Pathologie (Heidelberg, Germany)最新文献_第2页

[Rare diseases: the tip of an iceberg]. [罕见疾病：冰山一角]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-05-01 Epub Date: 2025-04-29 DOI: 10.1007/s00292-025-01427-9

Philipp Ströbel

引用次数: 0

Mitteilungen der Deutschen Gesellschaft für Pathologie. 德国病理学会通讯。

Pathologie (Heidelberg, Germany) Pub Date : 2025-05-01 DOI: 10.1007/s00292-025-01428-8

引用次数: 0

[New methods at the transition from research to routine diagnostics]. [从研究向常规诊断过渡的新方法]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-05-01 Epub Date: 2025-01-22 DOI: 10.1007/s00292-024-01412-8

Argyris Papantonis, Stephan Rogalla, Christian Dullin, Frauke Alves, Hanibal Bohnenberger

{"title":"[New methods at the transition from research to routine diagnostics].","authors":"Argyris Papantonis, Stephan Rogalla, Christian Dullin, Frauke Alves, Hanibal Bohnenberger","doi":"10.1007/s00292-024-01412-8","DOIUrl":"10.1007/s00292-024-01412-8","url":null,"abstract":"Background: Pathology, traditionally focused on classification and diagnosis, is continuously evolving through new technologies. Advances in proteomics, epigenetics, tissue staining, and 3D imaging expand the possibilities of classical morphology.Aim of the study: The aim of this study was to investigate how modern technologies can improve diagnostic accuracy and therapy selection and how they can be integrated into pathologic routine diagnostics.Materials and methods: Recent studies in proteomics, epigenetics, multiplex tissue staining, and 3D tissue imaging were analyzed to assess their application and the challenges of clinical implementation.Results: The analysis shows significant potential for pathologic diagnostics. Proteomics provides a deeper understanding of the molecular architecture of tumors, while epigenetics and 3D genome architecture offer new insights into genetic regulation and tumor heterogeneity. Multiplex tissue staining and 3D tissue imaging improve spatial tissue analysis.Discussion: Despite the potential to improve diagnostics, high costs, technical complexity, and lack of standardization hinder integration into clinical practice. Nevertheless, these technologies offer promising approaches for optimizing diagnostics and therapy selection. Research and interdisciplinary collaboration are crucial to successfully integrating these innovations into routine clinical practice.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"156-162"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Challenges in the research and diagnosis of rare diseases]. [罕见疾病研究和诊断的挑战]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-05-01 Epub Date: 2025-04-03 DOI: 10.1007/s00292-025-01426-w

Alexander Marx, Philipp Ströbel, Felix Bremmer, Daniel Nettersheim, Niels J Rupp, Eva Wardelmann, Wolfgang Hartmann

引用次数: 0

[Foundation models in pathology]. [病理学基础模型]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-05-01 Epub Date: 2025-04-24 DOI: 10.1007/s00292-025-01429-7

Frederick Klauschen, Jonas Dippel, Klaus-Robert Müller

引用次数: 0

[Tumor-in-tumor metastasis: a rare phenomenon]. [肿瘤内转移：一种罕见现象]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-05-01 Epub Date: 2024-11-02 DOI: 10.1007/s00292-024-01375-w

Felix Elsner, Katharina Keller, Florian Fuchs, Michael Uder, Arndt Hartmann

引用次数: 0

[Teaching pathology in Germany : The current state of teaching at pathological institutes of German universities in 2024]. 【德国病理学教学：2024年德国大学病理研究所教学现状】。

Pathologie (Heidelberg, Germany) Pub Date : 2025-05-01 Epub Date: 2025-03-07 DOI: 10.1007/s00292-025-01424-y

Alexander Fichtner, Christiane Kümpers

{"title":"[Teaching pathology in Germany : The current state of teaching at pathological institutes of German universities in 2024].","authors":"Alexander Fichtner, Christiane Kümpers","doi":"10.1007/s00292-025-01424-y","DOIUrl":"10.1007/s00292-025-01424-y","url":null,"abstract":"The teaching of pathology at the 36 university departments of pathology is influenced by different curriculum structures. Teaching formats and the number of course hours vary considerably in some cases, partly due to structural circumstances at different locations. The teaching content appears to be largely congruent. Most of the medical staff are involved in teaching. The postgraduate training assistants would like good training and time to prepare the courses. The institute directors predominantly rate teaching as very important or important for them personally, whereas their satisfaction with the overall teaching situation at the locations is rated as \"moderate.\" Students are largely satisfied with teaching. In addition to structured, interdisciplinary, and practical teaching, suggestions for improvement include, in particular, opportunities to participate in autopsies, the use of digital formats (e.g., in lectures, microscopy courses), a more precise introduction to the assessment of histopathological findings, and a better presentation of the fields of activity in pathology. Attempts should be made throughout Germany to standardize teaching more in order to better represent the subject to deaneries and examination offices. In addition, efforts should be made to modernize teaching content and methods to make the subject more attractive to potential new recruits.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"163-170"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Incidental diagnosis of lymphangioleiomyomatosis in gynecological surgery-a case series]. 【妇科手术中淋巴管平滑肌瘤病的偶然诊断-病例系列】。

Pathologie (Heidelberg, Germany) Pub Date : 2025-05-01 Epub Date: 2025-02-07 DOI: 10.1007/s00292-025-01414-0

Julia Müller, Blake Gilks, Jessica McAlpine, Grit Gesine Ruth Hiller, Anne Kathrin Höhn, Lars-Christian Horn

{"title":"[Incidental diagnosis of lymphangioleiomyomatosis in gynecological surgery-a case series].","authors":"Julia Müller, Blake Gilks, Jessica McAlpine, Grit Gesine Ruth Hiller, Anne Kathrin Höhn, Lars-Christian Horn","doi":"10.1007/s00292-025-01414-0","DOIUrl":"10.1007/s00292-025-01414-0","url":null,"abstract":"Background: Lymphangioleiomyomatosis (LAM) is a rare, slow progressing, low-grade neoplasia that primarily effects young women. The disease is well known for its pulmonary involvement with cystic destruction, but extra-pulmonary disease may occur. LAM is associated with mutations in the TSC 1 or TSC 2 genes and may develop sporadically or in the context of hereditary disease tuberous sclerosis complex (TSC). Incident LAM may represent the sentinel finding of the disease.Objective: Raising awareness for rare extrapulmonary LAM lesions in retroperitoneum and pelvic cavity.Methods: Data-based research was performed for LAM in gynecological surgical specimens. H&E-stained slides were re-examined, and immunohistochemical stains were re-evaluated. Clinical data were retrieved for the presence pulmonary LAM or TSC.Results: A total of 13 cases were identified. The age of the patients ranged from 32 to 77 years, and 8/13 were ≤ 55 years. Two women had a history of pulmonary LAM and TSC. Most women underwent surgery for gynecological malignancy. On histological examination, 10/13 patients presented LAM in 1 to 9 lymph nodes with a lesion size of 0.5 to 12.0 mm, mainly located subcapsular or in the nodal parenchyma. Three of the 13 women showed extranodal involvement of the retroperitoneum, myometrium, and the hilum of the ovary. Immunohistochemically LAM was positive for HMB45, desmin, and smooth muscle actin.Conclusion: LAM is a rare systemic disease that mainly involves the lungs. Nevertheless, extra-pulmonary manifestations may occur. It is important to report the incidental finding of even small foci of LAM within the pathology report. Incidental LAM may represent the sentinel lesion for pulmonary LAM and/or TSC.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"179-184"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum zu: Molekularpathologie des nichtkleinzelligen Lungenkarzinoms: aktuelle und kommende Biomarker. 非小细胞肺癌的分子病理学：当前和未来的生物标志物。

Pathologie (Heidelberg, Germany) Pub Date : 2025-04-23 DOI: 10.1007/s00292-025-01434-w

Helen Pasternack, Jutta Kirfel

引用次数: 0

[Prostate cancer in the biopsy : Diagnostic criteria, mimickers/pitfalls, and subtypes]. [前列腺癌活检：诊断标准，模仿/陷阱和亚型]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-04-22 DOI: 10.1007/s00292-025-01432-y

Glen Kristiansen, Marit Bernhardt

引用次数: 0