American Journal of Men's Health最新文献

{"title":"Is Lumbar Disk Herniation a Potential Risk Factor for Chronic Prostatitis/Chronic Pelvic Pain Syndrome? Insights From a Misdiagnosed Case.","authors":"Dawei Gao, Wenxiu Zhang, Chuyu Li, Yihan Jin, Sijia Sun, Xia Zhang, Shuyi Huang, Zhou Zhao, Baofang Jin, Dalin Sun","doi":"10.1177/15579883251377300","DOIUrl":"10.1177/15579883251377300","url":null,"abstract":"<p><p>Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a complex condition characterized by heterogeneous symptoms and unclear pathogenesis, often posing diagnostic and therapeutic challenges. Lumbar disk herniation (LDH) may compress the dural sac and irritate the cauda equina, producing subclinical symptoms that overlap with those of CP/CPPS and increasing the likelihood of misdiagnosis. We report the case of a 61-year-old man with an 8-year history of CP/CPPS unresponsive to standard treatments, including phytotherapy, anti-inflammatory agents, and physical therapy. Further evaluation revealed lower-limb weakness and low-back pain; lumbar CT identified disk herniation with dural sac compression. Treatment was revised to include traditional Chinese medicine (Mai Xue Kang capsules and a modified Chaihu-Guizhi-Ganjiang Decoction) along with lifestyle modifications, resulting in significant symptom relief and no recurrence at 6-week follow-up. A review of the literature supports the potential for LDH to mimic CP/CPPS symptoms, highlighting a diagnostic blind spot. This case emphasizes the importance of considering spinal etiologies in refractory CP/CPPS and advocates for a broadened diagnostic framework to enable more personalized treatment strategies.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 5","pages":"15579883251377300"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wu Zi Yan Zong Wan Improves Triptolide-Induced Testicular Spermatogenic Dysfunction Through the Spermatogenic Microenvironment and the PLCγ/PKC Pathway.","authors":"Lei Zhang, Binghao Bao, Weizhen Wu, Haolang Wen, Suyan Tong, Xueyan Wang, Baoxing Liu","doi":"10.1177/15579883251371990","DOIUrl":"10.1177/15579883251371990","url":null,"abstract":"<p><p>Wu Zi Yan Zong Wan (WZYZW) is a traditional Chinese formula known for treating male infertility, though its mechanism of action is unclear. This study investigates how WZYZW may alleviate spermatogenic dysfunction in mouse testes induced by triptolide (TP). We established a TP-induced spermatogenic dysfunction mouse model and randomly divided 30 male C57BL/6J mice into five groups: control, model, and low-, medium-, and high-dose WZYZW groups (six mice per group). After a 35-day intervention, testicular tissues were analyzed for histopathology via hematoxylin-eosin and TUNEL staining. Protein expression of type I collagen, laminin, fibronectin, and spermatogonial stem cell (SSC) markers, including GFRα1, Ret, and PLZF, were evaluated by immunohistochemical staining. GDNF and CSF1 levels were measured by ELISA, and the PLCγ/PKC pathway was analyzed via Western blotting and quantitative reverse transcription polymerase chain reaction (qRT-PCR). Compared with the model group, WZYZW significantly increased testicular index (high-dose, <i>p</i> < .01), improved Johnsen score (all doses, <i>p</i> < .05), reduced spermatogenic cell apoptosis, and improved the spermatogenic microenvironment by increasings type I collagen (high-dose, <i>p</i> < .01), laminin (low-dose, <i>p</i> < .01; medium/high-dose, <i>p</i> < .05), fibronectin (high-dose, <i>p</i> < .01), GDNF (medium/high-dose, <i>p</i> < .05), and CSF1 (high-dose, <i>p</i> < .05). It significantly upregulated the expression of GFRα1, PLZF, C-kit, Ret, and SCF, with the improvement of GFRα1(medium/high-dose vs. low-dose, <i>p</i> < .01), Ret (medium/high-dose vs. low-dose, <i>p</i> < .05), SCF (high-dose vs. low-dose, <i>p</i> < .05) showing a certain dose-dependency. The qRT-PCR and Western blotting results showed that WZYZW significantly enhanced PLCγ/PKC pathway activity. The study indicates that WZYZW can improve the spermatogenic microenvironment and promote the self-renewal and differentiation of SSCs through the PLCγ/PKC pathway, thereby improving spermatogenic function.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 5","pages":"15579883251371990"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of A Body Shape Index and Body Roundness Index as Novel Anthropometric Indices With Semen Analysis Parameters and IVF Outcomes.","authors":"Ana Nikolic, Zeljko Mikovic, Vladimir Gerginic, Svetlana Dragojevic Dikic, Dragana Bojovic Jovic, Bojana Salovic, Milan Perovic","doi":"10.1177/15579883251380206","DOIUrl":"10.1177/15579883251380206","url":null,"abstract":"<p><p>Obesity-related pathophysiological mechanisms adversely affect human fertility and infertility treatment. Conventional anthropometric indices for assessing obesity poorly differentiate visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). This explains inconsistencies between the studies evaluating the influence of obesity on semen parameters and assisted reproductive technology (ART) outcomes. A Body Shape Index (ABSI) and body roundness index (BRI) are novel indices that offer better differentiation of VAT and SAT. Our study assessed the correlation between traditional and novel indices with semen parameters and ART outcomes.A cross-sectional study, conducted at a tertiary fertility center from January 2023 to March 2025, encompassed 319 men undergoing ART. They were divided into four groups based on body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), BRI, and ABSI quartiles. Anthropometric indices were measured and correlated with semen parameters (semen volume, sperm concentration, motility, and morphology) and ART outcomes (number of obtained embryos, transferred embryos, frozen embryos, and usable blastocyst development and embryo utilization rates).Our analysis revealed that anthropometric indices correlated differently with semen parameters and ART outcomes. BMI, BRI, and WHtR correlated negatively with semen parameters, whereas WHR and ABSI did not. ABSI negatively correlated with all analyzed ART outcomes, while WHR significantly correlated only with total number of embryos.Traditional anthropometric indices that inform us on general obesity are linked to semen analysis parameters. Novel indices that differentiate VAT and SAT are linked with ART outcomes, suggesting possible epigenetic consequences of increased VAT.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 5","pages":"15579883251380206"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Male Infertility Management: A Critical Appraisal of Clinical Practice Guidelines With the AGREE II Instrument.","authors":"Jie Li, Kecheng Li, Mingqiang Zhang, Jixuan Chen, Maoke Chen, Wenxuan Dong, Wenhao Yu, Lixing Lei, Yao Huang, Haodong Yang, Peixuan Ren, Qiang Zou, Longsheng Deng","doi":"10.1177/15579883251380203","DOIUrl":"10.1177/15579883251380203","url":null,"abstract":"<p><p>To systematically evaluate the quality of both domestic and international clinical practice guidelines for male infertility using the Appraisal of Guidelines for Research & Evaluation II (AGREE II) tool, identify methodological shortcomings, and propose evidence-based recommendations for improvement, this study was conducted. A systematic search of Chinese and English databases, along with official websites of international organizations, was undertaken to identify relevant guidelines. Four independent reviewers assessed the included guidelines employing the AGREE II tool, focusing on the rigor of development processes and the concordance and divergence among core recommendations. Ten guidelines were included, with only one rated \"recommendable\" using AGREE II criteria; others were \"conditionally recommendable\" or \"not recommendable.\" Key shortcomings included deficient rigor of development (Domain III: 34.4%), applicability (Domain V: 48.3%), and editorial independence (Domain VI: 23.5%). Eighteen core recommendations were identified. Domestic guidelines lacked transparent conflict of interest disclosures and multidisciplinary collaboration, whereas international guidelines demonstrated superior methodological rigor through interprofessional integration. Most guidelines failed to validate clinical impacts of recommendations, hindering practical implementation. This study represents the first systematic evaluation of male infertility guidelines at national and international levels, with comparative analysis of their recommendations. Findings reveal widespread deficiencies in methodological rigor, applicability, and editorial independence. Future guideline development should adopt standardized frameworks, enhance multidisciplinary collaboration, ensure editorial independence, and integrate evidence-based medicine to improve quality and clinical utility.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 5","pages":"15579883251380203"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Male Infertility and Its Correlates in Chuadanga District of Bangladesh.","authors":"Sazin Islam, Md Shariful Islam, Sharmin Akter, A M Mujahidul Islam, Md Ismail Tareque","doi":"10.1177/15579883251372452","DOIUrl":"10.1177/15579883251372452","url":null,"abstract":"<p><p>Male infertility is an escalating global health concern, yet it remains under-researched in Bangladesh. The factors contributing to this issue have not been thoroughly studied. This study aims to identify the factors associated with male infertility in the Chuadanga district of the Khulna division of Bangladesh. A cross-sectional study design was employed, involving 690 male participants seeking infertility treatment at community clinics and hospitals within the district. Participants were recruited through a two-stage sampling technique and interviewed using a structured questionnaire. The infertility status of the males served as the outcome variable, while sociodemographic characteristics, contextual factors, lifestyle behaviors, and health-related information were treated as explanatory variables. Data analysis employed descriptive statistics, Chi-square tests, and binary logistic regression models. The study revealed that 16.5% of participants were classified as infertile, while a substantial majority (83.9%) was aware of their condition. Key factors significantly associated with male infertility included educational attainment (AOR = 0.239, <i>p</i> = .032), occupation (AOR = .317, <i>p</i> = .044), monthly income (AOR = 6.324, <i>p</i> = 0.032), monthly expenditure (AOR = 0.184, <i>p</i> = 0.031), type of residence (AOR = 0.139, <i>p</i> < 0.001), sources of drinking water (AOR = 11.615, <i>p</i> < 0.001), and smoking habits (AOR = 3.304, <i>p</i> < 0.001) in the study area. This study underscores critical factors contributing to male infertility in Chuadanga, emphasizing the need for targeted public health interventions. Strategies should emphasize promoting healthy lifestyles, ensuring environmental safety, and improving access to clean drinking water. Raising awareness and enhancing education on male reproductive health can help improve outcomes and reduce infertility rates in low-resource settings.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 5","pages":"15579883251372452"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Men's Experiences with Fatherhood in Heterosexual Relationships: A Narrative Analysis.","authors":"Nina Gao, Christy Chan, Francine Darroch, Alex Broom, Sarah McKenzie, Jennifer Mootz, John L Oliffe","doi":"10.1177/15579883251381426","DOIUrl":"https://doi.org/10.1177/15579883251381426","url":null,"abstract":"<p><p>The restructuring of gender identities and shifting social expectations of fathers have resulted in increased interest in understanding contemporary discourses about involved fathering. This article contributes to that scholarship by providing a narrative analysis about men's experiences with fatherhood in heterosexual relationships. Drawing from a photovoice study with 16 fathers, we report three discrete but interrelated narratives. The first narrative <i>Sacrifices in being a provider</i> featured fathers' diverse alignments to traditional masculinities as well as investments in contemporary involved fathering. The second narrative <i>Balance in caring</i> encompassed fathers' efforts for adapting to ever-changing parenting responsibilities, and strategies for preserving intimate partnerships and a sense of self amid parenting demands. The final theme, <i>Liberation of contemporary father identities</i>, described participants' reflexive identity [re]construction of masculinity in experiencing fatherhood. These findings highlight a matrix of modern-day fathering expectations and fathers' relational practices in navigating shifting gender relations and masculinities.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 5","pages":"15579883251381426"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dehydroepiandrosterone Decline in Aging Males as a Predictor of Erectile Dysfunction and Mood Disorders in Patients With Benign Prostate Hyperplasia Undergoing Dutasteride Treatment.","authors":"Maja Sofronievska Glavinov, Senol Tahir, Stefan Arsov","doi":"10.1177/15579883251365091","DOIUrl":"https://doi.org/10.1177/15579883251365091","url":null,"abstract":"<p><p>Age-related decline in dehydroepiandrosterone (DHEA) and its sulfate metabolite, dehydroepiandrosterone-sulfate (DHEAS), affects steroid synthesis in men. DHEA(S) acts as a direct neurosteroid and weak androgen and is the unique steroid unaffected by dutasteride's inhibitory effect on 5α reductases. This study examined the relationship between dutasteride's side effects, specifically erectile dysfunction (ED) and mood disorders, and the age-related decline in DHEAS. The study included 250 patients with benign prostatic hyperplasia (BPH), divided into two age groups (<60 and ≥60 years), and treated with tamsulosin or tamsulosin plus dutasteride. DHEAS levels were measured, and patients were assessed for ED and mood disorders using standardized questionnaires. Some patients experienced worsening ED and mood disorders during the 6-month follow-up period. The study found a correlation between DHEAS levels and erectile function and mood status in both age groups receiving dutasteride combination therapy (<i>p</i> < .05). Regression analyses showed that DHEAS was a positive predictor for ED in older patients treated with tamsulosin (<i>p</i> < .001) and in both age groups receiving dutasteride combination therapy (<i>p</i> < .001). In addition, DHEAS was a significant negative predictor for mood changes in both age groups receiving combination therapy (<i>p</i> < .001). This study suggests that baseline DHEAS levels can predict changes in erectile function and mood status in BPH patients treated with dutasteride therapy. It is, therefore, recommended to perform DHEAS assessment before starting dutasteride treatment in order to reduce the risk of ED and mood disorders.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 4","pages":"15579883251365091"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total Round Cell Concentration in Semen and Its Association With Sperm DNA Fragmentation Index Among Ghanaian Males in Kumasi.","authors":"Evans Anokye Kumi, Victor Boachie Owusu, Peter Nyarko Coffie, Ebenezer Kojo Addae, Rex Kwadwo Mawuli Djokoto, Kweku Bedu-Addo, John Asiedu Larbi","doi":"10.1177/15579883251359420","DOIUrl":"10.1177/15579883251359420","url":null,"abstract":"<p><p>Male infertility affects millions worldwide, yet its underlying causes remain incompletely understood. Total round cell concentration (TRCC) in semen, particularly leukocytospermia, has been suggested as a biomarker of impaired sperm function. However, its relationship with sperm DNA fragmentation index (DFI) remains unclear, particularly in sub-Saharan Africa, where research is scarce. This study examines the prevalence of elevated TRCC and its associations with semen parameters and sperm DNA fragmentation among men attending a fertility clinic in Kumasi, Ghana. A cross-sectional study was conducted among 227 men, with semen samples analyzed following WHO guidelines. Sperm concentration, motility, and morphology were assessed, while TRCC was quantified using a Neubauer hemocytometer and light microscopy. Sperm DNA fragmentation was determined using the Sperm Chromatin Structure Assay, and multivariate logistic regression models were employed to evaluate associations between TRCC and semen quality parameters. Elevated TRCC was detected in 19.4% of participants. Higher TRCC levels were significantly associated with lower odds of oligozoospermia (c<i>OR</i> = 0.30; 95% CI [0.20, 0.92]; <i>p</i> = .030), a relationship that remained significant after adjusting for confounders (a<i>OR</i> = 0.18; 95% CI [0.05, 0.67]; <i>p</i> = .010). However, TRCC was not significantly associated with asthenozoospermia (<i>p</i> = .656) or teratozoospermia (<i>p</i> = .592). Additionally, no correlation was observed between TRCC and sperm DFI (<i>r</i> = .009, <i>p</i> = .958). It can therefore be concluded that the presence of round cells in semen does not influence sperm DNA integrity.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 4","pages":"15579883251359420"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating Parenthood Alone: A Mixed-Method Study of Single Fathers' Experiences and Needs Regarding Received Midwife and Child Health Nurse Support in Sweden.","authors":"Wells M B, Kerstis B","doi":"10.1177/15579883251363107","DOIUrl":"10.1177/15579883251363107","url":null,"abstract":"<p><p>This mixed methods study aimed to first quantitatively compare single fathers' levels of depressive symptoms, coparenting relationship quality, and father-infant bonding with coupled fathers, and then explore single fathers' experiences and needs regarding professional support during the perinatal and early parenting period. Fathers (<i>n</i> = 1,589, of which 25 were single fathers) completed an online survey regarding their depressive symptoms, coparenting relationship, and father-infant bonding. From the quantitative survey, six single fathers (mean age 35 years) consented to participate in an individual digital interview. Mann-Whitney <i>U</i> tests and chi-square tests were used to compare coupled and single fathers, while qualitative content analysis was used to analyze the interviews. Single fathers reported having more depressive symptoms and weaker coparenting relationships compared to coupled fathers but had similar levels of infant bonding. After qualitatively exploring single fathers' professional support needs during the transition to parenthood, one overarching theme was emphasized: <i>Wanting to be an equal parent</i>. This theme broke down into three categories: <i>Desire to be included, Need of support</i> and <i>Relationship with the child.</i> Single fathers can benefit from professional clinical support, where this support helps foster stronger coparenting relationships, improves paternal mental health, and promotes gender equality in parenting. For this to happen, fathers in general, and single fathers specifically, need to be seen as clients, with their own care needs. Guidelines and recommendations should be reviewed and clarified to encourage more egalitarian parenting, including considering giving fathers their own medical records and individualized visits. There is a need for further studies regarding single fathers' experiences and support needs.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 4","pages":"15579883251363107"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Family Motivation Enhance Men's Uptake of Cascade Screening for Familial <i>BRCA1/2</i> Mutations?","authors":"Giulia Ongaro, Serena Petrocchi, Mariarosaria Calvello, Bernardo Bonanni, Irene Feroce, Gabriella Pravettoni","doi":"10.1177/15579883251343962","DOIUrl":"10.1177/15579883251343962","url":null,"abstract":"<p><p>Pathogenic variants in the <i>BRCA1</i> and <i>BRCA2</i> genes increase the relative and absolute risks of developing breast, ovarian, prostate, and pancreatic cancer. Clinical guidelines recommend cascade screening (CS) to enhance the identification of at-risk relatives. Despite the benefits of CS in facilitating access to appropriate cancer screening and risk-reduction strategies, CS uptake remains relatively low, particularly among at-risk men. Men's decisions regarding CS appear to be driven more by familial rather than individual disease risk, framing the decision as a family duty. Little is known about the motivational factors that could encourage men's participation in CS. This randomized controlled trial aimed to evaluate the effectiveness of two first-person, gain-framed messages in promoting CS intention among at-risk men: one featuring a self-referred narrative (SM) and the other a family-referred narrative (FM). A total of 110 male first-degree relatives of female <i>BRCA1/2</i> carriers were randomized into two groups. <i>T</i>-tests revealed no significant difference between groups in perceived message quality. Additionally, after controlling for age, the type of message received did not significantly influence participants' levels of intention to undergo CS. These findings highlight the need for further exploration of the complex motivational factors influencing at-risk men's adherence to CS. Future research should consider alternative health communication strategies tailored to different motivational drivers.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 4","pages":"15579883251343962"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}