American Journal of Men's Health最新文献

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Culturally Modifying MassMen for Massachusetts Latino/x Men: Formative Research for the CDC-Funded Massachusetts Comprehensive Suicide Prevention Program. 马萨诸塞州拉丁裔/x男性的文化改变MassMen: cdc资助的马萨诸塞州综合自杀预防项目的形成性研究。
IF 2.1 4区 医学
American Journal of Men's Health Pub Date : 2025-03-01 Epub Date: 2025-04-14 DOI: 10.1177/15579883251328358
Airín D Martínez, Samantha Kloft, Delvis J Hernández, Parastoo Dezyani, Pablo Fernández, Geraldo Pagán, Mariel Batista, Oscar Torres, Kelley Cunningham
{"title":"Culturally Modifying MassMen for Massachusetts Latino/x Men: Formative Research for the CDC-Funded Massachusetts Comprehensive Suicide Prevention Program.","authors":"Airín D Martínez, Samantha Kloft, Delvis J Hernández, Parastoo Dezyani, Pablo Fernández, Geraldo Pagán, Mariel Batista, Oscar Torres, Kelley Cunningham","doi":"10.1177/15579883251328358","DOIUrl":"10.1177/15579883251328358","url":null,"abstract":"<p><p>Increasing suicide rates among Latino/x men in the United States, particularly in Massachusetts, underscore the critical need for culturally responsive suicide prevention interventions. This study applies Barrera and colleagues' best practices for culturally adapting behavioral health interventions to modify the MassMen website, a mental health resource for men. We conducted a community-engaged study using survey data and eight bilingual (English/Spanish) focus groups with Latino/x men (<i>N</i> = 31, ages 19-59). We applied the principles of grounded theory to analyze transcripts. Fifteen focus group participants completed post-year surveys evaluating cultural modifications. Participants revealed significant website limitations, including inadequate representation, poor Spanish translation, and cultural irrelevance. Key modifications included professionally translating the website, repositioning important information, and developing bilingual \"Everyday Stories\" videos featuring Latino/x men sharing mental health experiences. A follow-up survey demonstrated that 33.3% of participants revisited the website, and 46.7% referred others to it. Participants appreciated the new videos, reporting feeling \"seen\" and \"not alone.\" We engaged in three of five cultural adaptation processes to culturally modify MassMen for Latino/x men: information gathering, preliminary design, and preliminary testing. Despite limitations such as convenience sampling, a small sample size, and a 54% survey response rate, the study successfully illustrated the importance of community involvement in modifying a behavioral health intervention. Future directions include conducting focus groups with veterans and high-risk workers, applying intersectionality analysis, and expanding bilingual marketing strategies. These results emphasize the need to build relationships with Latino/x communities to promote suicide prevention resources.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251328358"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Different Intensities of Physical Activity and Risk of Male Genital Cancers: Exploring Potential Causal Relationships. 不同强度的体育活动与男性生殖器癌的风险:探讨潜在的因果关系。
IF 2.1 4区 医学
American Journal of Men's Health Pub Date : 2025-03-01 Epub Date: 2025-04-23 DOI: 10.1177/15579883251332732
Kexin Zhen, Lei Huo, Tao Zhu, Ya Li
{"title":"Different Intensities of Physical Activity and Risk of Male Genital Cancers: Exploring Potential Causal Relationships.","authors":"Kexin Zhen, Lei Huo, Tao Zhu, Ya Li","doi":"10.1177/15579883251332732","DOIUrl":"https://doi.org/10.1177/15579883251332732","url":null,"abstract":"<p><p>Physical activity is associated with cancer of the male genitalia. However, the genetic causality of this association remains unclear. In this study, Mendelian randomization (MR) was used to explore the potential causal relationship between different intensities of physical activity and cancer of the male genitalia. This study utilized single nucleotide polymorphisms (SNPs) associated with vigorous exercise obtained from published genome-wide association studies (GWAS) and summary genetic data associated with male genital cancer from published GWAS. The main analysis method used was the inverse variance weighted (IVW) method for two-sample MR analysis. The heterogeneity of the results was assessed using Cochran's Q statistic, while horizontal pleiotropy was assessed using MR-Egger. Sensitivity analysis included a \"leave-one-out\" test. The results showed that light DIY activity was a risk factor for male genital cancer (OR = 1.045, 95% confidence interval [1.004, 1.089], <i>p</i> = .033). The result passed the sensitivity test. This study found the effect of light DIY activities on male genital cancer. Future studies should further explore the impact of different types of physical activity on specific types of male genital cancer to improve relevant prevention strategies.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251332732"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effects of Xialiqi Capsules in Regulating the Pyroptosis of Prostate Epithelial Cells Via NLRP3/Caspase-1 Pathway for the Treatment of Chronic Prostatitis. 下利气胶囊通过NLRP3/Caspase-1通路调节前列腺上皮细胞凋亡治疗慢性前列腺炎的作用
IF 2.1 4区 医学
American Journal of Men's Health Pub Date : 2025-03-01 Epub Date: 2025-03-24 DOI: 10.1177/15579883251322958
Zhiming Hong, Zilong Chen, Wenshuo Chen, Junfeng Qiu, Shengjie Wang, Yi Wei, Jun Guo
{"title":"The Effects of Xialiqi Capsules in Regulating the Pyroptosis of Prostate Epithelial Cells Via NLRP3/Caspase-1 Pathway for the Treatment of Chronic Prostatitis.","authors":"Zhiming Hong, Zilong Chen, Wenshuo Chen, Junfeng Qiu, Shengjie Wang, Yi Wei, Jun Guo","doi":"10.1177/15579883251322958","DOIUrl":"10.1177/15579883251322958","url":null,"abstract":"<p><p>Chronic prostatitis (CNP) is a prevalent inflammatory disorder among men. The Xialiqi capsule has been reported to alleviate the clinical symptoms of CNP patients, which may be related to its anti-inflammatory effect; yet, its exact mechanism of action remains unclear. In this study, human normal prostate epithelial cells (RWPE-2 cells) were categorized into a control group, a model group, an inhibitor group, along with high, medium, and low drug-containing serum groups (5%, 10%, and 15%, respectively). With the exception of the control group, cell pyroptosis models were created by stimulating with lipopolysaccharide (100 ng/mL) and adenosine triphosphate (5 mM). Subsequently, drug-containing serum and the NOD-like receptor 3 (<i>NLRP3</i>) inhibitor (MCC950) were utilized to intervene with the model cells according to their respective groups. Post-administration of MCC950 and drug-containing serum, an improvement in cell viability was noted in the inhibitor group and medium-high dosage groups (by 20.5%, 38.2%, and 73.2%). Transmission electron microscopy indicated a reduction in the features characteristic of cell pyroptosis. Levels of nitric oxide, interleukin-18 (IL-18), and tumor necrosis factor-α in the cellular supernatant decreased significantly (60.7%, 21.6%, 33.7%, 41.8%; 49.2%, 54.8%, 53.5%, 69.3%; 31.3%, 44.4%, 38.1%, 51.2%). Immunofluorescence showed reduced fluorescence intensity of NLRP3 and Cysteine aspartate protease-1 (Caspase-1) proteins, and Western Blot analysis revealed a significant decline in the expression of NLRP3, pro-Caspase-1, and gasdermin D (20.5%, 45.9%, 58.1%, 74.8%; 23.2%, 36.7%, 51.6%, 51.9%; 15.4%, 28.6%, 33.1%, 39.2%). In vitro experiments suggest that the Xialiqi capsule may treat CNP by regulating prostate epithelial cell pyroptosis and reducing inflammatory factor release via inhibiting the NLRP3/Caspase-1 signaling pathway. This study offers a novel approach for future CNP treatment with traditional Chinese medicine preparations, deserving further promotion.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251322958"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two-Spirit, gay, bisexual, transgender and queer (2SGBTQ) men's suicidality in Canada: A Scoping Review. 双性恋、同性恋、双性恋、跨性别和酷儿(2SGBTQ)男性在加拿大的自杀行为:一项范围审查。
IF 2.1 4区 医学
American Journal of Men's Health Pub Date : 2025-03-01 DOI: 10.1177/15579883251321582
Calvin C Fernandez, Trevor Goodyear, Mark Gilbert, John L Oliffe
{"title":"Two-Spirit, gay, bisexual, transgender and queer (2SGBTQ) men's suicidality in Canada: A Scoping Review.","authors":"Calvin C Fernandez, Trevor Goodyear, Mark Gilbert, John L Oliffe","doi":"10.1177/15579883251321582","DOIUrl":"10.1177/15579883251321582","url":null,"abstract":"<p><p>Suicide is a leading cause of death in Canada, with men being three times more likely to die from suicide compared with the rest of the population. Among Canadian men, those who are Two-Spirit, gay, bisexual, transgender, and queer (2SGBTQ) are disproportionately impacted by suicidality. Drawing on this growing public health crisis, this current scoping review focuses on Canadian-based 2SGBTQ men to address the research question: <i>What is known about Canadian-based Two-Spirit, gay, bisexual, transgender, and queer (2SGBTQ) men's experiences with suicidality?</i> Keywords related to \"2SGBTQ men\" and \"suicidality\" were searched across five bibliographic databases to derive 25 articles for analysis. Three thematic findings were generated: (a) Methodological Approaches, (b) Social Identities and Stigma, and (c) Psychosocial Health Issues. First, we trace how the study designs, data sources, and sampling methods used in research influence how we know about 2SGBTQ men's suicidality. Second, we report on anti-gay, anti-trans, and HIV stigma as characterizing the diverse associations between 2SGBTQ men's multiple social identities and their suicidality risk. Third, we detail how psychosocial health issues, including mental illness, financial precarity, and substance use, exacerbate social stresses and related risks of suicidality for 2SGBTQ men. These findings map understandings about how suicide risk diversely manifests among subgroups of Canadian-based 2SGBTQ men and interconnections between 2SGBTQ men's social identities, stigma, and their psychosocial health issues. We draw on these learnings to recommend future research priorities regarding 2SGBTQ men's suicidality, alongside opportunities to advance knowledge to inform targeted suicide prevention interventions.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251321582"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Soft Tissue Inflammation of the Arm and Hand Caused by Human Bites. 人类咬伤引起的手臂和手的软组织炎症。
IF 2.1 4区 医学
American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241309766
Nguyen Dang Duc, Nguyen Phuong Sinh, Lam Nguyen Hong Anh
{"title":"Soft Tissue Inflammation of the Arm and Hand Caused by Human Bites.","authors":"Nguyen Dang Duc, Nguyen Phuong Sinh, Lam Nguyen Hong Anh","doi":"10.1177/15579883241309766","DOIUrl":"10.1177/15579883241309766","url":null,"abstract":"<p><p>Wounds caused by human bites have a high infection rate. A 59-year-old male patient came to our poison control center because of soft tissue injuries in the left arm and left hand, pain, swelling, and necrosis. Before entering the hospital, he had a high fever. Physical examination found that the patient's lips were dry, his tongue was dirty, his skin and mucous membranes were less pink, his pulse was 80 beats/min, and his temperature was 36.5°C. Information on May 9, 2024, the patient was bitten on the left arm by a child. The patient had a negative blood culture, a negative burn fluid culture, high-sensitivity C-reactive protein of blood chemistry is 458.1 mg/L, total blood cell analysis with white blood cell is 19.9 G/L, percent of neutrophil is 92.4, soft magnetic resonance imaging of the arm and hand areas with images is cellulitis under the skin of the left arm.The patient was injected with antitetanus toxin serum, antibiotics (Dalacin C, Linezonide, meropenem), and was infused paracetamol. After 1 day of treatment, the patient's condition did not improve and worsened, so the patient was transferred to the National Burn Hospital for further treatment. This article aims to talk about soft tissue injuries due to soft tissue inflammation or necrosis that can occur in patients who are bitten by human. This is the first patient with soft tissue damage with cellulitis under the skin of the left arm known at our poison center.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241309766"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Why Men Have Abortions: Quantitative and Qualitative Perspectives From Urban Family Planning Clinics in Chicago, Illinois, USA. 男性堕胎的原因:来自美国伊利诺斯州芝加哥市城市计划生育诊所的定量和定性视角。
IF 2.1 4区 医学
American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241307795
Jenna M Heath, Brian T Nguyen
{"title":"Why Men Have Abortions: Quantitative and Qualitative Perspectives From Urban Family Planning Clinics in Chicago, Illinois, USA.","authors":"Jenna M Heath, Brian T Nguyen","doi":"10.1177/15579883241307795","DOIUrl":"10.1177/15579883241307795","url":null,"abstract":"<p><p>Support for abortion is comparable between men and women in the United States; one in five reproductive age men reports abortion involvement. Yet, societal focus on abortion as a uniquely women's issue minimizes men's involvement in abortion. We conducted a secondary analysis of survey (<i>n</i> = 203) and interview data (<i>n</i> = 30) on male partner's experiences accompanying abortion recipients at two family planning clinics in Chicago, Illinois. Respondents identified reasons for abortion from a prepopulated 14-item list. We correlated reasons with respondent's abortion preference and decision satisfaction, characterizing this relationship via thematic analyses of interview transcripts. Nearly all men (97.5%) identified multiple reasons for abortion (median: 6/14), including: mistimed pregnancy (80%), impact on his/his partner's education/career (75%-80%), and finances (71%). Neither individual reasons nor number of reasons was significantly associated with abortion decision preference or decision satisfaction. While 41% would not have chosen abortion, only 10% reported dissatisfaction. Men's perception of decision concordance with their partner was significantly linked to their satisfaction (<i>p</i> < .01). Thematic analysis highlighted complex partner involvement, including shared and deferred decision-making and tension amid demonstrated support. Many abortion-accompanying men preferred to continue the pregnancy, yet very few reported dissatisfaction with the ultimate decision, which may be related to perceived decision concordance with their female partner. Men's decisions for abortion are complex and include varying degrees of male partner involvement and/or decision deferral to female partners.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241307795"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abnormal Ultrasound Characteristics of Seminal Vesicles in Patient With Anejaculation: A Case Report. 射精患者精囊超声异常特征1例。
IF 2.1 4区 医学
American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883251316257
Dawei Gao, Qi Gao, Han Yin, Baofang Jin, Dalin Sun
{"title":"Abnormal Ultrasound Characteristics of Seminal Vesicles in Patient With Anejaculation: A Case Report.","authors":"Dawei Gao, Qi Gao, Han Yin, Baofang Jin, Dalin Sun","doi":"10.1177/15579883251316257","DOIUrl":"10.1177/15579883251316257","url":null,"abstract":"<p><p>Anejaculation (AE) has long been a challenging issue in andrology due to its low clinical reporting rate, leading to an insufficient understanding within the academic community. This case report discusses a 52-year-old AE patient with a long-term history of diabetes mellitus. His seminal vesicles ultrasound images revealed a notable absence of anechoic polycyclic areas, a characteristic not previously reported in AE patients. We hypothesize that this finding is attributable to diabetes-induced seminal vesicles secretory dysfunction, leading to AE in this patient. This case underscores the importance of anechoic polycyclic areas in the physiology of ejaculation and highlights the necessity for further research into the correlation between these areas and various types of ejaculatory disorders, aiming to provide valuable insights for the medical community.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883251316257"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mental Health Literacy, Stigma, and Help-Seeking Behavior Among Black Male College Students in Historically Black Universities. 传统黑人大学黑人男大学生心理健康素养、耻感与求助行为
IF 2.1 4区 医学
American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883251318214
Bryan Gere, Nahal Salimi
{"title":"Mental Health Literacy, Stigma, and Help-Seeking Behavior Among Black Male College Students in Historically Black Universities.","authors":"Bryan Gere, Nahal Salimi","doi":"10.1177/15579883251318214","DOIUrl":"10.1177/15579883251318214","url":null,"abstract":"<p><p>Studies indicate that mental health literacy (MHL) is low among college students. Previous studies report that male college students score lower on MHL than female college students. MHL is connected to mental health help-seeking behavior. Black male college students are shown to be at higher risk for mental health problems such as depression, anxiety, and post-traumatic stress disorder, yet are less likely to seek help for these problems compared with other racial groups. Challenges with mental health can lead to significant negative consequences, such as poor academic performance, social isolation, and even suicide attempts. Stigma has been identified as an important factor that can influence the help-seeking behavior of male college students. Previous research has indicated that Black male college students in predominantly White institutions (PWIs) often struggle with seeking mental health compared with those in Historically Black Universities and Colleges (HBCUs). The purpose of the descriptive cross-sectional study was to investigate the relationships among MHL, stigma, and help-seeking behavior among Black males at HBCUs. The results indicate that having better mental health knowledge is linked to seeking help more often, stressing the need to enhance mental health understanding for better support-seeking. Seeking help was positively associated with reduced stigma. The implications for practitioners, policymakers, and administrators were explored, emphasizing the need for targeted, culturally sensitive interventions for young Black men in higher education. This study underscores the importance of addressing their specific challenges to enhance mental health and academic outcomes.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883251318214"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Clinical Effect of Acupuncture on Chronic Prostatitis: Meta Analysis. 针刺治疗慢性前列腺炎的临床疗效评价:Meta分析。
IF 2.1 4区 医学
American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241290035
Wen Fang, Shi Wang, Jin-Kai Dong, Jing-Yun Zhang, Xue-Chao Li, Cheng-Wei Fu, Qing-Guo Liu
{"title":"Evaluation of Clinical Effect of Acupuncture on Chronic Prostatitis: Meta Analysis.","authors":"Wen Fang, Shi Wang, Jin-Kai Dong, Jing-Yun Zhang, Xue-Chao Li, Cheng-Wei Fu, Qing-Guo Liu","doi":"10.1177/15579883241290035","DOIUrl":"10.1177/15579883241290035","url":null,"abstract":"<p><p>This study aims to evaluate the clinical efficacy of acupuncture and moxibustion in CP treatment and assess the quality of clinical literature. Controlled clinical trials (CCT) and randomized controlled trials (RCTs) from PubMed, Web of Science, NLM, CNKI, and Wanfang (January 2003 to January 2023) were analyzed. Relevant data were extracted and statistically analyzed using RevMan 5.1 software. Twenty high-quality papers (JADAD≥3) involving 1,661 patients were included. Meta-analysis showed a significant difference in the overall response rate between the test and control groups in CP treatment (odds ratio [OR] = 4.08 [95% CI = 3.13, 5.33], <i>p</i> < .001). The National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) posttreatment comparison showed significantly better symptom improvement in the acupuncture and moxibustion group (mean difference [MD] = -4.87 [95% CI = -6.145, -3.59]). Acupuncture and moxibustion significantly improve response rates and symptom scores in CP treatment compared with control treatments (drugs, sham acupuncture). This suggests that acupuncture and moxibustion are effective for CP and worth promoting, though further exploration of their mechanisms is needed.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241290035"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum Matrix Metalloproteinases and Risk of Urologic Cancers: A Bidirectional Mendelian Randomization Study. 血清基质金属蛋白酶与泌尿系统癌症的风险:一项双向孟德尔随机研究。
IF 2.1 4区 医学
American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241311229
BoWen Yang, XiaoYu Zeng, HanYu Wang, JiuHuan Feng, ShuFang Hou
{"title":"Serum Matrix Metalloproteinases and Risk of Urologic Cancers: A Bidirectional Mendelian Randomization Study.","authors":"BoWen Yang, XiaoYu Zeng, HanYu Wang, JiuHuan Feng, ShuFang Hou","doi":"10.1177/15579883241311229","DOIUrl":"10.1177/15579883241311229","url":null,"abstract":"<p><p>Many observational epidemiological studies have reported an association between matrix metalloproteinases (MMPs) and urologic cancers. However, the causal relationship between these two phenotypes remains uncertain. This study aims to examine the bidirectional causal relationship between serum MMPs and three urologic cancers: kidney, prostate, and bladder cancer. Using data from large-scale genome-wide association studies (GWAS), we employed two-sample Mendelian randomization (MR) methods to assess the causal relationship between serum MMPs and urologic cancers. We performed inverse variance-weighted MR as the primary method for calculating the overall effects of multiple instruments, while implementing additional MR methods and sensitivity analyses. Odds ratios (ORs) were employed to evaluate the causal relationship between serum MMPs and urologic cancers risk. Our findings indicated a causal relationship between serum MMP-3 levels and prostate cancer risk (OR = 1.07, 95% confidence interval [CI] = [1.02, 1.11], <i>p</i> = .003). There was a possible causal relationship between serum MMP-1 and prostate cancer (OR = 0.95, 95% CI = [0.92, 0.99], <i>p</i> = .02). Serum MMP-1 may also increase the risk of bladder cancer (OR = 1.24, 95% CI = [1.04, 1.49], <i>p</i> = .016). We did not find significant associations of the remaining MMPs with prostate, bladder, and kidney cancer. In reverse MR, no significant results were observed supporting the effect of urologic cancers on MMPs (<i>p</i> > .05). Our study provides evidence of a potential causal relationship between serum MMPs and both prostate cancer and bladder cancer. However, large-scale studies are necessary to confirm and reveal the underlying mechanisms of this association.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241311229"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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