Pathologie (Heidelberg, Germany)最新文献_第3页

[New methods at the transition from research to routine diagnostics]. [从研究向常规诊断过渡的新方法]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-01-22 DOI: 10.1007/s00292-024-01412-8

Argyris Papantonis, Stephan Rogalla, Christian Dullin, Frauke Alves, Hanibal Bohnenberger

{"title":"[New methods at the transition from research to routine diagnostics].","authors":"Argyris Papantonis, Stephan Rogalla, Christian Dullin, Frauke Alves, Hanibal Bohnenberger","doi":"10.1007/s00292-024-01412-8","DOIUrl":"https://doi.org/10.1007/s00292-024-01412-8","url":null,"abstract":"Background: Pathology, traditionally focused on classification and diagnosis, is continuously evolving through new technologies. Advances in proteomics, epigenetics, tissue staining, and 3D imaging expand the possibilities of classical morphology.Aim of the study: The aim of this study was to investigate how modern technologies can improve diagnostic accuracy and therapy selection and how they can be integrated into pathologic routine diagnostics.Materials and methods: Recent studies in proteomics, epigenetics, multiplex tissue staining, and 3D tissue imaging were analyzed to assess their application and the challenges of clinical implementation.Results: The analysis shows significant potential for pathologic diagnostics. Proteomics provides a deeper understanding of the molecular architecture of tumors, while epigenetics and 3D genome architecture offer new insights into genetic regulation and tumor heterogeneity. Multiplex tissue staining and 3D tissue imaging improve spatial tissue analysis.Discussion: Despite the potential to improve diagnostics, high costs, technical complexity, and lack of standardization hinder integration into clinical practice. Nevertheless, these technologies offer promising approaches for optimizing diagnostics and therapy selection. Research and interdisciplinary collaboration are crucial to successfully integrating these innovations into routine clinical practice.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[State of digitalization in dermatopathology]. [皮肤病理学数字化现状]。

Pathologie (Heidelberg, Germany) Pub Date : 2025-01-03 DOI: 10.1007/s00292-024-01401-x

Stephan A Braun, Paul Schmidle, Nicole Duschner, Jörg Schaller

引用次数: 0

[Clues in dermatopathological diagnostics]. [皮肤病理诊断的线索]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-12-09 DOI: 10.1007/s00292-024-01400-y

Almut Böer-Auer

引用次数: 0

[Establishment of a German ICCR dataset : Translation and integration of SNOMED CT using the example of TUR-B]. [德国ICCR数据集的建立：以turb为例的SNOMED CT的翻译和整合]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-12-05 DOI: 10.1007/s00292-024-01398-3

J Dörenberg, C J Schmidt, T Berlage, R Knüchel-Clarke

{"title":"[Establishment of a German ICCR dataset : Translation and integration of SNOMED CT using the example of TUR-B].","authors":"J Dörenberg, C J Schmidt, T Berlage, R Knüchel-Clarke","doi":"10.1007/s00292-024-01398-3","DOIUrl":"https://doi.org/10.1007/s00292-024-01398-3","url":null,"abstract":"Background: The structured recording of data from histopathological findings and their interoperability is critical for quality assurance in pathology.Materials and methods: To harmonize the content of the reports, the International Collaboration on Cancer Reporting (ICCR) has defined standardized datasets. These datasets are not yet available in German nationwide. This gap is addressed here using the transurethral bladder resection (TUR-B) dataset as a use case.Results: We describe the process of establishing the datasets by carrying out translation, mapping on SNOMED CT codes, and using SNOMED CTs hierarchy to fill dropdown menus. Furthermore, we identified rules for checking for self-consistency of reports by using the example of the TUR bladder.Discussion: With this article, we have created an example of a German version of the ICCR TUR‑B dataset including mapping to the SNOMED CT terminology. Further activities should include the definition of overarching cancer disease models to further exploit the potential of SNOMED CT.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Microsatellite instability-What should be considered in routine examinations?] [微卫星不稳定性--常规检查应注意什么？］

Pathologie (Heidelberg, Germany) Pub Date : 2024-11-19 DOI: 10.1007/s00292-024-01392-9

Wolfgang Dietmaier, Daniela Hirsch, Josef Rüschoff

引用次数: 0

[Granulomatous reaction to Dermalive filler]. [对 Dermalive 填充剂的肉芽肿反应]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-11-06 DOI: 10.1007/s00292-024-01384-9

Michael Bento Schmid, Natalja Denisjuk

引用次数: 0

[Tumor-in-tumor metastasis: a rare phenomenon]. [肿瘤内转移：一种罕见现象]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-11-02 DOI: 10.1007/s00292-024-01375-w

Felix Elsner, Katharina Keller, Florian Fuchs, Michael Uder, Arndt Hartmann

引用次数: 0

[SARIFA-a new multi-entity biomarker]. [SARIFA--一种新的多实体生物标记物]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-11-01 Epub Date: 2024-10-04 DOI: 10.1007/s00292-024-01368-9

Bianca Grosser, Nic G Reitsam, Przmyslaw Grochowski, Lukas Rentschler, Johanna Enke, Bruno Märkl

引用次数: 0

Subtyping of pancreatic neuroendocrine tumors by transcription factors, hormones, histology, and patient outcome. 通过转录因子、激素、组织学和患者预后对胰腺神经内分泌肿瘤进行亚型分类。

Pathologie (Heidelberg, Germany) Pub Date : 2024-11-01 Epub Date: 2024-10-08 DOI: 10.1007/s00292-024-01367-w

Elisa Moser, Ayako Ura, Günter Klöppel, Atsuko Kasajima

{"title":"Subtyping of pancreatic neuroendocrine tumors by transcription factors, hormones, histology, and patient outcome.","authors":"Elisa Moser, Ayako Ura, Günter Klöppel, Atsuko Kasajima","doi":"10.1007/s00292-024-01367-w","DOIUrl":"10.1007/s00292-024-01367-w","url":null,"abstract":"Background: Pancreatic neuroendocrine tumors (PanNETs) show pronounced heterogeneity in terms of hormone and transcription factor (TF) expression. TFs such as ARX and PDX1 are related to alpha- and beta-cell-type features, respectively, and partly associate with patient outcome. However, detailed studies correlating hormone expression, histology, and clinical data are lacking.Objective: The aim of this study was to identify subtypes of PanNETs that associate with histological, hormonal, and prognostic findings.Methods: A total of 185 resected PanNETs were divided into five subtypes (types A1, A2, B, C, and D) by cluster analysis based on expression of four TFs (ARX, PDX1, ISL1, and CDX2) and correlated to the expression of hormones and DAXX/ATRX as well as ALT activation status, histology, and progression-free survival.Results: Subgroup A1 (ISL1+/ARX+/PDX-/CDX2-) was most frequent (46%), followed by type B (18%; ISL1+/ARX-/PDX+/CDX2-), A2 (15%; ISL1+/ARX+/PDX+/CDX2-), C (15%; ISL1-/ARX-/PDX-/CDX2-), and D (5%; ISL1-/ARX-/PDX+/CDX2+). Subgroups A1 and A2 showed a strong association with a trabecular growth pattern and glucagon and pancreatic polypeptide (PP) expression (p < 0.001), while A2 was in addition associated with gastrin expression. Subgroup B was associated with insulin production (p < 0.001) and included all 17 insulinomas. Subgroup C was associated with solid morphology and expression of serotonin, calcitonin, and adrenocorticotropic hormone (ACTH). Subgroup D showed solid morphology, expression of ACTH, somatostatin, or serotonin and had the shortest disease-free survival (p < 0.01). ALT positivity was associated with poorer outcome in types A1 and A2 but not in other types.Conclusion: PanNETs can be categorized into five subgroups based on different TF signatures, which associate strongly with histology, hormone production, functionality, and patient outcome.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"20-25"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Report of the Young Pathology Working Group of the German Society for Pathology]. [德国病理学学会青年病理学工作组报告]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-11-01 Epub Date: 2024-11-07 DOI: 10.1007/s00292-024-01376-9

Stefanie Bobe, Philipp Jurmeister

引用次数: 0