American Journal of Men's Health最新文献

Total Round Cell Concentration in Semen and Its Association With Sperm DNA Fragmentation Index Among Ghanaian Males in Kumasi. 库马西加纳男性精液中总圆细胞浓度及其与精子DNA断裂指数的关系

IF 2.4 4区医学

American Journal of Men's Health Pub Date : 2025-07-01 Epub Date: 2025-07-30 DOI: 10.1177/15579883251359420

Evans Anokye Kumi, Victor Boachie Owusu, Peter Nyarko Coffie, Ebenezer Kojo Addae, Rex Kwadwo Mawuli Djokoto, Kweku Bedu-Addo, John Asiedu Larbi

{"title":"Total Round Cell Concentration in Semen and Its Association With Sperm DNA Fragmentation Index Among Ghanaian Males in Kumasi.","authors":"Evans Anokye Kumi, Victor Boachie Owusu, Peter Nyarko Coffie, Ebenezer Kojo Addae, Rex Kwadwo Mawuli Djokoto, Kweku Bedu-Addo, John Asiedu Larbi","doi":"10.1177/15579883251359420","DOIUrl":"https://doi.org/10.1177/15579883251359420","url":null,"abstract":"Male infertility affects millions worldwide, yet its underlying causes remain incompletely understood. Total round cell concentration (TRCC) in semen, particularly leukocytospermia, has been suggested as a biomarker of impaired sperm function. However, its relationship with sperm DNA fragmentation index (DFI) remains unclear, particularly in sub-Saharan Africa, where research is scarce. This study examines the prevalence of elevated TRCC and its associations with semen parameters and sperm DNA fragmentation among men attending a fertility clinic in Kumasi, Ghana. A cross-sectional study was conducted among 227 men, with semen samples analyzed following WHO guidelines. Sperm concentration, motility, and morphology were assessed, while TRCC was quantified using a Neubauer hemocytometer and light microscopy. Sperm DNA fragmentation was determined using the Sperm Chromatin Structure Assay, and multivariate logistic regression models were employed to evaluate associations between TRCC and semen quality parameters. Elevated TRCC was detected in 19.4% of participants. Higher TRCC levels were significantly associated with lower odds of oligozoospermia (cOR = 0.30; 95% CI [0.20, 0.92]; p = .030), a relationship that remained significant after adjusting for confounders (aOR = 0.18; 95% CI [0.05, 0.67]; p = .010). However, TRCC was not significantly associated with asthenozoospermia (p = .656) or teratozoospermia (p = .592). Additionally, no correlation was observed between TRCC and sperm DFI (r = .009, p = .958). It can therefore be concluded that the presence of round cells in semen does not influence sperm DNA integrity.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 4","pages":"15579883251359420"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating Parenthood Alone: A Mixed-Method Study of Single Fathers' Experiences and Needs Regarding Received Midwife and Child Health Nurse Support in Sweden. 独自为人父母：一项关于瑞典单身父亲在接受助产士和儿童保健护士支持方面的经验和需求的混合方法研究。

IF 2.4 4区医学

American Journal of Men's Health Pub Date : 2025-07-01 Epub Date: 2025-07-31 DOI: 10.1177/15579883251363107

Wells M B, Kerstis B

{"title":"Navigating Parenthood Alone: A Mixed-Method Study of Single Fathers' Experiences and Needs Regarding Received Midwife and Child Health Nurse Support in Sweden.","authors":"Wells M B, Kerstis B","doi":"10.1177/15579883251363107","DOIUrl":"https://doi.org/10.1177/15579883251363107","url":null,"abstract":"This mixed methods study aimed to first quantitatively compare single fathers' levels of depressive symptoms, coparenting relationship quality, and father-infant bonding with coupled fathers, and then explore single fathers' experiences and needs regarding professional support during the perinatal and early parenting period. Fathers (n = 1,589, of which 25 were single fathers) completed an online survey regarding their depressive symptoms, coparenting relationship, and father-infant bonding. From the quantitative survey, six single fathers (mean age 35 years) consented to participate in an individual digital interview. Mann-Whitney U tests and chi-square tests were used to compare coupled and single fathers, while qualitative content analysis was used to analyze the interviews. Single fathers reported having more depressive symptoms and weaker coparenting relationships compared to coupled fathers but had similar levels of infant bonding. After qualitatively exploring single fathers' professional support needs during the transition to parenthood, one overarching theme was emphasized: Wanting to be an equal parent. This theme broke down into three categories: Desire to be included, Need of support and Relationship with the child. Single fathers can benefit from professional clinical support, where this support helps foster stronger coparenting relationships, improves paternal mental health, and promotes gender equality in parenting. For this to happen, fathers in general, and single fathers specifically, need to be seen as clients, with their own care needs. Guidelines and recommendations should be reviewed and clarified to encourage more egalitarian parenting, including considering giving fathers their own medical records and individualized visits. There is a need for further studies regarding single fathers' experiences and support needs.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 4","pages":"15579883251363107"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Symptoms of Late-Onset Hypogonadism as a Potential Driver of Presenteeism. 迟发性性腺功能减退症作为出勤的潜在驱动因素的影响

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-07-01 Epub Date: 2025-07-08 DOI: 10.1177/15579883251343972

Tomoya Shirakawa, Hisamitsu Ide, Yoshihiro Ikehata, Yan Lu, Riyo Kinouchi, Takeshi Iwasa, Kaori Koga, Seiichiro Tateishi, Yoshihisa Fujino, Toshiyuki Yasui, Shigeo Horie

{"title":"Impact of Symptoms of Late-Onset Hypogonadism as a Potential Driver of Presenteeism.","authors":"Tomoya Shirakawa, Hisamitsu Ide, Yoshihiro Ikehata, Yan Lu, Riyo Kinouchi, Takeshi Iwasa, Kaori Koga, Seiichiro Tateishi, Yoshihisa Fujino, Toshiyuki Yasui, Shigeo Horie","doi":"10.1177/15579883251343972","DOIUrl":"10.1177/15579883251343972","url":null,"abstract":"Presenteeism, defined as attending work despite physical or mental health issues that impair full productivity, is a prevalent concern with significant implications for workplace efficiency and employee well-being. Testosterone, the primary male sex hormone, plays a vital role in sustaining physical energy, cognitive function, and emotional stability-key factors for optimal work performance. This study explores the association between late-onset hypogonadism (LOH) and presenteeism, emphasizing how LOH-related symptoms such as fatigue, reduced libido, erectile dysfunction, and mood disturbances may contribute to reduced workplace productivity. Data from 96 male patients aged 27 to 76 years, who sought treatment at a university hospital for LOH-related symptoms, were analyzed using blood tests and validated questionnaires, including the Aging Males' Symptoms (AMS) scale, Work Functioning Impairment Scale (WFun), and Sexual Health Inventory for Men. Significant correlations were observed between AMS scores and both work functioning impairment and erectile dysfunction, indicating a strong link between LOH symptoms and presenteeism. In addition, symptoms such as fatigue, diminished motivation, and poor sleep quality were identified as exacerbating factors for work-related impairments. The greatest strength of this study lies in its focus on clinically diagnosed LOH patients, a factor that significantly distinguishes it from prior research on presenteeism in general working populations. This study underscores the potential benefits of testosterone replacement therapy, lifestyle modifications, and workplace wellness programs in addressing presenteeism among employees with LOH. Further research is necessary to assess the efficacy of these interventions in mitigating presenteeism and improving employee well-being.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 4","pages":"15579883251343972"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "SPC25 activates the Warburg effect to inhibit ferroptosis in prostate cancer cells". “SPC25激活Warburg效应抑制前列腺癌细胞铁下垂”的勘误表。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-05-01 Epub Date: 2025-06-30 DOI: 10.1177/15579883241312480

引用次数: 0

Factors Associated With Prostate Cancer Screening Adherence Among Retired Men in Togo, 2023. 2023年多哥退休男性前列腺癌筛查依从性相关因素

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-05-01 Epub Date: 2025-06-25 DOI: 10.1177/15579883251344558

Diguibe Tien-Bale Bamide, Latame Komla Adoli, Sêdégnon Benoît Agossoukpe, Roméo Mèdéssè Togan, Hermine Tognon, Ismaël Simpore, Dieudonné Soubeiga

{"title":"Factors Associated With Prostate Cancer Screening Adherence Among Retired Men in Togo, 2023.","authors":"Diguibe Tien-Bale Bamide, Latame Komla Adoli, Sêdégnon Benoît Agossoukpe, Roméo Mèdéssè Togan, Hermine Tognon, Ismaël Simpore, Dieudonné Soubeiga","doi":"10.1177/15579883251344558","DOIUrl":"10.1177/15579883251344558","url":null,"abstract":"Prostate cancer is the leading male cancer in sub-Saharan Africa, with 74,878 (17.4%) new cases and 32,390 (11.6%) deaths in 2022. In Togo, the total number of prostate cancers was 726 in 2021. Screening methods are readily available in Togo. However, prostate cancer is still detected at a late stage. This study aimed to determine the factors associated with adherence to prostate cancer screening among retired men in Togo, 2023, using the Health Belief Model. A national descriptive and analytical exploratory cross-sectional study was carried out from March 1 to May 31, 2023. A total of 288 retirees were included. Overall, 54.9% of retirees perceived their vulnerability to prostate cancer, 54.9% perceived its severity, 52.4% perceived barriers to screening, 50.3% perceived benefits from screening, 53.1% perceived their self-efficacy for screening, and 55.2% perceived cues to action. A total of 83% of retirees agreed to undergo prostate cancer screening. The absence of a history of chronic pathology (adjust odds ratio [aOR] = 3.0, 95% CI [1.4, 6.2], p = .010), frequency of annual medical consultation (aOR = 0.3, 95% CI [0.1, 0.8], p = .020), perceived obstacles (aOR = 0.4, 95% CI [0.2, 0.9], p = .029) and perceived cues to action (aOR = 5.1, 95% CI [1.9, 15.1], p = .002) are significantly associated with adherence to prostate cancer screening. This study reported a high level of adherence to prostate cancer screening among retirees. It demonstrated that the absence of a history of chronic pathology, frequency of annual medical consultation, perceived barriers, and perceived incentive to action were significantly associated with adherence to prostate cancer screening.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 3","pages":"15579883251344558"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge, Attitude, and Prevalence of Sexual Violence Among Male Undergraduate Students in a Tertiary Institution in Lagos, Nigeria. 尼日利亚拉各斯一所高等院校男大学生的性暴力知识、态度和流行程度。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-05-01 Epub Date: 2025-06-25 DOI: 10.1177/15579883251350895

Chinazom J Ngini, Kofoworola A Odeyemi, Cassandra C Nwokoro

{"title":"Knowledge, Attitude, and Prevalence of Sexual Violence Among Male Undergraduate Students in a Tertiary Institution in Lagos, Nigeria.","authors":"Chinazom J Ngini, Kofoworola A Odeyemi, Cassandra C Nwokoro","doi":"10.1177/15579883251350895","DOIUrl":"10.1177/15579883251350895","url":null,"abstract":"Sexual violence robs victims of their autonomy and rights to consent. While myths and gender stereotypes allow the narrative that men cannot be victims thrive, stigma has contributed to the silence and invisibility of male victims of sexual violence. This descriptive, cross-sectional study aimed to assess the knowledge, attitude, and prevalence of male sexual violence among male undergraduates in a tertiary institution in Lagos, Nigeria. A multistage sampling method was used to recruit 400 respondents for this study. Data were collected using interviewer-administered semi-structured questionnaires. The data were analyzed using IBM Statistical Package for Social Sciences Version 26. Chi-Square test was used to test for association between categorical variables and a statistical significance level of 5% (p < .05) was set. The mean age of the respondents was 22.7 ± 4.10 years. Most (75%) had good knowledge about sexual violence and 98% had positive attitudes regarding male sexual violence. Thirteen percent, 16%, and 10% of the respondents reported being victims of child sexual abuse, sexual harassment, and sexual assault, respectively. Violence experienced in childhood was found to be a predisposing factor for re-victimization in adulthood (p value of .000). A multi-sectoral approach to curb sexual violence is recommended.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 3","pages":"15579883251350895"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Androgen Deprivation to Precision Therapy: A Bibliometric Review of Global Research Trends (2008-2023). 从雄激素剥夺到精确治疗：全球研究趋势的文献计量回顾（2008-2023）。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-05-01 Epub Date: 2025-06-20 DOI: 10.1177/15579883251346819

Longjun Huang, Wenjuan He, Yong Guo

{"title":"From Androgen Deprivation to Precision Therapy: A Bibliometric Review of Global Research Trends (2008-2023).","authors":"Longjun Huang, Wenjuan He, Yong Guo","doi":"10.1177/15579883251346819","DOIUrl":"10.1177/15579883251346819","url":null,"abstract":"This review employs bibliometric methods to map the evolving landscape of prostate cancer endocrine therapy research over the past 15 years. Through analysis of 961 articles from the Web of Science Core Collection, we identified key trends in therapeutic innovation and clinical translation. The United States emerged as the dominant contributor (34.96% of publications), with Harvard University and the University of California System leading institutional output. Three paradigm shifts emerged: early stage research focused on optimizing androgen deprivation therapy (ADT) efficacy (2008-2013), followed by castration-resistant prostate cancer (CRPC) drug development (2014-2016), and recent emphasis on combination therapies and molecular targeting (2017-2023). The top 50 most cited papers confirmed that keyword clusters directly corresponded to pivotal trials, including TAMPEDE (NCT00268476) and PROSPER (NCT02003924). The translational science spectrum model revealed that 68% of current clinical applications originated from basic research on androgen receptor variants. Emerging frontiers include prostate-specific membrane antigen-targeted radioligand therapy and immunotherapy-ADT synergies. This synthesis provides clinicians with an evidence-based roadmap to navigate therapeutic advancements while highlighting the critical need for international collaboration in addressing persistent challenges such as treatment resistance.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 3","pages":"15579883251346819"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Putative Predictive Value of Etiological and Clinical Factors on Sperm Retrieval Outcomes in Non-Obstructive Azoospermia Using Micro-TESE: A Retrospective Study. 病因学和临床因素对非阻塞性无精子症患者精子恢复结果的推测预测价值：一项回顾性研究。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-05-01 Epub Date: 2025-05-24 DOI: 10.1177/15579883251338483

Samaneh Harimi, Mohsen Ahrari, Ali Sadeghi, Samane Eskandarian, Safiyehsadat Heydari, Farzaneh Fesahat

{"title":"Putative Predictive Value of Etiological and Clinical Factors on Sperm Retrieval Outcomes in Non-Obstructive Azoospermia Using Micro-TESE: A Retrospective Study.","authors":"Samaneh Harimi, Mohsen Ahrari, Ali Sadeghi, Samane Eskandarian, Safiyehsadat Heydari, Farzaneh Fesahat","doi":"10.1177/15579883251338483","DOIUrl":"10.1177/15579883251338483","url":null,"abstract":"Non-obstructive azoospermia (NOA) is a condition of testicular failure caused by various factors. To retrieve sperm in NOA patients, microdissection testicular sperm extraction (micro-TESE) is a highly effective technique. The present study aimed to evaluate successful sperm retrieval (SSR) in NOA patients across different etiologies in the Iranian population to identify predictive factors. This retrospective analysis included 566 NOA patients undergoing micro-TESE from 2018 to 2023, with 58 histories of Cryptorchidism, 40 Klinefelter syndrome (KS), 6 Y chromosomal microdeletions (YCMDs), 6 histories of chemotherapy, 5 mumps orchitis, and 451 patients with idiopathic reasons. The overall SSR was 43.2%, with a significantly lower SSR in the KS group (p = .012). Patients with higher average ages tended to have higher SSR rates, especially in the idiopathic group. Hormone levels differed among the groups, with higher follicle-stimulating hormone and luteinizing hormone levels in the YCMDs group, higher testosterone levels in the idiopathic and Cryptorchidism groups, and higher prolactin levels in the KS group. There were no significant differences in other clinical characteristics between the SSR and sperm retrieval failure groups, except for a positive relationship between prolactin levels and SSR rates in the KS group (r = .45, p = .003). Our data underscores that underlying etiology and genetic background may reveal more valuable predictive value than age, hormone levels, and testicular volume. This finding suggests that no patient with NOA should be deprived of micro-TESE based on candidate predictors of SSR presented to date.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 3","pages":"15579883251338483"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-05-01 Epub Date: 2025-05-15 DOI: 10.1177/15579883251333619

Louis Fox, Charlotte Moss, Tobias Gregor Hauser, Isolt Reardon, Netty Kinsella, Walter Cazzaniga, Mieke Van Hemelrijck, David Nicol

{"title":"Health-Related Quality of Life Following Treatment for Testicular Cancer: A Qualitative Systematic Review.","authors":"Louis Fox, Charlotte Moss, Tobias Gregor Hauser, Isolt Reardon, Netty Kinsella, Walter Cazzaniga, Mieke Van Hemelrijck, David Nicol","doi":"10.1177/15579883251333619","DOIUrl":"10.1177/15579883251333619","url":null,"abstract":"Testicular cancer (TCa) can precipitate ongoing psychosocial/physical morbidity post-treatment, despite high rates of cure. We conducted a systematic review to synthesise three decades of primary qualitative research on health-related quality of life (HRQoL) to inform the design of supportive care pathways. We queried MEDLINE/PubMed, PsycINFO, CINAHL, and Web of Science for all qualitative studies published up to 26 October 2022 examining issues relevant to HRQoL in post-treatment TCa patients. Two independent reviewers appraised included studies for methodological quality using established guidance for evidence-based public health policy and analysed findings via thematic synthesis. Studies were analytically weighted by study quality. Studies were evaluated using GRADE-CERQual to produce confidence levels in findings. We included 18 studies, comprising 387 participants. Seven studies were graded high quality, eight medium quality, and three low quality. Emergent analytical themes were: (a) Residual psychological injury; (b) Information deficits and unnecessary anxiety; (c) Thwarted life trajectory; (d) Social disruption; (e) Undermined youth; (f) Health service abandonment; (g) Long-term sexual problems; and (h) Maladaptive coping and post-traumatic stress. All findings were deemed 'high confidence', except theme (g), which was of 'moderate confidence'. A limitation of the review was the relative dominance of Anglophone countries in the included studies. Some men treated for TCa are at risk of a range of post-treatment HRQoL issues, particularly psychosocial issues. Some individuals may be more at risk than others, based on specific personality traits, access to accurate and complete information about treatment recovery, and individual coping responses.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 3","pages":"15579883251333619"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of the Ratio of Second to Fourth Digit Length and Phthalate Exposure With Sexual Function in Japanese Men Seeking Fertility Treatment. 在寻求生育治疗的日本男性中，第二到第四手指长度的比例和邻苯二甲酸盐暴露与性功能的关系。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-05-01 Epub Date: 2025-07-01 DOI: 10.1177/15579883251352972

Kazumitsu Yamasaki, Masahiro Uchida, Yuki Mizuno, Teruaki Iwamoto, Shoko Konishi

{"title":"Association of the Ratio of Second to Fourth Digit Length and Phthalate Exposure With Sexual Function in Japanese Men Seeking Fertility Treatment.","authors":"Kazumitsu Yamasaki, Masahiro Uchida, Yuki Mizuno, Teruaki Iwamoto, Shoko Konishi","doi":"10.1177/15579883251352972","DOIUrl":"10.1177/15579883251352972","url":null,"abstract":"Sexual dysfunction, which is increasingly recognized as a cause of male infertility, may be influenced by environmental factors such as phthalic acid diesters (phthalates) and prenatal androgen exposure. This study aimed to investigate the association between male sexual function and recent exposure to phthalates and prenatal testosterone. The cross-sectional study included 177 males seeking fertility treatment. The index-to-ring-finger length ratio (2D:4D) was calculated as a measure of prenatal androgen exposure. To evaluate recent phthalate exposure, urinary concentrations of seven phthalate metabolites were measured. Their associations with International Index of Erectile Function (IIEF) scores were analyzed using generalized linear models. One standard deviation increase of mono-methyl phthalate was negatively associated with IIEF domains A (erectile function; exponentiated coefficient, 0.95; exponentiated 95% confidence interval, CI, [0.91, 0.98]) and D (intercourse satisfaction; exponentiated coefficient, 0.91; exponentiated [0.85, 0.97]). While mono-butyl phthalate was positively associated with domain A, mono-ethyl phthalate, monobenzyl phthalate, and the molar sum of di (2-ethylhexyl) phthalate metabolites showed no significant association with IIEF domain scores. When the serum testosterone concentration was included as an exposure variable, the overall association between urinary phthalates and IIEF domain scores remained similar. The left- and right-hand 2D:4D ratios did not show significant associations with any IIEF domain scores. Recent phthalate exposure may affect male sexual function by decreasing testosterone levels and other potential mechanisms.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 3","pages":"15579883251352972"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0