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[Tumor-in-tumor metastasis: a rare phenomenon]. [肿瘤内转移：一种罕见现象]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-02 DOI: 10.1007/s00292-024-01375-w
Felix Elsner, Katharina Keller, Florian Fuchs, Michael Uder, Arndt Hartmann
{"title":"[Tumor-in-tumor metastasis: a rare phenomenon].","authors":"Felix Elsner, Katharina Keller, Florian Fuchs, Michael Uder, Arndt Hartmann","doi":"10.1007/s00292-024-01375-w","DOIUrl":"https://doi.org/10.1007/s00292-024-01375-w","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[SARIFA-a new multi-entity biomarker]. [SARIFA--一种新的多实体生物标记物]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-01 Epub Date: 2024-10-04 DOI: 10.1007/s00292-024-01368-9
Bianca Grosser, Nic G Reitsam, Przmyslaw Grochowski, Lukas Rentschler, Johanna Enke, Bruno Märkl
{"title":"[SARIFA-a new multi-entity biomarker].","authors":"Bianca Grosser, Nic G Reitsam, Przmyslaw Grochowski, Lukas Rentschler, Johanna Enke, Bruno Märkl","doi":"10.1007/s00292-024-01368-9","DOIUrl":"10.1007/s00292-024-01368-9","url":null,"abstract":"<p><p>A stroma a‑reactive invasion front area (SARIFA) is a new prognostic biomarker in carcinomas. Essentially, SARIFA describes the occurrence of direct contact between at least five tumor cells and adipocytes. This phenomenon is extremely easy and quick to identify, shows an extremely low interobserver variability, and does not require any additional staining as it can be identified on standard HE sections. The prognostic efficiency has now been demonstrated in gastric, colorectal, pancreatic, and prostate carcinoma.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"397-403"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Why tumors of the urinary bladder?] [为什么是膀胱肿瘤？]
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-01 Epub Date: 2024-10-25 DOI: 10.1007/s00292-024-01355-0
N T Gaisa, A Hartmann
{"title":"[Why tumors of the urinary bladder?]","authors":"N T Gaisa, A Hartmann","doi":"10.1007/s00292-024-01355-0","DOIUrl":"https://doi.org/10.1007/s00292-024-01355-0","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":"45 6","pages":"361-362"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[New edition of the Paris classification 2022: What is new?] [新版《2022 年巴黎分级》：有哪些新内容？］
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-01 Epub Date: 2024-07-03 DOI: 10.1007/s00292-024-01340-7
Tatjana Vlajnic, Lukas Bubendorf
{"title":"[New edition of the Paris classification 2022: What is new?]","authors":"Tatjana Vlajnic, Lukas Bubendorf","doi":"10.1007/s00292-024-01340-7","DOIUrl":"10.1007/s00292-024-01340-7","url":null,"abstract":"<p><p>As an internationally accepted diagnostic system, the Paris classification has achieved a global breakthrough in the standardization of diagnoses in urine cytology. Based on experience over the past few years since its first publication, the new edition of the Paris classification refines the diagnostic criteria and discusses diagnostic pitfalls. While the detection of high-grade urothelial carcinoma remains the main focus, other aspects of urine cytology, including cytology of the upper urinary tract and the associated challenges, have also been addressed. Low-grade urothelial neoplasia is no longer listed as a separate category but is now included in the category \"negative for high-grade urothelial carcinoma\" (NGHUC). Essentially, the Paris classification provides an important basis for estimating the risk of malignancy and further clinical management.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"389-396"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11511721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[FGFR2/3 in urothelial carcinoma]. [尿路癌中的表皮生长因子受体 2/3］
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-01 Epub Date: 2024-09-18 DOI: 10.1007/s00292-024-01363-0
Michael Rose, Nadine T Gaisa
{"title":"[FGFR2/3 in urothelial carcinoma].","authors":"Michael Rose, Nadine T Gaisa","doi":"10.1007/s00292-024-01363-0","DOIUrl":"10.1007/s00292-024-01363-0","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"409-411"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pediatric soft tissue tumors : Tumors of uncertain origin]. [小儿软组织肿瘤：来源不明的肿瘤]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-01 Epub Date: 2024-10-02 DOI: 10.1007/s00292-024-01356-z
K Greimelmaier, C Vokuhl
{"title":"[Pediatric soft tissue tumors : Tumors of uncertain origin].","authors":"K Greimelmaier, C Vokuhl","doi":"10.1007/s00292-024-01356-z","DOIUrl":"10.1007/s00292-024-01356-z","url":null,"abstract":"<p><p>Soft tissue tumors of childhood are an extremely heterogeneous group of tumors that require precise diagnosis for therapy. In this article, selected tumors of uncertain origin that exhibit characteristic histological, immunophenotypical, and molecular features are addressed. Angiomatoid fibrous histiocytoma, alveolar soft part sarcoma, extrarenal rhabdoid tumor, synovial sarcoma, and desmoplastic small round cell tumor differ in their pathology, their clinical behavior, and prognosis.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"412-421"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cyst of Hattori-a rare lesion in the posterior mediastinum]. [服部囊肿--后纵隔的罕见病变]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-01 Epub Date: 2024-05-10 DOI: 10.1007/s00292-024-01334-5
Felix Elsner, Koblandy Khamitov, Maximilian Hinsen, Horia Sirbu, Arndt Hartmann
{"title":"[Cyst of Hattori-a rare lesion in the posterior mediastinum].","authors":"Felix Elsner, Koblandy Khamitov, Maximilian Hinsen, Horia Sirbu, Arndt Hartmann","doi":"10.1007/s00292-024-01334-5","DOIUrl":"10.1007/s00292-024-01334-5","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"359-360"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Muscle-invasive and metastatic urothelial carcinoma of the urinary bladder : Current state of histopathologic, molecular, and immunologic prognostic and predictive factors]. [膀胱肌肉浸润性和转移性尿路上皮癌 ：组织病理学、分子和免疫学预后和预测因素的现状]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-01 Epub Date: 2024-08-07 DOI: 10.1007/s00292-024-01347-0
Simone Bertz, Veronika Bahlinger, Fabienne Lange, Arndt Hartmann, Markus Eckstein
{"title":"[Muscle-invasive and metastatic urothelial carcinoma of the urinary bladder : Current state of histopathologic, molecular, and immunologic prognostic and predictive factors].","authors":"Simone Bertz, Veronika Bahlinger, Fabienne Lange, Arndt Hartmann, Markus Eckstein","doi":"10.1007/s00292-024-01347-0","DOIUrl":"10.1007/s00292-024-01347-0","url":null,"abstract":"<p><strong>Background: </strong>Muscle-invasive and metastatic urothelial carcinoma (UC) represents a heterogeneous disease entity with numerous morphological, molecular, and immunological phenotypes.</p><p><strong>Aims: </strong>This article aims to provide an overview of current histopathological, molecular, and immunological prognostic and predictive factors in muscle-invasive and metastatic UC.</p><p><strong>Results and discussion: </strong>Muscle-invasive and metastatic UC exhibits a wide range of divergent differentiations and histological subtypes. The correct diagnosis of these morphological variants is essential, as they may determine the clinical course and may also present specific and potentially therapeutically targetable molecular alterations (e.g., HER2 alterations in micropapillary UC). The morphological subtypes largely correlate with the six molecular consensus subtypes. Furthermore, morphological and molecular subtypes are associated with immunological properties that are relevant for modern immunotherapies, such as the PD-L1 status. Numerous immunotherapy studies in the setting of curatively treatable muscle-invasive UC will be reported in 2024 and 2025, likely leading to an increasing number of PD-L1 testing indications.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"363-370"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Solitary fibrous tumor in a thyroid follicular adenoma]. [甲状腺滤泡腺瘤中的孤立性纤维瘤]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-01 Epub Date: 2024-09-12 DOI: 10.1007/s00292-024-01353-2
Sarah Theurer, Simon Schimmack, Hideo A Baba
{"title":"[Solitary fibrous tumor in a thyroid follicular adenoma].","authors":"Sarah Theurer, Simon Schimmack, Hideo A Baba","doi":"10.1007/s00292-024-01353-2","DOIUrl":"10.1007/s00292-024-01353-2","url":null,"abstract":"<p><p>A 28-year-old female patient developed a 5.5 cm progressive thyroid nodule that was surgically removed due to local symptoms. Histologically, a solitary fibrous tumor (SFT) in a thyroid adenoma was diagnosed. The tumor had a specific NAB2-STAT6 fusion.Solitary fibrous tumors rarely occur in the thyroid gland and are described as both primary and secondary manifestations. The diagnosis, prognosis assessment and treatment decision are carried out analogously to SFT of other localizations.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"404-408"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11511758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mimickers and diagnostic pitfalls of urinary bladder cancer]. [膀胱癌的模仿者和诊断陷阱]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-11-01 Epub Date: 2024-05-30 DOI: 10.1007/s00292-024-01335-4
K Lindemann-Docter, N T Gaisa
{"title":"[Mimickers and diagnostic pitfalls of urinary bladder cancer].","authors":"K Lindemann-Docter, N T Gaisa","doi":"10.1007/s00292-024-01335-4","DOIUrl":"10.1007/s00292-024-01335-4","url":null,"abstract":"<p><p>Urothelial carcinoma (UC) is by far the most common malignant neoplasm of the urinary bladder; however, there are both benign and malignant changes of the urothelium which morphologically resemble urothelial carcinomas or other carcinomas of the urinary bladder. Thus, these mimickers can cause problems in the histomorphological diagnosis. This article provides an overview of possible mimickers and pitfalls of bladder cancer as well as practical notes on the diagnostic procedure, partly using case studies.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"371-380"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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