American Journal of Men's Health最新文献_第2页

Persistent Urethral Burning Without Identifiable Infection: A Case Report Highlighting Diagnostic Challenges and Integrative Symptom-Oriented Management. 无可识别感染的持续性尿道灼烧：一个强调诊断挑战和综合症状导向治疗的病例报告。

IF 2.4 4区医学

American Journal of Men's Health Pub Date : 2026-07-01 Epub Date: 2026-07-29 DOI: 10.1177/15579883261466474

Xudong Hu, Dawei Gao, Shanshan Tong, Xiaojing Zheng, Dalin Sun

{"title":"Persistent Urethral Burning Without Identifiable Infection: A Case Report Highlighting Diagnostic Challenges and Integrative Symptom-Oriented Management.","authors":"Xudong Hu, Dawei Gao, Shanshan Tong, Xiaojing Zheng, Dalin Sun","doi":"10.1177/15579883261466474","DOIUrl":"10.1177/15579883261466474","url":null,"abstract":"Persistent urethral burning without identifiable infection represents a diagnostically challenging condition in male urology and may lead to repeated empirical treatment with limited benefit. We report the case of a 35-year-old man who experienced isolated urethral burning for approximately six years after an initial urinary tract infection. Despite repeated evaluations and multiple conventional treatments, his symptoms persisted. Laboratory investigations, including urinalysis, urine culture, gonococcal smear examination, and prostatic fluid analysis, showed no evidence of active infection or clinically significant prostatic inflammation. Transabdominal pelvic ultrasonography revealed only mild nonspecific prostatic changes without major structural abnormalities. Given the chronic refractory symptoms and negative diagnostic findings, an integrative symptom-oriented management strategy incorporating a modified Gancao Xiexin decoction was initiated. The patient reported gradual improvement, with the visual analogue scale score decreasing from 8 at baseline to 4 after one week and to 0 after two months. Anxiety, sleep quality, bowel habits, and overall well-being also improved, and no adverse effects or symptom recurrence were reported during follow-up. This case highlights the diagnostic uncertainty associated with persistent urethral burning without identifiable infection and suggests that noninfectious pain-related mechanisms may deserve consideration in selected patients. The observed improvement should be interpreted as a temporal association rather than evidence of therapeutic efficacy, and further studies are needed to clarify the underlying mechanisms and evaluate integrative management approaches for chronic unexplained urethral pain conditions.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 4","pages":"15579883261466474"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148617957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concurrent Jackstone Calculus and Prostate Cancer: Should They Be Treated Concurrently or Sequentially? Jackstone结石和前列腺癌：是同时治疗还是依次治疗？

IF 2.4 4区医学

American Journal of Men's Health Pub Date : 2026-07-01 Epub Date: 2026-07-30 DOI: 10.1177/15579883261459755

Shuo Tian, Huijuan Li, Yuliang Jiang, Cheng Wang, Shuze Liu, Fei Wu, Hao Ning

{"title":"Concurrent Jackstone Calculus and Prostate Cancer: Should They Be Treated Concurrently or Sequentially?","authors":"Shuo Tian, Huijuan Li, Yuliang Jiang, Cheng Wang, Shuze Liu, Fei Wu, Hao Ning","doi":"10.1177/15579883261459755","DOIUrl":"10.1177/15579883261459755","url":null,"abstract":"Jackstone calculus is a rare urinary stone morphology with a distinctive spiculated appearance, most often reported in the bladder and usually associated with urinary stasis or outlet obstruction. We report a 70-year-old man with 1 year of progressive dysuria and intermittent interruption of urinary stream despite tamsulosin and finasteride. Urinalysis showed pyuria, hematuria, and bacteriuria. Ultrasonography and pelvic computed tomography identified an irregular star-shaped bladder stone and marked prostatic enlargement, with an estimated prostate volume of approximately 125 mL on ultrasonography. Serum total prostate-specific antigen was 16.2 ng/mL, with a free-to-total ratio of 0.138. Systematic transrectal biopsy showed adenocarcinoma in 2 of 12 cores, Gleason score 3 + 3 = 6 (Grade Group 1). After multidisciplinary discussion, the patient underwent laparoscopic radical prostatectomy with concomitant intact stone removal. The 3.1-cm stone showed classic jackstone morphology. Final pathology showed Gleason 3 + 4 = 7 adenocarcinoma (Grade Group 2), upgraded from biopsy, with negative surgical margins. Telephone follow-up at 1, 3, and 12 months showed sustained improvement of lower urinary tract symptoms without recurrent urinary tract infection-related symptoms. Postoperative imaging and prostate-specific antigen data were unavailable. This case is relevant to men's health because a visually distinctive bladder stone may coexist with clinically relevant prostatic disease. In men with lower urinary tract symptoms and abnormal prostate-specific antigen values, bladder outlet obstruction, infection, or bladder stones should not preclude further oncologic evaluation. In selected patients in whom definitive prostate surgery is chosen, combined stone removal can be a practical single-stage approach.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 4","pages":"15579883261459755"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13491357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Easy to Lose and Risky to Regain? A Scoping Review of Experimentally Manipulated Masculinity Threat and Men's Health. 易失难重？实验操纵的男子气概威胁与男性健康的范围综述。

IF 2.4 4区医学

American Journal of Men's Health Pub Date : 2026-07-01 Epub Date: 2026-08-03 DOI: 10.1177/15579883261473332

Rae-Marie Breakspear, Zerevan Bindal, Frances S Chen, Toni Schmader

{"title":"Easy to Lose and Risky to Regain? A Scoping Review of Experimentally Manipulated Masculinity Threat and Men's Health.","authors":"Rae-Marie Breakspear, Zerevan Bindal, Frances S Chen, Toni Schmader","doi":"10.1177/15579883261473332","DOIUrl":"10.1177/15579883261473332","url":null,"abstract":"BackgroundMen live shorter lives and suffer more often from preventable diseases than women. This health pattern is associated with masculine norms that incentivize health-risk behavior. Masculinity threats represent a potential mechanism by which masculinity norms causally impact men's health behavior. In this scoping review, we map experimental evidence for health effects and moderators of masculinity threat.MethodsFollowing PRISMA-ScR guidance, we conducted a scoping review of experimentally manipulated masculinity threat and men's health across PsycNet, CINAHL, SCOPUS, MEDLINE, Embase, and Web of Science. Searches were supplemented using Consensus AI, Google Scholar and web searches. We included experimental studies with male participants manipulating masculinity threat and measuring health-related outcomes.ResultsA total of k = 38 experiments across 25 papers were included, covering food and beverage intake (k = 16), emotional well-being and physiological stress (k = 9), body image and fitness (k = 6), risk-taking behaviors (k = 5), and interpersonal relationships (k = 2). Masculinity threat was consistently associated with a preference for stereotypically masculine foods, particularly meat. Effects in other domains were mixed or limited. We found that endorsement of masculinity-related traits, and beliefs about the precarious nature of manhood, most consistently shaped when, and for whom, masculinity threats motivated compensatory reactions or disengagement.ConclusionFindings may inform public health messaging by showing that challenges to men's masculine status can lead to health risk behavior. This review aims to guide future research to clarify existing patterns and explore new health domains and moderators related to masculinity threat.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 4","pages":"15579883261473332"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13434934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occupational Heat Exposure and Fertility Stress as Independent Factors of Low Semen Quality: A Multidimensional Analysis. 职业热暴露和生育应激是低精液质量的独立因素：一个多维分析。

IF 2.4 4区医学

American Journal of Men's Health Pub Date : 2026-07-01 Epub Date: 2026-07-08 DOI: 10.1177/15579883261454721

Ningning Han, Zhijuan Liu, Lijuan He, Rui Han

{"title":"Occupational Heat Exposure and Fertility Stress as Independent Factors of Low Semen Quality: A Multidimensional Analysis.","authors":"Ningning Han, Zhijuan Liu, Lijuan He, Rui Han","doi":"10.1177/15579883261454721","DOIUrl":"10.1177/15579883261454721","url":null,"abstract":"Semen quality is a key factor in male reproductive health. The multifactorial etiology of male infertility involves complex interactions between environmental exposures and psychological states. The \"mind-body\" interaction, specifically the synergistic impact of lifestyle, social support, and fertility stress on semen quality, remains underexplored. This cross-sectional study recruited 485 men from our hospital between May 2021 and April 2023. Participants were categorized into normal (n = 256) and low semen quality (n = 229) groups based on WHO Laboratory Manual for the Examination and Processing of Human Semen (6th Edition). Participants completed the Social Support Rating Scale (SSRS), Fertility-related Quality of Life (FertiQoL), and Fertility Problem Inventory (FPI). Backward stepwise logistic regression was employed to identify independent predictors. Occupational heat exposure was the strongest risk factor (adjusted odds ratio [OR] = 4.188, 95% confidence interval [CI]: [1.527, 11.484], p = .005). Higher fertility-related stress showed a trend toward an independent association with low semen quality (adjusted OR = 1.005 per point, 95% CI: [1.000, 1.011], p = .068). Higher education level was a protective factor of semen quality (adjusted OR = .624, 95% CI: [0.415, 0.937], p = .023). Clinical management of male infertility should integrate psychological screening with occupational health guidance to optimize reproductive outcomes.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 4","pages":"15579883261454721"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13346715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148403279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Longitudinal Investigation of the Emotional Experience of Men Using Medically Assisted Reproduction. 使用医学辅助生殖的男性情感体验的纵向调查。

IF 2.4 4区医学

American Journal of Men's Health Pub Date : 2026-07-01 Epub Date: 2026-07-30 DOI: 10.1177/15579883261455616

Ariel Trépanier Freire, Audrey Brassard, Natalie O Rosen, Laurie R Beauvilliers, Sophie Bergeron, Katherine Péloquin

{"title":"A Longitudinal Investigation of the Emotional Experience of Men Using Medically Assisted Reproduction.","authors":"Ariel Trépanier Freire, Audrey Brassard, Natalie O Rosen, Laurie R Beauvilliers, Sophie Bergeron, Katherine Péloquin","doi":"10.1177/15579883261455616","DOIUrl":"10.1177/15579883261455616","url":null,"abstract":"The diagnosis of infertility and medically assisted reproduction (MAR) can have significant emotional consequences for couples. Little is known about male partners' emotional experience during MAR with their partner. This longitudinal study examined the emotional experience of 154 North American men (mean age = 34.12, SD = 5.22) toward their partner over 12 to 18 months of MAR treatment. Results indicate that men initially reported high levels of positive emotions, including gratitude, compassion, and admiration. Over time, however, these positive experiences declined, while negative emotions, such as concern, helplessness, resentment, and a feeling of alienation, increased significantly after one year of treatment. These findings contribute to a limited body of research on men's experiences in infertility care and highlight the evolving emotional challenges they face. Greater recognition of these experiences may help inform clinical practices and better support male partners throughout the MAR process.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 4","pages":"15579883261455616"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13491367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health Conditions and Health Care Access Among Filipino Men in the Cruise Line Industry: A Scoping Review. 菲律宾男性在邮轮行业的健康状况和医疗保健：范围审查。

IF 2.4 4区医学

American Journal of Men's Health Pub Date : 2026-07-01 Epub Date: 2026-08-10 DOI: 10.1177/15579883261443704

Mary Dioise Ramos, Andre A Rosario, Lorraine S Evangelista

{"title":"Health Conditions and Health Care Access Among Filipino Men in the Cruise Line Industry: A Scoping Review.","authors":"Mary Dioise Ramos, Andre A Rosario, Lorraine S Evangelista","doi":"10.1177/15579883261443704","DOIUrl":"10.1177/15579883261443704","url":null,"abstract":"Filipino men form a substantial proportion of the global seafaring workforce, particularly in the cruise line industry. The psychosocial, occupational, and environmental conditions influence their health, presenting challenges that are overlooked and unacknowledged and necessitating a systematic mapping of their health conditions and health care access. This scoping review aims to map the literature on the health conditions of Filipino men working in cruise lines to (1) describe prevalent health conditions; (2) identify mental health issues; (3) summarize the psychosocial, occupational, and environmental factors influencing health; (4) explore facilitators and barriers to health care access; and (5) characterize initiatives, interventions, and support systems. The Joanna Briggs Institute (JBI) Scoping Reviews methodology was utilized and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). PubMed, CINAHL, Embase, Scopus, Web of Science, and relevant maritime health databases were searched from January 2010 to August 2025. In total, 20 publications were included. Filipino men working in cruise lines face a wide range of risk factors for physical and mental health conditions. Occupational hazards, such as noise, vibration, and poor workspace layout, coupled with limited access to fresh food and exercise, aggravate these conditions. While health promotion programs appeared in the literature, onboard health services are often limited, leading to reliance on repatriation and underreporting due to fear of job loss or stigma. A critical need remains for enhanced onboard medical services, culturally sensitive mental health support, robust legal protection, and comprehensive health promotion programs that address the various domains of their profession.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 4","pages":"15579883261443704"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body Roundness Index and Prevalent Erectile Dysfunction in Adult Men: A Survey-Weighted Cross-Sectional Analysis of NHANES 2001-2004. 成年男性体圆度指数和普遍勃起功能障碍：2001-2004年NHANES调查加权横断面分析。

IF 2.4 4区医学

American Journal of Men's Health Pub Date : 2026-07-01 Epub Date: 2026-08-13 DOI: 10.1177/15579883261479006

Cheng Chen, Saiyang Li, Xiaoshuang Liu, Xingliang Feng

{"title":"Body Roundness Index and Prevalent Erectile Dysfunction in Adult Men: A Survey-Weighted Cross-Sectional Analysis of NHANES 2001-2004.","authors":"Cheng Chen, Saiyang Li, Xiaoshuang Liu, Xingliang Feng","doi":"10.1177/15579883261479006","DOIUrl":"10.1177/15579883261479006","url":null,"abstract":"Body roundness index (BRI), calculated from height and waist circumference, summarizes abdominal body shape and may capture central adiposity not fully described by body mass index. We examined the association between BRI and prevalent erectile dysfunction (ED) among men aged 20 years or older in the 2001-2004 National Health and Nutrition Examination Survey. ED was defined using a standardized erectile-function question. Primary analyses incorporated NHANES 4-year mobile examination center weights, strata, and primary sampling units, and analyses involving homeostasis model assessment of insulin resistance (HOMA-IR) used 4-year fasting subsample weights. The primary cohort included 3,850 men, of whom 1,024 met the study definition of ED, corresponding to a weighted ED prevalence of 17.8%. After adjustment for demographic, socioeconomic, and behavioral factors, each 1-unit higher BRI was associated with higher odds of ED (odds ratio [OR] = 1.17, 95% confidence interval [CI] = 1.11-1.24). Men in the highest BRI quartile had higher odds of ED than those in the lowest quartile (OR = 1.74, 95% CI = 1.27-2.38). Spline analysis did not support significant nonlinearity (P = .36). In the fasting subsample, each 1-unit higher BRI was associated with a 32% higher geometric mean HOMA-IR. An exploratory statistical decomposition was used to describe the HOMA-IR-related component of the BRI-ED association. Higher BRI was associated with prevalent ED, supporting the clinical relevance of abdominal body shape in men's cardiometabolic and sexual-health assessment.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 4","pages":"15579883261479006"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13473785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health and Sexual Health Care-Seeking Behaviours of Culturally and Linguistically Diverse Men in Australia: Findings From the Ten to Men Longitudinal Study. 澳大利亚文化和语言多样化男性的健康和性保健寻求行为：从10到男性纵向研究的结果

IF 2.4 4区医学

American Journal of Men's Health Pub Date : 2026-05-01 Epub Date: 2026-05-12 DOI: 10.1177/15579883261438785

Patience Castleton, Zelalem Mengesha, Mumtaz Begum, Zohra S Lassi

{"title":"Health and Sexual Health Care-Seeking Behaviours of Culturally and Linguistically Diverse Men in Australia: Findings From the Ten to Men Longitudinal Study.","authors":"Patience Castleton, Zelalem Mengesha, Mumtaz Begum, Zohra S Lassi","doi":"10.1177/15579883261438785","DOIUrl":"10.1177/15579883261438785","url":null,"abstract":"Men represent more than half of the world's migrant population, yet their health care challenges remain under researched. Evidence highlights that culturally and linguistically diverse (CALD) men face substantial barriers to health care access post-migration, particularly in sexual and reproductive health (SRH). This study aimed to analyse health care access, including SRH, among Australian-born and CALD men, using data from the Ten to Men Longitudinal study, collected across four waves (2013-2022), including 12,661 non-CALD and 1,106 CALD men. Cross-sectional analyses of data from the first and last waves compared access to SRH and health care between these men, with longitudinal analyses conducted for outcomes measured across multiple waves. Overall, CALD men were less likely to have accessed health care in the last 12 months compared with non-CALD men, including specialist, allied and mental health care. CALD men were more likely to encounter socio-economic (odds ratio [OR]: 1.17; 95% confidence interval [CI]: 0.69, 1.97) and COVID-19 barriers (2.01; 95% CI: 1.22, 3.34) when accessing health care. Similar patterns were observed in SRH access, where CALD men were less likely to seek medical help (OR: 0.59; 95% CI: 0.28, 1.21) than non-CALD men, consistent with longitudinal findings. CALD men were less likely to seek health care or seek medical professionals for SRH and were more likely to face socio-economic barriers than non-CALD men. The findings underscore the urgent need for increased accessibility to culturally sensitive health care immediately post-migration. Tailoring information and services to diverse languages and cultural needs, alongside policy reforms addressing socio-cultural barriers, is essential to ensure equitable and inclusive health care systems.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 3","pages":"15579883261438785"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13172675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147924586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Evaluation of a Bispecific Single-Chain Antibody Targeting PSMA and CD3 to Enhance T-Cell-Mediated Lysis. 一种靶向PSMA和CD3的双特异性单链抗体的开发和评估，以增强t细胞介导的裂解。

IF 2.4 4区医学

American Journal of Men's Health Pub Date : 2026-05-01 Epub Date: 2026-05-06 DOI: 10.1177/15579883261439951

Mustafa Abdulkareem Aljaberi, Elyes Chabchoub

{"title":"Development and Evaluation of a Bispecific Single-Chain Antibody Targeting PSMA and CD3 to Enhance T-Cell-Mediated Lysis.","authors":"Mustafa Abdulkareem Aljaberi, Elyes Chabchoub","doi":"10.1177/15579883261439951","DOIUrl":"10.1177/15579883261439951","url":null,"abstract":"Prostate cancer is among the most prevalent malignancies in men worldwide and is associated with poor outcomes in advanced stages. Conventional therapies, including androgen deprivation and chemotherapy, provide limited benefit and are often accompanied by significant toxicity. This study aimed to evaluate the efficacy and immunological impact of a novel bispecific single-chain antibody targeting prostate-specific membrane antigen (PSMA) and CD3 in preclinical models. A bispecific single-chain variable fragment (scFv) antibody was engineered to simultaneously bind PSMA on tumor cells and CD3 on T cells. The construct was expressed in mammalian cell lines, and its purity, specificity, and binding affinity were characterized. In vivo efficacy was assessed in murine xenograft models of prostate cancer, with treatment groups receiving human T cells with or without the bispecific antibody. Tumor growth, survival, and immunological responses were evaluated using flow cytometry, immunohistochemistry, and histopathological analysis. The bispecific antibody demonstrated high purity (mean 97.7%), strong binding affinity to PSMA (Kd 0.23 nM) and CD3 (Kd 0.30 nM), and specificity >99%. In vivo, treatment significantly reduced tumor growth (75.45 ± 3.52 mm³ vs. 543.39 ± 44.35 mm³ in controls at Day 28; Student's t-test, t(28) = 40.52, p < .001) and prolonged survival (59.00 ± 0.84 vs. 31.00 ± 0.84 days; Log-rank test, p < .001). Enhanced T-cell activation, infiltration, and IFN-γ release were observed, accompanied by increased tumor necrosis and apoptosis. The PSMA-CD3 bispecific antibody effectively redirected T-cell cytotoxicity against prostate cancer cells, resulting in robust antitumor activity and survival benefit. These findings support further translational development of bispecific immunotherapies for advanced prostate cancer.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 3","pages":"15579883261439951"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Staged Rehabilitation Training on Urinary Incontinence Recovery After Radical Prostatectomy: A Retrospective Analysis. 分阶段康复训练对根治性前列腺切除术后尿失禁恢复的影响：回顾性分析。

IF 2.4 4区医学

American Journal of Men's Health Pub Date : 2026-05-01 Epub Date: 2026-05-15 DOI: 10.1177/15579883261447659

Yenuan Hu, Li Yao, Chuan Liu, Jing Tian, Aihong Liu

{"title":"Impact of Staged Rehabilitation Training on Urinary Incontinence Recovery After Radical Prostatectomy: A Retrospective Analysis.","authors":"Yenuan Hu, Li Yao, Chuan Liu, Jing Tian, Aihong Liu","doi":"10.1177/15579883261447659","DOIUrl":"10.1177/15579883261447659","url":null,"abstract":"To evaluate the clinical impact of staged rehabilitation training on the recovery of urinary incontinence (UI) after radical prostatectomy (RP) for prostate cancer and to identify factors associated with recovery outcomes and training adherence. In this retrospective cohort study, 169 patients who underwent robot-assisted RP at our hospital between June 2023 and December 2024 were included. Based on postoperative management with/without staged rehabilitation training, patients were assigned to a rehabilitation group or a conventional group. The rehabilitation group received a structured and staged pelvic floor muscle-training and behavioral-guidance protocol, whereas the conventional group received only basic health education. UI recovery rates and scores on the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) were compared at 1, 3, and 6 months postoperatively. Independent predictors of UI recovery were analyzed using a Cox proportional-hazards model. Within the rehabilitation group, factors associated with adherence were examined using logistic regression. The rehabilitation group showed significantly higher UI recovery rates at all postoperative time points and lower ICIQ-SF scores. Staged rehabilitation training was an independent protective factor for UI recovery (hazard ratio [HR] = 2.048), whereas older age (HR = 0.765) and higher Gleason score (HR = 0.551) were independent risk factors. Within the rehabilitation group, higher adherence was associated with better recovery and lower ICIQ-SF scores (all p < .05). Logistic regression further indicated that age was an independent predictor of adherence (odds ratio [OR] = 0.713). Staged rehabilitation training distinctly accelerates UI recovery after RP and serves as an independent facilitator of continence restoration.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 3","pages":"15579883261447659"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13180129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0