Pathologie (Heidelberg, Germany)最新文献_第4页

Hans Konrad Müller-Hermelink : 21.06.1943–11.05.2024. Hans Konrad Müller-Hermelink : 21.06.1943-11.05.2024.

Pathologie (Heidelberg, Germany) Pub Date : 2024-10-31 DOI: 10.1007/s00292-024-01371-0

Andreas Rosenwald, German Ott

引用次数: 0

[Circumscribed choroidal hemangioma in Sturge-Weber syndrome]. [Sturge-Weber综合征中的环状脉络膜血管瘤]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-10-29 DOI: 10.1007/s00292-024-01373-y

Anna Vetter, Annette Zimpfer, Björn Schneider, Andreas Erbersdobler, Tobias Brockmann, Thomas Fuchsluger, Claudia Brockmann

引用次数: 0

[A lump in the male breast-case report of an unusual tumor manifestation]. [男性乳房肿块--异常肿瘤表现的病例报告]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-10-16 DOI: 10.1007/s00292-024-01369-8

Torsten Hansen, E Z Kovacs, J Kriegsmann, S M Jud

引用次数: 0

[Unusual proliferation of the fallopian tube]. [输卵管异常增生]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-10-11 DOI: 10.1007/s00292-024-01370-1

Angelina Vlaški, Vanessa Neukunft, Andrea Maria Gassel, Frederick Klauschen, Doris Mayr

引用次数: 0

Subtyping of pancreatic neuroendocrine tumors by transcription factors, hormones, histology, and patient outcome. 通过转录因子、激素、组织学和患者预后对胰腺神经内分泌肿瘤进行亚型分类。

Pathologie (Heidelberg, Germany) Pub Date : 2024-10-08 DOI: 10.1007/s00292-024-01367-w

Elisa Moser, Ayako Ura, Günter Klöppel, Atsuko Kasajima

{"title":"Subtyping of pancreatic neuroendocrine tumors by transcription factors, hormones, histology, and patient outcome.","authors":"Elisa Moser, Ayako Ura, Günter Klöppel, Atsuko Kasajima","doi":"10.1007/s00292-024-01367-w","DOIUrl":"https://doi.org/10.1007/s00292-024-01367-w","url":null,"abstract":"Background: Pancreatic neuroendocrine tumors (PanNETs) show pronounced heterogeneity in terms of hormone and transcription factor (TF) expression. TFs such as ARX and PDX1 are related to alpha- and beta-cell-type features, respectively, and partly associate with patient outcome. However, detailed studies correlating hormone expression, histology, and clinical data are lacking.Objective: The aim of this study was to identify subtypes of PanNETs that associate with histological, hormonal, and prognostic findings.Methods: A total of 185 resected PanNETs were divided into five subtypes (types A1, A2, B, C, and D) by cluster analysis based on expression of four TFs (ARX, PDX1, ISL1, and CDX2) and correlated to the expression of hormones and DAXX/ATRX as well as ALT activation status, histology, and progression-free survival.Results: Subgroup A1 (ISL1+/ARX+/PDX-/CDX2-) was most frequent (46%), followed by type B (18%; ISL1+/ARX-/PDX+/CDX2-), A2 (15%; ISL1+/ARX+/PDX+/CDX2-), C (15%; ISL1-/ARX-/PDX-/CDX2-), and D (5%; ISL1-/ARX-/PDX+/CDX2+). Subgroups A1 and A2 showed a strong association with a trabecular growth pattern and glucagon and pancreatic polypeptide (PP) expression (p < 0.001), while A2 was in addition associated with gastrin expression. Subgroup B was associated with insulin production (p < 0.001) and included all 17 insulinomas. Subgroup C was associated with solid morphology and expression of serotonin, calcitonin, and adrenocorticotropic hormone (ACTH). Subgroup D showed solid morphology, expression of ACTH, somatostatin, or serotonin and had the shortest disease-free survival (p < 0.01). ALT positivity was associated with poorer outcome in types A1 and A2 but not in other types.Conclusion: PanNETs can be categorized into five subgroups based on different TF signatures, which associate strongly with histology, hormone production, functionality, and patient outcome.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic issues in neuroendocrine neoplasms of the lung. 肺部神经内分泌肿瘤的诊断问题。

Pathologie (Heidelberg, Germany) Pub Date : 2024-10-02 DOI: 10.1007/s00292-024-01360-3

Atsuko Kasajima, Günter Klöppel

引用次数: 0

[Reinhard Spanel : 4 March 1943-28 March 2024]. [莱因哈特-斯帕内尔：1943 年 3 月 4 日至 2024 年 3 月 28 日]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-09-26 DOI: 10.1007/s00292-024-01359-w

Jörg Placke

引用次数: 0

[Report of the German Society of Pathology Working Group on Pediatric and Fetal Pathology]. [德国病理学会小儿和胎儿病理学工作组报告]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-09-26 DOI: 10.1007/s00292-024-01358-x

Elise Gradhand, Thomas Hager

引用次数: 0

[Histopathological diagnostics for assessment questions of tendo-, ligamento-, and meniscus pathologies]. [腱、韧带和半月板病变评估问题的组织病理学诊断]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-09-24 DOI: 10.1007/s00292-024-01354-1

Veit Krenn, Lara Blümke, Ralf Dieckmann

{"title":"[Histopathological diagnostics for assessment questions of tendo-, ligamento-, and meniscus pathologies].","authors":"Veit Krenn, Lara Blümke, Ralf Dieckmann","doi":"10.1007/s00292-024-01354-1","DOIUrl":"https://doi.org/10.1007/s00292-024-01354-1","url":null,"abstract":"This review article presents the possibilities and limitations of histopathological diagnostics on the issues of joint diseases, including in the context of the medical insurance inquiries, which consider the important articular, non-osseous compartments, especially of the tendons, ligaments, and meniscus. Essential for expert assessments is the causal clarification of whether the continuity disruption has been induced exogenously by trauma or endogenously based on tissue that is functionally impaired and thus degeneratively altered. The degree of degeneration/texture disorder is determined by means of the degeneration-score, which is set in a semiquantitative, three-stage grading. Grades 1 and 2 are summed up as low-grade degeneration and compared to grade 3, high-grade degeneration. Age determination of continuity disruption is based on the assessment of the morphology of discontinuity and on the assessment of hemosiderin deposits. The tasks of histopathological diagnostics thus consist of the detection and grading of textural disorder (degeneration), the determination of the histopathologic age of existing continuity disruptions, and particularly the diagnosis of clinically/radiologically undiagnosed diseases, which may be relevant for pathogenesis. In the case of contradictory diagnoses from different diagnostic disciplines and in the case of imprecise and potentially even contradictory patient information, purely legal, judicial decisions may be necessary. In this case the legally binding assessment within the framework of legal evidence evaluation then arises.","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Report of the German Society of Pathology Working Group on Bone, Joint, and Soft Tissue Pathology]. [德国病理学会骨、关节和软组织病理学工作组报告]。

Pathologie (Heidelberg, Germany) Pub Date : 2024-09-24 DOI: 10.1007/s00292-024-01357-y

Thomas F E Barth, Bruno Märkl

引用次数: 0