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Pathologie (Heidelberg, Germany)最新文献

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[The biomarker MGMT (O6-methylguanine-DNA methyltransferase) in tumor pathology]. [肿瘤病理中的生物标志物MGMT （o6 -甲基鸟嘌呤- dna甲基转移酶）]。
Pathologie (Heidelberg, Germany) Pub Date : 2025-06-20 DOI: 10.1007/s00292-025-01451-9
Christian Hartmann, Ulrich Lehmann
{"title":"[The biomarker MGMT (O<sup>6</sup>-methylguanine-DNA methyltransferase) in tumor pathology].","authors":"Christian Hartmann, Ulrich Lehmann","doi":"10.1007/s00292-025-01451-9","DOIUrl":"https://doi.org/10.1007/s00292-025-01451-9","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Adult rhabdomyoma : Rare differential diagnosis in frozen section examination]. 成人横纹肌瘤：罕见的冷冻切片鉴别诊断。
Pathologie (Heidelberg, Germany) Pub Date : 2025-06-10 DOI: 10.1007/s00292-025-01443-9
Marvin Seidel, Martin Bredt, Hans Kreipe, Nora Schaumann
{"title":"[Adult rhabdomyoma : Rare differential diagnosis in frozen section examination].","authors":"Marvin Seidel, Martin Bredt, Hans Kreipe, Nora Schaumann","doi":"10.1007/s00292-025-01443-9","DOIUrl":"https://doi.org/10.1007/s00292-025-01443-9","url":null,"abstract":"<p><p>We report on a 73-year-old patient with formerly diagnosed melanoma and newly recognized tumor formation within the larynx. In a frozen section specimen, there was no indication of malignancy. Differential diagnosis favored a granular cell tumor at first. Immunohistochemistry and histomorphology after tissue transfer into paraffin led to the diagnosis of adult rhabdomyoma. This case report examines the histomorphologic and immunhistochemic differential diagnosis of large-cell laryngeal lesions with special focus on the challenges associated with frozen section specimens.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Morphomolecular subtyping of hepatocellular adenoma]. 肝细胞腺瘤的形态分子分型。
Pathologie (Heidelberg, Germany) Pub Date : 2025-06-05 DOI: 10.1007/s00292-025-01444-8
Beate K Straub, Lukas Müller, Diane S Duret, Marcell Tóth, Jens Mittler, Peter Schirmacher
{"title":"[Morphomolecular subtyping of hepatocellular adenoma].","authors":"Beate K Straub, Lukas Müller, Diane S Duret, Marcell Tóth, Jens Mittler, Peter Schirmacher","doi":"10.1007/s00292-025-01444-8","DOIUrl":"https://doi.org/10.1007/s00292-025-01444-8","url":null,"abstract":"<p><p>Hepatocellular adenomas (HCAs) are rare benign hepatocellular neoplasia that typically occur in a non-cirrhotic liver in young women on contraceptive therapy or in metabolic liver disease. HCAs may be subtyped radiologically and histologically, controlled under discontinuation of contraceptives, and resected in the case of malignant transformation potential or an HCA size of more than 5 cm.Histologically, HCAs present as well-differentiated hepatocellular neoplasms, which in contrast to focal nodular hyperplasia (FNH) lack portal tract-like structures. Prognostically relevant morphomolecular HCA subtypes have been described. HNF1A-inactivated HCAs often show a prominent steatosis and loss of L‑FABP. Inflammatory HCAs (IHCAs) are characterized morphologically by a prominent inflammatory infiltrate and ectatic sinusoids and show a positive immune reaction with antibodies against serum amyloid A and CRP. In contrast to other HCAs, β‑catenin-activated HCAs due to CTNNB1 mutation in exon 3 occur relatively more frequently in men (for example after intake of anabolic steroids) and have a significantly increased risk of transformation in a hepatocellular carcinoma (HCC) in comparison to CTNNB1 mutations in exons 7 and 8. CTNNB1 mutations may also occur in IHCAs (b-IHCA). Sonic hedgehog-activated HCAs show increased ASS1 expression and have a high risk of rupture and bleeding.Concerning differential diagnosis, it is important to distinguish HCAs from FNH, which cover a clinically similar patient group, and from highly differentiated HCC, which occur more frequently in men at an increased patient age and in chronic liver disease.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Legal aspects of copyright and data protection in the use of pathology images on social media]. [在社交媒体上使用病理图像时版权和数据保护的法律问题]。
Pathologie (Heidelberg, Germany) Pub Date : 2025-06-04 DOI: 10.1007/s00292-025-01430-0
Carola Sieling, Mareike Julia von Petersdorff-Campen
{"title":"[Legal aspects of copyright and data protection in the use of pathology images on social media].","authors":"Carola Sieling, Mareike Julia von Petersdorff-Campen","doi":"10.1007/s00292-025-01430-0","DOIUrl":"https://doi.org/10.1007/s00292-025-01430-0","url":null,"abstract":"<p><strong>Background: </strong>Because of digitalization in pathology, more and more patient images are being used outside of the patient file.</p><p><strong>Question: </strong>What copyright and data protection aspects in the German legal area must be considered when using images from pathology on social media?</p><p><strong>Material and methods: </strong>Research and analysis of the legal basis in German copyright and data protection law.</p><p><strong>Results: </strong>German legislation provides clear guidelines regarding authorship and the rights to use images. The General Data Protection Regulation (GDPR) is particularly strict when it comes to handling health data. According to some voices, anonymization is not only difficult to implement in the age of digitalization and increasing networking and processing of data, but it is also unclear when exactly anonymization has taken place. However, one thing is certain: anonymized data do not fall under the GDPR.</p><p><strong>Conclusions: </strong>When publishing images from pathology on social media, data protection law must be observed in particular, since the data in question are health data and thus personal data that are particularly worthy of protection. Without anonymization, it is necessary to obtain patient consent that complies with data protection regulations. Furthermore, copyright aspects must be considered for images from pathology as photographic works.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Atypical mycobacteriosis of the skin]. [非典型皮肤分枝杆菌病]。
Pathologie (Heidelberg, Germany) Pub Date : 2025-06-02 DOI: 10.1007/s00292-025-01442-w
Anna Vetter, Hilte Geerdes-Fenge, Marco Saß, Maja Hühns, Anne-Sophie Becker
{"title":"[Atypical mycobacteriosis of the skin].","authors":"Anna Vetter, Hilte Geerdes-Fenge, Marco Saß, Maja Hühns, Anne-Sophie Becker","doi":"10.1007/s00292-025-01442-w","DOIUrl":"https://doi.org/10.1007/s00292-025-01442-w","url":null,"abstract":"<p><p>A 60-year-old immunocompetent patient presented with painless subcutaneous nodules on the right hand and forearm that progressed over several weeks. Nodules were clinically classified as a soft tissue tumor of primarily mesenchymal origin. After extirpation of two nodules for diagnostic clarification, histology showed a chronic granulomatous inflammation of the dermis and subcutis with central eosinophilic necrosis including cell debris. Light microscopy showed no acid-fast rods, but molecular diagnostics revealed DNA of Mycobacterium haemophilum as a nontuberculoid mycobacterium (NTM). The infection was identified as the cause of the nodules based on the classic histomorphology of necrotizing-granulomatous inflammation in addition to PCR-based pathogen diagnostics. This case illustrates the clinical presence of mycobacterial infections, especially in extrapulmonary and extranodal localizations. In addition to cutaneous foci of infection, NTM infections may cause multisystem disease involving the joint system, depending on the host's immunocompetence, which can be treated with antibiotics.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[New WHO Reporting System for Lung Cytopathology]. [新的WHO肺细胞病理学报告系统]。
Pathologie (Heidelberg, Germany) Pub Date : 2025-05-27 DOI: 10.1007/s00292-025-01436-8
Marianne Engels
{"title":"[New WHO Reporting System for Lung Cytopathology].","authors":"Marianne Engels","doi":"10.1007/s00292-025-01436-8","DOIUrl":"https://doi.org/10.1007/s00292-025-01436-8","url":null,"abstract":"<p><p>The new WHO Reporting System for Lung Cytopathology (World Health Organization Reporting System) is an international and standardized reporting system for cytology of the respiratory tract. Five diagnostic categories are defined: \"insufficient/inadequate/non-diagnostic\", \"benign\", \"atypical\", \"suspicious for malignancy\", \"malignant\". The WHO Reporting System is intended to be also applicable in countries with limited resources. Therefore, classification into the five diagnostic categories is based upon cytomorphology. The key diagnostic cytopathological features are described in the WHO Reporting System and differential diagnoses and ancillary testing are also covered, especially immunocytochemistry and molecular pathology.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Oral squamous cell carcinoma and oral epithelial dysplasia : Pre- and postoperative diagnostics]. [口腔鳞状细胞癌和口腔上皮异常增生：术前和术后诊断]。
Pathologie (Heidelberg, Germany) Pub Date : 2025-05-27 DOI: 10.1007/s00292-025-01435-9
Jan Liese, Anne-Sophie Becker
{"title":"[Oral squamous cell carcinoma and oral epithelial dysplasia : Pre- and postoperative diagnostics].","authors":"Jan Liese, Anne-Sophie Becker","doi":"10.1007/s00292-025-01435-9","DOIUrl":"https://doi.org/10.1007/s00292-025-01435-9","url":null,"abstract":"<p><p>Among non-cutaneous head and neck tumours, oral squamous cell carcinoma is one of the most common entities and is clinically characterized by functionally limiting therapies and a high recurrence rate. The majority of oral squamous cell carcinomas arise from potentially malignant diseases of the oral mucosa, which are often biopsied for preventive and diagnostic purposes. This article provides the histological criteria for grading oral epithelial dysplasia, with a scheme to help classify p53 staining and estimate prognosis. As oral cancer is still a morphologically defined entity, the histological subtypes and prognostic parameters that can be determined by light microscopy are presented. Future treatment approaches are outlined, which cannot be compared to other tumour entities due to the lack of therapeutically useful molecular alterations in oral squamous cell carcinoma.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Udo Martin Helmchen : 12 February 1939-18 January 2025]. [Udo Martin Helmchen: 1939年2月12日至2025年1月18日]。
Pathologie (Heidelberg, Germany) Pub Date : 2025-05-06 DOI: 10.1007/s00292-025-01439-5
Andreas Erbersdobler
{"title":"[Udo Martin Helmchen : 12 February 1939-18 January 2025].","authors":"Andreas Erbersdobler","doi":"10.1007/s00292-025-01439-5","DOIUrl":"https://doi.org/10.1007/s00292-025-01439-5","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Molecular pathology in non-small-cell lung cancer: current and emerging biomarkers]. [非小细胞肺癌的分子病理学：当前和新兴的生物标志物]。
Pathologie (Heidelberg, Germany) Pub Date : 2025-05-01 Epub Date: 2025-04-03 DOI: 10.1007/s00292-025-01433-x
Helen Pasternack, Jutta Kirfel
{"title":"[Molecular pathology in non-small-cell lung cancer: current and emerging biomarkers].","authors":"Helen Pasternack, Jutta Kirfel","doi":"10.1007/s00292-025-01433-x","DOIUrl":"10.1007/s00292-025-01433-x","url":null,"abstract":"<p><p>In the classification of lung cancer, the basic division into small cell and non-small cell carcinomas continues to apply. Despite the same histological subtyping, it is known that there are defined genetic changes in the tumor cells that significantly determine tumor growth as \"drivers\", so that their blockade can significantly influence the clinical course. Thus, in the last 10 years, the treatment of lung cancer has been increasingly supplemented by the establishment of tumor-specific targeted drugs and immunomodulatory approaches. This development has led to increasingly differentiated and individualized approaches to treatment. Pathology and especially molecular pathological diagnostics play a central role here, as an increasing number of biomarkers must be examined.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"185-193"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Colon polyps-nomenclature, histology, and molecular pathology]. 结肠息肉——命名、组织学和分子病理学。
Pathologie (Heidelberg, Germany) Pub Date : 2025-05-01 Epub Date: 2025-04-16 DOI: 10.1007/s00292-025-01438-6
Jens Neumann
{"title":"[Colon polyps-nomenclature, histology, and molecular pathology].","authors":"Jens Neumann","doi":"10.1007/s00292-025-01438-6","DOIUrl":"https://doi.org/10.1007/s00292-025-01438-6","url":null,"abstract":"<p><p>Polyps are macroscopically visible protrusions of the mucosa in hollow organs. In the colon, epithelial neoplasms deriving from the mucosa dominate. These can be classified based on their morphology into classic and serrated adenomas and show different degrees of epithelial dysplasia. The histological subtypes show various molecular alterations and can be assigned to different pathways of carcinogenesis. These must be separated from hamartomatous polyps of the colon mucosa, which can occur sporadically or as part of hereditary syndromes.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":"46 3","pages":"171-178"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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