American Journal of Men's Health最新文献

{"title":"Retraction Notice: \"Direct and Gradual Electrical Testicular Shocks Stimulate Spermatogenesis and Activate Sperms in Infertile Men: A Randomized Controlled Trial\".","authors":"","doi":"10.1177/15579883251369956","DOIUrl":"10.1177/15579883251369956","url":null,"abstract":"","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 4","pages":"15579883251369956"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Physical Activities on Men's Mental Health: A Focus on Bipolar Disorder Prevention.","authors":"Jie Liu, Sheng Zheng, Peiqi Yu, Xiaomeng Shi","doi":"10.1177/15579883251359452","DOIUrl":"https://doi.org/10.1177/15579883251359452","url":null,"abstract":"<p><p>Bipolar disorder (BD) is a prevalent psychiatric condition characterized by extreme mood fluctuations between manic and depressive episodes, significantly affecting social and occupational functioning. The etiology of BD is multifactorial, involving genetic, environmental, and lifestyle factors. While previous research has focused on the genetic and environmental contributors to BD, the role of physical activity as a modifiable lifestyle factor remains underexplored. This study investigates the causal relationship between different types of physical activity, particularly heavy do-it-yourself (DIY) activities, and BD using Mendelian randomization (MR). The study employs MR to examine the causal link between physical activity and BD. Genetic variants associated with various forms of physical activity were selected from large-scale genome-wide association studies. The study uses several MR techniques, including inverse variance weighting (IVW), MR-Egger, and weighted median methods, to analyze the relationship between physical activity (e.g., heavy DIY, light DIY, vigorous exercise, and walking) and BD. Instrumental variables were chosen based on their strong association with physical activity and their independence from other potential confounders. The MR analysis revealed a significant causal relationship between heavy DIY activities and reduced BD risk (<i>OR</i> = 0.333; 95% CI [0.111, 0.997]; <i>p</i> = .049). In contrast, no significant causal associations were found for the other types of physical activity examined. The IVW method indicated significant heterogeneity, prompting the use of a random-effects model, which confirmed that the results were not biased by heterogeneity or pleiotropy. Sensitivity analyses, including MR-Egger and MR-PRESSO, showed no significant pleiotropy, reinforcing the reliability of the findings. Leave-One-Out analysis and funnel plots further supported the robustness of the causal estimate. This study provides compelling evidence for the protective role of heavy DIY activities in reducing the risk of BD, suggesting that high-intensity physical activities may have a beneficial impact on mood regulation and the prevention of BD. The findings highlight the importance of considering gender differences in physical activity interventions for BD prevention and management. Future research should explore the neurobiological mechanisms underlying this association and further investigate the effectiveness of different types of physical activities in BD prevention and treatment strategies.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 4","pages":"15579883251359452"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Plyometric Training on Lower-Limb Explosive Power and Its Retention After Detraining in Sprinters.","authors":"Chang Shuai, Wang Xiangyu, Li Zihao, Ji Xinqi, Guomin Li","doi":"10.1177/15579883251363089","DOIUrl":"10.1177/15579883251363089","url":null,"abstract":"<p><p>Lower-limb explosive power is crucial for sprinters and jumpers, directly influencing performance in speed and jumping ability. Traditional strength training approaches often fail to maintain explosive power in the long term, particularly after periods of detraining. Investigating training methods that can both enhance and sustain lower-limb explosive power is important for improving athletic performance. This study aimed to examine the effects of a 6-week plyometric training program on enhancing and maintaining lower-limb explosive power in sprinters. Forty male sprinters were randomly assigned to either an experimental (plyometric training) or a control (traditional strength training) group (age: 20.2 ± 1.6 years, height: 182 ± 6.2 cm, weight: 72.1 ± 5.3 kg). Training was conducted three times per week for 6 weeks, followed by a 2-week detraining period. Lower-limb explosive power was assessed using the mean power in the squat jump and countermovement jump, 30 m sprints, 100 m sprints, standing long jumps, and standing triple jumps at baseline, post-training, and after the detraining phase. A significant group-by-time interaction effect was observed for key performance indicators, including squat jump power (η_<i>p</i>² = .173, <i>p</i> < .001) and 30 m sprint time (η_<i>p</i>² = .315, <i>p</i> < .001). Post-training, the plyometric group significantly increased squat jump power by 28.5% (<i>p</i> < .001) and was faster than the control group in the 30 m sprint (<i>p</i> < .05). After the 2-week detraining period, the plyometric group's performance in vertical jumps and the 100 m sprint remained significantly higher than baseline (<i>p</i> < .01), an effect not observed in the control group for sprint performance. Plyometric training significantly enhanced lower-limb explosive power and demonstrated strong retention of these gains after a 2-week detraining period. These adaptations appear more longer-lasting than those from traditional strength training, particularly for the specific demands of sprinting. These findings provide valuable insights for designing training regimens to achieve lasting improvements in explosive performance for athletes.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 4","pages":"15579883251363089"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Symptoms of Late-Onset Hypogonadism as a Potential Driver of Presenteeism.","authors":"Tomoya Shirakawa, Hisamitsu Ide, Yoshihiro Ikehata, Yan Lu, Riyo Kinouchi, Takeshi Iwasa, Kaori Koga, Seiichiro Tateishi, Yoshihisa Fujino, Toshiyuki Yasui, Shigeo Horie","doi":"10.1177/15579883251343972","DOIUrl":"10.1177/15579883251343972","url":null,"abstract":"<p><p>Presenteeism, defined as attending work despite physical or mental health issues that impair full productivity, is a prevalent concern with significant implications for workplace efficiency and employee well-being. Testosterone, the primary male sex hormone, plays a vital role in sustaining physical energy, cognitive function, and emotional stability-key factors for optimal work performance. This study explores the association between late-onset hypogonadism (LOH) and presenteeism, emphasizing how LOH-related symptoms such as fatigue, reduced libido, erectile dysfunction, and mood disturbances may contribute to reduced workplace productivity. Data from 96 male patients aged 27 to 76 years, who sought treatment at a university hospital for LOH-related symptoms, were analyzed using blood tests and validated questionnaires, including the Aging Males' Symptoms (AMS) scale, Work Functioning Impairment Scale (WFun), and Sexual Health Inventory for Men. Significant correlations were observed between AMS scores and both work functioning impairment and erectile dysfunction, indicating a strong link between LOH symptoms and presenteeism. In addition, symptoms such as fatigue, diminished motivation, and poor sleep quality were identified as exacerbating factors for work-related impairments. The greatest strength of this study lies in its focus on clinically diagnosed LOH patients, a factor that significantly distinguishes it from prior research on presenteeism in general working populations. This study underscores the potential benefits of testosterone replacement therapy, lifestyle modifications, and workplace wellness programs in addressing presenteeism among employees with LOH. Further research is necessary to assess the efficacy of these interventions in mitigating presenteeism and improving employee well-being.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 4","pages":"15579883251343972"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Genetic Risk of DKK3 and SLAMF6 in Erectile Dysfunction: A Comprehensive Analysis Based on Mendelian Randomization.","authors":"Guangqiang Zhu, Chunlin Tan, Yugen Li","doi":"10.1177/15579883251368307","DOIUrl":"https://doi.org/10.1177/15579883251368307","url":null,"abstract":"<p><p>Erectile dysfunction (ED) is a multifactorial disorder that significantly impacts men's physical and mental health, as well as their interpersonal relationships, and traditional treatment options for this condition still face many challenges and limitations. This study aimed to identify key genetic factors associated with ED risk through Mendelian randomization analysis by integrating data from expression quantitative trait loci and protein quantitative trait loci across multiple cohorts. We also evaluated the roles of metabolic pathways using data from 1,400 plasma metabolites. Single-cell RNA sequencing (ScRNA-Seq) was used to analyze gene expression patterns of ED-related genes in various cell types, while molecular docking was employed to identify potential drug targets. Our findings indicate that DKK3 plays a protective role (<i>OR</i> = 0.8555, <i>p</i> = .0087), while SLAMF6 is associated with increased ED risk (<i>OR</i> = 1.2613, <i>p</i> = .0433). Metabolites such as piperine and choline phosphate mediate ED onset. ScRNA-Seq reveals reduced DKK3 expression in endothelial and smooth muscle cells and increased SLAMF6 expression in T cells, highlighting the roles of vascular homeostasis imbalance and immune dysregulation in ED pathogenesis. Molecular docking screens four small molecules, including icariin, luteolin, Danshenol A, and Danshenxinkun A as potential therapeutic agents. This study identified DKK3 and SLAMF6 as novel therapeutic targets for ED, provided a foundation for precision medicine based on vascular-immune regulation, and underscored the need for further mechanistic studies and clinical validation.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 4","pages":"15579883251368307"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"SPC25 activates the Warburg effect to inhibit ferroptosis in prostate cancer cells\".","authors":"","doi":"10.1177/15579883241312480","DOIUrl":"10.1177/15579883241312480","url":null,"abstract":"","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 3","pages":"15579883241312480"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Prostate Cancer Screening Adherence Among Retired Men in Togo, 2023.","authors":"Diguibe Tien-Bale Bamide, Latame Komla Adoli, Sêdégnon Benoît Agossoukpe, Roméo Mèdéssè Togan, Hermine Tognon, Ismaël Simpore, Dieudonné Soubeiga","doi":"10.1177/15579883251344558","DOIUrl":"10.1177/15579883251344558","url":null,"abstract":"<p><p>Prostate cancer is the leading male cancer in sub-Saharan Africa, with 74,878 (17.4%) new cases and 32,390 (11.6%) deaths in 2022. In Togo, the total number of prostate cancers was 726 in 2021. Screening methods are readily available in Togo. However, prostate cancer is still detected at a late stage. This study aimed to determine the factors associated with adherence to prostate cancer screening among retired men in Togo, 2023, using the Health Belief Model. A national descriptive and analytical exploratory cross-sectional study was carried out from March 1 to May 31, 2023. A total of 288 retirees were included. Overall, 54.9% of retirees perceived their vulnerability to prostate cancer, 54.9% perceived its severity, 52.4% perceived barriers to screening, 50.3% perceived benefits from screening, 53.1% perceived their self-efficacy for screening, and 55.2% perceived cues to action. A total of 83% of retirees agreed to undergo prostate cancer screening. The absence of a history of chronic pathology (adjust odds ratio [aOR] = 3.0, 95% CI [1.4, 6.2], <i>p</i> = .010), frequency of annual medical consultation (aOR = 0.3, 95% CI [0.1, 0.8], <i>p</i> = .020), perceived obstacles (aOR = 0.4, 95% CI [0.2, 0.9], <i>p</i> = .029) and perceived cues to action (aOR = 5.1, 95% CI [1.9, 15.1], <i>p</i> = .002) are significantly associated with adherence to prostate cancer screening. This study reported a high level of adherence to prostate cancer screening among retirees. It demonstrated that the absence of a history of chronic pathology, frequency of annual medical consultation, perceived barriers, and perceived incentive to action were significantly associated with adherence to prostate cancer screening.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 3","pages":"15579883251344558"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude, and Prevalence of Sexual Violence Among Male Undergraduate Students in a Tertiary Institution in Lagos, Nigeria.","authors":"Chinazom J Ngini, Kofoworola A Odeyemi, Cassandra C Nwokoro","doi":"10.1177/15579883251350895","DOIUrl":"10.1177/15579883251350895","url":null,"abstract":"<p><p>Sexual violence robs victims of their autonomy and rights to consent. While myths and gender stereotypes allow the narrative that men cannot be victims thrive, stigma has contributed to the silence and invisibility of male victims of sexual violence. This descriptive, cross-sectional study aimed to assess the knowledge, attitude, and prevalence of male sexual violence among male undergraduates in a tertiary institution in Lagos, Nigeria. A multistage sampling method was used to recruit 400 respondents for this study. Data were collected using interviewer-administered semi-structured questionnaires. The data were analyzed using IBM Statistical Package for Social Sciences Version 26. Chi-Square test was used to test for association between categorical variables and a statistical significance level of 5% (<i>p</i> < .05) was set. The mean age of the respondents was 22.7 ± 4.10 years. Most (75%) had good knowledge about sexual violence and 98% had positive attitudes regarding male sexual violence. Thirteen percent, 16%, and 10% of the respondents reported being victims of child sexual abuse, sexual harassment, and sexual assault, respectively. Violence experienced in childhood was found to be a predisposing factor for re-victimization in adulthood (<i>p</i> value of .000). A multi-sectoral approach to curb sexual violence is recommended.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 3","pages":"15579883251350895"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Androgen Deprivation to Precision Therapy: A Bibliometric Review of Global Research Trends (2008-2023).","authors":"Longjun Huang, Wenjuan He, Yong Guo","doi":"10.1177/15579883251346819","DOIUrl":"10.1177/15579883251346819","url":null,"abstract":"<p><p>This review employs bibliometric methods to map the evolving landscape of prostate cancer endocrine therapy research over the past 15 years. Through analysis of 961 articles from the Web of Science Core Collection, we identified key trends in therapeutic innovation and clinical translation. The United States emerged as the dominant contributor (34.96% of publications), with Harvard University and the University of California System leading institutional output. Three paradigm shifts emerged: early stage research focused on optimizing androgen deprivation therapy (ADT) efficacy (2008-2013), followed by castration-resistant prostate cancer (CRPC) drug development (2014-2016), and recent emphasis on combination therapies and molecular targeting (2017-2023). The top 50 most cited papers confirmed that keyword clusters directly corresponded to pivotal trials, including TAMPEDE (NCT00268476) and PROSPER (NCT02003924). The translational science spectrum model revealed that 68% of current clinical applications originated from basic research on androgen receptor variants. Emerging frontiers include prostate-specific membrane antigen-targeted radioligand therapy and immunotherapy-ADT synergies. This synthesis provides clinicians with an evidence-based roadmap to navigate therapeutic advancements while highlighting the critical need for international collaboration in addressing persistent challenges such as treatment resistance.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 3","pages":"15579883251346819"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Putative Predictive Value of Etiological and Clinical Factors on Sperm Retrieval Outcomes in Non-Obstructive Azoospermia Using Micro-TESE: A Retrospective Study.","authors":"Samaneh Harimi, Mohsen Ahrari, Ali Sadeghi, Samane Eskandarian, Safiyehsadat Heydari, Farzaneh Fesahat","doi":"10.1177/15579883251338483","DOIUrl":"10.1177/15579883251338483","url":null,"abstract":"<p><p>Non-obstructive azoospermia (NOA) is a condition of testicular failure caused by various factors. To retrieve sperm in NOA patients, microdissection testicular sperm extraction (micro-TESE) is a highly effective technique. The present study aimed to evaluate successful sperm retrieval (SSR) in NOA patients across different etiologies in the Iranian population to identify predictive factors. This retrospective analysis included 566 NOA patients undergoing micro-TESE from 2018 to 2023, with 58 histories of Cryptorchidism, 40 Klinefelter syndrome (KS), 6 Y chromosomal microdeletions (YCMDs), 6 histories of chemotherapy, 5 mumps orchitis, and 451 patients with idiopathic reasons. The overall SSR was 43.2%, with a significantly lower SSR in the KS group (<i>p</i> = .012). Patients with higher average ages tended to have higher SSR rates, especially in the idiopathic group. Hormone levels differed among the groups, with higher follicle-stimulating hormone and luteinizing hormone levels in the YCMDs group, higher testosterone levels in the idiopathic and Cryptorchidism groups, and higher prolactin levels in the KS group. There were no significant differences in other clinical characteristics between the SSR and sperm retrieval failure groups, except for a positive relationship between prolactin levels and SSR rates in the KS group (<i>r</i> = .45, <i>p</i> = .003). Our data underscores that underlying etiology and genetic background may reveal more valuable predictive value than age, hormone levels, and testicular volume. This finding suggests that no patient with NOA should be deprived of micro-TESE based on candidate predictors of SSR presented to date.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 3","pages":"15579883251338483"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}