Pathologie (Heidelberg, Germany)最新文献_第2页

[Tumor-in-tumor metastasis: a rare phenomenon]. [肿瘤内转移：一种罕见现象]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-05-01 Epub Date: 2024-11-02 DOI: 10.1007/s00292-024-01375-w

Felix Elsner, Katharina Keller, Florian Fuchs, Michael Uder, Arndt Hartmann

引用次数: 0

[Teaching pathology in Germany : The current state of teaching at pathological institutes of German universities in 2024]. 【德国病理学教学：2024年德国大学病理研究所教学现状】。

Pathologie (Heidelberg, Germany) Pub Date : 2025-05-01 Epub Date: 2025-03-07 DOI: 10.1007/s00292-025-01424-y

Alexander Fichtner, Christiane Kümpers

{"title":"[Teaching pathology in Germany : The current state of teaching at pathological institutes of German universities in 2024].","authors":"Alexander Fichtner, Christiane Kümpers","doi":"10.1007/s00292-025-01424-y","DOIUrl":"10.1007/s00292-025-01424-y","url":null,"abstract":"The teaching of pathology at the 36 university departments of pathology is influenced by different curriculum structures. Teaching formats and the number of course hours vary considerably in some cases, partly due to structural circumstances at different locations. The teaching content appears to be largely congruent. Most of the medical staff are involved in teaching. The postgraduate training assistants would like good training and time to prepare the courses. The institute directors predominantly rate teaching as very important or important for them personally, whereas their satisfaction with the overall teaching situation at the locations is rated as \"moderate.\" Students are largely satisfied with teaching. In addition to structured, interdisciplinary, and practical teaching, suggestions for improvement include, in particular, opportunities to participate in autopsies, the use of digital formats (e.g., in lectures, microscopy courses), a more precise introduction to the assessment of histopathological findings, and a better presentation of the fields of activity in pathology. Attempts should be made throughout Germany to standardize teaching more in order to better represent the subject to deaneries and examination offices. In addition, efforts should be made to modernize teaching content and methods to make the subject more attractive to potential new recruits.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"163-170"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Incidental diagnosis of lymphangioleiomyomatosis in gynecological surgery-a case series]. 【妇科手术中淋巴管平滑肌瘤病的偶然诊断-病例系列】。

Pathologie (Heidelberg, Germany) Pub Date : 2025-05-01 Epub Date: 2025-02-07 DOI: 10.1007/s00292-025-01414-0

Julia Müller, Blake Gilks, Jessica McAlpine, Grit Gesine Ruth Hiller, Anne Kathrin Höhn, Lars-Christian Horn

{"title":"[Incidental diagnosis of lymphangioleiomyomatosis in gynecological surgery-a case series].","authors":"Julia Müller, Blake Gilks, Jessica McAlpine, Grit Gesine Ruth Hiller, Anne Kathrin Höhn, Lars-Christian Horn","doi":"10.1007/s00292-025-01414-0","DOIUrl":"10.1007/s00292-025-01414-0","url":null,"abstract":"Background: Lymphangioleiomyomatosis (LAM) is a rare, slow progressing, low-grade neoplasia that primarily effects young women. The disease is well known for its pulmonary involvement with cystic destruction, but extra-pulmonary disease may occur. LAM is associated with mutations in the TSC 1 or TSC 2 genes and may develop sporadically or in the context of hereditary disease tuberous sclerosis complex (TSC). Incident LAM may represent the sentinel finding of the disease.Objective: Raising awareness for rare extrapulmonary LAM lesions in retroperitoneum and pelvic cavity.Methods: Data-based research was performed for LAM in gynecological surgical specimens. H&E-stained slides were re-examined, and immunohistochemical stains were re-evaluated. Clinical data were retrieved for the presence pulmonary LAM or TSC.Results: A total of 13 cases were identified. The age of the patients ranged from 32 to 77 years, and 8/13 were ≤ 55 years. Two women had a history of pulmonary LAM and TSC. Most women underwent surgery for gynecological malignancy. On histological examination, 10/13 patients presented LAM in 1 to 9 lymph nodes with a lesion size of 0.5 to 12.0 mm, mainly located subcapsular or in the nodal parenchyma. Three of the 13 women showed extranodal involvement of the retroperitoneum, myometrium, and the hilum of the ovary. Immunohistochemically LAM was positive for HMB45, desmin, and smooth muscle actin.Conclusion: LAM is a rare systemic disease that mainly involves the lungs. Nevertheless, extra-pulmonary manifestations may occur. It is important to report the incidental finding of even small foci of LAM within the pathology report. Incidental LAM may represent the sentinel lesion for pulmonary LAM and/or TSC.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"179-184"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum zu: Molekularpathologie des nichtkleinzelligen Lungenkarzinoms: aktuelle und kommende Biomarker. 非小细胞肺癌的分子病理学：当前和未来的生物标志物。

Pathologie (Heidelberg, Germany) Pub Date : 2025-04-23 DOI: 10.1007/s00292-025-01434-w

Helen Pasternack, Jutta Kirfel

引用次数: 0

[Prostate cancer in the biopsy : Diagnostic criteria, mimickers/pitfalls, and subtypes]. [前列腺癌活检：诊断标准，模仿/陷阱和亚型]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-04-22 DOI: 10.1007/s00292-025-01432-y

Glen Kristiansen, Marit Bernhardt

引用次数: 0

[Grossing and reporting of the radical prostatectomy specimen]. 【根治性前列腺切除术标本的总收入和报告】。

Pathologie (Heidelberg, Germany) Pub Date : 2025-04-09 DOI: 10.1007/s00292-025-01431-z

Marit Bernhardt, Glen Kristiansen

引用次数: 0

[Legal and organizational aspects of autopsy in Germany]. [德国尸体解剖的法律和组织方面]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-03-17 DOI: 10.1007/s00292-025-01425-x

B Märkl, T Schaller

{"title":"[Legal and organizational aspects of autopsy in Germany].","authors":"B Märkl, T Schaller","doi":"10.1007/s00292-025-01425-x","DOIUrl":"https://doi.org/10.1007/s00292-025-01425-x","url":null,"abstract":"The article explores the legal and organizational aspects of autopsies in Germany. Despite their importance in clinical medicine, the number of clinical autopsies has been declining for decades due to work-related, organizational, and legal challenges. The COVID-19 pandemic led to a temporary resurgence of interest in autopsies, although this interest has since waned. Initiatives like the National Autopsy Network (NATON) and the National Autopsy Register (NAREG) have been established to promote research and quality assurance.Legally, autopsies in Germany are regulated at both federal and state levels. Variations in regulations between states, especially concerning consent and the definition of a corpse, complicate the process. Social insurance-related autopsies are crucial in clarifying occupational diseases and accidents.Organizationally, autopsies require consent from relatives, which is often a challenging step. However, the introduction of remuneration for clinical autopsies has improved the framework. Initiatives such as the S1 guideline and international research projects have reinforced the role of autopsies. The article underscores the importance of autopsies in quality assurance and research, especially given the rise in occupational diseases and the need for improved clinical diagnoses.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Exanthematic drug eruption]. [外显药物喷发]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-03-01 Epub Date: 2025-02-18 DOI: 10.1007/s00292-025-01418-w

Mirjana Ziemer, Elisabeth Livingstone

{"title":"[Exanthematic drug eruption].","authors":"Mirjana Ziemer, Elisabeth Livingstone","doi":"10.1007/s00292-025-01418-w","DOIUrl":"10.1007/s00292-025-01418-w","url":null,"abstract":"Background: Besides reactions of the IgE-mediated immediate type, medicamentous therapies can cause a variety of different mucocutaneous adverse events. Exanthematous manifestations require a fast and certain diagnosis due to their extent, sometimes rapid progression, and mucous membrane or organ involvement.Objectives: The spectrum of non-IgE-mediated exanthematic drug reactions is covered.Material and methods: The most relevant reactions are portrayed clinically and histopathologically.Results: Displayed are classical maculo-papular drug eruption, lichenoid drug reaction, acute generalized exanthematic pustulosis (AGEP), severe potentially life-threatening drug reactions such as Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) as well as generalized bullous fixed drug eruption (GBFDE), drug reaction with eosinophilia and systemic symptoms (DRESS), and some others.Conclusions: Cutaneous drug-related side effects cover a broad spectrum. Important for the correct treatment is a reliable diagnosis. In the case of severe, life-threatening drug reactions, however, permanent discontinuation of the drug is essential.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"90-100"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Clues in dermatopathological diagnostics]. [皮肤病理诊断的线索]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-03-01 Epub Date: 2024-12-09 DOI: 10.1007/s00292-024-01400-y

Almut Böer-Auer

引用次数: 0

[HSVN - hepatic small vessel neoplasm]. [HSVN - 肝小血管肿瘤]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-03-01 Epub Date: 2024-08-14 DOI: 10.1007/s00292-024-01349-y

Su Ir Lyu, Jörn Meinel, Uta Drebber

引用次数: 0