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[Neuroendocrine tumors].
Pathologie (Heidelberg, Germany) Pub Date : 2025-03-01 Epub Date: 2025-02-19 DOI: 10.1007/s00292-025-01415-z
Aziz Chouchane, Konstantin Bräutigam, Aurel Perren
{"title":"[Neuroendocrine tumors].","authors":"Aziz Chouchane, Konstantin Bräutigam, Aurel Perren","doi":"10.1007/s00292-025-01415-z","DOIUrl":"10.1007/s00292-025-01415-z","url":null,"abstract":"<p><p>Neuroendocrine tumors (NETs) are a diverse group of neoplasms that originate from neuroendocrine cells throughout the body. Diagnosing NETs presents unique challenges due to their varied presentation, morphology, and biological behavior. This article provides an overview of the key diagnostic principles relevant to general pathologists, emphasizing the importance of a multidisciplinary approach that integrates clinical, radiological, histopathological, and immunohistochemical data. The emergence of new markers as well as recent advances in molecular pathology and the application of grading systems are discussed, highlighting their impact on prognosis and therapeutic strategies.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"127-136"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum zu: Können wir trotz des rasanten Fortschritts in der Medizin und der wachsenden diagnostischen Anforderungen Generalist*innen bleiben?
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-13 DOI: 10.1007/s00292-025-01423-z
Beatrix Zeller
{"title":"Erratum zu: Können wir trotz des rasanten Fortschritts in der Medizin und der wachsenden diagnostischen Anforderungen Generalist*innen bleiben?","authors":"Beatrix Zeller","doi":"10.1007/s00292-025-01423-z","DOIUrl":"10.1007/s00292-025-01423-z","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Incidental diagnosis of lymphangioleiomyomatosis in gynecological surgery-a case series].
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-07 DOI: 10.1007/s00292-025-01414-0
Julia Müller, Blake Gilks, Jessica McAlpine, Grit Gesine Ruth Hiller, Anne Kathrin Höhn, Lars-Christian Horn
{"title":"[Incidental diagnosis of lymphangioleiomyomatosis in gynecological surgery-a case series].","authors":"Julia Müller, Blake Gilks, Jessica McAlpine, Grit Gesine Ruth Hiller, Anne Kathrin Höhn, Lars-Christian Horn","doi":"10.1007/s00292-025-01414-0","DOIUrl":"https://doi.org/10.1007/s00292-025-01414-0","url":null,"abstract":"<p><strong>Background: </strong>Lymphangioleiomyomatosis (LAM) is a rare, slow progressing, low-grade neoplasia that primarily effects young women. The disease is well known for its pulmonary involvement with cystic destruction, but extra-pulmonary disease may occur. LAM is associated with mutations in the TSC 1 or TSC 2 genes and may develop sporadically or in the context of hereditary disease tuberous sclerosis complex (TSC). Incident LAM may represent the sentinel finding of the disease.</p><p><strong>Objective: </strong>Raising awareness for rare extrapulmonary LAM lesions in retroperitoneum and pelvic cavity.</p><p><strong>Methods: </strong>Data-based research was performed for LAM in gynecological surgical specimens. H&E-stained slides were re-examined, and immunohistochemical stains were re-evaluated. Clinical data were retrieved for the presence pulmonary LAM or TSC.</p><p><strong>Results: </strong>A total of 13 cases were identified. The age of the patients ranged from 32 to 77 years, and 8/13 were ≤ 55 years. Two women had a history of pulmonary LAM and TSC. Most women underwent surgery for gynecological malignancy. On histological examination, 10/13 patients presented LAM in 1 to 9 lymph nodes with a lesion size of 0.5 to 12.0 mm, mainly located subcapsular or in the nodal parenchyma. Three of the 13 women showed extranodal involvement of the retroperitoneum, myometrium, and the hilum of the ovary. Immunohistochemically LAM was positive for HMB45, desmin, and smooth muscle actin.</p><p><strong>Conclusion: </strong>LAM is a rare systemic disease that mainly involves the lungs. Nevertheless, extra-pulmonary manifestations may occur. It is important to report the incidental finding of even small foci of LAM within the pathology report. Incidental LAM may represent the sentinel lesion for pulmonary LAM and/or TSC.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Risk area 'misdiagnosis'-Risks of criminal liability and behavioural tips in pathological practice].
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-03 DOI: 10.1007/s00292-025-01413-1
Vincent Burgert
{"title":"[Risk area 'misdiagnosis'-Risks of criminal liability and behavioural tips in pathological practice].","authors":"Vincent Burgert","doi":"10.1007/s00292-025-01413-1","DOIUrl":"https://doi.org/10.1007/s00292-025-01413-1","url":null,"abstract":"<p><p>The article presents the concept of misdiagnosis or malpractice to practising pathologists from a medical and legal perspective and highlights similarities and differences in this respect. In particular, the risk of criminal liability for pathologists in the context of their practice activities is addressed and the relationship between the legal judgements of criminal, civil and professional law is examined in more detail. Due to the lack of an existing reversal of the burden of proof in criminal law, the constellation may arise in practice that a treatment error under civil law is assumed. However, such a qualification does not necessarily lead to a criminal accusation. Furthermore, the field of professional law, which is often pushed into the background for practising lawyers, is also emphasised. Criminal sanctions often hit a practitioner less severely than, for example, the withdrawal of a licence to practise under professional law. Close dovetailing of criminal, civil and professional law advice is essential in this respect. Pathologists are also given tips on how to behave based on many years of criminal defence practice in order to enable an adequate defence at an early stage in the event of a confrontation with criminal charges.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Important changes to the 2022 WHO classification of testicular tumours : A guide for diagnostics].
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-01 Epub Date: 2025-01-23 DOI: 10.1007/s00292-024-01403-9
Alexander Fichtner, Martin Zielke, Felix Bremmer
{"title":"[Important changes to the 2022 WHO classification of testicular tumours : A guide for diagnostics].","authors":"Alexander Fichtner, Martin Zielke, Felix Bremmer","doi":"10.1007/s00292-024-01403-9","DOIUrl":"10.1007/s00292-024-01403-9","url":null,"abstract":"<p><p>The 5th Edition of the \"WHO Classification of Tumours: Urinary and Male Genital Tumours\" introduces several significant updates to the classification of testicular tumours. These updates include revised terminology for special germ cell tumour subtypes (neuroectodermal and neuroendocrine tumours) of the testis. Additionally, the signet-ring stromal tumour and myoid gonadal stromal tumour have been introduced as distinct entities within the sex-cord stromal tumours. Moreover, new combined sections have been created for lymphatic neoplasms and soft tissue tumours of the urinary and male genital tract.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"27-33"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Undifferentiated and dedifferentiated renal cell carcinomas : Morphomolecular aspects and differential diagnosis in light of recent developments]. 【未分化和去分化肾细胞癌：形态分子方面和鉴别诊断的最新进展】。
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-01 Epub Date: 2024-12-30 DOI: 10.1007/s00292-024-01409-3
Abbas Agaimy, Arndt Hartmann
{"title":"[Undifferentiated and dedifferentiated renal cell carcinomas : Morphomolecular aspects and differential diagnosis in light of recent developments].","authors":"Abbas Agaimy, Arndt Hartmann","doi":"10.1007/s00292-024-01409-3","DOIUrl":"10.1007/s00292-024-01409-3","url":null,"abstract":"<p><p>Histological subtyping of diverse renal cell carcinomas (RCCs) has seen significant changes during the last two decades. This resulted in the introduction of several new phenotypically and genetically defined entities, many which are also listed in the current WHO classification. Some of these well-defined entities may, under certain circumstances, undergo a process of dedifferentiation resulting in loss of their phenotypic and immunohistochemical features, hence adopting a non-descript anaplastic morphology. Accordingly, the original entity-defining tumor clone might be either totally overgrown and lost or just be missed by sampling the tumor. This final common pathway of dedifferentiation results in several oncological disadvantages and prevents a histology-tailored approach to systemic therapy. In addition, the possibility of inherited cancer as in the case of SDH- and FH-deficient RCC would be easily overlooked if the exact subtyping is not possible. This overview article illuminates the main RCC subtypes that may undergo dedifferentiation and their differential diagnostic approach.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"40-47"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Ecological sustainability of deep learning in pathology : A modeling study]. [病理学深度学习的生态可持续性：一项建模研究]。
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-01 Epub Date: 2024-11-22 DOI: 10.1007/s00292-024-01382-x
Saskia von Stillfried, Peter Boor
{"title":"[Ecological sustainability of deep learning in pathology : A modeling study].","authors":"Saskia von Stillfried, Peter Boor","doi":"10.1007/s00292-024-01382-x","DOIUrl":"10.1007/s00292-024-01382-x","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"48-50"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitteilungen der Österreichischen Gesellschaft für Klinische Pathologie und Molekularpathologie.
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-01 DOI: 10.1007/s00292-024-01404-8
{"title":"Mitteilungen der Österreichischen Gesellschaft für Klinische Pathologie und Molekularpathologie.","authors":"","doi":"10.1007/s00292-024-01404-8","DOIUrl":"https://doi.org/10.1007/s00292-024-01404-8","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":"46 1","pages":"76"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitteilungen der IAP.
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-01 DOI: 10.1007/s00292-025-01417-x
{"title":"Mitteilungen der IAP.","authors":"","doi":"10.1007/s00292-025-01417-x","DOIUrl":"https://doi.org/10.1007/s00292-025-01417-x","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":"46 1","pages":"74-75"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Circumscribed choroidal hemangioma in Sturge-Weber syndrome]. [Sturge-Weber综合征中的环状脉络膜血管瘤]。
Pathologie (Heidelberg, Germany) Pub Date : 2025-02-01 Epub Date: 2024-10-29 DOI: 10.1007/s00292-024-01373-y
Anna Vetter, Annette Zimpfer, Björn Schneider, Andreas Erbersdobler, Tobias Brockmann, Thomas Fuchsluger, Claudia Brockmann
{"title":"[Circumscribed choroidal hemangioma in Sturge-Weber syndrome].","authors":"Anna Vetter, Annette Zimpfer, Björn Schneider, Andreas Erbersdobler, Tobias Brockmann, Thomas Fuchsluger, Claudia Brockmann","doi":"10.1007/s00292-024-01373-y","DOIUrl":"10.1007/s00292-024-01373-y","url":null,"abstract":"<p><p>We report on a 19-year-old patient with Sturge-Weber syndrome (SWS), accompanied by a Naevus flammeus, secondary glaucoma, and glaucomatous optic atrophy of the right eye. The painful and blind eye was enucleated. Histopathological analysis revealed a circumscribed choroidal hemangioma around the optic nerve and a smaller extrascleral hemangioma. Molecular genetic testing excluded GNA11, GNAQ, or GNAS mutations. Our work illuminates the clinical, histological, and molecular genetic aspects of this rare case, contributing to the differential diagnosis of ocular conditions in patients with SWS.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"51-55"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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