American Journal of Men's Health最新文献

{"title":"Health-Related Quality of Life Following Treatment for Testicular Cancer: A Qualitative Systematic Review.","authors":"Louis Fox, Charlotte Moss, Tobias Gregor Hauser, Isolt Reardon, Netty Kinsella, Walter Cazzaniga, Mieke Van Hemelrijck, David Nicol","doi":"10.1177/15579883251333619","DOIUrl":"10.1177/15579883251333619","url":null,"abstract":"<p><p>Testicular cancer (TCa) can precipitate ongoing psychosocial/physical morbidity post-treatment, despite high rates of cure. We conducted a systematic review to synthesise three decades of primary qualitative research on health-related quality of life (HRQoL) to inform the design of supportive care pathways. We queried MEDLINE/PubMed, PsycINFO, CINAHL, and Web of Science for all qualitative studies published up to 26 October 2022 examining issues relevant to HRQoL in post-treatment TCa patients. Two independent reviewers appraised included studies for methodological quality using established guidance for evidence-based public health policy and analysed findings via thematic synthesis. Studies were analytically weighted by study quality. Studies were evaluated using GRADE-CERQual to produce confidence levels in findings. We included 18 studies, comprising 387 participants. Seven studies were graded high quality, eight medium quality, and three low quality. Emergent analytical themes were: (a) Residual psychological injury; (b) Information deficits and unnecessary anxiety; (c) Thwarted life trajectory; (d) Social disruption; (e) Undermined youth; (f) Health service abandonment; (g) Long-term sexual problems; and (h) Maladaptive coping and post-traumatic stress. All findings were deemed 'high confidence', except theme (g), which was of 'moderate confidence'. A limitation of the review was the relative dominance of Anglophone countries in the included studies. Some men treated for TCa are at risk of a range of post-treatment HRQoL issues, particularly psychosocial issues. Some individuals may be more at risk than others, based on specific personality traits, access to accurate and complete information about treatment recovery, and individual coping responses.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 3","pages":"15579883251333619"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing Mental Health Stigma and the Challenges Faced by Sexual Minority Men: Insights from the Philippines.","authors":"Rowalt Alibudbud","doi":"10.1177/15579883251338694","DOIUrl":"10.1177/15579883251338694","url":null,"abstract":"","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 3","pages":"15579883251338694"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Earlier Apoptosis in Human Sperm: Its Correlation with Semen Parameters and Assisted Reproduction Outcome.","authors":"Xuhui Yang, Yonghua Hu, Yuan Fei Wu, Jie Zhang, Zhicheng Huang, Feng He","doi":"10.1177/15579883251328353","DOIUrl":"https://doi.org/10.1177/15579883251328353","url":null,"abstract":"<p><p>The combination of Syto16/7-AAD allows the detection of apoptosis at an earlier stage than that of annexin V/7-AAD. The effects of the earlier apoptosis of spermatozoa on fertilization rate and post-embryonic development have not been investigated systematically. The objective of this study is to assess the relationship between the earlier apoptosis of spermatozoa in IVF patients and seminal parameters (concentration and morphology), to assess the effect of the earlier apoptosis of spermatozoa on ART outcomes, especially with regard to clinical pregnancy. The earlier apoptosis of spermatozoa was detected by syto16/7AAD using flow cytometry (FCM) in 98 couples (98 IVF) before and after density gradient centrifugation (DGC), and its relationships with the fertilization rate, the normal fertilization rate, the cleavage rate, the good embryo rate and the cumulative clinical pregnancy rate were assessed. Meanwhile, the correlation with seminal parameters (concentration, motility and morphology) was also analyzed. The rate of the earlier apoptosis was significantly negatively correlated to sperm concentration(<i>r</i> = -.302, <i>p</i> = .003) and membrane integrity rate(<i>r</i> = -.862; <i>p</i> < .01) after DGC. There was also a positive correlation between the rate of the earlier apoptosis and sperm mortality rate (<i>r</i> = .225, <i>p</i> = .027) after DGC. A highly significantly negative correlation was found between the rate of the earlier apoptosis and outcomes in IVF patients: the fertilization rate and the normal fertilization rate decreased as the rate of the earlier apoptosis increased (<i>r</i> = -.271, -.288; <i>p</i> = .008,.004). The cumulative clinical pregnancy rate also significantly differed between patients with the earlier apoptotic rate ≥15% and <15% (57.89% vs. 81.69%, <i>p</i> < .01) after DGC. The earlier apoptosis of spermatozoa seems to affect fertilization, however, it does not affect the early embryo development proficiency in IVF procedures. Because of the decreased fertilization rate, the earlier apoptosis of spermatozoa can compromise the number of available embryos and good embryos, resulting in cumulative clinical pregnancy loss.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251328353"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"They're Lacking Purpose. It's a Recipe for Suicide.\": Masculinity and Gender-Based Inequalities in Deaths of Despair in England.","authors":"Timothy Price","doi":"10.1177/15579883251329715","DOIUrl":"https://doi.org/10.1177/15579883251329715","url":null,"abstract":"<p><p>This qualitative study explores the factors contributing to gender-based inequalities in \"deaths of despair\" (DoD) - those deaths from suicide, drug overdoses, and alcohol-specific causes - among men in two deindustrialised towns in North East England. Understanding gender-based disparities in these causes of death sheds important light on how social and economic factors intersect with certain facets of masculinity, such as stoicism and self-reliance, to drive vulnerability. Data were collected through semi-structured interviews and one focus group with 54 stakeholders - people whose work is related to DoD, such as mental health treatment and public health practice - and community members in Middlesbrough and South Tyneside, two towns with above average rates of DoD. Participants included both men and women, predominantly of middle-age or older, with most participants unemployed or retired. Data were analysed using Iterative Categorisation, with findings interpreted through thematic analysis. The study generated three key themes: industrial history and masculinity, masculinity and class, and masculinity as a barrier to help-seeking. The findings demonstrate that economic decline following deindustrialisation resulted in distress and created unique risk factors for substance use and self-harm for men. These results suggest that effective interventions to reduce DoD among men in post-industrial settings must avoid pathologising masculinity itself. Instead, strategies should focus on the broader structural forces that undermine men's access to stable, fulfilling employment and offering forms of support that are compatible with masculine identity. By addressing these determinants, interventions can more effectively close gender-based inequalities and reduce the rate of DoD in deindustrialised areas.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251329715"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What It Means to Become a Father.","authors":"Åsa Leanderz, Maria Henricson, Frida Lygnegård, Caroline Bäckström, Margaretha Larsson","doi":"10.1177/15579883251323251","DOIUrl":"10.1177/15579883251323251","url":null,"abstract":"<p><p>For fathers, the transition to parenthood can be experienced as an emotional phase. Fathers often state feeling overlooked and unsupported during their transition to parenthood. This study addressed this issue by exploring what it means to become a father-a qualitative design with a phenomenological hermeneutical approach. Data were collected through open-ended interviews with 19 fathers living in Sweden. The participants were encouraged to reflect on the meaning of becoming a father. Becoming a father means feeling connectedness to their child, their partner, and their friends, as well as creating strategies entailing flexibility, engagement, management, support, and solitude in their new situation. Fathers use digital media for support to create strategies, but it can evoke anxiety. The meaning of becoming a father concludes that they are deeply affected by the new situation. To support fathers during their transition to parenthood, midwives and child healthcare nurses should facilitate reflective conversations with them about their experiences of becoming a father. This study was guided by the Consolidated Criteria for Reporting Qualitative Research Checklist.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251323251"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Financial Strain Across 25 years and Men's Lower Urinary Tract Symptoms: A Life Course Perspective.","authors":"Sonya S Brady, Andrés Arguedas, Jared D Huling, Gerhard Hellemann, Cora E Lewis, David R Jacobs, Cynthia S Fok, Stephen K Van Den Eeden, Alayne D Markland","doi":"10.1177/15579883251330117","DOIUrl":"10.1177/15579883251330117","url":null,"abstract":"<p><p>This research utilizes Coronary Artery Risk Development in Young Adults (CARDIA) cohort study data to examine whether financial strain is associated with subsequent lower urinary tract symptoms among men and whether healthcare barriers, health risk behaviors, and comorbid conditions explain this association. CARDIA recruited Black and White participants aged 18 to 30 years at baseline (1985-1986) from four United States cities. The analytic sample was comprised of men with complete data for analyses involving financial strain trajectories across 7 assessments (<i>n</i> = 602) and mediation tests of data collected at 4 assessments (<i>n</i> = 634). The outcome variable, assessed when the mean age of men was 50 years, was the American Urologic Association Symptom Index score, recoded into four symptom categories: none (6.3%); mild (62.6%), moderate (28.5%), and severe (2.6%). Symptom category was regressed on financial strain variables, adjusting for age, race, education, and self-reported benign prostatic hyperplasia. Regression analyses and structural equation modeling tested potential mediators. Compared to not being financially strained across early and midlife adulthood, experiencing more than one shift in financial strain was associated with 84% greater odds (95% confidence interval [1.24, 2.75]) of being categorized into a worse symptom category. Structural equation modeling showed that both difficulty receiving healthcare and depressive symptoms explained an association between difficulty paying for medical care and worse symptoms. Additional research is needed to confirm findings and examine other mechanisms that may further explain associations between financial strain and symptoms, such as stress responses. Accumulated evidence may inform future prevention interventions, including integrated healthcare approaches.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251330117"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caffeine and Beetroot Juice Optimize 1,000-m Performance: Shapley Additive Explanations Analysis.","authors":"Xiao Liu, Lei Huo, Feng Wang, Tian Wang, Wenchao Rong, Yu He","doi":"10.1177/15579883251327907","DOIUrl":"10.1177/15579883251327907","url":null,"abstract":"<p><p>The 1,000-m run is a key component of university physical fitness assessments. Effective supplementation strategies to enhance performance and recovery in this test remain underexplored. This study aimed to evaluate the effects of caffeine (CAF) and beetroot juice (BJ) on 1,000-m performance and used SHapley Additive exPlanations (SHAP) analysis to identify key influencing factors. A randomized crossover design compared the effects of CAF (6 mg/kg body weight), BJ (70 mL providing 6.4 mmol of <math><mrow><msubsup><mrow><mi>NO</mi></mrow><mrow><mn>3</mn></mrow><mrow><mo>-</mo></mrow></msubsup></mrow></math>), and their combination with placebo (PLA) on 1,000-m running performance. Twenty healthy male participants took part in the study. Physiological, nutritional, and behavioral data were collected during each condition. SHAP analysis of a multilayer perceptron model quantified the relative importance of various performance determinants, providing a clear assessment of their contribution to the outcome. The CAF + BJ group performed significantly better than PLA (<i>p</i> < .01) in the first 1,000-m run and outperformed both PLA and BJ in the second run (<i>p</i> < .01). Performance declined after recovery in BJ (<i>p</i> < .01) and PLA (<i>p</i> < .01) but improved in CAF + BJ (<i>p</i> < .01). Post-exercise heart rate and blood lactate were highest in CAF + BJ and CAF, with CAF showing significantly higher lactate levels at 10, 15, and 20 min post-exercise compared to CAF + BJ (<i>p</i> < .01). SHAP analysis ranked body fat percentage > weight > age > nighttime sleep duration > nutritional strategy > average vertical jump height > grip strength > resting heart rate > time since last meal > alcohol consumption > height > smoking frequency. This study suggests that CAF and BJ supplementation may improve 1,000-m performance. SHAP analysis introduced a novel framework for identifying key factors, offering insights for targeted interventions. Tailored dietary supplement strategies that address critical physiological and lifestyle factors are important. Combining supplementation with these approaches can further enhance performance and recovery.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251327907"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Race and Obesity Among Non-Hispanic White and Non-Hispanic Black Men by Education Level.","authors":"Corina Mills, Hossein Zare, Genie Han, Courtney Thomas Tobin, Roland J Thorpe","doi":"10.1177/15579883251329679","DOIUrl":"10.1177/15579883251329679","url":null,"abstract":"<p><p>Prior disparities in obesity research emphasize socioeconomic status as a potential driver of White-Black differences in obesity prevalence, but there is a paucity of research examining the influence of education on the observed racial difference among men. The objective of this study was to determine whether the relationship between race and obesity varies by education level among Non-Hispanic White (NHW) and Non-Hispanic Black (NHB) men. We used 1999 to 2016 National Health and Nutrition Examination Survey data consisting of a sample of 13,583 men (9,459 NHW and 4,124 NHB). Race and Ethnicity were determined by self-reports of whether they were Hispanic or not and their racial group. Education was based on self-reporting of the highest grade level or level of school completed and categorized as: less than high school, high school diploma or General Equivalency Diploma, some college or associate degree, and college degree or above. Thirty-four percent of the men were obese (body mass index [BMI] > 30 kg/m²); a higher proportion of NHB men reported being obese than NHW men (36.0%, <i>n</i> = 1,508, vs. 33.8%, <i>n</i> = 3,140; <i>p</i> = .049). Adjusting for age, marital status, income, insurance status, smoking status, drinking status, self-rated health, physical inactivity, and the number of chronic conditions, NHB men with a college degree or above had a higher prevalence of obesity (prevalence ratio: 1.21, confidence interval [1.06, 1.39]) than NHW men. Findings suggest that among college-educated NHW and NHB men, there is a relationship between race/ethnicity and obesity prevalence.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251329679"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Varicocelectomy on Assisted Reproductive Technology Outcomes of Infertile Patients with Varicocele: A Systematic Review and Meta-Analysis.","authors":"Wending Teng, Jianfeng Xiao, Qian Xu, Penghao Li","doi":"10.1177/15579883251334561","DOIUrl":"https://doi.org/10.1177/15579883251334561","url":null,"abstract":"<p><p>Varicocele can lead to impaired semen parameters and induce infertility. Varicocelectomy is considered the gold standard for varicocele treatment. However, its impact on improving assisted reproductive technologies (ARTs) outcomes remains contentious. This study seeks to compare reproductive outcomes between infertile men who underwent varicocelectomy and those who did not prior to ARTs. In addition, it evaluates the influence of types of fertilization, couples' ages, and treatment years on clinical pregnancy rates. A comprehensive search was conducted through February 2023 across eight electronic databases using combinations of relevant keywords. Observational and randomized controlled trials (RCTs) were included. Fourteen eligible studies (<i>n</i> = 1,705) were included: 12 retrospective studies (<i>n</i> = 1,467) and 2 prospective studies (<i>n</i> = 238). Pooled results indicated that infertile men who received varicocelectomy had a significantly higher clinical pregnancy rate compared to the control group (OR: 1.38, 95% CI [1.05, 1.83]; <i>I</i>² = 36%, <i>p</i> = .02). The live birth rate was also significantly higher in the treatment group (OR: 2.18, [1.58, 3.01]; <i>p</i> < .00001; <i>I</i>² = 0%). However, miscarriage rates did not significantly differ (OR: 1.07; [0.57, 1.98]; <i>I</i>² = 0%, <i>p</i> = .84). Varicocelectomy significantly improved sperm concentration and normal morphology rate, but did not result in a significant enhancement in sperm motility. Men who underwent varicocelectomy between 2012 and 2019 and subsequently received intracytoplasmic sperm injection exhibited improved outcomes, particularly when their female partners were under 30 years of age. Larger, high-quality RCTs are needed to clarify benefits or avoid unnecessary treatments.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251334561"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"Modulation of NRF2 and CYP24A1 Pathways by Hookah Smoke: Implications for Male Reproductive Health\".","authors":"Helmi Ben Saad","doi":"10.1177/15579883251324038","DOIUrl":"10.1177/15579883251324038","url":null,"abstract":"","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251324038"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}