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Pathologie (Heidelberg, Germany)最新文献

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[Benign mesothelial tumors]. [良性间皮瘤]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-05-02 DOI: 10.1007/s00292-024-01333-6
Iris Tischoff, Anja Theile
{"title":"[Benign mesothelial tumors].","authors":"Iris Tischoff, Anja Theile","doi":"10.1007/s00292-024-01333-6","DOIUrl":"10.1007/s00292-024-01333-6","url":null,"abstract":"<p><p>Benign mesothelial tumors are rarer than malignant mesotheliomas and are often found in the peritoneum as incidental findings in women. They include the adenomatoid tumor (AT), the well-differentiated mesothelial tumor (WDPMT), the mesothelioma in situ (MIS), and the solid papillary mesothelial tumor (SPMT). ATs are always benign and predominantly manifest in the genital tract. WDPMTs can develop multifocally and are prone to recurrence, particularly in the case of incomplete resection. Only MISs are considered a confirmed precursor lesion of malignant mesothelioma according to the currently valid World Health Organization (WHO) classifications. As with malignant mesothelioma, alterations of BAP1, MTAP, and p16 are detectable for MIS in contrast to the other three tumors. SPMTs cannot be clearly assigned to the other mesothelial tumors and have so far only been described in the peritoneum in women with a benign course.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"324-332"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesothelioma: molecular pathology and biomarkers. 间皮瘤：分子病理学和生物标志物。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-08-07 DOI: 10.1007/s00292-024-01344-3
Yin P Hung
{"title":"Mesothelioma: molecular pathology and biomarkers.","authors":"Yin P Hung","doi":"10.1007/s00292-024-01344-3","DOIUrl":"10.1007/s00292-024-01344-3","url":null,"abstract":"<p><p>Diffuse mesotheliomas are characterized by recurrent genomic alterations involving tumor suppressors and epigenetic regulators such as BAP1, CDKN2A, MTAP, and NF2. Depending on the differential diagnosis as informed by histologic assessment, one can apply the appropriate immunohistochemical and/or molecular panels to reach the correct pathologic diagnosis, sometimes even in cases with limited tissues. Biomarkers aid in the diagnosis of mesothelioma in the following scenarios: 1) For a tumor that is overtly malignant, how can one distinguish mesothelioma from other tumors? 2) For a mesothelial proliferation, how can one distinguish mesothelioma from a reactive process? To distinguish mesotheliomas from carcinomas, at least two positive and two negative markers are currently recommended. To distinguish sarcomatoid mesothelioma from pleomorphic carcinoma, even more markers-and sometimes molecular testing-are needed. To distinguish mesothelioma from reactive mesothelial conditions, useful immunohistochemical biomarkers include BAP1, MTAP, and merlin, which serve as surrogates for the corresponding gene mutation status. In patients with unusual clinical history, for tumors with a peculiar microscopic appearance, and/or in cases with an equivocal immunophenotypic profile, molecular testing can help to exclude mimics and to confirm the pathologic diagnosis.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"316-323"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cystic granulomatous lymphadenitis]. [囊性肉芽肿性淋巴结炎]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-07-01 Epub Date: 2024-03-08 DOI: 10.1007/s00292-024-01316-7
Michaela Seyfarth, Ivan De la Peña Thevenet, Birgit Bassaly, Martin A Schneider, Stefan Gattenlöhner
{"title":"[Cystic granulomatous lymphadenitis].","authors":"Michaela Seyfarth, Ivan De la Peña Thevenet, Birgit Bassaly, Martin A Schneider, Stefan Gattenlöhner","doi":"10.1007/s00292-024-01316-7","DOIUrl":"10.1007/s00292-024-01316-7","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"237-238"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Renal pathology]. [肾脏病理学］
Pathologie (Heidelberg, Germany) Pub Date : 2024-07-01 Epub Date: 2024-06-25 DOI: 10.1007/s00292-024-01337-2
Kerstin Amann
{"title":"[Renal pathology].","authors":"Kerstin Amann","doi":"10.1007/s00292-024-01337-2","DOIUrl":"https://doi.org/10.1007/s00292-024-01337-2","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":"45 4","pages":"239-240"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Renal involvement in systemic diseases]. [全身性疾病中的肾脏受累]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.1007/s00292-024-01338-1
Renate Kain
{"title":"[Renal involvement in systemic diseases].","authors":"Renate Kain","doi":"10.1007/s00292-024-01338-1","DOIUrl":"10.1007/s00292-024-01338-1","url":null,"abstract":"<p><strong>Background: </strong>Diseases of the nonneoplastic renal parenchyma occur in the context of a number of disorders that affect the organism systemically and can thus represent a differential diagnosis for autoimmunological kidney diseases.</p><p><strong>Purpose: </strong>Two common autoimmunologic diseases of the kidney, namely antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and systemic lupus erythematosus (SLE), are presented and put into context of the broader field of renal diseases. Novel diagnostic and therapeutic approaches are discussed.</p><p><strong>Materials and methods: </strong>A review of the recent literature and an overview of the disease presentation are provided.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"261-268"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Lynch syndrome]. [林奇综合征］
Pathologie (Heidelberg, Germany) Pub Date : 2024-07-01 Epub Date: 2024-06-12 DOI: 10.1007/s00292-024-01339-0
Verena Steinke-Lange, Elke Holinski-Feder
{"title":"[Lynch syndrome].","authors":"Verena Steinke-Lange, Elke Holinski-Feder","doi":"10.1007/s00292-024-01339-0","DOIUrl":"10.1007/s00292-024-01339-0","url":null,"abstract":"<p><p>Patients with Lynch syndrome, one of the most common hereditary tumor predisposition syndromes, harbor an increased risk for a broad spectrum of especially gastrointestinal and gynecological tumors. Causative for the syndrome are variants in DNA mismatch repair genes, which are passed on to the offspring at a 50% chance (autosomal dominant inheritance). The tumor tissue of these patients usually shows microsatellite instability, which is of increasing relevance regarding prognosis and therapeutic decisions. The detection of a causative genetic variant in a patient enables predictive testing of family members to provide relief to noncarriers and provide carriers with intensified risk-adapted surveillance. In addition, chemoprevention with aspirin (acetylsalicylic acid) has been proven useful for chemoprevention in studies. Therefore, the diagnosis of Lynch syndrome is important for patients and their relatives.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"290-299"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Introduction to renal pathology]. [肾脏病理学入门]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-07-01 Epub Date: 2024-03-21 DOI: 10.1007/s00292-024-01310-z
Maike Büttner-Herold, Kerstin Amann
{"title":"[Introduction to renal pathology].","authors":"Maike Büttner-Herold, Kerstin Amann","doi":"10.1007/s00292-024-01310-z","DOIUrl":"10.1007/s00292-024-01310-z","url":null,"abstract":"<p><p>In recent decades, nephropathology has developed worldwide as a subspeciality of pathology, which requires special methodological and technical equipment to process the material and specific clinical and pathological expertise to interpret the findings. These special requirements mean that nephropathology is not available at all pathology institutes, but is carried out on a large scale in a few highly specialised centres. The history of nephropathology, or in a narrower sense the specialised histopathological examination of kidney biopsies, began in 1958 with the first use or performance of a kidney biopsy [1]. It thus replaced the practice of urinalysis, which had been common since the Middle Ages, as a diagnostic tool for kidney diseases. Specialised techniques such as immunofluorescence or immunohistology but also electron microscopy are required to assess specific renal changes, for which the examination of renal biopsies is one of the few remaining routine applications today. In Germany and German-speaking countries, the discipline developed thanks to the work of outstanding people in the field of pathology who were primarily involved in this discipline and had the necessary technical and human resources in their laboratories to ensure that these biopsies could be analysed.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"241-245"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitteilungen der Deutschen Gesellschaft für Pathologie. Mitteilungen der Deutschen Gesellschaft für Pathologie.
Pathologie (Heidelberg, Germany) Pub Date : 2024-05-01 DOI: 10.1007/s00292-024-01323-8
{"title":"Mitteilungen der Deutschen Gesellschaft für Pathologie.","authors":"","doi":"10.1007/s00292-024-01323-8","DOIUrl":"https://doi.org/10.1007/s00292-024-01323-8","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":"45 3","pages":"233-234"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Xanthogranulomatous adrenalitis : A rare and difficult differential diagnosis of adrenal gland tumors]. [黄疽性肾上腺炎：肾上腺肿瘤罕见且难以鉴别诊断的疾病]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-05-01 Epub Date: 2024-03-12 DOI: 10.1007/s00292-024-01312-x
Wolfgang Saeger, Andreas M Luebke, S T Mekoula, Jörg-Michael Pahnke
{"title":"[Xanthogranulomatous adrenalitis : A rare and difficult differential diagnosis of adrenal gland tumors].","authors":"Wolfgang Saeger, Andreas M Luebke, S T Mekoula, Jörg-Michael Pahnke","doi":"10.1007/s00292-024-01312-x","DOIUrl":"10.1007/s00292-024-01312-x","url":null,"abstract":"<p><p>A radiologically diagnosed tumor in a 29-year-old woman with a fever of around 39 °C was operated on under the suspicion of cholecystitis or a liver abscess. A solid tumor was found in the adrenal gland and resected. The frozen section findings did not reveal a clear diagnosis of entity and assignment. Histologically, the tumor was found to consist of densely clustered large histiocyte-like cells with expression of vimentin, CD68, and CD163 as well as negativity for keratin, langerin, and SMA. We diagnosed xanthogranulomatous adrenalitis and discussed the differential diagnoses (Langerhans cell histiocytosis, Rosai-Dorfman disease, malakoplakia, Erdheim-Chester disease).</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"218-222"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11045564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Fluorescence confocal microscopy-complete digitization of pathology]. [荧光共聚焦显微镜--病理学完全数字化]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-05-01 Epub Date: 2024-03-06 DOI: 10.1007/s00292-024-01311-y
Andreas G Loth, Anne Fassl, Felix K H Chun, Jens Köllermann, Sylvia Hartmann, Steffen Gretser, Paul K Ziegler, Nadine Flinner, Falko Schulze, Peter J Wild, Maximilian N Kinzler
{"title":"[Fluorescence confocal microscopy-complete digitization of pathology].","authors":"Andreas G Loth, Anne Fassl, Felix K H Chun, Jens Köllermann, Sylvia Hartmann, Steffen Gretser, Paul K Ziegler, Nadine Flinner, Falko Schulze, Peter J Wild, Maximilian N Kinzler","doi":"10.1007/s00292-024-01311-y","DOIUrl":"10.1007/s00292-024-01311-y","url":null,"abstract":"<p><strong>Background: </strong>Fluorescence-based confocal microscopy (FCM) can be used to create virtual H&E sections in real time. So far, FCM has been used in dermato-, uro-, and gynecopathology. FCM allows the creation of a completely digitized frozen section, which could potentially replace conventional frozen sections in the future.</p><p><strong>Objective: </strong>The aim of the current work is to implement FCM technology as a component of fully digitized processes in the pathological workflow. For this purpose, the current use of FCM in liver transplant pathology will be extended to other disciplines such as urology and otorhinolaryngology.</p><p><strong>Materials and methods: </strong>The FCM technique continues to be used prospectively on native tissue samples from potential donor livers. Conventional frozen sections are used comparatively to virtual FCM scans.</p><p><strong>Results: </strong>The data show a nearly perfect agreement for the detection of cholangitis, fibrosis, and malignancy, and a high level of agreement for, e.g., macrovesicular steatosis, inflammation, steatohepatitis, and necrosis between virtual FCM scans and conventional routine diagnostic frozen sections.</p><p><strong>Conclusion: </strong>Since the availability of time- and cost-intensive frozen section diagnostics in the context of transplant pathology in continuous operation (24/7) is now only established at very few university centers in Germany due to an increasing shortage of specialists, the use of FCM could be an important building block in the current process leading towards a fully digitized pathology workflow and should thus be extended to various disciplines.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"211-217"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11045597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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