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[Important changes to the 2022 WHO classification of testicular tumours : A guide for diagnostics].
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-01 Epub Date: 2025-01-23 DOI: 10.1007/s00292-024-01403-9
Alexander Fichtner, Martin Zielke, Felix Bremmer
{"title":"[Important changes to the 2022 WHO classification of testicular tumours : A guide for diagnostics].","authors":"Alexander Fichtner, Martin Zielke, Felix Bremmer","doi":"10.1007/s00292-024-01403-9","DOIUrl":"10.1007/s00292-024-01403-9","url":null,"abstract":"<p><p>The 5th Edition of the \"WHO Classification of Tumours: Urinary and Male Genital Tumours\" introduces several significant updates to the classification of testicular tumours. These updates include revised terminology for special germ cell tumour subtypes (neuroectodermal and neuroendocrine tumours) of the testis. Additionally, the signet-ring stromal tumour and myoid gonadal stromal tumour have been introduced as distinct entities within the sex-cord stromal tumours. Moreover, new combined sections have been created for lymphatic neoplasms and soft tissue tumours of the urinary and male genital tract.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"27-33"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Undifferentiated and dedifferentiated renal cell carcinomas : Morphomolecular aspects and differential diagnosis in light of recent developments]. 【未分化和去分化肾细胞癌：形态分子方面和鉴别诊断的最新进展】。
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-01 Epub Date: 2024-12-30 DOI: 10.1007/s00292-024-01409-3
Abbas Agaimy, Arndt Hartmann
{"title":"[Undifferentiated and dedifferentiated renal cell carcinomas : Morphomolecular aspects and differential diagnosis in light of recent developments].","authors":"Abbas Agaimy, Arndt Hartmann","doi":"10.1007/s00292-024-01409-3","DOIUrl":"10.1007/s00292-024-01409-3","url":null,"abstract":"<p><p>Histological subtyping of diverse renal cell carcinomas (RCCs) has seen significant changes during the last two decades. This resulted in the introduction of several new phenotypically and genetically defined entities, many which are also listed in the current WHO classification. Some of these well-defined entities may, under certain circumstances, undergo a process of dedifferentiation resulting in loss of their phenotypic and immunohistochemical features, hence adopting a non-descript anaplastic morphology. Accordingly, the original entity-defining tumor clone might be either totally overgrown and lost or just be missed by sampling the tumor. This final common pathway of dedifferentiation results in several oncological disadvantages and prevents a histology-tailored approach to systemic therapy. In addition, the possibility of inherited cancer as in the case of SDH- and FH-deficient RCC would be easily overlooked if the exact subtyping is not possible. This overview article illuminates the main RCC subtypes that may undergo dedifferentiation and their differential diagnostic approach.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"40-47"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Ecological sustainability of deep learning in pathology : A modeling study]. [病理学深度学习的生态可持续性：一项建模研究]。
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-01 Epub Date: 2024-11-22 DOI: 10.1007/s00292-024-01382-x
Saskia von Stillfried, Peter Boor
{"title":"[Ecological sustainability of deep learning in pathology : A modeling study].","authors":"Saskia von Stillfried, Peter Boor","doi":"10.1007/s00292-024-01382-x","DOIUrl":"10.1007/s00292-024-01382-x","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"48-50"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitteilungen der Österreichischen Gesellschaft für Klinische Pathologie und Molekularpathologie.
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-01 DOI: 10.1007/s00292-024-01404-8
{"title":"Mitteilungen der Österreichischen Gesellschaft für Klinische Pathologie und Molekularpathologie.","authors":"","doi":"10.1007/s00292-024-01404-8","DOIUrl":"https://doi.org/10.1007/s00292-024-01404-8","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":"46 1","pages":"76"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitteilungen der IAP.
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-01 DOI: 10.1007/s00292-025-01417-x
{"title":"Mitteilungen der IAP.","authors":"","doi":"10.1007/s00292-025-01417-x","DOIUrl":"https://doi.org/10.1007/s00292-025-01417-x","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":"46 1","pages":"74-75"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Circumscribed choroidal hemangioma in Sturge-Weber syndrome]. [Sturge-Weber综合征中的环状脉络膜血管瘤]。
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-01 Epub Date: 2024-10-29 DOI: 10.1007/s00292-024-01373-y
Anna Vetter, Annette Zimpfer, Björn Schneider, Andreas Erbersdobler, Tobias Brockmann, Thomas Fuchsluger, Claudia Brockmann
{"title":"[Circumscribed choroidal hemangioma in Sturge-Weber syndrome].","authors":"Anna Vetter, Annette Zimpfer, Björn Schneider, Andreas Erbersdobler, Tobias Brockmann, Thomas Fuchsluger, Claudia Brockmann","doi":"10.1007/s00292-024-01373-y","DOIUrl":"10.1007/s00292-024-01373-y","url":null,"abstract":"<p><p>We report on a 19-year-old patient with Sturge-Weber syndrome (SWS), accompanied by a Naevus flammeus, secondary glaucoma, and glaucomatous optic atrophy of the right eye. The painful and blind eye was enucleated. Histopathological analysis revealed a circumscribed choroidal hemangioma around the optic nerve and a smaller extrascleral hemangioma. Molecular genetic testing excluded GNA11, GNAQ, or GNAS mutations. Our work illuminates the clinical, histological, and molecular genetic aspects of this rare case, contributing to the differential diagnosis of ocular conditions in patients with SWS.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"51-55"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Tumor of the gastric wall - but it's not GIST]. [胃壁肿瘤--但不是 GIST]。
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-01 Epub Date: 2024-07-16 DOI: 10.1007/s00292-024-01341-6
Torsten Hansen, Christopher Becker, Lara Blümke, Detlef Ockert
{"title":"[Tumor of the gastric wall - but it's not GIST].","authors":"Torsten Hansen, Christopher Becker, Lara Blümke, Detlef Ockert","doi":"10.1007/s00292-024-01341-6","DOIUrl":"10.1007/s00292-024-01341-6","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Urinary bladder: tumor precursors and non-invasive carcinoma]. [膀胱：肿瘤前体和非浸润性癌]。
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-01 Epub Date: 2024-11-12 DOI: 10.1007/s00292-024-01385-8
Fabienne Lange, Arndt Hartmann, Markus Eckstein
{"title":"[Urinary bladder: tumor precursors and non-invasive carcinoma].","authors":"Fabienne Lange, Arndt Hartmann, Markus Eckstein","doi":"10.1007/s00292-024-01385-8","DOIUrl":"10.1007/s00292-024-01385-8","url":null,"abstract":"<p><strong>Background: </strong>In recent years, our understanding of the genesis and development of urothelial carcinomas (UC) has expanded considerably thanks to advancing molecular classifications. These advances have led to significant changes in the 5th edition of the WHO classification of tumors of the urinary tract and male genitalia. The new findings allow both the introduction of modern diagnostic approaches and a return to proven methods in the evaluation of precursor lesions and non-invasive carcinomas.</p><p><strong>Aims: </strong>This article is intended to provide a summarized overview of the various precursor lesions and pathways of urothelial carcinoma.</p><p><strong>Results and discussion: </strong>The changes and clarifications in the 5th edition of the WHO classification reflect the progress made in the molecular and morphological characterization of urothelial carcinomas. These adjustments provide an improved basis for diagnosis and treatment and emphasize the importance of differentiated molecular profiles for the classification and treatment of UC. Despite all this, conventional histology remains the gold standard for the diagnosis and classification of non-invasive carcinomas and precursor lesions.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"21-26"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Molecularly defined renal cell carcinomas].
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-01 Epub Date: 2025-01-27 DOI: 10.1007/s00292-024-01408-4
C Stöhr, A Fiegl, C Bercebal, A Agaimy, A Hartmann
{"title":"[Molecularly defined renal cell carcinomas].","authors":"C Stöhr, A Fiegl, C Bercebal, A Agaimy, A Hartmann","doi":"10.1007/s00292-024-01408-4","DOIUrl":"10.1007/s00292-024-01408-4","url":null,"abstract":"<p><strong>Background: </strong>The latest edition of the WHO classification of urinary and male genital tumours was published in 2022. The revision was based on the newest scientific literature. This article summarizes the updated recommendations regarding the classification of molecularly defined tumours.</p><p><strong>Results and conclusions: </strong>The current edition of the WHO classification of tumours introduced the new category of molecularly defined tumours. This category includes TFE3-rearranged RCC, TFEB-altered RCC, ELOC-mutated RCC, FH-deficient RCC, SDH-deficient RCC, ALK-rearranged RCC and SMARCB1-deficient RCC. The change reflects the importance of the respective alterations with regard to tumour biology and future treatment options. Simultaneously, the diagnosis of these tumours, which sometimes can show equivocal morphologies, is facilitated.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"5-12"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Histomorphologically defined renal cell carcinomas 2025 : Current WHO classification and emerging future subtypes]. [组织形态学定义的肾细胞癌2025：当前WHO分类和未来新出现的亚型]。
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-01 Epub Date: 2025-01-16 DOI: 10.1007/s00292-024-01406-6
C Stöhr, A Fiegl, C Bercebal, A Agaimy, A Hartmann
{"title":"[Histomorphologically defined renal cell carcinomas 2025 : Current WHO classification and emerging future subtypes].","authors":"C Stöhr, A Fiegl, C Bercebal, A Agaimy, A Hartmann","doi":"10.1007/s00292-024-01406-6","DOIUrl":"10.1007/s00292-024-01406-6","url":null,"abstract":"<p><strong>Background: </strong>The latest edition of the WHO classification of urinary and male genital tumours was published in 2022. The revision was based on the newest scientific literature. This article summarizes the updated recommendations regarding the classification of histomorphologically defined tumours.</p><p><strong>Results and conclusions: </strong>The current edition of the WHO classification made some adjustments on the classification of histomorphologically defined tumour types. Papillary renal cell carcinoma is no longer categorized into two subtypes. Also, the new classification recognized the benign nature of clear cell papillary tumours, which are no longer regarded as carcinomas. Finally, several emerging renal tumours were introduced.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"13-20"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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