{"title":"[Molecular pathology in non-small-cell lung cancer: current and emerging biomarkers].","authors":"Helen Pasternack, Jutta Kirfel","doi":"10.1007/s00292-025-01433-x","DOIUrl":"https://doi.org/10.1007/s00292-025-01433-x","url":null,"abstract":"<p><p>In the classification of lung cancer, the basic division into small cell and non-small cell carcinomas continues to apply. Despite the same histological subtyping, it is known that there are defined genetic changes in the tumor cells that significantly determine tumor growth as \"drivers\", so that their blockade can significantly influence the clinical course. Thus, in the last 10 years, the treatment of lung cancer has been increasingly supplemented by the establishment of tumor-specific targeted drugs and immunomodulatory approaches. This development has led to increasingly differentiated and individualized approaches to treatment. Pathology and especially molecular pathological diagnostics play a central role here, as an increasing number of biomarkers must be examined.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexander Marx, Philipp Ströbel, Felix Bremmer, Daniel Nettersheim, Niels J Rupp, Eva Wardelmann, Wolfgang Hartmann
{"title":"[Challenges in the research and diagnosis of rare diseases].","authors":"Alexander Marx, Philipp Ströbel, Felix Bremmer, Daniel Nettersheim, Niels J Rupp, Eva Wardelmann, Wolfgang Hartmann","doi":"10.1007/s00292-025-01426-w","DOIUrl":"https://doi.org/10.1007/s00292-025-01426-w","url":null,"abstract":"<p><p>Molecular methods have improved the diagnosis of many rare tumors but have also revealed their limitations. Gene fusions that originally appeared specific occur \"promiscuously\" in biologically distinct mesenchymal and epithelial tumors, underscoring the importance of integrated morphologic-molecular diagnostics. By contrast, similar tumor biology-which is difficult to prove in rare tumors-supports the concept of entity-defining gene fusions for a spectrum of morphologically diverse tumors. Still other rare tumors have no diagnostically or prognostically helpful molecular profile, and their rarity and lack of authentic tumor models are obstacles to the use of, for example, new single-cell-based molecular or AI-assisted morphological methods and preclinical functional analyses. These peculiarities of rare tumors are illustrated by thymic, testicular, salivary gland, and soft tissue neoplasms.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Legal and organizational aspects of autopsy in Germany].","authors":"B Märkl, T Schaller","doi":"10.1007/s00292-025-01425-x","DOIUrl":"https://doi.org/10.1007/s00292-025-01425-x","url":null,"abstract":"<p><p>The article explores the legal and organizational aspects of autopsies in Germany. Despite their importance in clinical medicine, the number of clinical autopsies has been declining for decades due to work-related, organizational, and legal challenges. The COVID-19 pandemic led to a temporary resurgence of interest in autopsies, although this interest has since waned. Initiatives like the National Autopsy Network (NATON) and the National Autopsy Register (NAREG) have been established to promote research and quality assurance.Legally, autopsies in Germany are regulated at both federal and state levels. Variations in regulations between states, especially concerning consent and the definition of a corpse, complicate the process. Social insurance-related autopsies are crucial in clarifying occupational diseases and accidents.Organizationally, autopsies require consent from relatives, which is often a challenging step. However, the introduction of remuneration for clinical autopsies has improved the framework. Initiatives such as the S1 guideline and international research projects have reinforced the role of autopsies. The article underscores the importance of autopsies in quality assurance and research, especially given the rise in occupational diseases and the need for improved clinical diagnoses.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Teaching pathology in Germany : The current state of teaching at pathological institutes of German universities in 2024].","authors":"Alexander Fichtner, Christiane Kümpers","doi":"10.1007/s00292-025-01424-y","DOIUrl":"https://doi.org/10.1007/s00292-025-01424-y","url":null,"abstract":"<p><p>The teaching of pathology at the 36 university departments of pathology is influenced by different curriculum structures. Teaching formats and the number of course hours vary considerably in some cases, partly due to structural circumstances at different locations. The teaching content appears to be largely congruent. Most of the medical staff are involved in teaching. The postgraduate training assistants would like good training and time to prepare the courses. The institute directors predominantly rate teaching as very important or important for them personally, whereas their satisfaction with the overall teaching situation at the locations is rated as \"moderate.\" Students are largely satisfied with teaching. In addition to structured, interdisciplinary, and practical teaching, suggestions for improvement include, in particular, opportunities to participate in autopsies, the use of digital formats (e.g., in lectures, microscopy courses), a more precise introduction to the assessment of histopathological findings, and a better presentation of the fields of activity in pathology. Attempts should be made throughout Germany to standardize teaching more in order to better represent the subject to deaneries and examination offices. In addition, efforts should be made to modernize teaching content and methods to make the subject more attractive to potential new recruits.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Exanthematic drug eruption].","authors":"Mirjana Ziemer, Elisabeth Livingstone","doi":"10.1007/s00292-025-01418-w","DOIUrl":"10.1007/s00292-025-01418-w","url":null,"abstract":"<p><strong>Background: </strong>Besides reactions of the IgE-mediated immediate type, medicamentous therapies can cause a variety of different mucocutaneous adverse events. Exanthematous manifestations require a fast and certain diagnosis due to their extent, sometimes rapid progression, and mucous membrane or organ involvement.</p><p><strong>Objectives: </strong>The spectrum of non-IgE-mediated exanthematic drug reactions is covered.</p><p><strong>Material and methods: </strong>The most relevant reactions are portrayed clinically and histopathologically.</p><p><strong>Results: </strong>Displayed are classical maculo-papular drug eruption, lichenoid drug reaction, acute generalized exanthematic pustulosis (AGEP), severe potentially life-threatening drug reactions such as Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) as well as generalized bullous fixed drug eruption (GBFDE), drug reaction with eosinophilia and systemic symptoms (DRESS), and some others.</p><p><strong>Conclusions: </strong>Cutaneous drug-related side effects cover a broad spectrum. Important for the correct treatment is a reliable diagnosis. In the case of severe, life-threatening drug reactions, however, permanent discontinuation of the drug is essential.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"90-100"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Clues in dermatopathological diagnostics].","authors":"Almut Böer-Auer","doi":"10.1007/s00292-024-01400-y","DOIUrl":"10.1007/s00292-024-01400-y","url":null,"abstract":"<p><p>Numerous diagnostic clues are used in routine dermatopathological diagnostics. Ideally, a diagnostic clue can lead directly to a specific diagnosis and save further time-consuming additional diagnostic procedures. This article discusses the concept of \"clues to diagnosis\" starting from its historical beginnings with a review of relevant studies and including current literature. Selected clues to dermatophytosis, psoriasis, and mycosis fungoides are analyzed. In addition, some newer and still little-known dermatopathological clues to inflammatory and infectious skin disease are presented. The aim is to specify the use of clues on the basis of current findings and to draw attention to scientifically sound clues.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"81-89"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[A lump in the male breast-case report of an unusual tumor manifestation].","authors":"Torsten Hansen, E Z Kovacs, J Kriegsmann, S M Jud","doi":"10.1007/s00292-024-01369-8","DOIUrl":"10.1007/s00292-024-01369-8","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"118-121"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[News from the world of dermatopathology].","authors":"Dieter Metze, Erhard Bierhoff","doi":"10.1007/s00292-025-01422-0","DOIUrl":"https://doi.org/10.1007/s00292-025-01422-0","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":"46 2","pages":"78-80"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J Dörenberg, C J Schmidt, T Berlage, R Knüchel-Clarke
{"title":"[Establishment of a German ICCR dataset : Translation and integration of SNOMED CT using the example of TUR-B].","authors":"J Dörenberg, C J Schmidt, T Berlage, R Knüchel-Clarke","doi":"10.1007/s00292-024-01398-3","DOIUrl":"10.1007/s00292-024-01398-3","url":null,"abstract":"<p><strong>Background: </strong>The structured recording of data from histopathological findings and their interoperability is critical for quality assurance in pathology.</p><p><strong>Materials and methods: </strong>To harmonize the content of the reports, the International Collaboration on Cancer Reporting (ICCR) has defined standardized datasets. These datasets are not yet available in German nationwide. This gap is addressed here using the transurethral bladder resection (TUR-B) dataset as a use case.</p><p><strong>Results: </strong>We describe the process of establishing the datasets by carrying out translation, mapping on SNOMED CT codes, and using SNOMED CTs hierarchy to fill dropdown menus. Furthermore, we identified rules for checking for self-consistency of reports by using the example of the TUR bladder.</p><p><strong>Discussion: </strong>With this article, we have created an example of a German version of the ICCR TUR‑B dataset including mapping to the SNOMED CT terminology. Further activities should include the definition of overarching cancer disease models to further exploit the potential of SNOMED CT.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"108-114"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}