Pathologie (Heidelberg, Germany)最新文献

[Morphologic and clinical spectrum of large gland lesions of the prostate. German version]. 前列腺大腺体病变的形态学和临床谱。德国版)。

IF 0.6

Pathologie (Heidelberg, Germany) Pub Date : 2025-08-01 DOI: 10.1007/s00292-025-01453-7

Sara E Wobker, Murali Varma

引用次数: 0

Current grading of prostate cancer. 前列腺癌的当前分级。

IF 0.6

Pathologie (Heidelberg, Germany) Pub Date : 2025-07-30 DOI: 10.1007/s00292-025-01450-w

Yosamin Gonzalez Belisario, Geert J L H van Leenders

引用次数: 0

Grossing and reporting of the radical prostatectomy specimen. 根治性前列腺切除术标本的观察与报道。

IF 0.6

Pathologie (Heidelberg, Germany) Pub Date : 2025-07-30 DOI: 10.1007/s00292-025-01456-4

Marit Bernhardt, Glen Kristiansen

引用次数: 0

[Neuroendocrine differentiation in prostate neoplasms. German version]. 前列腺肿瘤的神经内分泌分化。德国版)。

Pathologie (Heidelberg, Germany) Pub Date : 2025-07-16 DOI: 10.1007/s00292-025-01447-5

Rainer Grobholz

{"title":"[Neuroendocrine differentiation in prostate neoplasms. German version].","authors":"Rainer Grobholz","doi":"10.1007/s00292-025-01447-5","DOIUrl":"https://doi.org/10.1007/s00292-025-01447-5","url":null,"abstract":"Neuroendocrine (NE) cells in the prostate are part of the diffuse NE system and are found in both the normal prostate and acinar adenocarcinomas, occasionally exhibiting Paneth cell-like morphology.NE cells produce peptide hormones and biogenic amines that influence the differentiation and growth of the prostate glands through paracrine signaling; however, they do not show proliferative activity and lack androgen receptors (AR).Prostate tumors with NE differentiation are classified into five groups: (1) acinar adenocarcinomas with partial NE differentiation, detectable only by immunohistochemistry, (2) adenocarcinomas with Paneth cell-like differentiation, (3) NE tumors/carcinoids (NET), (4) small cell NE carcinomas (SCNEC), and (5) large cell NE carcinomas (LCNEC).The significance of partial and Paneth cell-like differentiation in adenocarcinomas remains under discussion and plays a minor role in routine diagnostics. NETs are extremely rare and appear to behave similarly to NETs of the gastrointestinal tract. In contrast, SCNECs and LCNECs are aggressive tumors with important clinical relevance, as they have a poor prognosis and require aggressive treatment.Therapy-associated neuroendocrine prostate carcinomas (t-NEPC) are recognized as a distinct entity for the first time in the WHO classification (5th edition, 2022). It arises through transdifferentiation via epigenetic changes following androgen deprivation and is characterized by AR loss and high proliferation, among other features. As with primary NE carcinomas, aggressive therapy is indicated. Therefore, a follow-up biopsy is recommended for castration-resistant progressive prostate cancer to confirm this aggressive phenotype.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Pathology of liver tumours in animal models]. [动物模型肝脏肿瘤病理]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-07-14 DOI: 10.1007/s00292-025-01452-8

Thomas Metzler, Margaret Tulessin, Tanja Groll, Mahsa Rezvan, Anna-Chiara Riedl, Heike Aupperle-Lellbach, Robert Klopfleisch, Carolin Mogler, Katja Steiger

{"title":"[Pathology of liver tumours in animal models].","authors":"Thomas Metzler, Margaret Tulessin, Tanja Groll, Mahsa Rezvan, Anna-Chiara Riedl, Heike Aupperle-Lellbach, Robert Klopfleisch, Carolin Mogler, Katja Steiger","doi":"10.1007/s00292-025-01452-8","DOIUrl":"https://doi.org/10.1007/s00292-025-01452-8","url":null,"abstract":"Background: Liver tumours are common and deadly diseases in humans and are often associated with a poor prognosis. To better understand the mechanisms and potential therapies for hepatocellular carcinoma and cholangiocarcinoma, experimental animal models are used in preclinical research and spontaneously occurring tumours in companion animals can also be investigated as models.Objective: We provide an overview of commonly used animal models in hepatic cancer research, including their applications, advantages, and disadvantages. Additionally, we present pathological findings of the most frequent spontaneous liver neoplasms in dogs and cats.Materials and methods: We performed a review of the scientific literature and of findings in animal models. Additionally, we performed an analysis of case statistics from a veterinary pathology submission laboratory.Results: Mouse models are most frequently used in the study of hepatic tumours. These include xenografts, in which human tumour cells are injected, chemically and diet-induced models for studying environmental and metabolic factors, and genetically modified mice. In addition to mice, other species such as rats, rabbits, and woodchucks are also utilized. Woodchucks carry their own hepatitis virus, making them particularly suitable for investigating viral pathogenesis. Furthermore, domestic animals such as dogs and cats develop spontaneous liver neoplasms, which makes them valuable models. Dogs predominantly develop hepatocellular adenomas and carcinomas, whereas benign, cystic bile duct lesions are more common in cats.Conclusions: A wide range of animal models is available for various research questions. Choosing the appropriate model is crucial for the success of any study and depends on multiple factors.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Current grading of prostate cancer. German version]. 目前前列腺癌的分级。德国版)。

Pathologie (Heidelberg, Germany) Pub Date : 2025-07-02 DOI: 10.1007/s00292-025-01446-6

Yosamin Gonzalez Belisario, Geert J L H van Leenders

引用次数: 0

[Atypical mycobacteriosis of the skin]. [非典型皮肤分枝杆菌病]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-07-01 Epub Date: 2025-06-02 DOI: 10.1007/s00292-025-01442-w

Anna Vetter, Hilte Geerdes-Fenge, Marco Saß, Maja Hühns, Anne-Sophie Becker

{"title":"[Atypical mycobacteriosis of the skin].","authors":"Anna Vetter, Hilte Geerdes-Fenge, Marco Saß, Maja Hühns, Anne-Sophie Becker","doi":"10.1007/s00292-025-01442-w","DOIUrl":"10.1007/s00292-025-01442-w","url":null,"abstract":"A 60-year-old immunocompetent patient presented with painless subcutaneous nodules on the right hand and forearm that progressed over several weeks. Nodules were clinically classified as a soft tissue tumor of primarily mesenchymal origin. After extirpation of two nodules for diagnostic clarification, histology showed a chronic granulomatous inflammation of the dermis and subcutis with central eosinophilic necrosis including cell debris. Light microscopy showed no acid-fast rods, but molecular diagnostics revealed DNA of Mycobacterium haemophilum as a nontuberculoid mycobacterium (NTM). The infection was identified as the cause of the nodules based on the classic histomorphology of necrotizing-granulomatous inflammation in addition to PCR-based pathogen diagnostics. This case illustrates the clinical presence of mycobacterial infections, especially in extrapulmonary and extranodal localizations. In addition to cutaneous foci of infection, NTM infections may cause multisystem disease involving the joint system, depending on the host's immunocompetence, which can be treated with antibiotics.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"236-239"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Law and assessment]. [法律与评估]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-07-01 Epub Date: 2025-06-25 DOI: 10.1007/s00292-025-01445-7

Matthias M Gaida, Wilfried Roth

引用次数: 0

[Histopathological diagnostics for assessment questions of tendo-, ligamento-, and meniscus pathologies]. [腱、韧带和半月板病变评估问题的组织病理学诊断]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-07-01 Epub Date: 2024-09-24 DOI: 10.1007/s00292-024-01354-1

Veit Krenn, Lara Blümke, Ralf Dieckmann

{"title":"[Histopathological diagnostics for assessment questions of tendo-, ligamento-, and meniscus pathologies].","authors":"Veit Krenn, Lara Blümke, Ralf Dieckmann","doi":"10.1007/s00292-024-01354-1","DOIUrl":"10.1007/s00292-024-01354-1","url":null,"abstract":"This review article presents the possibilities and limitations of histopathological diagnostics on the issues of joint diseases, including in the context of the medical insurance inquiries, which consider the important articular, non-osseous compartments, especially of the tendons, ligaments, and meniscus. Essential for expert assessments is the causal clarification of whether the continuity disruption has been induced exogenously by trauma or endogenously based on tissue that is functionally impaired and thus degeneratively altered. The degree of degeneration/texture disorder is determined by means of the degeneration-score, which is set in a semiquantitative, three-stage grading. Grades 1 and 2 are summed up as low-grade degeneration and compared to grade 3, high-grade degeneration. Age determination of continuity disruption is based on the assessment of the morphology of discontinuity and on the assessment of hemosiderin deposits. The tasks of histopathological diagnostics thus consist of the detection and grading of textural disorder (degeneration), the determination of the histopathologic age of existing continuity disruptions, and particularly the diagnosis of clinically/radiologically undiagnosed diseases, which may be relevant for pathogenesis. In the case of contradictory diagnoses from different diagnostic disciplines and in the case of imprecise and potentially even contradictory patient information, purely legal, judicial decisions may be necessary. In this case the legally binding assessment within the framework of legal evidence evaluation then arises.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"213-219"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Risk area 'misdiagnosis'-Risks of criminal liability and behavioural tips in pathological practice]. 【风险领域的“误诊”——病理实践中的刑事责任风险与行为提示】。

Pathologie (Heidelberg, Germany) Pub Date : 2025-07-01 Epub Date: 2025-02-03 DOI: 10.1007/s00292-025-01413-1

Vincent Burgert

{"title":"[Risk area 'misdiagnosis'-Risks of criminal liability and behavioural tips in pathological practice].","authors":"Vincent Burgert","doi":"10.1007/s00292-025-01413-1","DOIUrl":"10.1007/s00292-025-01413-1","url":null,"abstract":"The article presents the concept of misdiagnosis or malpractice to practising pathologists from a medical and legal perspective and highlights similarities and differences in this respect. In particular, the risk of criminal liability for pathologists in the context of their practice activities is addressed and the relationship between the legal judgements of criminal, civil and professional law is examined in more detail. Due to the lack of an existing reversal of the burden of proof in criminal law, the constellation may arise in practice that a treatment error under civil law is assumed. However, such a qualification does not necessarily lead to a criminal accusation. Furthermore, the field of professional law, which is often pushed into the background for practising lawyers, is also emphasised. Criminal sanctions often hit a practitioner less severely than, for example, the withdrawal of a licence to practise under professional law. Close dovetailing of criminal, civil and professional law advice is essential in this respect. Pathologists are also given tips on how to behave based on many years of criminal defence practice in order to enable an adequate defence at an early stage in the event of a confrontation with criminal charges.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"199-206"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0