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[Report of the German Society of Pathology Working Group on Uropathology]. [德国病理学学会泌尿病理学工作组报告]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-24 DOI: 10.1007/s00292-024-01361-2
Henning Reis, Felix Bremmer
{"title":"[Report of the German Society of Pathology Working Group on Uropathology].","authors":"Henning Reis, Felix Bremmer","doi":"10.1007/s00292-024-01361-2","DOIUrl":"https://doi.org/10.1007/s00292-024-01361-2","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Report of the German Society of Pathology Thoracic Pathology Working Group]. [德国病理学会胸腔病理学工作组报告]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-24 DOI: 10.1007/s00292-024-01362-1
Christiane Kümpers, Maximilian von Laffert
{"title":"[Report of the German Society of Pathology Thoracic Pathology Working Group].","authors":"Christiane Kümpers, Maximilian von Laffert","doi":"10.1007/s00292-024-01362-1","DOIUrl":"https://doi.org/10.1007/s00292-024-01362-1","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Report of the cardiac, vascular, renal, and transplantation pathology working group]. [心脏、血管、肾脏和移植病理学工作组报告]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-09 DOI: 10.1007/s00292-024-01352-3
J H Bräsen, J Wohlschläger
{"title":"[Report of the cardiac, vascular, renal, and transplantation pathology working group].","authors":"J H Bräsen, J Wohlschläger","doi":"10.1007/s00292-024-01352-3","DOIUrl":"https://doi.org/10.1007/s00292-024-01352-3","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The EGFR biomarker in tumor pathology]. [肿瘤病理学中的表皮生长因子受体生物标记物]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-08-07 DOI: 10.1007/s00292-024-01342-5
Ulrich Lehmann, Albrecht Stenzinger
{"title":"[The EGFR biomarker in tumor pathology].","authors":"Ulrich Lehmann, Albrecht Stenzinger","doi":"10.1007/s00292-024-01342-5","DOIUrl":"10.1007/s00292-024-01342-5","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"344-346"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Endometrial carcinoma: molecular classification in routine pathology]. [子宫内膜癌：常规病理学中的分子分类]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-08-14 DOI: 10.1007/s00292-024-01345-2
Udo Siebolts, Birgid Schömig-Markiefka, Janna Siemanowski-Hrach, Sabine Merkelbach-Bruse
{"title":"[Endometrial carcinoma: molecular classification in routine pathology].","authors":"Udo Siebolts, Birgid Schömig-Markiefka, Janna Siemanowski-Hrach, Sabine Merkelbach-Bruse","doi":"10.1007/s00292-024-01345-2","DOIUrl":"10.1007/s00292-024-01345-2","url":null,"abstract":"<p><p>The molecular classification of endometrial carcinoma defines four main groups: polymerase‑ɛ(PolE) gene mutated, microsatellite unstable (MSI), p53 abnormal tumors and tumors with no specific molecular profile (NSMP). This classification provides significant insights into the prognosis and therapeutic decisions. Each group exhibits unique genetic profiles identified through immunohistochemistry and molecular diagnostics, enabling personalized treatment. The identification of these molecular signatures necessitates precise analytical methods, selected based on the local circumstances at each site. The approach to molecular classification highlights the critical role of pathology in the diagnosis and emphasizes the necessity of collaboration between the clinic and pathology.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"347-354"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141977413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Quantification of Ki-67 in PitNET (pituitary neuroendocrine tumors)/adenomas]. [PitNET（垂体神经内分泌肿瘤）/腺瘤中 Ki-67 的定量]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-07-11 DOI: 10.1007/s00292-024-01319-4
Judith Klein, Kai Saeger, Wolfgang Saeger
{"title":"[Quantification of Ki-67 in PitNET (pituitary neuroendocrine tumors)/adenomas].","authors":"Judith Klein, Kai Saeger, Wolfgang Saeger","doi":"10.1007/s00292-024-01319-4","DOIUrl":"10.1007/s00292-024-01319-4","url":null,"abstract":"<p><p>This study is the first to compare the determination of the Ki-67 index in pituitary neuroendocrine tumors (PitNET)/pituitary adenomas by pathologists with a computerized method (Cognition MasterSuite from VMScope, Berlin, Germany). PitNET/pituitary adenomas often show a low proliferation index. Observer variability is high, especially when estimating in this low percentage range. A more reliable determination would be possible using the four-eyes principle, but this cannot be realized continuously; thus, digital image analysis is a promising solution. In the study, there was clear agreement between the Ki-67 estimate by two experienced pathologists and the determination with the aid of digital image analysis. The digital image analysis system is excellent for determining the proliferation rate of PitNET/pituitary adenomas and can therefore be used to determine the \"third\" and \"fourth eye\".</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"339-343"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11343892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mesothelioma-30 years after the asbestos ban in Germany]. [德国禁止使用石棉 30 年后的间皮瘤]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-07-31 DOI: 10.1007/s00292-024-01350-5
T Kraus, D Jonigk
{"title":"[Mesothelioma-30 years after the asbestos ban in Germany].","authors":"T Kraus, D Jonigk","doi":"10.1007/s00292-024-01350-5","DOIUrl":"10.1007/s00292-024-01350-5","url":null,"abstract":"<p><p>In 1993, a total asbestos ban was introduced in Germany. Thirty years later, mesothelioma is still one of the most frequent occupational diseases. Recent data on incidence, mortality, recognized occupational diseases, early detection, and assessment are presented in this article.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"305-308"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mesotheliomas-current status in etiology, diagnostics, and molecular pathology]. [间皮瘤--病因学、诊断学和分子病理学现状]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-08-23 DOI: 10.1007/s00292-024-01348-z
Andrea Tannapfel, Iris Tischoff
{"title":"[Mesotheliomas-current status in etiology, diagnostics, and molecular pathology].","authors":"Andrea Tannapfel, Iris Tischoff","doi":"10.1007/s00292-024-01348-z","DOIUrl":"https://doi.org/10.1007/s00292-024-01348-z","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":"45 5","pages":"303-304"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Benign mesothelial tumors]. [良性间皮瘤]。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-05-02 DOI: 10.1007/s00292-024-01333-6
Iris Tischoff, Anja Theile
{"title":"[Benign mesothelial tumors].","authors":"Iris Tischoff, Anja Theile","doi":"10.1007/s00292-024-01333-6","DOIUrl":"10.1007/s00292-024-01333-6","url":null,"abstract":"<p><p>Benign mesothelial tumors are rarer than malignant mesotheliomas and are often found in the peritoneum as incidental findings in women. They include the adenomatoid tumor (AT), the well-differentiated mesothelial tumor (WDPMT), the mesothelioma in situ (MIS), and the solid papillary mesothelial tumor (SPMT). ATs are always benign and predominantly manifest in the genital tract. WDPMTs can develop multifocally and are prone to recurrence, particularly in the case of incomplete resection. Only MISs are considered a confirmed precursor lesion of malignant mesothelioma according to the currently valid World Health Organization (WHO) classifications. As with malignant mesothelioma, alterations of BAP1, MTAP, and p16 are detectable for MIS in contrast to the other three tumors. SPMTs cannot be clearly assigned to the other mesothelial tumors and have so far only been described in the peritoneum in women with a benign course.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"324-332"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesothelioma: molecular pathology and biomarkers. 间皮瘤：分子病理学和生物标志物。
Pathologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-08-07 DOI: 10.1007/s00292-024-01344-3
Yin P Hung
{"title":"Mesothelioma: molecular pathology and biomarkers.","authors":"Yin P Hung","doi":"10.1007/s00292-024-01344-3","DOIUrl":"10.1007/s00292-024-01344-3","url":null,"abstract":"<p><p>Diffuse mesotheliomas are characterized by recurrent genomic alterations involving tumor suppressors and epigenetic regulators such as BAP1, CDKN2A, MTAP, and NF2. Depending on the differential diagnosis as informed by histologic assessment, one can apply the appropriate immunohistochemical and/or molecular panels to reach the correct pathologic diagnosis, sometimes even in cases with limited tissues. Biomarkers aid in the diagnosis of mesothelioma in the following scenarios: 1) For a tumor that is overtly malignant, how can one distinguish mesothelioma from other tumors? 2) For a mesothelial proliferation, how can one distinguish mesothelioma from a reactive process? To distinguish mesotheliomas from carcinomas, at least two positive and two negative markers are currently recommended. To distinguish sarcomatoid mesothelioma from pleomorphic carcinoma, even more markers-and sometimes molecular testing-are needed. To distinguish mesothelioma from reactive mesothelial conditions, useful immunohistochemical biomarkers include BAP1, MTAP, and merlin, which serve as surrogates for the corresponding gene mutation status. In patients with unusual clinical history, for tumors with a peculiar microscopic appearance, and/or in cases with an equivocal immunophenotypic profile, molecular testing can help to exclude mimics and to confirm the pathologic diagnosis.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"316-323"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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