American Journal of Men's Health最新文献

{"title":"A Combination of <i>Cuscuta chinensis</i> and <i>Lycium barbarum</i> Ameliorates Spermatogenic Impairment in Mice and Is Associated With Modulation of the miR-21/PTEN/PI3K/AKT/mTOR Signaling Axis.","authors":"Haoran Chang, Junlong Feng, Lixing Lei, Xiangfa Lin, Maoke Chen, Zixiang Gao, Jisheng Wang, Haisong Li","doi":"10.1177/15579883261492747","DOIUrl":"https://doi.org/10.1177/15579883261492747","url":null,"abstract":"<p><p>SC-FL is a traditional Chinese herbal formula that has been used for kidney tonification and the clinical treatment of oligospermia and asthenospermia. This medicinal compound comprises dodder seed (<i>Cuscuta chinensis Lam</i>.) and wolfberry fruit (<i>Lycium barbarum L</i>.). However, the precise mechanisms of SC-FL remain undetermined. Therefore, this study aimed to identify potential therapeutic targets of SC-FL in oligoasthenozoospermia and validate these targets <i>in vivo</i>. To establish a spermatogenic dysfunction model, male BALB/c mice were administered glucosides of <i>Tripterygium wilfordii</i> Hook. f. (GTW) and then treated with SC-FL. Furthermore, the expression of microRNA-21 (miR-21), key PI3K/AKT/mTOR signaling pathway-related proteins and mRNAs, as well as molecular markers of cell proliferation and apoptosis, was evaluated. The results indicated that the mouse body weight did not significantly differ across SC-FL-treated groups compared to the GTW group (non-treated model group); however, the high-dose SC-FL mice showed significantly higher testicular weight (<i>p < 0.05</i>). Both medium- and high-dose SC-FL mice showed significantly increased sperm concentration and motility relative to the GTW group (<i>p < 0.01</i>). Histological analysis by hematoxylin and eosin staining revealed that SC-FL treatment alleviated GTW-induced testicular tissue damage and preserved testicular structure. SC-FL treatment reduced serum IL-6 and TNF-α levels and decreased PTEN mRNA and protein expression. It also increased miR-21, PI3K, AKT, and mTOR mRNA expression and increased the phosphorylated protein levels of PI3K, AKT, and mTOR, whereas total PI3K, AKT, and mTOR protein abundance remained relatively unchanged. In conclusion, SC-FL increased sperm concentration and motility and reduced serum inflammatory cytokine levels in mice. These beneficial effects were accompanied by increased miR-21 expression, decreased PTEN expression, and increased phosphorylation of PI3K, AKT, and mTOR. These findings indicate an association between the protective effects of SC-FL and alterations in the miR-21/PTEN/PI3K/AKT/mTOR signaling axis, but do not establish causal mediation by this pathway.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 5","pages":"15579883261492747"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Locating Masculinity in Men's Health Research, Policy, and Practice.","authors":"Paul Galdas","doi":"10.1177/15579883261485352","DOIUrl":"https://doi.org/10.1177/15579883261485352","url":null,"abstract":"<p><p>How masculinity is conceptualised shapes what men's health research and policy define as a problem and where intervention is directed. A substantial psychological and behavioural literature has operationalised masculinity-related constructs through individual measures of attitudes, conformity, and gender role conflict. These measures can produce useful evidence, but when individual scores are treated as proxies for masculinity itself, the individual risks becoming both the unit of measurement and the assumed location of the problem. This paper examines the movement from relational theories of masculinity to individualised forms of explanation across men's health research, policy, and practice. It argues that individual, service, and structural factors are frequently identified without adequately explaining the mechanisms through which relationships, institutions, and material conditions produce, reinforce, or change gendered health practices. A relational approach does not displace individual agency or behavioural intervention. Rather, it widens the unit of analysis and intervention to include the settings that give practices their gendered meanings, distribute their social costs, and shape whether healthier alternatives are credible and available. The paper concludes that men's health policy and practice should examine and act upon these mechanisms rather than treating masculinity primarily as a set of attributes carried by individual men.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 5","pages":"15579883261485352"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Male-Factor Infertility Risk Perceptions Among Young Adults in Ontario.","authors":"Bridget K Williams, Nurasha G Fernando, Karen P Phillips","doi":"10.1177/15579883261493647","DOIUrl":"https://doi.org/10.1177/15579883261493647","url":null,"abstract":"<p><p>Understanding male-factor infertility (MFI) risk perception among emerging adults can inform development of sexual and reproductive health (SRH) interventions. This study aimed to evaluate the influence of sociodemographic characteristics on perceptions of substance use behaviors and bioenvironmental risks to male fertility. An online survey was administered to Ontario post-secondary students from May ̶ October 25, 2022, assessing their perceptions of 15 MFI risk factors. Associations between sociodemographic characteristics and high-risk perceptions were first assessed by bivariate analyses, with significant characteristics treated as potential covariates, along with gender, for regression analysis. Multiple linear regression models evaluated perceptions for selected well-established risk factors: alcohol, obesity, recreational drug use, and cigarette smoking. Respondents rated most risk factors as no to slight MFI risks, with environmental chemical exposure, and untreated sexually transmitted infections perceived as moderate to high MFI risk. Racialized identity was the most common characteristic associated with high MFI risk perception in bivariate analyses, while age was negatively associated. In regression models, cis men perceived alcohol consumption and cigarette smoking as greater risks to male fertility compared with cis women. Given that our sample considered most substance use behaviors and bioenvironmental factors as no to slight risks to MFI, this may indicate lack of fertility awareness or sexual and reproductive health literacy. Interventions and related public health policy that focus on men's health and recognize the potential influences of sociodemographic characteristics on MFI risk perception are recommended for emerging young adults.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 5","pages":"15579883261493647"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Bacterial Infection to Emerging Microbiome Signals in Prostatitis: A Bibliometric Analysis, 1985-2026.","authors":"Botao Yu, Chunling Wang, Ningying Zhou, Min Yin","doi":"10.1177/15579883261495668","DOIUrl":"https://doi.org/10.1177/15579883261495668","url":null,"abstract":"<p><p>Prostatitis research has expanded from conventional bacterial infection models to microbiome approaches. This expansion has not resolved uncertainty about the scale of the newer literature or the visibility of clinical and methodological information in indexed fields. To quantify this expansion, this bibliometric analysis mapped publication patterns and assessed prespecified indexed-field indicators in the modern microbiome, gut microbiome, and Mendelian randomization (MR) subcorpora. The Web of Science Core Collection was searched on June 2, 2026. Eligible records were English-language Articles and Reviews with prostatitis or chronic pelvic pain syndrome in the title. The microbiology criterion required a related concept in the title, abstract, or author keywords. The analysis covered annual publication output, country-level publication output and co-authorship, cited-reference frequencies, author-keyword co-occurrence, and prespecified term-defined subcorpora. Among 755 eligible records, modern microbiome terms occurred in 71 (9.40%), gut microbiome terms in 40 (5.30%), and MR in 5 (0.66%). China and the United States led country-level publication output, whereas the strongest bilateral co-authorship links were Belgium-Italy and Canada-United States. Within the modern microbiome subcorpus, 46 records (64.8%) contained terms indicating a clinical phenotype, 46 (64.8%) named a specimen, and 38 (53.5%) mentioned a molecular microbiome method. Terms indicating a longitudinal or interventional design appeared in 16 records (22.5%), while no terms indicating independent or external validation appeared in the indexed fields. Microbiome work remains a recent but still small branch of prostatitis microbiology, and the findings support longitudinal designs, standardized sampling, and independent validation for clinically interpretable research.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 5","pages":"15579883261495668"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrepant BMI Discrimination for Erectile Dysfunction Across NHANES 2001-2004 Analyses.","authors":"Queenne Kimverlee C Landingin, Jang Roy Son, Jaylord C Claro","doi":"10.1177/15579883261492742","DOIUrl":"https://doi.org/10.1177/15579883261492742","url":null,"abstract":"","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 5","pages":"15579883261492742"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"What are you Complaining About, How Hard can a Woman Hit?\": Male Experiences of Gender-Based Violence and Help-Seeking in England.","authors":"Tarela Juliet Ike, Dung Ezekiel Jidong, Evangelyn Ebi Ayobi, Mieyebi Lawrence Ike, Samuel Oluwasogo Dada, Peremi Richmond Ike, Rukevwe Francis Doghor, Tariq Mahmood","doi":"10.1177/15579883261418920","DOIUrl":"https://doi.org/10.1177/15579883261418920","url":null,"abstract":"<p><p>Gender-based violence constitutes a significant global concern. Yet, most research focuses on women, with limited studies examining the lived experiences of Black, Asian and Minority Ethnic (BAME) male victims of gender-based violence and help-seeking behavior from a co-production research approach underpinned by intersectionality theory. Our study makes an original contribution to fill this gap. 30 BAME male participants with lived experience of gender-based violence were recruited from England (Middlesbrough, Bradford, Nottingham, and Manchester). Two focus groups, comprising five participants each, and 20 individual interviews were conducted. Thematic analysis from an intersectionality theoretical lens was used to analyze the dataset. The study found that exploitation of unequal power dynamics, double victimization characterized by societal-induced silence, mental distress, and suicidal ideation, intersect to limit help-seeking behavior. It also found that systemic disadvantages in societal and service providers' responses to abuse further limit help-seeking. The study recommends the need for psychosocial interventions alongside awareness creation to address the barrier to help-seeking behavior of male victims affected by gender-based violence.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 5","pages":"15579883261418920"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyaluronan-Binding Protein 1 (HBAP-1) in Male Reproduction.","authors":"Mahdi Dehghan-Manshadi, Farzaneh Fesahat, Hossein Ansariniya","doi":"10.1177/15579883261499125","DOIUrl":"https://doi.org/10.1177/15579883261499125","url":null,"abstract":"<p><p>Hyaluronan-binding protein 1 (HABP1), alternatively designated as p32, C1QBP, gC1qR, or HIV TAP (Tat-associated protein), is a highly conserved eukaryotic protein expressed across taxa from yeast to mammals, and is localized on the cell surface of diverse cell types. This protein exists in two distinct functional forms: firstly, a pro-protein exclusively found in male germ cells, suggesting its crucial role in spermatogenic differentiation; and secondly, a mature, post-translationally cleaved form localized on the sperm surface. Due to its specific affinity for hyaluronan (HA) a key constituent of reproductive fluids the mature form is actively involved in sperm penetration, sperm-oocyte interaction, and subsequent fertilization by mature human spermatozoa. This review aims to comprehensively elucidate the key functions of HABP1, with a specific focus on its implications in reproductive science.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 5","pages":"15579883261499125"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Omics Mechanisms to Clinical Translation.","authors":"Esli Joy Fernando","doi":"10.1177/15579883261499226","DOIUrl":"https://doi.org/10.1177/15579883261499226","url":null,"abstract":"","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 5","pages":"15579883261499226"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Testosterone Therapy Adherence and Quality of Life Monitoring in Men With Hypogonadism: A Quality Improvement Project Using Patient-Reported Outcome Measures.","authors":"Candice Abrams, Kathryn Evans Kreider, Eleanor L Stevenson, Julie A Thompson","doi":"10.1177/15579883261466002","DOIUrl":"10.1177/15579883261466002","url":null,"abstract":"<p><p>Testosterone deficiency syndrome in men is common and associated with substantial symptom burden and reduced quality of life. Although testosterone replacement therapy (TRT) can improve patient-reported outcomes, real-world benefit depends on consistent adherence and structured follow-up. In outpatient settings, adherence and symptoms are rarely assessed using validated patient-reported outcome measures (PROMs), limiting treatment monitoring. This project implemented a structured PROM workflow including the Morisky Medication Adherence Scale (MMAS-8), Aging Males' Symptoms (AMS) scale, and Short Form-8 Health Survey (SF-8™) to improve testosterone therapy adherence, symptom and quality of life monitoring in an outpatient men's health clinic. A quality improvement initiative was conducted among adult men receiving TRT. Participants completed validated PROMs at baseline, 6 weeks, and 12 weeks. Primary outcomes included adherence (MMAS-8) and PROM completion; secondary outcomes included follow-up attendance, quality of life (SF-8 PCS/MCS), symptom severity (AMS total/domains), and objective measures (testosterone and BMI). Fifty-four participants enrolled, and 50 completed 12-week follow-up (92.6% retention). MMAS-8 scores improved from baseline (<i>M</i> = 5.26, <i>SD</i> = 2.32) to 6 weeks (<i>M</i> = 6.29, <i>SD</i> = 1.52) and 12 weeks (<i>M</i> = 7.19, <i>SD</i> = 0.89) (<i>p</i> < .001). AMS total scores decreased over time (<i>p</i> = .006), with improvements across psychological (<i>p</i> = .032), somatic (<i>p</i> = .002), and sexual domains (<i>p</i> = .011). Testosterone levels increased (<i>p</i> = .014), while BMI remained unchanged. Integrating PROMs into routine TRT follow-up was feasible and associated with improved adherence, high engagement, and meaningful improvements in patient-reported symptoms and quality of life.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 4","pages":"15579883261466002"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13519181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Burden of Otitis Media Among U.S. Males: Trends, Risk Factors, and Public Health Implications.","authors":"Hao Fang, Wang Weitao, Wang Haiwei, Zhu Tao, Zhou Dingkun, Li Haoran, Ji Shaojie","doi":"10.1177/15579883261465989","DOIUrl":"10.1177/15579883261465989","url":null,"abstract":"<p><p>BackgroundOtitis media includes acute otitis media, otitis media with effusion, and chronic suppurative otitis media. It causes substantial morbidity, especially among children and older adults. This study assessed the burden of otitis media among U.S. males from 1990 to 2021.MethodsUsing Global Burden of Disease 2021 estimates, we analyzed incidence, deaths, and disability-adjusted life years (DALYs) for otitis media among U.S. males. Age-specific patterns were described, and temporal trends in age-standardized rates were evaluated using Joinpoint regression. Attributable risk factors, particularly smoking and secondhand smoke exposure, were examined.ResultsOtitis media cases increased from approximately 4.10 million in 1990 to 4.57 million in 2021, while the age-standardized incidence rate rose from 3,899.1 to 4,146.8 per 100,000 population. Deaths decreased from 32.3 to 21.2, although Joinpoint analysis showed increasing mortality during 2010-2019. DALYs increased from 24,304.9 to 26,872.8, whereas the age-standardized DALY rate decreased from 20.9 to 18.9 per 100,000. The highest incidence and DALY burden occurred among children aged 5-9 years, while deaths were concentrated mainly among older adults. Behavioral risks, especially tobacco use and secondhand smoke exposure, were the leading attributable risk factors.ConclusionOtitis media remains an important health burden among U.S. males, with distinct age-specific patterns. Targeted prevention, smoking-related risk reduction, and early diagnosis and treatment in children and older adults may help reduce its future burden.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 4","pages":"15579883261465989"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148628992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}