American Journal of Men's Health最新文献_第5页

Perceptions, Attitudes, and Experiences Regarding Mental Health Care Among Young Black Men.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241310755

Cortney VanHook

{"title":"Perceptions, Attitudes, and Experiences Regarding Mental Health Care Among Young Black Men.","authors":"Cortney VanHook","doi":"10.1177/15579883241310755","DOIUrl":"10.1177/15579883241310755","url":null,"abstract":"Mental health service research has insufficiently examined young Black men's (YBM; ages 18-25) mental health care consumption patterns, obscuring their unmet mental health needs. Concurrently, the literature indicates YBM face unmet service needs that impede their ability to address numerous negative social determinants of health (e.g., high adverse childhood experiences, low socioeconomic status, etc.). Because preventing or treating mental health issues at or near onset can dramatically improve outcomes, this study utilizes thematic analysis to elucidate the factors most consequential to YBM's experiences as mental health service consumers. Eight YBM (Mage = 21.1 years) were purposively recruited to participate in semi-structured interviews to discuss attitudes regarding mental health care and cultural attitudes, gender-based attitudes, structural racism, and transition to adulthood. Of the eight participants, five had active health insurance, six had received mental health services before age 18 years, and three were currently receiving mental health services. Participants were attuned to their mental health needs and rejected stigmatizing attitudes about mental illness. Most participants reported hesitation about taking psychiatric medications. Participants had limited resources and encountered structural barriers to accessing mental health services. Most participants did not perceive racism as a source of mental distress. Culturally informed, consumer-oriented research is critical to tailoring and strengthening YBM's mental health care. Future research should employ a population health approach to promote YBM's mental health service uptake in adulthood.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241310755"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Reich's Vegetotherapy on Emotional Regulation and Postural Balance in Military Personnel: A Non-Pharmacological Approach to Combat Stress.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241309041

Sana Khadhrani, Imed Touhemi, Amri Hammami, Chiraz Goumni, Jihen Khalfoun, Mohanad Omar, Rebai Haithem, Abderraouf Ben Abderrahman

{"title":"The Impact of Reich's Vegetotherapy on Emotional Regulation and Postural Balance in Military Personnel: A Non-Pharmacological Approach to Combat Stress.","authors":"Sana Khadhrani, Imed Touhemi, Amri Hammami, Chiraz Goumni, Jihen Khalfoun, Mohanad Omar, Rebai Haithem, Abderraouf Ben Abderrahman","doi":"10.1177/15579883241309041","DOIUrl":"10.1177/15579883241309041","url":null,"abstract":"Military operations subject soldiers to intense stress, which can adversely affect both their emotional regulation and physical balance. This study examines the effectiveness of Reich's vegetotherapy (VGT), an alternative non-pharmacological intervention, in improving these critical areas among military personnel. A total of 29 soldiers, with an average age of 30, were randomly assigned to either an experimental group (EG; 15 soldiers) or a control group (CG; 14 soldiers). Over a period of 6 weeks, the EG participated in twice-weekly VGT sessions, while the CG received no intervention. The intervention group showed a significant reduction in anxiety levels, with scores improving from the beginning to the end of the test (p = .001) and a significant time × group interaction (p = .003). The EG experienced a greater improvement (-68%) compared to the CG (-9%) (p = .036). In the open-eyes postural balance test, the EG showed a significant improvement (p = .029), with a time × group interaction effect (p = .04), although no significant difference was found between the groups (p > .05). The EG improved more (-36%) compared to the CG (24%). In addition, anger levels significantly improved post-intervention (p = .001), with a significant time × group interaction (p = .001). These findings suggest that Reich's VGT may serve as an effective method for mitigating stress-related impairments in military personnel. Further research with larger sample sizes is necessary to validate these results and explore its broader applications.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241309041"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guijiajiao-Lujiaojiao Synergistically Promote Spermatogenesis in Tripterygium Wilfordii Polyglycoside-Induced Oligoasthenozoospermia Rats via PI3K/AKT Signaling Pathway. 通过PI3K/AKT信号通路协同促进三味子多糖苷诱导的少精子症大鼠的精子发生

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-11-01 DOI: 10.1177/15579883241293941

Nianwen Huang, Haisong Li, Longji Sun, Junlong Feng, Zixiang Gao, Zhechao Lin, Yong Yang, Bin Wang, Jisheng Wang

{"title":"Guijiajiao-Lujiaojiao Synergistically Promote Spermatogenesis in Tripterygium Wilfordii Polyglycoside-Induced Oligoasthenozoospermia Rats via PI3K/AKT Signaling Pathway.","authors":"Nianwen Huang, Haisong Li, Longji Sun, Junlong Feng, Zixiang Gao, Zhechao Lin, Yong Yang, Bin Wang, Jisheng Wang","doi":"10.1177/15579883241293941","DOIUrl":"10.1177/15579883241293941","url":null,"abstract":"Guijiajiao-Lujiaojiao (GL) is a combination of Traditional Chinese Medicine (TCM) that can be used to treat oligoasthenozoospermia (OAS). However, its mechanistic role in OAS needs to be better understood and necessitates more studies. This study was planned to investigate GL's therapeutic effects and its mechanistic role in the tripterygium wilfordii polyglycoside (GTW)-induced OAS rat model. In total, 60 Sprague-Dawley (SD) rats at 8 weeks of age were assigned to six groups: blank (NC), model (GTW), GL low-dose (GL-L, 0.3 g/kg/day), GL medium-dose (GL-M, 0.6 g/kg/day), GL high-dose (GL-H, 1.2 g/kg/day), and GL high-dose + PI3K inhibitor LY294002 (GL-H 1.2 g/kg/day + LY 1.2 mg/kg/day) groups. The model was characterized after 8 weeks to examine sperm concentration and viability, serum hormone levels, testes histopathology, and specific protein markers. The treatment efficacy was evaluated by mRNA and protein expression levels, among other parameters. Compared with the GTW group, the viability and concentration of rat spermatozoa were significantly increased after GL intervention (p < .01). Meanwhile, the serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and T hormones in rats in the GL-M and GL-H groups were significantly higher than those in the GTW group (p < .05). Furthermore, GL enhanced the proliferation of spermatogenic cells by modulating the PI3K/AKT signaling pathway, increasing and decreasing the levels of Bcl-2 and Bax proteins, respectively. It is concluded that the mechanism by which GL effectively enhanced the spermatogenic function of the GTW-induced OAS model may be attributed to the PI3K/AKT signaling pathway activation and the elevation of serum LH, FSH, and T hormone levels.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 6","pages":"15579883241293941"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late-Onset Familial Systemic Lupus Erythematosus With Lupus Nephritis in an 82-Year-Old Male: A Case Report and Literature Review. 一名 82 岁男性的晚发性家族性系统性红斑狼疮伴狼疮性肾炎：病例报告和文献综述。

IF 4.6 4区医学

American Journal of Men's Health Pub Date : 2024-11-01 DOI: 10.1177/15579883241293781

Sanda Mrabet, Raja Boukadida, Emah Sidina, Dorsaf Zellama, Abdellatif Achour

引用次数: 0

"Men Need Role Models": Exploring the Facilitators and Barriers for Yoga Participation Among Men. "男人需要榜样"：探索男性参与瑜伽的促进因素和障碍。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-11-01 DOI: 10.1177/15579883241298663

Jonathan Y Cagas, Stuart J H Biddle, Oscar Castro, Ineke Vergeer

{"title":"\"Men Need Role Models\": Exploring the Facilitators and Barriers for Yoga Participation Among Men.","authors":"Jonathan Y Cagas, Stuart J H Biddle, Oscar Castro, Ineke Vergeer","doi":"10.1177/15579883241298663","DOIUrl":"10.1177/15579883241298663","url":null,"abstract":"Yoga is a holistic form of physical activity taken up for various reasons, including physical and mental health, and sometimes spirituality. Despite the growing popularity of yoga as a form of health-enhancing physical activity, data show the uptake among men to be consistently low compared to women. To gain an understanding of barriers and facilitators for yoga uptake and adherence among men, four focus group discussions (three male groups, one female group) and three individual interviews were undertaken. Using thematic analysis, three themes were developed: (a) encouragement, advice, and support from trusted others, (b) confronting gender-related perceptions and issues, and (c) getting to the benefits. The findings suggest that men are more likely to take up yoga when encouraged by trusted others and male role models. Men face gender-related challenges that can be overcome by educating them about yoga, focusing on its physical benefits, and experiencing the benefits of yoga firsthand. To encourage more men into yoga, yoga teachers need to create an inclusive environment that welcomes men and caters to their needs. These findings provide valuable insight into the unique challenges experienced by men in pursuing and practicing yoga regularly. They may be used to develop targeted recruitment and marketing strategies to draw more men into yoga and encourage them to stay, which is essential for experiencing the many long-term health benefits of yoga.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 6","pages":"15579883241298663"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental Health Stigma Reduction Interventions Among Men: A Systematic Review. 减少男性心理健康污名化的干预措施：系统回顾。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-11-01 DOI: 10.1177/15579883241299353

Jack Sweeney, Shane O'Donnell, Emilie Roche, P J White, Paula Carroll, Noel Richardson

{"title":"Mental Health Stigma Reduction Interventions Among Men: A Systematic Review.","authors":"Jack Sweeney, Shane O'Donnell, Emilie Roche, P J White, Paula Carroll, Noel Richardson","doi":"10.1177/15579883241299353","DOIUrl":"10.1177/15579883241299353","url":null,"abstract":"Stigma surrounding mental health, particularly among men, remains a significant barrier to men engaging with support services for their mental health. Despite increasing evidence of interventions targeting different aspects of stigma reduction, there is a notable gap in the literature concerning male-specific mental health stigma reduction interventions and on the underlying behavior change techniques (BCTs) used to reduce stigma. The purpose of this review is to synthesize the evidence relating to the impact of mental health stigma reduction interventions among men and to explore the underlying BCTs associated with each intervention. The review was restricted to empirical research reporting on interventions targeting mental health stigma in male-dominated populations. The quality appraisal was conducted using the Mixed Methods Analysis Tool and a narrative synthesis was conducted. Fourteen articles reporting on 11 interventions were included for review, while 20 outcome measures were used. Perceived public stigma attracted the largest number of interventions with a lesser focus on self or personal stigma. Nineteen BCTs were identified across the interventions with information about health consequences and self-monitoring of behavior being the most common followed by credible source, social contact, and behavior practice/rehearsal. This is discussed in relation to the wider literature. The methodological issues highlighted in the articles limit the conclusions and recommendations that can be drawn from the review. Recommendations for further research include standardizing the scales used in stigma measurement, in-depth reporting of intervention descriptions, and greater use of theory to guide intervention development.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 6","pages":"15579883241299353"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11585030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Freehand Transperineal Prostate Biopsy Under Local Anesthesia Without Antibiotics in Outpatient Settings. 局麻下无抗生素徒手前列腺经会阴活检在门诊的作用。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-11-01 DOI: 10.1177/15579883241302045

Gonglin Tang, Rui Yang, Jianing Sun, Feng Zhang, Jitao Wu, Hongwei Zhao

{"title":"The Role of Freehand Transperineal Prostate Biopsy Under Local Anesthesia Without Antibiotics in Outpatient Settings.","authors":"Gonglin Tang, Rui Yang, Jianing Sun, Feng Zhang, Jitao Wu, Hongwei Zhao","doi":"10.1177/15579883241302045","DOIUrl":"10.1177/15579883241302045","url":null,"abstract":"The objectives of this study were to evaluate and compare the application of freehand transperineal prostate biopsy (FTPB) under local anesthesia (LA) versus systematic transperineal prostate biopsy (STPB) in an outpatient setting without antibiotics. A total of 218 biopsy-naive patients with suspicion of prostate cancer (PCa) based on multiparametric magnetic resonance imaging (mpMRI) were retrospectively analyzed. Suspicious areas on mpMRI were graded using the Prostate Imaging Reporting and Data System version 2.1 (PI-RADS v2.1). FTPB was performed for each suspicious lesion, followed by a 12-core STPB under LA. Histopathological outcomes, complications, and tolerability were recorded. The results showed that PCa was detected in 129 (59.17%) patients, with 104 (47.71%) being clinically significant prostate cancer (csPCa). There was agreement between FTPB and STPB in 94 (72.88%) patients. FTPB diagnosed fewer PCa cases but more csPCa cases than STPB. LA-FTPB was well-tolerated with no severe complications. The conclusions suggest that FTPB under LA in an outpatient setting without antibiotics is safe, feasible, and efficient.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 6","pages":"15579883241302045"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress Appraisal Mediates the Association Between Adverse Childhood Experiences and Depression Among Black Same-Gender-Loving Men: An African-Centered Interpretation. 压力评估对童年不良经历与黑人同性爱男性抑郁之间的关联具有中介作用：以非洲为中心的解读》。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-11-01 DOI: 10.1177/15579883241299343

Jonathan Mathias Lassiter, Ashley Foye, Kainaat Anwar

{"title":"Stress Appraisal Mediates the Association Between Adverse Childhood Experiences and Depression Among Black Same-Gender-Loving Men: An African-Centered Interpretation.","authors":"Jonathan Mathias Lassiter, Ashley Foye, Kainaat Anwar","doi":"10.1177/15579883241299343","DOIUrl":"10.1177/15579883241299343","url":null,"abstract":"Black same-gender-loving (SGL) men (BSGLM) bear a disproportionate burden of depression. Adverse childhood experiences (ACEs) have been found to predict depression among this group. However, little research has examined the mechanisms that may account for this relationship. This study aimed to examine how stress appraisal explained the association between ACEs and depression. This cross-sectional study leveraged survey data from 169 BSGLM residing in the United States. Utilizing Hayes' PROCESS Macro (Model 4), we found that five different dimensions of stress appraisal were significant partial mediators of the association between ACEs and depression. Specifically, ACEs predicted lower levels of stress appraisal dimensions consistent with an optimal worldview, which in turn were inversely associated with depressive symptoms. ACEs predicted higher levels of stress appraisal dimensions consistent with a suboptimal worldview, which in turn were positively associated with depressive symptoms. Effects sizes ranged from small to large. Implications of these findings for clinical care and research with BSGLM were discussed.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 6","pages":"15579883241299343"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SPC25 Activates the Warburg Effect to Inhibit Ferroptosis in Prostate Cancer Cells. SPC25 激活沃伯格效应，抑制前列腺癌细胞的铁凋亡

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-11-01 DOI: 10.1177/15579883241297880

Mingqiang Su, Jingxian Luo, Wei Chen, Xianyong Li, Dayong Ye, Xiaofu Zeng, Guangqing Fu, Weiwei Xie, Yong Liang

{"title":"SPC25 Activates the Warburg Effect to Inhibit Ferroptosis in Prostate Cancer Cells.","authors":"Mingqiang Su, Jingxian Luo, Wei Chen, Xianyong Li, Dayong Ye, Xiaofu Zeng, Guangqing Fu, Weiwei Xie, Yong Liang","doi":"10.1177/15579883241297880","DOIUrl":"10.1177/15579883241297880","url":null,"abstract":"SPC25 is associated with unfavorable outcomes in various cancers, but its role in prostate cancer (PRAD) is unclear. More research is needed on glycolysis and ferroptosis targets in PRAD. Bioinformatics tools were used to analyze SPC25 expression disparities. Gene set enrichment analysis (GSEA) identified pathways enriched by SPC25 and its correlation with glycolytic proteins. SPC25 mRNA transcriptional activity was analyzed by quantitative polymerase chain reaction (qPCR), while protein levels of SPC25, glycolytic markers, and ferroptosis markers were assessed using Western blot. CCK-8 was used to evaluate the effects of SPC25 on cell survival. Ferroptosis levels were measured by flow cytometry and assays for Fe2+ and malondialdehyde (MDA) content. Glycolytic capacity was assessed using glucose uptake assays, lactate tests, and a Seahorse XF analyzer. In PRAD tissues and cells, SPC25 was notably upregulated and correlated with adverse outcomes. It enhanced cancer cell vitality. GSEA showed SPC25's strong association with ferroptosis and glycolytic pathways, while Pearson correlation analysis indicated a positive relationship between SPC25 and glycolytic proteins. Overexpression of SPC25 in cell lines noticeably curbed the accumulation of lipid reactive oxygen species, MDA formation, and Fe2+ content, while it augmented the protein expression of ferroptosis markers. SPC25 stimulated an increase in cellular extracellular acidification rate, glucose uptake, and lactate secretion, while it dampened oxygen consumption rate, and this effect could be counteracted by 2-deoxy-d-glucose (2-DG). Conversely, 2-DG mitigated the ferroptosis indicators that were diminished by SPC25 downregulation, including the reduction of ferroptosis marker protein expression. By upregulating glycolysis in PRAD cells, SPC25 suppresses the occurrence of ferroptosis.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 6","pages":"15579883241297880"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinformatics Combined With Experimental Modeling to Study the Molecular Mechanism of Xuefu Zhuyu Decoction to Improve Erectile Dysfunction Associated With Asthma in Rats. 生物信息学与实验模型相结合研究学府煎剂改善哮喘大鼠勃起功能障碍的分子机制

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-11-01 DOI: 10.1177/15579883241293936

Junlong Feng, Sheng Deng, Xuefeng Gong, Bin Wang, Longji Sun, Huanan Zhang, Zixiang Gao, Hui Chen, Kali Zou, Jiaqi Yang, Haisong Li, Jisheng Wang

{"title":"Bioinformatics Combined With Experimental Modeling to Study the Molecular Mechanism of Xuefu Zhuyu Decoction to Improve Erectile Dysfunction Associated With Asthma in Rats.","authors":"Junlong Feng, Sheng Deng, Xuefeng Gong, Bin Wang, Longji Sun, Huanan Zhang, Zixiang Gao, Hui Chen, Kali Zou, Jiaqi Yang, Haisong Li, Jisheng Wang","doi":"10.1177/15579883241293936","DOIUrl":"10.1177/15579883241293936","url":null,"abstract":"Asthma is associated with chronic systemic inflammation, and inflammatory factors can damage vascular endothelial cells, thus impairing erectile function (ED). Xuefu Zhuyu decoction (XFZYD) can inhibit inflammation and promote angiogenesis, which in turn improves asthma as well as ED, but its exact mechanism of action is not yet clear. This study investigates the mechanism underlying the beneficial effect of XFZYD on asthma-associated ED. High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was used to analyze the constituents of XFZYD, and network pharmacology analysis was used to predict the target genes of XFZYD. Sprague-Dawley rats in the asthma model with erectile dysfunction were divided into the model, XFZYD low-, medium-, and high-dose group (3.09, 6.17, and 12.34 g/kg), with drug intervention for 8 weeks. We assessed the interleukin 6 (IL-6), vascular endothelial growth factor A (VEGFA), and tumor necrosis factor (TNF) protein levels in the penile tissue. We discovered that after treatment with XFZYD (3.09, 6.17, and 12.34 g/kg), the number of erections significantly increased (1.17 ± 0.41, 1.50 ± 0.55, and 1.67 ± 0.52), the density of endothelial cells in the corpus cavernosum of the penis increased, the expression level of IL-6 was reduced (7.5%, 21.2%, and 24.4%), the expression level of VEGFA was reduced (7.8%, 25%, and 28.4%), and the expression level of TNF was reduced (13.5%, 30.6%, and 32.4%). The in vivo experiments indicate that XFZYD may improve ED in asthma model rats by inhibiting inflammation and reducing vascular permeability. This study provides new insights into the mechanism of action of XFZYD in the treatment of asthma leading to ED.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 6","pages":"15579883241293936"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0