American Journal of Men's Health最新文献

{"title":"Effect of Timing of Branched-Chain Amino Acid Supplementation on Muscle Recovery after Resistance Training in Healthy Males.","authors":"Kebin Meng","doi":"10.1177/15579883251332731","DOIUrl":"https://doi.org/10.1177/15579883251332731","url":null,"abstract":"<p><p>This study aimed to investigate the effects of different timing of branched-chain amino acid (BCAA) supplementation (pre-/post-exercise) on the recovery of delayed-onset muscle soreness (DOMS) and associated inflammatory factors after resistance training. A double-blind randomized controlled experimental design was used in this study. Twenty-four untrained male college students volunteered to receive BCAA supplementation and completed resistance training. Participants were randomly assigned to the BCAA and placebo groups and sequentially performed two experiments of pre-exercise supplementation and post-exercise supplementation. Thus, four groups were formed: the BCAA-PRE group, the BCAA-POST group, the PLCB-PRE group, and the PLCB-POST group. Muscle soreness, countermovement jump (CMJ), and related blood parameters [interleukin-6 (IL-6), C-reactive protein (CRP), creatine kinase (CK), blood lactate (B[La])] were measured 30 min, 24 and 48 hr after resistance training. BCAA post-exercise supplementation significantly reduced muscle soreness scores compared to the placebo group at 48 hr after resistance training (<i>p</i> < .05). At 24 hr after resistance training, the BCAA group significantly reduced serum IL-6 and CRP (<i>p</i> < .05), in addition, the BCAA-POST group had lower serum IL-6 and CRP than the BCAA-PRE group (<i>p</i> < .05). No significant difference between groups was detected for CMJ or B[La] (<i>p</i> > .05). Resistance training induced the development of DOMS accompanied by elevated inflammatory factors (CRP and IL-6) and muscle proteins (CK). Compared to pre-exercise BCAA supplementation, post-exercise supplementation was observed to be more effective in alleviating the symptoms of DOMS and reducing inflammatory factors. However, it does not change the state of neuromuscular recovery.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251332731"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Current Status of Clinical Trial Registrations in Andrological Diseases: Insights from ClinicalTrials.gov and ICTRP Databases.","authors":"Li-Xing Lei, Ke-Cheng Li, Wen-Hao Yu, Jun-Long Feng, Hua-Nan Zhang, Mao-Ke Chen, Wen-Xuan Dong, Ji-Xuan Chen, Jie Li, Ji-Sheng Wang, Liang Han, Bin Wang","doi":"10.1177/15579883251325478","DOIUrl":"https://doi.org/10.1177/15579883251325478","url":null,"abstract":"<p><p>This study aims to analyze the registration information and outcome transparency for five common andrological diseases, as well as the factors influencing result availability. A comprehensive search was performed on ClinicalTrials.gov and the International Clinical Trials Registry Platform (ICTRP) to retrieve all clinical trial registration data related to the five defined andrological diseases from the inception of these databases up to September 1, 2024. The search extracted key trial details, including status, type, intervention, and result availability. Of 8,132 trials retrieved, 642 were analyzed. Among these, 259 trials (40.34%) reported results via ClinicalTrials.gov, ICTRP, or publications, while 113 trials (17.60%) made results publicly available on ClinicalTrials.gov or ICTRP. Among the five andrological diseases, male infertility had the highest rate of result availability (37/74, 50%), whereas benign prostatic hyperplasia exhibited the lowest (71/190, 37.37%). No significant differences were found across diseases (χ² = 3.722, <i>df</i> = 4, <i>p</i> = .435). Factors such as study status, blinding, interventions, center type, location, and duration significantly influenced result availability, whereas study type, stage, funding, outcome indicators, and sample size did not. Clinical trials on andrological conditions show major gaps in registration and result disclosure, with low reporting rates and prevalent non-reporting and selective reporting. Developed countries dominate trial registration and result disclosure while developing countries have limited participation. Trial characteristics also influence result disclosure rates. These challenges compromise the integrity and credibility of research data, impede clinical practice, and hinder the progress of medical research. Measures are needed to improve transparency, reduce selective reporting, and enhance the rigor and credibility of andrology research.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251325478"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Tai Chi Softball on Health-Related Outcomes in Elderly Men.","authors":"XiaoDong Cheng, Naichun Ji","doi":"10.1177/15579883251332745","DOIUrl":"https://doi.org/10.1177/15579883251332745","url":null,"abstract":"<p><p>This study aimed to investigate the effects of Tai Chi Softball (TCSB) training on the physical health of older men, with a focus on improvements in muscle strength, flexibility, balance, and blood lipid profiles. A 12-week randomized controlled trial was conducted, recruiting 140 men aged 55-65 years. Participants were randomly assigned to either a Tai Chi Softball group (TCSBG, <i>N</i> = 70) or a control group (CG, <i>N</i> = 70). The TCSBG engaged in TCSB training sessions 4 to 5 times per week, with each session lasting 70 to 90 min, while the CG maintained their usual daily routines without any additional interventions. Measurements were taken before and after the intervention and included waist-to-hip ratio (WHR), handgrip strength (HS), sit-and-reach (SAR), single-leg stance (SLS), vital capacity (VC), heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol. The results revealed that after 12 weeks of TCSB training, participants in the TCSBG showed significant improvements (<i>p</i> < .05) in HS, SAR, and SLS, indicating enhanced muscle strength, flexibility, and balance, respectively. The VC also increased significantly, while both SBP and DBP decreased notably (<i>p</i> < .05). Moreover, significant reductions were observed in TC, TG, and LDL-C levels <i>p</i> < .05). In conclusion, TCSB training demonstrated efficacy in improving muscle strength, flexibility, balance, cardiorespiratory fitness, and blood lipid profiles in older men. These findings suggest that TCSB training can mitigate age-related declines in physical function and reduce cardiovascular risk in older men.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251332745"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Qualitative Exploration of Factors Influencing Prostate Cancer Adjustment Among Older Adults: A Social Ecological Model.","authors":"Mehdi Nakhodaeezadeh, Reza Fadayevatan, Mahshid Foroughan, Fatemeh Raeesi Dehkordi, Nasibeh Zanjari","doi":"10.1177/15579883251315177","DOIUrl":"10.1177/15579883251315177","url":null,"abstract":"<p><p>This study investigates the multifaceted factors influencing adjustment to prostate cancer among older men in Esfahan, Iran, using the social ecological model (SEM) as a guiding framework. We employed a qualitative approach, conducting semistructured interviews with 19 men diagnosed with prostate cancer, aged 63 to 92 years (mean age = 71), and six key informants, including spouses and health care professionals. We thematically analyzed the data to identify challenges and facilitators in the intrapersonal, interpersonal, and environmental domains of the SEM. The findings revealed a dynamic interplay of factors shaping the adjustment process. Intrapersonal challenges included physical degeneration, psychological distress, stigma, and role reversal, countered by coping strategies such as adopting healthy habits and spirituality. Interpersonal dynamics encompassed family strain and denial, yet the presence of familial support and self-care significantly enhanced adjustment. On an environmental level, financial burdens and health care barriers posed significant challenges. The study furthermore highlighted critical issues like \"dysmedication\" and \"body occupation\" which impede effective coping. A complex network of personal, relational, and systemic factors influences the adjustment to prostate cancer among older Iranian men. We urgently need tailored, culturally sensitive interventions to address health care inequities, alleviate economic pressures, and enhance psychosocial support networks, thereby empowering older adults to navigate this challenging journey with greater resilience and dignity.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251315177"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Just Treat Me Delicately\": A Qualitative Exploration of What Works to Engage Australian Men in Health Care Encounters.","authors":"Zac E Seidler, Michelle Sheldrake, Simon Rice, Michael J Wilson, Ruben Benakovic, Krista Fisher, Margaret A McGee","doi":"10.1177/15579883241311557","DOIUrl":"10.1177/15579883241311557","url":null,"abstract":"<p><p>There is growing consensus for upskilling the health care workforce on gender-responsive strategies to more effectively connect and respond to men during health care encounters. To inform health practitioner education, the primary aim of this study was to gain insights from a diverse sample of men in Australia on their experiences and expectations when engaging with health care practitioners. Thirty-two men (18-70 years, median 33) participated in eight online focus group discussions. A combined deductive and inductive thematic analysis was undertaken to reconcile their expectations with prior published approaches for practitioners to engage men in care and identify new themes. Participants desired a genuine relationship, signaled by upfront and informal communication, active listening, and enquiry. In structuring treatment, participants sought transparency and respect for autonomy. Regarding the therapeutic alliance, avoiding gender stereotyping and empathetic, sensitive, and holistic care were valued by men. These expectations for how practitioners engage with men in care were reflected in their advice for health practitioner student training and aligned with approaches published previously. Participant insights were synthesized into four outcomes, for men, of successful engagement: legitimize the relationship to build trust, create a safe space to facilitate disclosure, empower men, and assess and treat the whole man through a biopsychosocial lens. In conclusion, men seek authentic connection and a caring style that allows them to legitimize and forge an ongoing relationship with their practitioner. These outcomes of successful engagement are key to developing consumer-informed health practitioner education and competencies on gender-responsive health care for men.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883241311557"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Systemic Drug Targets for Anti-cavernous Fibrosis in the Treatment of Erectile Dysfunction, Guided by Genome-Wide Mendelian Randomization.","authors":"Zilong Chen, Quan Wang, Lianqin Zhang, Junfeng Qiu, Yangling Zeng, Hao Kuang, Chunxiu Chen, Zhiming Hong","doi":"10.1177/15579883251323187","DOIUrl":"10.1177/15579883251323187","url":null,"abstract":"<p><p>The treatment of erectile dysfunction (ED) remains a significant challenge. Mendelian randomization (MR) is being increasingly utilized to identify novel therapeutic targets. In this study, we carried out a genome-wide MR analysis on druggable targets with the aim of pinpointing latent therapeutic alternatives for ED. We collected data on the druggable genes and filtered out those associated with blood eQTLs, then performed two-sample MR and colocalization analyses using ED genome-wide association data to screen genes significantly linked to the condition. In addition, we carried out phenome-wide studies, enrichment analysis, protein network modeling, drug prediction, and molecular docking. We screened 3,953 druggable genes from the DGIdb and 4,463 from a review. Following data integration, 74 potential druggable genes were found to potentially regulate corpus cavernosum fibrosis. MR analysis of eQTL data uncovered five drug targets (TGFBR2, ABCC6, ABCB4, EGF, and SMAD3) significantly associated with ED risk. Colocalization analysis suggested a shared causal variant between ED susceptibility and TGFBR2, with a posterior probability (PPH4) exceeding 80%. Drug predictions utilizing DSigDB identified nolone phenylpropionate, sorafenib, and NVP-TAE684 as significantly associated with TGFBR2. Finally, molecular docking indicated strong binding affinities between these candidate drugs and the protein encoded by TGFBR2 (Vina score < -50). Through MR and colocalization analyses, the present study identified five potential drug targets for ED, with TGFBR2 showing remarkable relevance in blood. These findings offer valuable insights and potential leads for the development of more effective ED therapies, which may also contribute to cutting down the expenses involved in drug development.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251323187"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticipated Stigma from Family and Loneliness Among Chinese Gay Men: The Mediating Role of Guilt and the Moderating Role of Self-Compassion.","authors":"Yang Yang, Wu Yifei, Cao Jun, Hou Liang, Gao Chen","doi":"10.1177/15579883251327905","DOIUrl":"10.1177/15579883251327905","url":null,"abstract":"<p><p>In China, men are responsible for continuing the family line and the primary source of pressure for adult Chinese gay men comes from the expectations and demands of patrilineal nuclear families in general, parents in particular, and pressure to comply with social sexual orientation and identity norms and to perpetuate the family. Previous studies on the loneliness of LGBT individuals have paid less attention to the loneliness of gay men from a Chinese cultural perspective. This study investigated the relationship between anticipated stigma from family and loneliness among gay men. A sample of 408 gay men in China was recruited to investigate the associations between anticipated stigma from family, loneliness, guilt, and self-compassion using the 6-item University of California Los Angeles Loneliness Scale, the Anticipated Stigma Questionnaire, the Chinese version of the Guilt Inventory, and the Chinese version of the Self-Compassion Scale. The results showed that gay men's anticipated stigma from family was positively associated with loneliness, guilt mediated the relationship between anticipated stigma from family and loneliness, and the isolation dimension of self-compassion moderated the relationship between anticipated stigma from family and guilt. The presence of high self-compassion mitigated the positive association between anticipated stigma from family and guilt.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251327905"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy and Safety of Botulinum Toxin A Injection into the Bulbospongiosus Muscle for Treating Lifelong Premature Ejaculation: A Systematic Review and Meta-Analysis.","authors":"Dawei Gao, Chuyu Li, Yihan Jin, Dalin Sun, Zifeng Chen, Bo Tang, Weiping Chen, Baofang Jin","doi":"10.1177/15579883251328312","DOIUrl":"10.1177/15579883251328312","url":null,"abstract":"<p><p>Botulinum toxin A (BoNT/A) injections into the bulbospongiosus muscle have emerged as a novel treatment for lifelong premature ejaculation (PE), though efficacy remains controversial. This study evaluates BoNT/A's efficacy and safety through a comprehensive search of PubMed, Embase, Cochrane Library, Web of Science, ClinicalTrials.gov, and ISRCTN registry. We included randomized controlled trials, prospective, and retrospective studies, focusing on intravaginal ejaculation latency time (IELT) and adverse events. Four studies (three meta-analyzed) involving 263 patients were analyzed. BoNT/A increased IELT by 37.87 s at 1 month (MD, 37.87; 95% CI, -2.86 to 78.59; <i>p</i> = .07; <i>I</i>² = 96%), 11.52 s at 3 months (MD, 11.52; 95% CI, -16.91 to 39.94; <i>p</i> = .43; <i>I</i>² = 95%), and 2.41 s at 6 months (MD, 2.41; 95% CI, -9.19 to 14.00; <i>p</i> = 0.68; <i>I</i>² = 77%). Short-term IELT improvement was observed but lacked statistical significance (<i>p</i> > .05), with high heterogeneity (<i>I</i>² = 96%). Long-term effects diminished, suggesting declining efficacy. Adverse events occurred in 10.9% of patients, primarily erectile dysfunction (<i>n</i> = 5), and urinary disorders (<i>n</i> = 5). While current evidence does not definitively support BoNT/A's efficacy, limited studies and methodological heterogeneity suggest that further research is warranted. Future studies should employ larger, multicenter designs, optimize injection methods, doses, and protocols, and identify suitable patient populations to validate BoNT/A's clinical benefits.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251328312"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Centrosome Replication-Related Genes in Prostate Cancer Based on Transcriptomic and Mendelian Randomization.","authors":"Qizhong Lu, Yufan Wu, Qiwei Yu, Jun Ouyang","doi":"10.1177/15579883251319125","DOIUrl":"10.1177/15579883251319125","url":null,"abstract":"<p><p>Prostate cancer (PCa) is a significant global health concern, with its incidence and mortality rates projected to rise due to population aging. In this study, we utilized PCa transcriptome data from public databases and applied bioinformatics methods to identify three prognostic genes (<i>CDC20</i>, <i>RAD51</i>, and <i>TTK</i>) related to centrosome duplication in PCa. <i>CDC20</i> is involved in cell cycle regulation, <i>RAD51</i> in deoxyribonucleic acid double-strand break repair, and <i>TTK</i> in spindle assembly checkpoint function and cell proliferation. We constructed a risk model and a nomogram model, both demonstrating moderate to good predictive performance with area under the curve values ranging from 0.611 to 0.765 at different time points. Gene set enrichment analysis revealed that these genes were enriched in 64 pathways, including the cell cycle pathway, which is dysregulated in cancer. Furthermore, we analyzed the immune microenvironment and identified 13 differential immune cells and 13 differential immune checkpoints between high- and low-risk groups, providing insights into potential immunotherapy targets for PCa. In conclusion, this study contributes to a deeper understanding of PCa pathogenesis and lays important theoretical and experimental foundations for developing new diagnostic markers and treatment strategies. Future research requires more clinical samples and continued monitoring of the mechanism of these genes in PCa.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251319125"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heavy DIY Activities as a Potential Preventative for Stress Urinary Incontinence.","authors":"Kai Liu, Xiaogang Lian, Ting Wang, Zhu Tao","doi":"10.1177/15579883251336056","DOIUrl":"https://doi.org/10.1177/15579883251336056","url":null,"abstract":"<p><p>Physical activity is associated with stress urinary incontinence (SUI). The genetic causality of this association remains unclear. This study used the Mendelian randomization (MR) method to explore the potential causal relationship between physical activity and SUI risk using heavy do-it-yourself (DIY), light DIY, strenuous sports, walking for pleasure, and other exercises as proxies. We selected single nucleotide polymorphisms associated with physical activity from published genome-wide association studies (GWAS). Statistics of SUI come from the GWAS database. MR estimation was performed using the inverse variance weighting method, the MR-Egger method, and the weighted median method. Sensitivity analyses were performed using Cochran's <i>Q</i> test, MR-Egger intercept, MR-pleiotropy residuals, outlier methods, leave-one-out analysis, and funnel plots. The results showed that there was a causal relationship between heavy DIY and SUI (<i>OR</i> = 0.9712, 95% confidence interval [0.951, 0.9918], <i>p</i> = .006), while no significant causal relationship was found between other physical activities and SUI. These findings were robust across multiple sensitivity analyses. This MR study demonstrates the causal relationship between heavy DIY and SUI, helping doctors and researchers better recommend preventive and treatment measures to patients, while also providing specific directions for improving their lifestyle in men and women suffering from SUI.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251336056"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}