American Journal of Men's Health最新文献_第3页

Beyond the Comfort Zone: Strenuous Sports as a Preventive Tactic Against Benign Prostatic Hyperplasia.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241311209

Wei Zhang, Gang Li, Chengya Hao, Aijun Cheng

{"title":"Beyond the Comfort Zone: Strenuous Sports as a Preventive Tactic Against Benign Prostatic Hyperplasia.","authors":"Wei Zhang, Gang Li, Chengya Hao, Aijun Cheng","doi":"10.1177/15579883241311209","DOIUrl":"10.1177/15579883241311209","url":null,"abstract":"Strenuous sports are associated with an enlarged prostate. However, the genetic causality of this association remains unclear. In this study, Mendelian randomization (MR) was used to explore the potential causal relationship between strenuous sports and prostatic hypertrophy. The study utilizes single nucleotide polymorphisms (SNPs) associated with strenuous sports obtained from published genome-wide association studies (GWAS), alongside summarized genetic data related to benign prostatic hyperplasia (BPH) from published GWAS. The primary analytical method used is the Inverse Variance-Weighted (IVW) approach for two-sample MR analysis. Heterogeneity of the results is assessed using Cochran's Q-statistic, while horizontal pleiotropy is evaluated using MR-Egger. Sensitivity analyses include \"leave-one-out\" tests. The findings indicate a protective causal effect of strenuous sports on BPH (OR = 0.927, 95% CI: [0.870, 0.988]; p = .020). Results from the Weighted Median (WM) method (OR = 0.904, 95% CI: [0.837, 0.978]; p = .011) support this discovery. Using Mendelian randomization, the study provides reliable causal evidence linking high-intensity exercise to a reduced risk of BPH, overcoming biases seen in traditional observational studies. The study demonstrates a causal protective effect of strenuous sports on BPH, suggesting exercise as a preventive strategy for prostate health.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241311209"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Matrix Metalloproteinases and Risk of Urologic Cancers: A Bidirectional Mendelian Randomization Study.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241311229

BoWen Yang, XiaoYu Zeng, HanYu Wang, JiuHuan Feng, ShuFang Hou

{"title":"Serum Matrix Metalloproteinases and Risk of Urologic Cancers: A Bidirectional Mendelian Randomization Study.","authors":"BoWen Yang, XiaoYu Zeng, HanYu Wang, JiuHuan Feng, ShuFang Hou","doi":"10.1177/15579883241311229","DOIUrl":"10.1177/15579883241311229","url":null,"abstract":"Many observational epidemiological studies have reported an association between matrix metalloproteinases (MMPs) and urologic cancers. However, the causal relationship between these two phenotypes remains uncertain. This study aims to examine the bidirectional causal relationship between serum MMPs and three urologic cancers: kidney, prostate, and bladder cancer. Using data from large-scale genome-wide association studies (GWAS), we employed two-sample Mendelian randomization (MR) methods to assess the causal relationship between serum MMPs and urologic cancers. We performed inverse variance-weighted MR as the primary method for calculating the overall effects of multiple instruments, while implementing additional MR methods and sensitivity analyses. Odds ratios (ORs) were employed to evaluate the causal relationship between serum MMPs and urologic cancers risk. Our findings indicated a causal relationship between serum MMP-3 levels and prostate cancer risk (OR = 1.07, 95% confidence interval [CI] = [1.02, 1.11], p = .003). There was a possible causal relationship between serum MMP-1 and prostate cancer (OR = 0.95, 95% CI = [0.92, 0.99], p = .02). Serum MMP-1 may also increase the risk of bladder cancer (OR = 1.24, 95% CI = [1.04, 1.49], p = .016). We did not find significant associations of the remaining MMPs with prostate, bladder, and kidney cancer. In reverse MR, no significant results were observed supporting the effect of urologic cancers on MMPs (p > .05). Our study provides evidence of a potential causal relationship between serum MMPs and both prostate cancer and bladder cancer. However, large-scale studies are necessary to confirm and reveal the underlying mechanisms of this association.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241311229"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hirudin-Based Treatment of Diabetes-Induced Erectile Dysfunction Through Inhibition of the HIF-1α to Regulate RhoA/ROCK Signaling Pathway: An In Vivo Animal Experiment.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241310763

Longji Sun, Nianwen Huang, Chao Yang, Junlong Feng, Hui Chen, Weidong Feng, Zixiang Gao, Bin Wang, Jisheng Wang

{"title":"Hirudin-Based Treatment of Diabetes-Induced Erectile Dysfunction Through Inhibition of the HIF-1α to Regulate RhoA/ROCK Signaling Pathway: An In Vivo Animal Experiment.","authors":"Longji Sun, Nianwen Huang, Chao Yang, Junlong Feng, Hui Chen, Weidong Feng, Zixiang Gao, Bin Wang, Jisheng Wang","doi":"10.1177/15579883241310763","DOIUrl":"10.1177/15579883241310763","url":null,"abstract":"Diabetes-induced erectile dysfunction (DIED) is a type of refractory erectile dysfunction which can be clinically treated using the traditional Chinese medicine leech whose main ingredient is hirudin. Oxidative stress can damage vascular endothelial cells, affect blood circulation, and induce fibrosis of smooth muscle cells. This study assessed the efficacy of hirudin in treating DIED before exploring its potential mechanism of action. DIED was induced in rats using streptozotocin, while experimental apomorphine was used to screen for erectile dysfunction models. The rats were then divided into four groups: a blank control group (NC group), a model group (M group), a hirudin group (H group), and an inhibitor group (YC group). After 2 weeks, the serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide (NO) were determined. The histological features and HIF-1α/RhoA/ROCK signaling pathway-related proteins of the penile corpus cavernosum were detected. Erectile function improved in the H and YC groups without significantly affecting body weight and blood glucose levels, with histopathological analysis also showing improvement in penile structure in these groups. In addition, the expression of HIF-1α/RhoA/ROCK signaling pathway-related proteins was lower in the penile cavernous tissue of rats in the H and YC groups (p < .05), with the serum levels of NO and SOD also being higher in these groups (p < .05). The serum level of MDA decreased in the YC and H groups (p < .05). In this study, only animal experiments were conducted to investigate the regulation of Rho/ROCK pathway by HIF-1α. Cellular studies of the underlying mechanisms are lacking.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241310763"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can We Predict the Outcome of Micro Testicular Sperm Extraction in Non-Obstructive Azoospermia From Preoperative Hormonal Profile, Testicular Volume, and Patients Health Factors: A Retrospective Cross-Sectional Study.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883251320017

Mohammad Al-Zubi, Sawsan Al-Khawaldeh, Mos'ab Mallak, Muthanna Al-Dghaim, Raneem Zytoon, Rahaf Abbas, Ahmad Alhabahbeh, Marah Alfadel, Saleh Abuorouq, Mohammad Radhi Al-Magableh, Ahmed Nemer Alkhateeb, Mosab Radwan Alboon, Saddam Al Demour, Samer Fathi Al-Rawashdah

{"title":"Can We Predict the Outcome of Micro Testicular Sperm Extraction in Non-Obstructive Azoospermia From Preoperative Hormonal Profile, Testicular Volume, and Patients Health Factors: A Retrospective Cross-Sectional Study.","authors":"Mohammad Al-Zubi, Sawsan Al-Khawaldeh, Mos'ab Mallak, Muthanna Al-Dghaim, Raneem Zytoon, Rahaf Abbas, Ahmad Alhabahbeh, Marah Alfadel, Saleh Abuorouq, Mohammad Radhi Al-Magableh, Ahmed Nemer Alkhateeb, Mosab Radwan Alboon, Saddam Al Demour, Samer Fathi Al-Rawashdah","doi":"10.1177/15579883251320017","DOIUrl":"10.1177/15579883251320017","url":null,"abstract":"Infertility is characterized by the inability to conceive even after engaging in regular unprotected sexual intercourse for a period of 12 months or longer. Azoospermia affects around 1% of men. Approximately 60% of men diagnosed with azoospermia will have non-obstructive azoospermia (NOA). The main aim of this study is to investigate the potential relationship between preoperative hormonal profiles, testicular volume, and patient health factors with microdissection testicular sperm extraction (micro-TESE) outcomes in individuals with NOA. A retrospective analysis of 152 patients who underwent a micro-TESE operation for NOA at our center from January 2020 to December 2022 was conducted. Both groups were compared for age, follicle-stimulating hormone (FSH), luteinizing hormone (LH), total and free testosterone, testicular volume before the operation, previous TESE, smoking, and medical illnesses. A relationship is considered significant when the p value is less than .05. A total of 152 NOA patients were enrolled in this study. Patients were divided into two groups: first group, in whom sperms were identified during the procedure, representing 72 (47.3%) of patients, and the second group (52.7%) of patients, in whom no sperms were found. Results reveal that free testosterone level, total testosterone level, smoking, and previous TESE operation are significantly related to positive surgical results (p value < .05). Our findings suggest that preoperative total and free testosterone levels, smoking status, and previous micro-TESE operation may significantly affect the outcomes of micro-TESE.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883251320017"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclosporine A Decreased Paclitaxel Resistance in Prostate Cancer Cells by Inhibiting MTDH Expression. 环孢素A通过抑制MTDH表达降低前列腺癌细胞紫杉醇耐药。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241310834

Jiangtao Li, Yuzhi Li, Xiaohong Zhang, Kun Liu, Shiping Yang, Zhang Liu, Sheng Cao, Dongfei Ren, Menghui Cui, Jia Su, Zewang Zhen, Donghong Zhang

{"title":"Cyclosporine A Decreased Paclitaxel Resistance in Prostate Cancer Cells by Inhibiting MTDH Expression.","authors":"Jiangtao Li, Yuzhi Li, Xiaohong Zhang, Kun Liu, Shiping Yang, Zhang Liu, Sheng Cao, Dongfei Ren, Menghui Cui, Jia Su, Zewang Zhen, Donghong Zhang","doi":"10.1177/15579883241310834","DOIUrl":"10.1177/15579883241310834","url":null,"abstract":"This study aims to investigate the effect and mechanism of cyclosporine A (CsA) on paclitaxel-resistant prostate cancer cells. Paclitaxel-resistant prostate cancer cell lines were established by gradual increment method. The proliferation of cells was tested using MTT and colony formation assay. Western blot was used to detect protein expression. Expression levels of gene mRNA were detected using real-time polymerase chain reaction (RT-PCR). Xenografts in nude mice were used to validate the conclusion in vitro. The results showed that CsA could increase the sensitivity of prostate cancer cells to paclitaxel. Treatment of paclitaxel-resistant prostate cancer cell lines with CsA gradients decreased metadherin (MTDH) protein expression. RT-PCR showed that CsA could decrease the mRNA level of MTDH. Overexpression of MTDH in prostate cancer cells increases paclitaxel resistance in prostate cancer cells. Conversely, knockdown of MTDH reduced paclitaxel resistance in prostate cancer cells. Treating cells with CsA failed to reduce paclitaxel resistance in prostate cancer cells when MTDH was overexpressed. Xenografts in nude mice yielded consistent conclusions with the in vitro results. In conclusion, CsA can reduce the resistance of prostate cancer cells to paclitaxel. In vitro and in vivo experiments have shown that CsA can reduce paclitaxel resistance in prostate cancer cells by decreasing MTDH expression. In clinical practice, CsA can be used in combination with paclitaxel to improve the therapeutic effect on prostate cancer. MTDH may serve as a novel target for treating paclitaxel resistance in prostate cancer.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241310834"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relative Fat Mass, A Better Predictor of Erectile Dysfunction: Insights From the NHANES 2001-2004.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241311218

BoWen Yang, HanYu Wang, Luyi Tang, JiuHuan Feng, ShuFang Hou

{"title":"Relative Fat Mass, A Better Predictor of Erectile Dysfunction: Insights From the NHANES 2001-2004.","authors":"BoWen Yang, HanYu Wang, Luyi Tang, JiuHuan Feng, ShuFang Hou","doi":"10.1177/15579883241311218","DOIUrl":"10.1177/15579883241311218","url":null,"abstract":"Obesity is a significant factor contributing to erectile dysfunction (ED). Early detection of ED generally results in improved treatment outcomes. Our study aims to elucidate the association between relative fat mass (RFM) and ED by analyzing data from the National Health and Nutrition Inspection Survey (NHANES) spanning 2001 to 2004. We used data from NHANES 2001-2004, employing weighted, multivariable-adjusted logistic regression to assess the relationship between RFM and the risk of ED. Additional analyses included subgroup analysis, smooth curve fitting, and threshold effect analysis. Subsequently, the predictive utility of RFM, body mass index (BMI), and waist circumference (WC) for ED was evaluated using the receiver operating characteristic curve and area under the curve (AUC) calculations. A total of 3,947 American male participants were included in this retrospective study within NHANES. Weighted multivariate logistic regression analysis indicated that, after adjusting for potential confounding factors, RFM was positively associated with the risk of ED (OR = 1.03, 95% CI = 1.01-1.05, p < .001). No significant saturation effects between RFM and ED were observed (all ps > .05). In addition, RFM demonstrated superior predictive capability for ED (AUC = 0.644) compared with BMI (AUC = 0.525) and WC (AUC = 0.612). Our findings suggest that higher RFM levels are associated with an increased risk of ED, highlighting its potential utility as a predictive marker for this condition.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241311218"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of NLRP3 Inflammasome Activation by QYHT Decoction: Implications for the Treatment of Erectile Dysfunction in Hyperuricemia.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883251318307

Pingyu Ge, Yinxue Guo, Bangwei Che, Hang Jin, Lan Chen, Zhichao Chen, Kaifa Tang

{"title":"Modulation of NLRP3 Inflammasome Activation by QYHT Decoction: Implications for the Treatment of Erectile Dysfunction in Hyperuricemia.","authors":"Pingyu Ge, Yinxue Guo, Bangwei Che, Hang Jin, Lan Chen, Zhichao Chen, Kaifa Tang","doi":"10.1177/15579883251318307","DOIUrl":"10.1177/15579883251318307","url":null,"abstract":"Hyperuricemia (HUA) causes vascular endothelial dysfunction and oxidative stress, and simultaneously activates the NLRP3 inflammasome, leading to inflammatory reactions and erectile dysfunction (ED). This study aimed to investigate the effects of QYHT (Quyuhuatanerxian decoction) decoction on the NLRP3 inflammasome and explore its potential in treating HUA-induced ED. This study employed four treatment methods: (a) treating HUA-induced ED patients with QYHT and analyzing changes in gut microbiota abundance and fecal metabolites through 16S sequencing; (b) establishing an HUA-induced ED rat model, treating with different doses of QYHT, and examining changes in serum metabolites; (c) conducting fecal microbiota transplantation (FMT) therapy; evaluating erectile function, oxidative stress, inflammatory response, and NLRP3 inflammasome activation levels; and (d) exploring key monomeric compounds and potential targets in QYHT through network pharmacology and molecular docking. The treatment with QYHT and FMT increased testosterone levels, reduced oxidative stress and inflammatory marker levels, and inhibited the expressions of NLRP3-related factors. QYHT affected the gut microbiota structure and metabolite levels. The key components were linoleoyl acetate and mandanol, and the target was JAK2. QYHT decoction regulates the distribution of gut microbiota, improves amino acid metabolism, and effectively inhibits the activation of NLRP3 inflammasomes. This, in turn, enhances erectile function and reduces oxidative stress and inflammatory response levels, leading to successful treatment of HUA-induced ED.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883251318307"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thanks to Reviewers.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883251322307

引用次数: 0

Compliance With Routine Health Checkup Visits Among California-Based Minority Men: A Survey Study. 加州少数族裔男性的例行健康检查依从性：一项调查研究。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241309752

Selin Aras, Angela Bakaj, Lucas Calica, David Solario, Chidumebi Ezenwoko, Leslie Soto, Amonda Berishaj, Ozlem Equils

{"title":"Compliance With Routine Health Checkup Visits Among California-Based Minority Men: A Survey Study.","authors":"Selin Aras, Angela Bakaj, Lucas Calica, David Solario, Chidumebi Ezenwoko, Leslie Soto, Amonda Berishaj, Ozlem Equils","doi":"10.1177/15579883241309752","DOIUrl":"10.1177/15579883241309752","url":null,"abstract":"The literature on health care disparities among U.S. minority men remains limited, and post-pandemic changes in the health care delivery system may uniquely affect this population. We assessed the factors influencing California-based minority men's compliance with routine health checkup. An IRB-approved survey was conducted electronically by convenience sampling between October 2022 and July 2023. Data was collected on demographics, socioeconomic status, health insurance, and routine checkup attendance. Health insurance literacy was assessed by self-reported ability to locate insurance-covered clinics and health care information. The data was analyzed using random forest modeling with both feature importance and SHAP values for interpretability, and logistic regression analysis. A total of 266 male respondents participated. Of these, 60.5% were under 30 years old, and 66.9% identified as Latino/Hispanic.The majority were employed (82.7%), insured (84.9%), and earned less than $50,000 annually (64.5%). While 71.8% were connected to a clinic or hospital, only 50.8% attended routine health checkup, and 6.8% had visited a doctor in the past year. Key factors influencing compliance included zip code, connection to a clinic and the ability to locate a clinic covered by insurance. These findings highlight that half of insured minority men in California under 60 years of age are not attending routine checkups, suggesting significant barriers related to accessibility and health insurance literacy. Addressing these disparities could improve health care utilization and outcomes in this population.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241309752"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variation in Clinically Significant Prostate Cancer on Fusion Biopsy of PI-RADS 3-5 Lesions Based on Ethnicity.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883251315099

Beth Edelblute, Ahmed Aly, Zhe Jing, Abdul WasayMahmood, Kara Watts, Alex Sankin, Pedro Maria, Khurshid Guru, Ahmed Aboumohamed

{"title":"Variation in Clinically Significant Prostate Cancer on Fusion Biopsy of PI-RADS 3-5 Lesions Based on Ethnicity.","authors":"Beth Edelblute, Ahmed Aly, Zhe Jing, Abdul WasayMahmood, Kara Watts, Alex Sankin, Pedro Maria, Khurshid Guru, Ahmed Aboumohamed","doi":"10.1177/15579883251315099","DOIUrl":"10.1177/15579883251315099","url":null,"abstract":"Our aim is to investigate the prevalence of clinically significant prostate cancer (Gleason score 3+4 or higher) on fusion biopsy for Prostate Imaging Reporting and Data System (PI-RADS) 3-5 lesions based on ethnicity. A retrospective analysis was conducted on patients who underwent fusion biopsy between 2016 and 2022 at two institutions. The prevalence of Gleason score 3+4 or higher within each ethnic group (Caucasian, African American, and Hispanics) was assessed. Possible correlation between PI-RADS lesion score and race was also assessed. Among the 918 patients included in the analysis, 54% were Caucasian, 29% were African American, and 17% were Hispanic. A total of 1,384 lesions were identified (PI-RADS 3-34%, PI-RADS 4-40%, and PI-RADS 5-26%). The prevalence of clinically significant prostate cancer by PI-RADS score and ethnicity was similar: (PI-RADS 3-Caucasian 13%, African American 13%, and Hispanic 9%, p = .45; PI-RADS 4-Caucasian 42%, African American 34%, and Hispanic 38%, p = .29; PI-RADS 5-Caucasian 63%, African American 64%, and Hispanic 51%, p = .38). In conclusion, the prevalence of clinically significant cancer did not significantly differ across PI-RADS 3-5 among different ethnicities on image-guided fusion biopsy.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883251315099"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0