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[Urinary bladder: tumor precursors and non-invasive carcinoma]. [膀胱：肿瘤前体和非浸润性癌]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-12 DOI: 10.1007/s00292-024-01385-8
Fabienne Lange, Arndt Hartmann, Markus Eckstein
{"title":"[Urinary bladder: tumor precursors and non-invasive carcinoma].","authors":"Fabienne Lange, Arndt Hartmann, Markus Eckstein","doi":"10.1007/s00292-024-01385-8","DOIUrl":"https://doi.org/10.1007/s00292-024-01385-8","url":null,"abstract":"<p><strong>Background: </strong>In recent years, our understanding of the genesis and development of urothelial carcinomas (UC) has expanded considerably thanks to advancing molecular classifications. These advances have led to significant changes in the 5th edition of the WHO classification of tumors of the urinary tract and male genitalia. The new findings allow both the introduction of modern diagnostic approaches and a return to proven methods in the evaluation of precursor lesions and non-invasive carcinomas.</p><p><strong>Aims: </strong>This article is intended to provide a summarized overview of the various precursor lesions and pathways of urothelial carcinoma.</p><p><strong>Results and discussion: </strong>The changes and clarifications in the 5th edition of the WHO classification reflect the progress made in the molecular and morphological characterization of urothelial carcinomas. These adjustments provide an improved basis for diagnosis and treatment and emphasize the importance of differentiated molecular profiles for the classification and treatment of UC. Despite all this, conventional histology remains the gold standard for the diagnosis and classification of non-invasive carcinomas and precursor lesions.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Report of the Molecular Pathology Working Group of the German Society for Pathology]. [德国病理学学会分子病理学工作组报告]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-11 DOI: 10.1007/s00292-024-01378-7
N Pfarr, V Tischler, J Sperveslage
{"title":"[Report of the Molecular Pathology Working Group of the German Society for Pathology].","authors":"N Pfarr, V Tischler, J Sperveslage","doi":"10.1007/s00292-024-01378-7","DOIUrl":"https://doi.org/10.1007/s00292-024-01378-7","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Report of the Young Pathology Working Group of the German Society for Pathology]. [德国病理学学会青年病理学工作组报告]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-07 DOI: 10.1007/s00292-024-01376-9
Stefanie Bobe, Philipp Jurmeister
{"title":"[Report of the Young Pathology Working Group of the German Society for Pathology].","authors":"Stefanie Bobe, Philipp Jurmeister","doi":"10.1007/s00292-024-01376-9","DOIUrl":"https://doi.org/10.1007/s00292-024-01376-9","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements in mass spectrometry-based proteomics: a new era in pathology research and diagnostics. 基于质谱的蛋白质组学的进步：病理学研究和诊断的新时代。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-07 DOI: 10.1007/s00292-024-01390-x
Tilman Werner, Matthias Fahrner, Oliver Schilling
{"title":"Advancements in mass spectrometry-based proteomics: a new era in pathology research and diagnostics.","authors":"Tilman Werner, Matthias Fahrner, Oliver Schilling","doi":"10.1007/s00292-024-01390-x","DOIUrl":"https://doi.org/10.1007/s00292-024-01390-x","url":null,"abstract":"<p><strong>Background: </strong>Mass spectrometry (MS)-based proteomics is rapidly transforming pathology research and diagnostics by enabling comprehensive studies of protein expression and post-translational modifications (PTMs).</p><p><strong>Objective: </strong>This article discusses recent advancements in MS-based proteomics, focusing on emerging technologies in sample preparation, MS instrumentation, and data analysis. These developments are scrutinized for their applications in clinical cohort studies and molecular pathology diagnostics.</p><p><strong>Materials and methods: </strong>The article reviews innovations in automated sample preparation, chromatography systems, advanced MS technologies, and proteomic data analysis in the context of pathology. Specific applications such as liquid biopsy, spike-in heavy peptide panels, immunopeptidomics, and PTM screening are highlighted alongside opportunities for data integration.</p><p><strong>Results: </strong>Recent technological improvements have significantly increased the throughput, precision, and scope of proteomic studies, enabling the analysis of large clinical cohorts and small specimens with unprecedented sensitivity. Advanced MS techniques have broadened applications, opening new avenues for discovery and diagnosis of marker proteins and therapeutic targets.</p><p><strong>Conclusion: </strong>Advancements in MS-based proteomics have created new opportunities in clinical research and diagnostics. By facilitating more comprehensive and integrated analyses of proteomes, these technologies are set to play a pivotal role in the future of personalized medicine and pathology research.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Report of the German Society for Pathology Head and Neck Pathology Working Group : 107th Annual Meeting of the German Society for Pathology, Garching near Munich, May 2024]. [德国病理学学会头颈部病理学工作组报告：第 107 届德国病理学学会年会，2024 年 5 月，慕尼黑附近的加兴]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-07 DOI: 10.1007/s00292-024-01388-5
N Rupp
{"title":"[Report of the German Society for Pathology Head and Neck Pathology Working Group : 107th Annual Meeting of the German Society for Pathology, Garching near Munich, May 2024].","authors":"N Rupp","doi":"10.1007/s00292-024-01388-5","DOIUrl":"https://doi.org/10.1007/s00292-024-01388-5","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Granulomatous reaction to Dermalive filler]. [对 Dermalive 填充剂的肉芽肿反应]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-06 DOI: 10.1007/s00292-024-01384-9
Michael Bento Schmid, Natalja Denisjuk
{"title":"[Granulomatous reaction to Dermalive filler].","authors":"Michael Bento Schmid, Natalja Denisjuk","doi":"10.1007/s00292-024-01384-9","DOIUrl":"https://doi.org/10.1007/s00292-024-01384-9","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Report of the German Society for Pathology Cytopathology Working Group]. [德国病理学会细胞病理学工作组报告]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-04 DOI: 10.1007/s00292-024-01379-6
Dietmar Schmidt
{"title":"[Report of the German Society for Pathology Cytopathology Working Group].","authors":"Dietmar Schmidt","doi":"10.1007/s00292-024-01379-6","DOIUrl":"https://doi.org/10.1007/s00292-024-01379-6","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Report of the German Society for Pathology Gastroenteropathology Working Group]. [德国病理学学会胃肠病理学工作组报告]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-04 DOI: 10.1007/s00292-024-01380-z
Jens Neumann, Alexander Quaas
{"title":"[Report of the German Society for Pathology Gastroenteropathology Working Group].","authors":"Jens Neumann, Alexander Quaas","doi":"10.1007/s00292-024-01380-z","DOIUrl":"https://doi.org/10.1007/s00292-024-01380-z","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Report of the Gynaecological and Breast Pathology Working Group of the German Society of Pathology : 2024 DGP Annual Conference]. [德国病理学学会妇科和乳腺病理学工作组报告：2024 年 DGP 年会]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-04 DOI: 10.1007/s00292-024-01372-z
Eike Burandt, Ramona Erber
{"title":"[Report of the Gynaecological and Breast Pathology Working Group of the German Society of Pathology : 2024 DGP Annual Conference].","authors":"Eike Burandt, Ramona Erber","doi":"10.1007/s00292-024-01372-z","DOIUrl":"https://doi.org/10.1007/s00292-024-01372-z","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Report of the German Society for Pathology Dermatopathology Working Group]. [德国病理学学会皮肤病理学工作组报告]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-04 DOI: 10.1007/s00292-024-01377-8
S A Braun, E Bierhoff, D Metze
{"title":"[Report of the German Society for Pathology Dermatopathology Working Group].","authors":"S A Braun, E Bierhoff, D Metze","doi":"10.1007/s00292-024-01377-8","DOIUrl":"https://doi.org/10.1007/s00292-024-01377-8","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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