Pathologie (Heidelberg, Germany)最新文献_第9页

[Histopathologic diagnosis of solid and cystic pancreatic lesions with a focus on ductal adenocarcinoma : A vademecum for daily practice]. [胰腺实性和囊性病变的组织病理学诊断，重点是导管腺癌：日常实践手册]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2024-01-08 DOI: 10.1007/s00292-023-01288-0

Irene Esposito, Aslihan Yavas, Lena Häberle

{"title":"[Histopathologic diagnosis of solid and cystic pancreatic lesions with a focus on ductal adenocarcinoma : A vademecum for daily practice].","authors":"Irene Esposito, Aslihan Yavas, Lena Häberle","doi":"10.1007/s00292-023-01288-0","DOIUrl":"10.1007/s00292-023-01288-0","url":null,"abstract":"Pancreas pathology is constantly evolving and can present various challenges for pathologists. This paper is focused on providing helpful hints for daily routine diagnostics. During histopathological analysis of pancreas biopsies, pancreatic ductal adenocarcinoma must be distinguished not only from other solid neoplasms, but especially from its mimicker, autoimmune pancreatitis. This can be achieved by a systematic workup following clear diagnostic criteria. When analyzing samples from cystic pancreatic lesions, mucin-producing neoplasms must be detected due to their role as pancreatic cancer precursors; molecular analyses can help considerably with their detection and distinction. During frozen section examination, evaluation of the pancreatic neck margin and analysis of unclear lesions of the liver are two important tasks, which are explained further in this article. A special challenge is the evaluation of neoadjuvant treated pancreatic cancer, which requires a detailed macroscopic and microscopic workup. Finally, current advances in precision oncology and emerging approaches for pancreatic cancer within this field are discussed. With the advancement of technical possibilities and their increasingly broad implementation, the classification systems in pancreatic pathology will continue to gain in complexity, but also in accuracy.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"5-18"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139405579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Standardized and quality-assured predictive PD-L1 testing in the upper gastrointestinal tract. German version]. [上消化道 PD-L1 预测性标准化和质量保证检测。德文版]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2024-01-03 DOI: 10.1007/s00292-023-01215-3

G Baretton, F Lordick, T Gaiser, R Hofheinz, D Horst, S Lorenzen, M Möhler, C Röcken, P Schirmacher, M Stahl, P Thuss-Patience, K Tiemann

{"title":"[Standardized and quality-assured predictive PD-L1 testing in the upper gastrointestinal tract. German version].","authors":"G Baretton, F Lordick, T Gaiser, R Hofheinz, D Horst, S Lorenzen, M Möhler, C Röcken, P Schirmacher, M Stahl, P Thuss-Patience, K Tiemann","doi":"10.1007/s00292-023-01215-3","DOIUrl":"10.1007/s00292-023-01215-3","url":null,"abstract":"As a result of the high approval dynamics and the growing number of immuno-oncological therapy concepts, the complexity of therapy decisions and control in the area of carcinomas of the esophagus, gastroesophageal junction and stomach is constantly increasing. Since the treatment indication for PD‑1 inhibitors that are currently approved in the European Union is often linked to the expression of PD-L1 (programmed cell death-ligand 1), the evaluation of tissue-based predictive markers by the pathologist is of crucial importance for treatment stratification. Even though the immunohistochemical analysis of the PD-L1 expression status is one of the best studied, therapy-relevant biomarkers for an immuno-oncological treatment, due to the high heterogeneity of carcinomas of the upper gastrointestinal tract, there are challenges in daily clinical diagnostic work with regard to implementation, standardization and interpretation of testing. An interdisciplinary group of experts from Germany has taken a position on relevant questions from daily pathological and clinical practice, which concern the starting material, quality-assured testing and the interpretation of pathological findings, and has developed recommendations for structured reporting.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"51-58"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10827825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Pancreatic pathology-the Prof. Günter Klöppel school]. [胰腺病理学--Günter Klöppel 教授学校]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2024-01-30 DOI: 10.1007/s00292-023-01290-6

Aurel Perren, Irene Esposito

引用次数: 0

Mitteilungen der Deutschen Gesellschaft für Pathologie. Mitteilungen der Deutschen Gesellschaft für Pathologie.

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 DOI: 10.1007/s00292-023-01296-0

引用次数: 0

[Challenges of cytopathological pancreas diagnostics]. [胰腺细胞病理学诊断的挑战]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2023-12-05 DOI: 10.1007/s00292-023-01277-3

Martin Schramm, Christina Neppl

{"title":"[Challenges of cytopathological pancreas diagnostics].","authors":"Martin Schramm, Christina Neppl","doi":"10.1007/s00292-023-01277-3","DOIUrl":"10.1007/s00292-023-01277-3","url":null,"abstract":"The cytologic diagnostics of solid and cystic pancreatic lesions with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is an integral part of the clinical workup and the decision of a surgical versus a conservative approach. Cystic lesions are increasingly being diagnosed due to improved imaging and represent numerous neoplastic as well as non-neoplastic epithelial and non-epithelial entities, which differ in biological behavior and prognosis. In particular, the differentiation of mucinous and non-mucinous cysts is significant for further clinical management. Regressive cellular changes, gastrointestinal contaminants, and overlapping morphologic changes of reactively altered ductal epithelial cells and cells of well-differentiated neoplasms and preneoplasms are special challenges of cytological diagnostics. For a uniform cytological classification of findings, an internationally developed seven-level classification system has been published and co-published by the World Health Organization (WHO). This classification system takes into account both morphological findings and further procedures on cytological material such as next-generation sequencing and immunocytochemistry and is based on the WHO classification for pancreatic tumors. Against this background, important cytologic diagnostic criteria of various solid and cystic lesions relevant in clinical practice are presented in this article, considering diagnostic possibilities and pitfalls as well as differential diagnoses.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"19-27"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138489299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Awards in pathology-a man's world?] 【悲情奖——男人的世界？】

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2023-10-20 DOI: 10.1007/s00292-023-01239-9

Elisa Malik, Thorsten Halling, Annegret Dreher, Chantal Marazia, Irene Esposito, Adrian Loerbroks, Nils Hansson

{"title":"[Awards in pathology-a man's world?]","authors":"Elisa Malik, Thorsten Halling, Annegret Dreher, Chantal Marazia, Irene Esposito, Adrian Loerbroks, Nils Hansson","doi":"10.1007/s00292-023-01239-9","DOIUrl":"10.1007/s00292-023-01239-9","url":null,"abstract":"Background: Awards provide their recipients with fame and recognition, and subsequently facilitate publications and acquisition of external funding through increased visibility. We hypothesize that despite increasing representation in pathology, women are underrepresented as awardees in the German Society of Pathology and consequently there is an associated imbalance between genders.Material and methods: Published data from the German Society of Pathology on female awardees during the period from 2000 to 2022 were examined. Only awards specifically dedicated to the field of pathology were considered. In addition, the publicly available data of the German Medical Association on gender and age distribution of pathologists in Germany were considered as reference material.Results: A total of six different awards were included in the analysis. Among the 143 awardees across 150 individual awards in the period from 2000 to 2022, 55 (38.4%) of the awardees were female compared to an average percentage of 31% of women working in the field of pathology in the 23-year period under consideration. Consequently, female awardees in pathology were not underrepresented when compared to the national figures on the proportion of women in the field of pathology. However, the distribution of female awardees across individual awards suggests that women were increasingly represented in less prestigious research and doctoral awards, while men made up a large proportion of awardees of honorary awards (0% women) and prestigious awards (17% women).","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10827953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Multiple neuroendocrine tumors of the pancreas]. [胰腺多发性神经内分泌肿瘤]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2024-01-05 DOI: 10.1007/s00292-023-01289-z

Bence Sipos

引用次数: 0

[Practical application of immunohistochemistry in pancreatic neuroendocrine neoplasms : Tips and pitfalls]. [免疫组化在胰腺神经内分泌肿瘤中的实际应用：技巧与陷阱]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2024-01-04 DOI: 10.1007/s00292-023-01276-4

Konstantin Bräutigam, Aziz Chouchane, Björn Konukiewitz, Aurel Perren

{"title":"[Practical application of immunohistochemistry in pancreatic neuroendocrine neoplasms : Tips and pitfalls].","authors":"Konstantin Bräutigam, Aziz Chouchane, Björn Konukiewitz, Aurel Perren","doi":"10.1007/s00292-023-01276-4","DOIUrl":"10.1007/s00292-023-01276-4","url":null,"abstract":"Pancreatic neuroendocrine neoplasms (PanNEN) are rather rare entities. Morphology, combined with immunohistochemistry, allows typing and grading, thereby leading therapeutic decisions. Depending on tumor stage and differential diagnosis, a broad diagnostic panel may be required. The present work summarizes the minimal diagnostic, prognostic, and predictive markers in PanNEN.Markers of choice for defining a neuroendocrine phenotype are synaptophysin, chromogranin A, and INSM1. The proliferation fraction Ki67 is indispensable for grading, while p53 and Rb1 can help in the differentiation from neuroendocrine carcinoma (NEC). Transcription factors, such as cdx2, TTF‑1, and Islet‑1, can indicate the site of a primary tumor in the setting of a cancer of unknown primary (CUP). DAXX/ATRX immunohistochemistry has mainly prognostic value. Molecular pathology studies currently have little practical value in the diagnosis of PanNEN.An important pitfall in routine diagnostics is the wide spectrum of differential diagnoses mimicking neuroendocrine neoplasms. An expanded immunohistochemical panel is strongly recommended in case of doubt.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"35-41"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10827836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitteilungen der Österreichischen Gesellschaft für Klinische Pathologie und Molekularpathologie. Mitteilungen der Österreichischen Gesellschaft für Klinische Pathologie und Molekularpathologie.

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 DOI: 10.1007/s00292-023-01292-4

引用次数: 0

[Sharply defined ulcerations of the colon excluding the terminal ileum]. [明确定义的结肠溃疡，不包括末端回肠]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2023-10-20 DOI: 10.1007/s00292-023-01240-2

Mirjam Forberger, Lena Seidemann, Henning Trawinski, Hendrik Bläker, Maximilian von Laffert

引用次数: 0