Open research Europe最新文献

{"title":"Co-designing ab initio electronic structure methods on a RISC-V vector architecture.","authors":"Rogeli Grima Torres, Pablo Vizcaíno, Filippo Mantovani, José Julio Gutiérrez Moreno","doi":"10.12688/openreseurope.18321.1","DOIUrl":"10.12688/openreseurope.18321.1","url":null,"abstract":"<p><p><i>Ab initio</i> electronic structure applications are among the most widely used in High-Performance Computing (HPC), and the eigenvalue problem is often their main computational bottleneck. This article presents our initial efforts in porting these codes to a RISC-V prototype platform leveraging a wide Vector Processing Unit (VPU). Our software tester is based on a mini-app extracted from the ELPA eigensolver library. The user-space emulator Vehave and a RISC-V vector architecture implemented on an FPGA were tested. Metrics from both systems and different vectorisation strategies were extracted, ranging from the simplest and most portable one (using autovectorisation and assisting this by fusing loops in the code) to the more complex one (using intrinsics). We observed a progressive reduction in the number of vectorised instructions, executed instructions and computing cycles with the different methodologies, which will lead to a substantial speed-up in the calculations. The obtained outcomes are crucial in advancing the porting of computational materials and molecular science codes to (post)-exascale architectures using RISC-V-based technologies fully developed within the EU. Our evaluation also provides valuable feedback for hardware designers, engineers and compiler developers, making this use case pivotal for co-design efforts.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"4 ","pages":"165"},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11358678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational Diabetes Mellitus: Unveiling Maternal Health Dynamics from Pregnancy Through Postpartum Perspectives.","authors":"Marina Mora-Ortiz, Lorenzo Rivas-García","doi":"10.12688/openreseurope.18026.1","DOIUrl":"10.12688/openreseurope.18026.1","url":null,"abstract":"<p><p>Gestational Diabetes Mellitus (GDM) is the most frequent pregnancy-related medical issue and presents significant risks to both maternal and foetal health, requiring monitoring and management during pregnancy. The prevalence of GDM has surged globally in recent years, mirroring the rise in diabetes and obesity rates. Estimated to affect from 5% to 25% of pregnancies, GDM impacts approximately 21 million live births annually, according to the International Diabetes Federation (IDF). However, consensus on diagnostic approaches remains elusive, with varying recommendations from international organizations, which makes the comparison between research complicated. Compounding concerns are the short-term and long-term complications stemming from GDM for mothers and offspring. Maternal outcomes include heightened cardiovascular risks and a notable 70% risk of developing Type 2 Diabetes Mellitus (T2DM) within a decade postpartum. Despite this, research into the metabolic profiles associated with a previous GDM predisposing women to T2D remains limited. While genetic biomarkers have been identified, indicating the multifaceted nature of GDM involving hormonal changes, insulin resistance, and impaired insulin secretion, there remains a dearth of exploration into the enduring health implications for both mothers and their children. Furthermore, offspring born to mothers with GDM have been shown to face an increased risk of obesity and metabolic syndrome during childhood and adolescence, with studies indicating a heightened risk ranging from 20% to 50%. This comprehensive review aims to critically assess the current landscape of Gestational Diabetes Mellitus (GDM) research, focusing on its prevalence, diagnostic challenges, and health impacts on mothers and offspring. By examining state-of-the-art knowledge and identifying key knowledge gaps in the scientific literature, this review aims to highlight the multifaceted factors that have hindered a deeper understanding of GDM and its long-term consequences. Ultimately, this scholarly exploration seeks to promote further investigation into this critical area, improving health outcomes for mothers and their children.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"4 ","pages":"164"},"PeriodicalIF":0.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of flip-chip technology for the optical drive of superconducting circuits.","authors":"Oliver Kieler, Hao Tian, Marco Kraus, Shekhar Priyadarshi, Judith Felgner, Alexander Fernandez Scarioni, Johannes Kohlmann, Mark Bieler","doi":"10.12688/openreseurope.17481.2","DOIUrl":"10.12688/openreseurope.17481.2","url":null,"abstract":"<p><p>We discuss the flip-chip mounting process of photodiodes and fiber sleeves on silicon substrates to meet the increasing demand for fabrication of highly integrated and hybrid quantum circuits for operation at cryogenic temperatures. To further increase the yield and success rate of the flip-chip procedure, the size of the gold stud bumps, and flip-chip parameters were optimized. Moreover, to connect optical fibers to the photodiodes in an optimal position, the fiber sleeves were aligned with specially fabricated alignment circles before applying thermocompression with the flip-chip machine. The mounted photodiodes were tested at both room temperature and cryogenic temperature, and we find that mechanical imperfections of the sleeve-ferrule combination limit the overall alignment accuracy. The experimental results show that our flip-chip process is very reliable and promising for various optical and electrical applications and, thus, paves the way for fabrication of hybrid chips, multi-chip modules and chip-on-chip solutions, which are operated at cryogenic temperatures.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"4 ","pages":"97"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11585851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotics in honey: a comprehensive review on occurrence and analytical methodologies.","authors":"Helena Rodrigues, Marta Leite, Beatriz Oliveira, Andreia Freitas","doi":"10.12688/openreseurope.17664.2","DOIUrl":"https://doi.org/10.12688/openreseurope.17664.2","url":null,"abstract":"<p><p>Honey is a food of great nutritional importance and has always been used for human consumption. The production of honey and other beekeeping products depends on the proper functioning of this extremely important sector, as it has a direct impact on other sectors such as agriculture. The decline in bee colony numbers has been linked, among other factors, to bacterial diseases affecting bees, including American and European foulbrood, and <i>Nosema</i> spp. disease. In this matter, prophylactic or therapeutic use of veterinary drugs in apiculture is common but can lead to their accumulation in bees and in honey. Consumption of contaminated honey can have adverse effects such as allergic or hypersensitivity reactions, carcinogenicity, reproductive effects, and teratogenicity. Commission Regulation (EU) N ^⍛ 37/2010 sets MRLs for antibiotics in various foods, but these limits are not set for api-products. The lack of harmonized rules has led some countries to set recommended concentrations and minimum performance limits. Nonetheless, to achieve this goal, development of accurate and precise analytical methodologies is crucial. In recent years, the analysis of antibiotics in honey has led to the development of methods in an extensive range of families, including aminoglycosides, amphenicols, lincosamides, macrolides, nitroimidazoles, quinolones, sulfonamides, tetracyclines and nitrofurans. This review work entails an in-depth exploration of occurrence studies, extraction methodologies, and analytical techniques for the determination of antibiotics in apiculture products. It was found that the most used extraction methods include solid-phase extraction, dispersed solid or liquid phase extraction and QuEChERS. Due to the complexity of the honey matrix, samples are often diluted or acidified using McIlvaine buffer, H ₂O, MeOH, acidified ACN and TCA solution. This is usually followed by a purification step using SPE cartridges or PSA. Golden analytical methodologies include high-performance liquid chromatography coupled to a triple quadrupole mass spectrometer (MS/MS) with Orbitrap or Q-ToF detectors.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"4 ","pages":"125"},"PeriodicalIF":0.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SentemQC - A novel and cost-efficient method for quality assurance and quality control of high-resolution frequency sensor data in fresh waters.","authors":"Sofie Gyritia Madsen Van't Veen, Brian Kronvang, Joachim Audet, Thomas Alexander Davidson, Erik Jeppesen, Esben Astrup Kristensen, Søren Erik Larsen, Jane Rosenstand Laugesen, Eti Ester Levi, Anders Nielsen, Peter Mejlhede Andersen","doi":"10.12688/openreseurope.18134.1","DOIUrl":"10.12688/openreseurope.18134.1","url":null,"abstract":"<p><p>The growing use of sensors in fresh waters for water quality measurements generates an increasingly large amount of data that requires quality assurance (QA)/quality control (QC) before the results can be exploited. Such a process is often resource-intensive and may not be consistent across users and sensors. SentemQC (QA-QC of high temporal resolution sensor data) is a cost-efficient, and open-source Python approach developed to ensure the quality of sensor data by performing data QA and QC on large volumes of high-frequency (HF) sensor data. The SentemQC method is computationally efficient and features a six-step user-friendly setup for anomaly detection. The method marks anomalies in data using five moving windows. These windows connect each data point to neighboring points, including those further away in the moving window. As a result, the method can mark not only individual outliers but also clusters of anomalies. Our analysis shows that the method is robust for detecting anomalies in HF sensor data from multiple water quality sensors measuring nitrate, turbidity, oxygen, and pH. The sensors were installed in three different freshwater ecosystems (two streams and one lake) and experimental lake mesocosms. Sensor data from the stream stations yielded anomaly percentages of 0.1%, 0.1%, and 0.2%, which were lower than the anomaly percentages of 0.5%, 0.6%, and 0.8% for the sensors in Lake and mesocosms, respectively. While the sensors in this study contained relatively few anomalies (<2%), they may represent a best-case scenario in terms of use and maintenance. SentemQC allows the user to include the individual sensor uncertainty/accuracy when performing QA-QC. However, SentemQC cannot function independently. Additional QA-QC steps are crucial, including calibration of the sensor data to correct for zero offsets and implementation of gap-filling methods prior to the use of the sensor data for determination of final real-time concentrations and load calculations.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"4 ","pages":"244"},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges to ethical public engagement in research funding: a perspective from practice.","authors":"Kalli Giannelos, Martijn Wiarda, Neelke Doorn","doi":"10.12688/openreseurope.18126.2","DOIUrl":"https://doi.org/10.12688/openreseurope.18126.2","url":null,"abstract":"<p><p>European research funding organizations (RFOs) are increasingly experimenting with public engagement in their funding activities. This case study draws attention to the challenges they face in preparing, implementing, and evaluating ethical public engagement in the context of setting funding priorities, formulating calls for proposals, and evaluating project proposals. We discuss challenges related to seven themes: (1) recruiting participants; (2) commitments and expectations; (3) meaningful dialogue and equal engagement; (4) accommodating vulnerability; (5) funding call formulations; (6) lack of expertise in engagement ethics; and (7) uncertainty, resource constraints, and external factors. To address these challenges, we propose the following seven interventions: (1) developing comprehensive recruitment strategies with experienced recruiters and community organizations; (2) establishing clear communication of roles, expectations, and outcomes through codes of conduct; (3) training mediators to address power imbalances; (4) designing flexible engagement methods and providing tailored support; (5) implementing collaborative feedback loops for inclusive funding call formulation; (6) enhancing ethical standards through internal expertise and external advisory inputs; and (7) developing adaptive strategies for flexible and ethical public engagement. These recommendations emphasize the need for context-adaptive insights to support funding organizations to implement ethical public engagement activities, even when faced with organizational constraints and a lack of ethical expertise.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"4 ","pages":"179"},"PeriodicalIF":0.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 2024 inventory of test methods relevant to thyroid hormone system disruption for human health and environmental regulatory hazard assessment.","authors":"Lucia Vergauwen, Lola Bajard, Sabrina Tait, Ingrid Langezaal, Anita Sosnowska, Alessandra Roncaglioni, Ellen Hessel, Annick D van den Brand, Ann-Cathrin Haigis, Jiří Novák, Klára Hilscherová, Natalia Buławska, Nafsika Papaioannou, Elisavet Renieri, Eliana Spilioti, Anastasia Spyropoulou, Arno C Gutleb, Henrik Holbech, Dimitra Nikolopoulou, Miriam N Jacobs, Dries Knapen","doi":"10.12688/openreseurope.18739.1","DOIUrl":"10.12688/openreseurope.18739.1","url":null,"abstract":"<p><p>Thyroid hormone system disruption (THSD) is a growing concern in chemical hazard assessment due to its impact on human and environmental health and the scarce methods available for assessing the THSD potential of chemicals. In particular, the general lack of validated in silico and <i>in vitro</i> methods for assessing THS activity is of high concern. This manuscript provides an inventory of test methods relevant to THSD. Building on the Organisation for Economic Co-operation and Development (OECD) Guidance Document 150 and recent international developments, we highlight progress in in silico and <i>in vitro</i> methods, as well as <i>in vivo</i> assays. The provided inventory categorizes available methods according to the levels of the OECD Conceptual Framework, with an assessment of the validation status of each method. At Level 1, 12 in silico models that have been statistically validated and are directly related to THSD have been identified. At Level 2, 67 <i>in vitro</i> methods have been listed including those assessed in key initiatives such as the European Union Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) validation study to identify potential thyroid disruptors. At Levels 3-5, THSD-sensitive endpoints are being included in existing fish-based OECD Test Guidelines to complement amphibian assays. In total, the inventory counts 108 entries comprising established methods (e.g., OECD Test Guidelines) as well as citable methods that are under further development and in some cases are ready for validation or in the initial stages of validation. This work aims to support the ongoing development of strategies for regulatory hazard assessment, such as integrated approaches to testing and assessment (IATAs), for endocrine disruptors, addressing critical gaps in the current testing landscape for THSD in both human and environmental health contexts.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"4 ","pages":"242"},"PeriodicalIF":0.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental impacts of drugs against parasitic vector-borne diseases and the need to integrate sustainability into their development and use.","authors":"Clara M Lima, Elisa Uliassi, Eli S J Thoré, Michael G Bertram, Luis Cardoso, Anabela Cordeiro da Silva, Maria Paola Costi, Harry P de Koning","doi":"10.12688/openreseurope.18008.2","DOIUrl":"https://doi.org/10.12688/openreseurope.18008.2","url":null,"abstract":"<p><strong>Background: </strong>The current scientific discourse on environmental impacts of veterinary medicines mostly focuses on ectoparasiticides. Meanwhile, the environmental impacts of widely prescribed drugs for the treatment of human and animal parasitic vector-borne diseases (PVBD) remain largely unexplored. There is thus a need for evidence-based information to support guidelines and protocols for sustainable One Health PVBD drug development and use, while promoting greener research practices. Here, we reflect on the potential environmental impacts of PVBD drugs in current use, and the environmental impact of our research practices for developing new antiparasitics.</p><p><strong>Methods: </strong>We conducted a survey of the membership of the \"One Health drugs against parasitic vector borne diseases in Europe and beyond\" Cooperation in Science and Technology (COST) Action 21111 (OneHealth <i>drugs</i>) to assess the current appreciation of sustainable drug design concepts and the extent to which One Health and sustainability principles are integrated into PVBD drug discovery and development. The survey also explored which human, technical, and funding resources are currently used in Europe and neighbouring countries in PVBD drugs research.</p><p><strong>Results: </strong>The survey was conducted and analysed by OneHealth <i>drugs</i> and garnered 89 respondents, representing a response rate of 66% from 32 countries, predominantly European. 87% of participating collaborators worked in Academia; research groups were small (60% with 1-4 researchers) and mostly consist of few researchers, mostly at early career stages (63% <35 years old). Collaborations were mostly between academics, and 60% collaborated with non-European researchers, while funding was mostly from national governments. Motivation for greener research practices was high but there was as yet low implementation of green strategies or the incorporation of ecotoxicological test in drug development workflows, due to cost and unfamiliarity.</p><p><strong>Conclusions: </strong>We highlight the need for early-ecotoxicological testing of new drug candidates and suggest best practices as we move towards standardized protocols in developing safe and efficacious PVBD drugs.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"4 ","pages":"207"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A literature review of \"lawful\" text and data mining.","authors":"Giorgos Vrakas","doi":"10.12688/openreseurope.18013.2","DOIUrl":"https://doi.org/10.12688/openreseurope.18013.2","url":null,"abstract":"<p><p>Text and data mining (TDM) is a process, typically automated, that looks for patterns in data that may otherwise remain unnoticed. In a world where data driven solutions play a progressively more important role, TDM has become a vital tool in sectors ranging from medicine, to commerce, gaining widespread attraction. Nevertheless, a variety of regulatory frameworks not always specifically attuned towards regulating TDM continue to apply concurrently. The literature within the context of regulatory frameworks governing TDM is a fragmented piecemeal of valuable insights into what \"lawful\" TDM resembles. This literature review adopts a grounded theory approach analysing 88 pieces of literature, collating views regarding \"lawful\" TDM, ultimately providing a holistic assessment of academics' and practitioners' views and opinions regarding the regulatory framework which governs TDM. A total of 7 categories were identified and each of these are analysed. Tables are provided in the Appendix (accessible here: https://doi.org/10.5281/zenodo.12654691)highlighting which scholarly works were used for each section of the literature review, but also how those works were used. It is ultimately concluded that the regulatory frameworks that apply to users conducting TDM are multifaceted, and ever-changing on a case-by-case basis. There is an ever-growing need for a holistic interpretation of the regulatory frameworks which apply, creating a map which would allow for users conducting TDM to navigate this complex web of legal rules.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"4 ","pages":"153"},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating immersion and migration decisions for agent-based modelling: A cautionary tale.","authors":"Jakub Bijak, Ariana Modirrousta-Galian, Philip A Higham, Toby Prike, Martin Hinsch, Sarah Nurse","doi":"10.12688/openreseurope.15581.3","DOIUrl":"10.12688/openreseurope.15581.3","url":null,"abstract":"<p><strong>Background: </strong>Agent-based modelling provides an appealing methodological choice for simulating human behaviour and decisions. The currently dominant approaches based on static transition rates or unverified assumptions are restrictive, and could be enhanced with insights from cognitive experiments on actual decision making. Here, one common concern is that standard surveys or experiments may lack ecological validity, limiting the extent to which research findings can be generalised to real-life settings. For complex, highly emotive decision-making scenarios, such as those related to irregular migration, the typically used short, methodical survey questions may not appropriately map onto complex real-world decisions of interest. Immersive contexts may offer more accurate representations of reality, potentially enhancing the usefulness of experimental information in multi-disciplinary modelling endeavours.</p><p><strong>Methods: </strong>This preregistered study, aimed directly at examining the effect of immersion on risk-taking in the context of migration decisions, and indirectly at informing a multi-disciplinary construction of an agent-based model of migration, presents a choice-based interactive fiction game in which players make migration decisions to advance through a story.</p><p><strong>Participants: </strong>(N = 1000 Prolific users) took part in one of four experimental conditions, three involving different renditions of the game attempting to create immersion, with the last condition presenting the decisions in standard survey format.</p><p><strong>Results: </strong>Although addressing the lack of ecological validity in survey data is important for improving agent-based modelling methodology, the experimental design used to tackle this issue, while responding directly to modelling needs, proved too complex. The created experimental conditions ended up too distinct from each other, involving stimuli that differed in quantity and content. This introduced several unintended and uncontrolled confounds, making it impossible to meaningfully interpret the results of this experiment on its own. Our results act as a cautionary tale for agent-based modellers, highlighting that the modelling needs should not override the principles of experimental design, and provide motivation for more rigorous research on this topic.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"3 ","pages":"34"},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}