Pathologie (Heidelberg, Germany)最新文献_第9页

[Digital transformation of a routine histopathology lab : Dos and don'ts!] [常规组织病理学实验室的数字化转型：该做的和不该做的！]

Pathologie (Heidelberg, Germany) Pub Date : 2024-03-01 Epub Date: 2024-01-08 DOI: 10.1007/s00292-023-01291-5

Viola Iwuajoku, Anette Haas, Kübra Ekici, Mohammad Zaid Khan, Fabian Stögbauer, Katja Steiger, Carolin Mogler, Peter J Schüffler

{"title":"[Digital transformation of a routine histopathology lab : Dos and don'ts!]","authors":"Viola Iwuajoku, Anette Haas, Kübra Ekici, Mohammad Zaid Khan, Fabian Stögbauer, Katja Steiger, Carolin Mogler, Peter J Schüffler","doi":"10.1007/s00292-023-01291-5","DOIUrl":"10.1007/s00292-023-01291-5","url":null,"abstract":"The implementation of digital histopathology in the laboratory marks a crucial milestone in the overall digital transformation of pathology. This shift offers a range of new possibilities, including access to extensive datasets for AI-assisted analyses, the flexibility of remote work and home office arrangements for specialists, and the expedited and simplified sharing of images and data for research, conferences, and tumor boards. However, the transition to a fully digital workflow involves significant technological and personnel-related efforts. It necessitates careful and adaptable change management to minimize disruptions, particularly in the personnel domain, and to prevent the loss of valuable potential from employees who may be resistant to change. This article consolidates our institute's experiences, highlighting technical and personnel-related challenges encountered during the transition to digital pathology. It also presents a comprehensive overview of potential difficulties at various interfaces when converting routine operations to a digital workflow.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"98-105"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10902067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Advances in computational quantitative nephropathology]. [计算定量肾病理学的进展]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-03-01 Epub Date: 2024-02-02 DOI: 10.1007/s00292-024-01300-1

Roman D Bülow, Patrick Droste, Peter Boor

{"title":"[Advances in computational quantitative nephropathology].","authors":"Roman D Bülow, Patrick Droste, Peter Boor","doi":"10.1007/s00292-024-01300-1","DOIUrl":"10.1007/s00292-024-01300-1","url":null,"abstract":"Background: Semiquantitative histological scoring systems are frequently used in nephropathology. In computational nephropathology, the focus is on generating quantitative data from histology (so-called pathomics). Several recent studies have collected such data using next-generation morphometry (NGM) based on segmentations by artificial neural networks and investigated their usability for various clinical or diagnostic purposes.Aim: To present an overview of the current state of studies regarding renal pathomics and to identify current challenges and potential solutions.Materials and methods: Due to the literature restriction (maximum of 30 references), studies were selected based on a database search that processed as much data as possible, used innovative methodologies, and/or were ideally multicentric in design.Results and discussion: Pathomics studies in the kidney have impressively demonstrated that morphometric data are useful clinically (for example, for prognosis assessment) and translationally. Further development of NGM requires overcoming some challenges, including better standardization and generation of prospective evidence.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"140-145"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139673813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Fundamentals in the pathology of testicular tumours]. [睾丸肿瘤病理学基础]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2024-01-24 DOI: 10.1007/s00292-023-01294-2

Alexander Fichtner, Felix Bremmer

引用次数: 0

[The biomarker POLE in tumor pathology]. [肿瘤病理学中的生物标志物 POLE]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2023-12-05 DOI: 10.1007/s00292-023-01284-4

Ulrich Lehmann, Albrecht Stenzinger

引用次数: 0

DKK 2024: „Gemeinsam für die beste Versorgung unserer Patient*innen“ : Interview mit Prof. Dr. Reinhard Büttner, Köln, Kongresspräsident des DKK 2024. d2024:“共同努力，确保患者得到最佳营养。”:科隆里德博士，d2024会议主席赖因哈特•布顿纳教授的采访。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 DOI: 10.1007/s00292-023-01287-1

Reinhard Büttner

引用次数: 0

[Exocrine meets neuroendocrine: mimickers of pancreatic neuroendocrine neoplasms]. [外分泌与神经内分泌：胰腺神经内分泌肿瘤的模仿者]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2023-12-13 DOI: 10.1007/s00292-023-01286-2

Eva Karamitopoulou-Diamantis

{"title":"[Exocrine meets neuroendocrine: mimickers of pancreatic neuroendocrine neoplasms].","authors":"Eva Karamitopoulou-Diamantis","doi":"10.1007/s00292-023-01286-2","DOIUrl":"10.1007/s00292-023-01286-2","url":null,"abstract":"Neuroendocrine neoplasms (NENs) originate from various epithelial or neuroectodermal tissues, can occur in any organ, including the pancreas, and are characterized by the expression of the neuroendocrine markers synaptophysin and chromogranin A. Pancreatic neuroendocrine tumors (PanNETs) are well-differentiated epithelial neoplasms with morphological and immunohistochemical features of neuroendocrine differentiation of low, intermediate, or high grade. Pancreatic neuroendocrine carcinomas (PanNECs) are clinically aggressive, high-grade (poorly differentiated) carcinomas with morphologic features suggesting neuroendocrine differentiation, a high proliferative rate (> 20 mitoses per 2 mm2 and Ki67 index > 20%), and immunohistochemical labeling for neuroendocrine markers. They include the small cell neuroendocrine carcinoma and the large cell neuroendocrine carcinoma categories.Neuroendocrine-like morphology coupled with immunohistochemical markers of neuroendocrine differentiation are highly specific. However, neuroendocrine markers may also be expressed in non-neuroendocrine neoplasms, which can therefore be confused with NENs. Mimickers of pancreatic NENs comprise a number of important pitfall tumors, including epithelial and non-epithelial neoplasms, such as acinar cell carcinomas, solid pseudopapillary neoplasms (SPNs), or even non-neoplastic lesions. All of these lesions have the expression of neuroendocrine markers in common, such as synaptophysin and chromogranin A, and although they are comparatively rare, they can cause considerable diagnostic problems. This review article deals with some of the most important mimickers of pancreatic neuroendocrine neoplasms and even non-neoplastic lesions, such as islet aggregation. The similarities and differences between these entities and pancreatic neuroendocrine neoplasms are highlighted, and key findings that facilitate the correct diagnosis are discussed.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"42-49"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138813539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Histopathologic diagnosis of solid and cystic pancreatic lesions with a focus on ductal adenocarcinoma : A vademecum for daily practice]. [胰腺实性和囊性病变的组织病理学诊断，重点是导管腺癌：日常实践手册]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2024-01-08 DOI: 10.1007/s00292-023-01288-0

Irene Esposito, Aslihan Yavas, Lena Häberle

{"title":"[Histopathologic diagnosis of solid and cystic pancreatic lesions with a focus on ductal adenocarcinoma : A vademecum for daily practice].","authors":"Irene Esposito, Aslihan Yavas, Lena Häberle","doi":"10.1007/s00292-023-01288-0","DOIUrl":"10.1007/s00292-023-01288-0","url":null,"abstract":"Pancreas pathology is constantly evolving and can present various challenges for pathologists. This paper is focused on providing helpful hints for daily routine diagnostics. During histopathological analysis of pancreas biopsies, pancreatic ductal adenocarcinoma must be distinguished not only from other solid neoplasms, but especially from its mimicker, autoimmune pancreatitis. This can be achieved by a systematic workup following clear diagnostic criteria. When analyzing samples from cystic pancreatic lesions, mucin-producing neoplasms must be detected due to their role as pancreatic cancer precursors; molecular analyses can help considerably with their detection and distinction. During frozen section examination, evaluation of the pancreatic neck margin and analysis of unclear lesions of the liver are two important tasks, which are explained further in this article. A special challenge is the evaluation of neoadjuvant treated pancreatic cancer, which requires a detailed macroscopic and microscopic workup. Finally, current advances in precision oncology and emerging approaches for pancreatic cancer within this field are discussed. With the advancement of technical possibilities and their increasingly broad implementation, the classification systems in pancreatic pathology will continue to gain in complexity, but also in accuracy.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"5-18"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139405579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Standardized and quality-assured predictive PD-L1 testing in the upper gastrointestinal tract. German version]. [上消化道 PD-L1 预测性标准化和质量保证检测。德文版]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2024-01-03 DOI: 10.1007/s00292-023-01215-3

G Baretton, F Lordick, T Gaiser, R Hofheinz, D Horst, S Lorenzen, M Möhler, C Röcken, P Schirmacher, M Stahl, P Thuss-Patience, K Tiemann

{"title":"[Standardized and quality-assured predictive PD-L1 testing in the upper gastrointestinal tract. German version].","authors":"G Baretton, F Lordick, T Gaiser, R Hofheinz, D Horst, S Lorenzen, M Möhler, C Röcken, P Schirmacher, M Stahl, P Thuss-Patience, K Tiemann","doi":"10.1007/s00292-023-01215-3","DOIUrl":"10.1007/s00292-023-01215-3","url":null,"abstract":"As a result of the high approval dynamics and the growing number of immuno-oncological therapy concepts, the complexity of therapy decisions and control in the area of carcinomas of the esophagus, gastroesophageal junction and stomach is constantly increasing. Since the treatment indication for PD‑1 inhibitors that are currently approved in the European Union is often linked to the expression of PD-L1 (programmed cell death-ligand 1), the evaluation of tissue-based predictive markers by the pathologist is of crucial importance for treatment stratification. Even though the immunohistochemical analysis of the PD-L1 expression status is one of the best studied, therapy-relevant biomarkers for an immuno-oncological treatment, due to the high heterogeneity of carcinomas of the upper gastrointestinal tract, there are challenges in daily clinical diagnostic work with regard to implementation, standardization and interpretation of testing. An interdisciplinary group of experts from Germany has taken a position on relevant questions from daily pathological and clinical practice, which concern the starting material, quality-assured testing and the interpretation of pathological findings, and has developed recommendations for structured reporting.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"51-58"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10827825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Pancreatic pathology-the Prof. Günter Klöppel school]. [胰腺病理学--Günter Klöppel 教授学校]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 Epub Date: 2024-01-30 DOI: 10.1007/s00292-023-01290-6

Aurel Perren, Irene Esposito

引用次数: 0

Mitteilungen der Deutschen Gesellschaft für Pathologie. Mitteilungen der Deutschen Gesellschaft für Pathologie.

Pathologie (Heidelberg, Germany) Pub Date : 2024-02-01 DOI: 10.1007/s00292-023-01296-0

引用次数: 0