Nianwen Huang, Haisong Li, Longji Sun, Junlong Feng, Zixiang Gao, Zhechao Lin, Yong Yang, Bin Wang, Jisheng Wang
{"title":"Guijiajiao-Lujiaojiao Synergistically Promote Spermatogenesis in Tripterygium Wilfordii Polyglycoside-Induced Oligoasthenozoospermia Rats via PI3K/AKT Signaling Pathway.","authors":"Nianwen Huang, Haisong Li, Longji Sun, Junlong Feng, Zixiang Gao, Zhechao Lin, Yong Yang, Bin Wang, Jisheng Wang","doi":"10.1177/15579883241293941","DOIUrl":"10.1177/15579883241293941","url":null,"abstract":"<p><p>Guijiajiao-Lujiaojiao (GL) is a combination of Traditional Chinese Medicine (TCM) that can be used to treat oligoasthenozoospermia (OAS). However, its mechanistic role in OAS needs to be better understood and necessitates more studies. This study was planned to investigate GL's therapeutic effects and its mechanistic role in the tripterygium wilfordii polyglycoside (GTW)-induced OAS rat model. In total, 60 Sprague-Dawley (SD) rats at 8 weeks of age were assigned to six groups: blank (NC), model (GTW), GL low-dose (GL-L, 0.3 g/kg/day), GL medium-dose (GL-M, 0.6 g/kg/day), GL high-dose (GL-H, 1.2 g/kg/day), and GL high-dose + PI3K inhibitor LY294002 (GL-H 1.2 g/kg/day + LY 1.2 mg/kg/day) groups. The model was characterized after 8 weeks to examine sperm concentration and viability, serum hormone levels, testes histopathology, and specific protein markers. The treatment efficacy was evaluated by mRNA and protein expression levels, among other parameters. Compared with the GTW group, the viability and concentration of rat spermatozoa were significantly increased after GL intervention (<i>p</i> < .01). Meanwhile, the serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and T hormones in rats in the GL-M and GL-H groups were significantly higher than those in the GTW group (<i>p</i> < .05). Furthermore, GL enhanced the proliferation of spermatogenic cells by modulating the PI3K/AKT signaling pathway, increasing and decreasing the levels of Bcl-2 and Bax proteins, respectively. It is concluded that the mechanism by which GL effectively enhanced the spermatogenic function of the GTW-induced OAS model may be attributed to the PI3K/AKT signaling pathway activation and the elevation of serum LH, FSH, and T hormone levels.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 6","pages":"15579883241293941"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sanda Mrabet, Raja Boukadida, Emah Sidina, Dorsaf Zellama, Abdellatif Achour
{"title":"Late-Onset Familial Systemic Lupus Erythematosus With Lupus Nephritis in an 82-Year-Old Male: A Case Report and Literature Review.","authors":"Sanda Mrabet, Raja Boukadida, Emah Sidina, Dorsaf Zellama, Abdellatif Achour","doi":"10.1177/15579883241293781","DOIUrl":"10.1177/15579883241293781","url":null,"abstract":"<p><p>Systemic lupus erythematosus (SLE) rarely occurs in men of any age. Late-onset SLE (typically after the age of 50) presents special challenges. We report a case of SLE with renal involvement in a very old man. The patient, who was 82 years old, presented with acute kidney injury and a family history of SLE. He was diagnosed with lupus nephritis based on clinical criteria, although no renal biopsy was performed. After starting corticosteroid therapy, his condition improved markedly, with recovery of renal function and resolution of proteinuria and hematuria. The patient's case is notable for its advanced age and familial context, with a milder form of lupus compared with his relatives. Despite the absence of severe kidney damage, the patient's treatment with corticosteroids was effective, reflecting the unique and rare nature of this case.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 6","pages":"15579883241293781"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan Y Cagas, Stuart J H Biddle, Oscar Castro, Ineke Vergeer
{"title":"\"Men Need Role Models\": Exploring the Facilitators and Barriers for Yoga Participation Among Men.","authors":"Jonathan Y Cagas, Stuart J H Biddle, Oscar Castro, Ineke Vergeer","doi":"10.1177/15579883241298663","DOIUrl":"10.1177/15579883241298663","url":null,"abstract":"<p><p>Yoga is a holistic form of physical activity taken up for various reasons, including physical and mental health, and sometimes spirituality. Despite the growing popularity of yoga as a form of health-enhancing physical activity, data show the uptake among men to be consistently low compared to women. To gain an understanding of barriers and facilitators for yoga uptake and adherence among men, four focus group discussions (three male groups, one female group) and three individual interviews were undertaken. Using thematic analysis, three themes were developed: (a) encouragement, advice, and support from trusted others, (b) confronting gender-related perceptions and issues, and (c) getting to the benefits. The findings suggest that men are more likely to take up yoga when encouraged by trusted others and male role models. Men face gender-related challenges that can be overcome by educating them about yoga, focusing on its physical benefits, and experiencing the benefits of yoga firsthand. To encourage more men into yoga, yoga teachers need to create an inclusive environment that welcomes men and caters to their needs. These findings provide valuable insight into the unique challenges experienced by men in pursuing and practicing yoga regularly. They may be used to develop targeted recruitment and marketing strategies to draw more men into yoga and encourage them to stay, which is essential for experiencing the many long-term health benefits of yoga.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 6","pages":"15579883241298663"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jack Sweeney, Shane O'Donnell, Emilie Roche, P J White, Paula Carroll, Noel Richardson
{"title":"Mental Health Stigma Reduction Interventions Among Men: A Systematic Review.","authors":"Jack Sweeney, Shane O'Donnell, Emilie Roche, P J White, Paula Carroll, Noel Richardson","doi":"10.1177/15579883241299353","DOIUrl":"10.1177/15579883241299353","url":null,"abstract":"<p><p>Stigma surrounding mental health, particularly among men, remains a significant barrier to men engaging with support services for their mental health. Despite increasing evidence of interventions targeting different aspects of stigma reduction, there is a notable gap in the literature concerning male-specific mental health stigma reduction interventions and on the underlying behavior change techniques (BCTs) used to reduce stigma. The purpose of this review is to synthesize the evidence relating to the impact of mental health stigma reduction interventions among men and to explore the underlying BCTs associated with each intervention. The review was restricted to empirical research reporting on interventions targeting mental health stigma in male-dominated populations. The quality appraisal was conducted using the Mixed Methods Analysis Tool and a narrative synthesis was conducted. Fourteen articles reporting on 11 interventions were included for review, while 20 outcome measures were used. Perceived public stigma attracted the largest number of interventions with a lesser focus on self or personal stigma. Nineteen BCTs were identified across the interventions with information about health consequences and self-monitoring of behavior being the most common followed by credible source, social contact, and behavior practice/rehearsal. This is discussed in relation to the wider literature. The methodological issues highlighted in the articles limit the conclusions and recommendations that can be drawn from the review. Recommendations for further research include standardizing the scales used in stigma measurement, in-depth reporting of intervention descriptions, and greater use of theory to guide intervention development.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 6","pages":"15579883241299353"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mingqiang Su, Jingxian Luo, Wei Chen, Xianyong Li, Dayong Ye, Xiaofu Zeng, Guangqing Fu, Weiwei Xie, Yong Liang
{"title":"SPC25 Activates the Warburg Effect to Inhibit Ferroptosis in Prostate Cancer Cells.","authors":"Mingqiang Su, Jingxian Luo, Wei Chen, Xianyong Li, Dayong Ye, Xiaofu Zeng, Guangqing Fu, Weiwei Xie, Yong Liang","doi":"10.1177/15579883241297880","DOIUrl":"10.1177/15579883241297880","url":null,"abstract":"<p><p>SPC25 is associated with unfavorable outcomes in various cancers, but its role in prostate cancer (PRAD) is unclear. More research is needed on glycolysis and ferroptosis targets in PRAD. Bioinformatics tools were used to analyze SPC25 expression disparities. Gene set enrichment analysis (GSEA) identified pathways enriched by SPC25 and its correlation with glycolytic proteins. SPC25 mRNA transcriptional activity was analyzed by quantitative polymerase chain reaction (qPCR), while protein levels of SPC25, glycolytic markers, and ferroptosis markers were assessed using Western blot. CCK-8 was used to evaluate the effects of SPC25 on cell survival. Ferroptosis levels were measured by flow cytometry and assays for Fe<sup>2+</sup> and malondialdehyde (MDA) content. Glycolytic capacity was assessed using glucose uptake assays, lactate tests, and a Seahorse XF analyzer. In PRAD tissues and cells, SPC25 was notably upregulated and correlated with adverse outcomes. It enhanced cancer cell vitality. GSEA showed SPC25's strong association with ferroptosis and glycolytic pathways, while Pearson correlation analysis indicated a positive relationship between SPC25 and glycolytic proteins. Overexpression of SPC25 in cell lines noticeably curbed the accumulation of lipid reactive oxygen species, MDA formation, and Fe<sup>2+</sup> content, while it augmented the protein expression of ferroptosis markers. SPC25 stimulated an increase in cellular extracellular acidification rate, glucose uptake, and lactate secretion, while it dampened oxygen consumption rate, and this effect could be counteracted by 2-deoxy-d-glucose (2-DG). Conversely, 2-DG mitigated the ferroptosis indicators that were diminished by SPC25 downregulation, including the reduction of ferroptosis marker protein expression. By upregulating glycolysis in PRAD cells, SPC25 suppresses the occurrence of ferroptosis.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 6","pages":"15579883241297880"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Junlong Feng, Sheng Deng, Xuefeng Gong, Bin Wang, Longji Sun, Huanan Zhang, Zixiang Gao, Hui Chen, Kali Zou, Jiaqi Yang, Haisong Li, Jisheng Wang
{"title":"Bioinformatics Combined With Experimental Modeling to Study the Molecular Mechanism of Xuefu Zhuyu Decoction to Improve Erectile Dysfunction Associated With Asthma in Rats.","authors":"Junlong Feng, Sheng Deng, Xuefeng Gong, Bin Wang, Longji Sun, Huanan Zhang, Zixiang Gao, Hui Chen, Kali Zou, Jiaqi Yang, Haisong Li, Jisheng Wang","doi":"10.1177/15579883241293936","DOIUrl":"10.1177/15579883241293936","url":null,"abstract":"<p><p>Asthma is associated with chronic systemic inflammation, and inflammatory factors can damage vascular endothelial cells, thus impairing erectile function (ED). Xuefu Zhuyu decoction (XFZYD) can inhibit inflammation and promote angiogenesis, which in turn improves asthma as well as ED, but its exact mechanism of action is not yet clear. This study investigates the mechanism underlying the beneficial effect of XFZYD on asthma-associated ED. High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was used to analyze the constituents of XFZYD, and network pharmacology analysis was used to predict the target genes of XFZYD. Sprague-Dawley rats in the asthma model with erectile dysfunction were divided into the model, XFZYD low-, medium-, and high-dose group (3.09, 6.17, and 12.34 g/kg), with drug intervention for 8 weeks. We assessed the interleukin 6 (IL-6), vascular endothelial growth factor A (VEGFA), and tumor necrosis factor (TNF) protein levels in the penile tissue. We discovered that after treatment with XFZYD (3.09, 6.17, and 12.34 g/kg), the number of erections significantly increased (1.17 ± 0.41, 1.50 ± 0.55, and 1.67 ± 0.52), the density of endothelial cells in the corpus cavernosum of the penis increased, the expression level of IL-6 was reduced (7.5%, 21.2%, and 24.4%), the expression level of VEGFA was reduced (7.8%, 25%, and 28.4%), and the expression level of TNF was reduced (13.5%, 30.6%, and 32.4%). The in vivo experiments indicate that XFZYD may improve ED in asthma model rats by inhibiting inflammation and reducing vascular permeability. This study provides new insights into the mechanism of action of XFZYD in the treatment of asthma leading to ED.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 6","pages":"15579883241293936"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"A Man Has to Show That He Is a Man From a Young Age\": Intimate Partner Violence for Young Male University Students in Brazil.","authors":"Caroline Izabela Silva, Daniella Yamada Baragatti, Natalia Rejane Salim, Leticia Scotto, Claudia Adao Alves, Caroline Grespan Forlani, Diene Monique Carlos","doi":"10.1177/15579883241299330","DOIUrl":"10.1177/15579883241299330","url":null,"abstract":"<p><p>Considering that men today face social and cultural pressures to behave in certain ways, the objective of this study was to analyze the construction of Intimate Partner Violence (IPV) from the perspective of university students who identify themselves as male in a developing country. This is a qualitative study carried out through semi-structured interviews, with 15 students from the state of São Paulo, Brazil, from May to July 2021. The data were analyzed thematically and anchored in the ecological framework of understanding violence. Two final themes were identified: \"'A man has to show that he is a man from a young age'-Social construction of violence\" and \"'At first it is hard to notice'-The subtlety of violence.\" It was identified that this phenomenon is configured as a historical, social, and cultural construction, mainly sustained by what is attributed to \"being a man\" in society and, consequently, the actions expected by this attribution. These perceptions are transversal in relationships within society and go beyond generations-and they are a layer in addition to memories of violence experienced or witnessed taking place in determining IPV experiences. Living in communities that legitimize gender inequities, generally in socioeconomically disadvantaged areas, is a prominent factor influencing IPV among the studied population. In this context, psychological violence emerges as preponderant and triggers other forms of violence, which are difficult to notice and veiled behind prejudices. Educational practices for healthy relationships are proposed and emphasized from basic to higher education as well as peer and professional support.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 6","pages":"15579883241299330"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arnai Johnson, Leslie Amonoo, Saria Lofton, Keesha L. Powell-Roach
{"title":"How Masculinity Impedes African American Men From Seeking Mental Health Treatment","authors":"Arnai Johnson, Leslie Amonoo, Saria Lofton, Keesha L. Powell-Roach","doi":"10.1177/15579883241278846","DOIUrl":"https://doi.org/10.1177/15579883241278846","url":null,"abstract":"This study addresses the pronounced mental health disparities faced by African American men, characterized by the heightened severity of mental health conditions and their reluctance to seek mental health treatment. Persistent neglect toward the mental health of African American men perpetuates systemic inequities and heightens the stigma surrounding mental well-being within their communities. This study investigates the interaction of masculinity, distrust in doctors, and parental support on attitudes influencing African American men’s reluctance to seek mental health care. A survey administered to 74 African American men revealed a negative correlation between masculinity and attitudes toward seeking mental health treatment. In contrast, no significant correlations were found between distrust in doctors and parental support on attitudes toward seeking mental health treatment. These findings were analyzed using Pearson’s correlation, underscoring the urgent need to address masculine norms in mental health discourse among African American men. Implications of the findings and future directions for masculinity in African American men are discussed.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"38 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retrograde Ejaculation Due to Posterior Urethral Stricture: A Rare Case Report","authors":"Lei Zheng, Lihong Wang, Hui Jiang, Tao Jiang","doi":"10.1177/15579883241276986","DOIUrl":"https://doi.org/10.1177/15579883241276986","url":null,"abstract":"Pelvic fracture is a serious injury, which has a profound impact on sexual function due to concurrent nervous and urethral injuries. In this case report, we describe a 29-year-old single man who had retrograde ejaculation as a result of a pelvic fracture-related posterior urethral stricture. The patient wanted to improve his ejaculatory ability after experiencing urethral stricture for 8 years and retrograde ejaculation for 3 years following the pelvic fracture. We precisely located and measured the patient’s urethral stricture using a retrograde urethrogram, and we used transrectal color Doppler ultrasound to track the patient’s ejaculation process in real time. Next, we used urethral balloon dilatation to relieve the urethral stricture. Urinary obstruction symptoms have completely resolved, and the patient was able to urinate without any obstructions. Meanwhile, the real-time transrectal color Doppler ultrasound result showed that some semen might ejaculate externally by passing through the initial stricture area, while some semen continued to flow retrogradely into the bladder.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"1 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carita Nordin-Remberger, Margareta Johansson, Karin S. Lindelöf, Michael B. Wells
{"title":"Support Needs, Barriers, and Facilitators for Fathers With Fear of Childbirth in Sweden: A Mixed-Method Study","authors":"Carita Nordin-Remberger, Margareta Johansson, Karin S. Lindelöf, Michael B. Wells","doi":"10.1177/15579883241272057","DOIUrl":"https://doi.org/10.1177/15579883241272057","url":null,"abstract":"The aim of this mixed-method study was to identify support needs, as well as barriers and facilitators to seeking support in a sample of Swedish fathers with a fear of childbirth (FOC). Participants completed an anonymous quantitative online survey ( N = 131), with three free-text items for those self-identifying as having an FOC ( N = 71) and five individual in-depth interviews. Data analysis included descriptive and chi-square analyses for quantitative data, and manifest content analysis for qualitative data. Those with a severe FOC were more likely to report having on-going mental health difficulties ( p = .039) and one fifth (21%) of the participants with severe FOC wanted to receive professional treatment, but only 8.1% received treatment. Most participants either preferred individual support or to receive support together with their partner. Fathers with severe FOC were more likely to report one or more barriers than those without FOC ( p = .005), where unwanted social stigma was the single largest barrier. Qualitative findings identified one main category: Expectant fathers missing and wishing for support for FOC composed four generic categories: (1) support in developing an understanding of their fear, (2) coping by being aware of feelings, (3) professional support through trust and respect, and (4) needing individualized support. To encourage healthy fathers, clinical professionals should find ways to support fathers, such as by providing them with their own perinatal appointments, asking them about their feelings, as well as screening, diagnosing, and treating fathers with severe FOC.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"1 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}