hunters, veterinarians, and human health professionals should be aware of this risk and take protective measures appropriate to the situation.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"208-214"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138178208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0