American Journal of Men's Health最新文献_第3页

The Efficacy of Cabazitaxel in Treating Prostate Cancer: A Systematic Review and Meta-Analysis. 卡巴他赛治疗前列腺癌的疗效：系统回顾与元分析》。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241285162

Hashim Talib Hashim, Mudassir Ahmad Khan, Safa Irfan Shah, Mohammedbaqer Ali Al-Ghuraibawi, Fatimah Abdullah Sulaiman, Jamil Nasrallah, Ralph Maroun, Ali Talib Hashim, Naseer Ahmed, Zahraa Hamaza Merza

{"title":"The Efficacy of Cabazitaxel in Treating Prostate Cancer: A Systematic Review and Meta-Analysis.","authors":"Hashim Talib Hashim, Mudassir Ahmad Khan, Safa Irfan Shah, Mohammedbaqer Ali Al-Ghuraibawi, Fatimah Abdullah Sulaiman, Jamil Nasrallah, Ralph Maroun, Ali Talib Hashim, Naseer Ahmed, Zahraa Hamaza Merza","doi":"10.1177/15579883241285162","DOIUrl":"10.1177/15579883241285162","url":null,"abstract":"Cabazitaxel, a second-generation taxane chemotherapy agent, has demonstrated efficacy in treating metastatic castration-resistant prostate cancer (mCRPC) in patients who have previously received docetaxel-based therapy. By targeting microtubule dynamics, cabazitaxel inhibits cancer cell division and induces apoptosis, thereby extending survival and delaying disease progression in this challenging patient population. A systematic review and meta-analysis were done by searching the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, MEDLINE (including MEDLINE InProcess; OvidSP), Web of Science, Embase (OvidSP), and Scopus databases. ROB2 Cochrane tools assessment for RCTs. In the analysis, we used RevMan Cochrane software. Our research reveals significantly improved outcomes in terms of patient survival rates, both progression-free survival (PFS) and overall survival (OS), for cabazitaxel over comparative treatment (PFS HR 0.77 [0.61, 0.97]) (OS HR 0.79 [0.70, 0.88]). The treatment response rates were also favorable for cabazitaxel, reported as PSA Reduction Response of more than 50% (PRR) (odds ratio (OR) = 1.59 [0.56, 4.52]) and tumor response rate (TRR) (OR = 2.34 [1.28, 4.28]). Cabazitaxel was associated with significantly more incidence of adverse events. The risk ratio (RR) for serious adverse events was 1.64 [1.14, 2.35] for cabazitaxel compared to the current regimen. A systematic review and meta-analysis were done by searching in the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, MEDLINE (including MEDLINE InProcess; OvidSP), Web of Science, Embase (OvidSP), and Scopus databases. ROB2 Cochrane tools assessment for RCTs. In the analysis, we used RevMan Cochrane software.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241285162"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Azoospermia Due to Functional and Partial Ejaculatory Duct Obstruction: A Rare Case Report and Literature Review. 功能性和部分性射精管阻塞导致的无精子症：罕见病例报告和文献综述。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241281668

Lei Zheng, Lihong Wang, Hui Jiang, Tao Jiang

{"title":"Azoospermia Due to Functional and Partial Ejaculatory Duct Obstruction: A Rare Case Report and Literature Review.","authors":"Lei Zheng, Lihong Wang, Hui Jiang, Tao Jiang","doi":"10.1177/15579883241281668","DOIUrl":"10.1177/15579883241281668","url":null,"abstract":"Ejaculatory duct obstruction (EDO) is a rare but treatable cause of male infertility. This case report describes a 28-year-old male with obstructive azoospermia. The patient came to our hospital after a fertility check-up revealed azoospermia. A subsequent semen analysis confirmed azoospermia. Transrectal ultrasonography (TRUS) and magnetic resonance imaging (MRI) revealed bilaterally enlarged seminal vesicles and thickened, calcified ejaculatory duct walls. The patient underwent transurethral seminal vesiculoscopy and transurethral resection of the ejaculatory ducts (TURED) for presumed partial EDO. Despite two transurethral seminal vesiculoscopy and TURED procedures, postoperative semen analysis still showed azoospermia. TRUS indicated non-contractile seminal vesicles and an unobstructed ejaculatory duct. The patient ultimately underwent percutaneous epididymal sperm aspiration for assisted reproductive technology and his spouse got pregnant. We identified a case of azoospermia caused by a rare combination of partial and functional ejaculatory duct obstruction. There are currently no reports of similar cases. This case report aims to provide valuable insights for diagnosing and treating EDO.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241281668"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11468320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Nomogram for Predicting Infertility Risk in Patients With Varicocele Using Inflammatory Markers. 利用炎症标志物预测精索静脉曲张患者不育风险的提名图。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241284975

Lihong Wang, Lei Zheng, Hui Jiang, Tao Jiang

{"title":"A Nomogram for Predicting Infertility Risk in Patients With Varicocele Using Inflammatory Markers.","authors":"Lihong Wang, Lei Zheng, Hui Jiang, Tao Jiang","doi":"10.1177/15579883241284975","DOIUrl":"10.1177/15579883241284975","url":null,"abstract":"The purpose of this study was to develop a nomogram using hemogram inflammatory markers to predict the risk of infertility in patients with varicocele (VC). Patients with VC from March 2022 to June 2024 were retrospectively investigated. We divided the patients into two groups based on their fertility status. A total of 162 patients were enrolled: 81 in the infertile group and 81 in the fertile group. Statistical differences were observed between the two groups in lymphocyte, monocyte, erythrocyte, red cell distribution width (RDW), mean erythrocyte volume (MCV), mean platelet volume (MPV), platelet distribution width (PDW), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), MPV/platelet ratio (MPVPR), and systemic inflammation response index (SIRI) (p < .05). The 162 patients were divided into a modeling cohort and a validation cohort in a 7:3 ratio. A predictive nomogram was constructed based on independent influencing factors identified through univariate and multivariate logistic regression analyses. Receiver operating characteristic curve analysis, calibration curve, and decision curve analysis were used to assess the model's performance. Multivariate logistic regression analysis indicated that erythrocyte count, PDW, NLR, and SIRI were independent influencing factors. The area under the curve for the nomogram predicting the risk of infertility in patients with VC was 0.869 in the validation cohort. The nomogram demonstrated good predictive performance. In this study, we developed an effective predictive nomogram for assessing the risk of infertility in VC patients using inflammatory markers. However, further external validation is crucial.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241284975"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11483678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective Evaluation of the Efficacy of Electrophysiological Appropriate Techniques for Nocturia Following Radical Prostatectomy. 回顾性评估电生理适当技术对根治性前列腺切除术后夜尿症的疗效。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241290837

Mei Yang, Xiaomei Wang, Chenyu Huang, Feng Gao, Liping He, Yasheng Huang, Jingyu Zhu, Qiqi Yu

{"title":"Retrospective Evaluation of the Efficacy of Electrophysiological Appropriate Techniques for Nocturia Following Radical Prostatectomy.","authors":"Mei Yang, Xiaomei Wang, Chenyu Huang, Feng Gao, Liping He, Yasheng Huang, Jingyu Zhu, Qiqi Yu","doi":"10.1177/15579883241290837","DOIUrl":"10.1177/15579883241290837","url":null,"abstract":"This study retrospectively examines the effectiveness of low-frequency electrical stimulation for addressing nocturia in patients experiencing urinary incontinence after undergoing radical prostatectomy. We reviewed the outcomes of 32 patients who had undergone radical prostatectomy and subsequently experienced urinary incontinence. These patients were divided into the control group (n = 16) who received pelvic floor muscle training and the treatment group (n = 16) who underwent electrophysiological appropriate technique treatment in conjunction with pelvic floor muscle training. We assessed changes in nocturnal voided volume, polyuria index, and nocturia-related quality of life at three different time points: before treatment, after 2 weeks, and at the 3-month follow-up. After 3-month follow-up, both groups exhibit reductions in nocturnal voided volume, and polyuria index compared with baseline and the 2-week mark (p < .05). Treatment group outperformed the control group (p < .05). The quality of life in the treatment group remained consistently high, while the control group did not show a statistically significant difference from baseline (p > .05). The total effective rate was significantly higher in the treatment group (93.75%) than in the control group (75.00%, p = .044). This retrospective analysis suggests that electrophysiological appropriate technique treatment effectively mitigates nocturnal, leading to improved quality of life in patients with urinary incontinence following radical prostatectomy in the near term.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241290837"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disability and Racial Justice Go Hand in Hand: A Commentary on Black Men and Firearm Violence. 残疾与种族正义齐头并进：黑人男子与枪支暴力评述》。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241266507

Nazsa S Baker, William Wical, Tiffany N Ricks

{"title":"Disability and Racial Justice Go Hand in Hand: A Commentary on Black Men and Firearm Violence.","authors":"Nazsa S Baker, William Wical, Tiffany N Ricks","doi":"10.1177/15579883241266507","DOIUrl":"10.1177/15579883241266507","url":null,"abstract":"Black men in the United States face disproportionately high rates of firearm violence, leading to death and disability more often than males of other racial/ethnic groups. Managing life after such injuries involves significant challenges in daily activities, employment, and pain management. Despite the critical impacts of firearm-related disabilities on Black men, their experiences remain largely unexplored by disability scholars, public health researchers, and practitioners. This oversight is alarming, as Black men with firearm-acquired disabilities encounter considerable structural barriers to achieving health and social objectives. Our team focuses on: (a) the experiences of Black men with firearm-acquired disabilities, (b) the lack of literature on their lived realities, and (c) new pathways for disability and public health research. Recognizing and addressing the invisibility of violently injured Black men in research is crucial for advancing equity, social justice, and representation across society. We argue that disability justice is a vital starting point for acknowledging the social experiences of gunshot wound survivors. More research is needed to understand the experiences of these young Black men who have been largely ignored in public health and disability narratives. It is essential for clinicians and policymakers to grasp how this neglect affects conventional views on health, accessibility, and well-being, underscoring the need for a more inclusive and equitable approach.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241266507"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Study of Sperm DNA Damage Mechanism Based on miRNA Sequencing. 基于 miRNA 测序的精子 DNA 损伤机制研究

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241286672

Feng Liu, Miaomiao Ma, Luyu Li, Yongtao Zhang, Yihan Shang, Quan Yuan, Baojun Ju, Zulong Wang

{"title":"A Study of Sperm DNA Damage Mechanism Based on miRNA Sequencing.","authors":"Feng Liu, Miaomiao Ma, Luyu Li, Yongtao Zhang, Yihan Shang, Quan Yuan, Baojun Ju, Zulong Wang","doi":"10.1177/15579883241286672","DOIUrl":"10.1177/15579883241286672","url":null,"abstract":"To analyze the differential expression profiles of microRNAs (miRNAs) in spermatozoa of patients with sperm DNA damage and to investigate the role of miRNAs in sperm DNA damage. Male infertility patients with sperm DNA damage who attended the First Affiliated Hospital of Henan University of Chinese Medicine from October 2023 to December 2023 were selected and included in this study as a case group. Fertile healthy men who were seen at the health check-up center during the same period and diagnosed by examination were also included as a control group. Sperm miRNA expression was detected in patients with sperm DNA damage (case group, n = 5) and healthy medical check-ups (control group, n = 5) using high-throughput sequencing technology. The differentially expressed miRNAs between the two groups were bioinformatically analyzed to explore the main biological functions of the target genes. We found that 63 miRNAs were significantly changed in the spermatozoa of patients with sperm DNA damage,|log2 (foldchange)| ≥ 1, p < .05. Gene Ontology (GO) enrichment analysis indicated that these differential miRNAs might be involved in developmental process, anatomical structure development, cellular macromolecule metabolic process, multicellular organism development, system development, and so on. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that that they mainly affect the PI3K-AKT signaling pathway. The present study suggests that the altered expression of miR-1255a, miR-921, and miR-3156-5p may play an important role in the sperm DNA damage process, and the mechanism may involve the phosphatidylinositol-3'-kinase-AKT (PI3K-AKT) signaling pathway.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241286672"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Creatinine and Cystatin C: A Measure of Renal Function in Men With Testosterone-Induced Muscle Hypertrophy. 肌酐和胱抑素 C睾酮诱发肌肉肥大男性的肾功能测量。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241286654

Rani Ashouri, Amica Lertkitcharoenpon, Michael Maidaa, Bobby Brunner, Oscar Velazquez, Larry Lipshultz, Kevin Campbell

{"title":"Creatinine and Cystatin C: A Measure of Renal Function in Men With Testosterone-Induced Muscle Hypertrophy.","authors":"Rani Ashouri, Amica Lertkitcharoenpon, Michael Maidaa, Bobby Brunner, Oscar Velazquez, Larry Lipshultz, Kevin Campbell","doi":"10.1177/15579883241286654","DOIUrl":"https://doi.org/10.1177/15579883241286654","url":null,"abstract":"Creatinine (Cr) is often used as a standalone gold standard marker of kidney function. Cystatin C (Cys C) is a less physiologically labile marker of renal function, particularly in certain subgroups. Herein, we analyze trends in cystatin C as compared to creatinine in men on testosterone replacement therapy with varying body mass indices and percent body fat (PBF). This retrospective analysis observes 227 men with testosterone-induced muscle hypertrophy who visited a men's health tertiary care clinic. All participants were characterized as competitive or recreational athletes. In patients with a normal body mass index (BMI), there was no clinically significant correlation between Cr and Cys C. Slight correlation was seen with overweight (R2 = .27) patients (p < .0001) and obese (R2 = .29) patients (p < .0001). Patients with PBF of 0%-10% (n = 22) exhibited minimal (R2 = .23) positive correlation between Cys C and Cr (p = .03). Positive correlation between Cys C and Cr in patients with PBF of 10%-20% was clinically negligible (R2 = .17, n = 87), modest (R2 = .49) in patients with PBF of 20%-30% (n = 42), and evident (R2 = 1.00) in patients >30% (n = 3) (p < .0001, respectively). Cystatin C measurements display less variance compared with creatinine at differing BMI distinctions. At the upper limit of BMI or PBF in our patient population, cystatin C exhibits minimal to moderate variability compared with creatinine.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241286654"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11483778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral Weight Management Interventions for Hispanic Men in the United States: A Systematic Review. 针对美国西班牙裔男性的行为体重管理干预：系统回顾。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241290344

Hana R Flaxman, Noelia G Hernandez, Brian Critelli, Brittney K Chong, Karolina Sadowska, Kevin Pain, Christopher J Gonzalez

{"title":"Behavioral Weight Management Interventions for Hispanic Men in the United States: A Systematic Review.","authors":"Hana R Flaxman, Noelia G Hernandez, Brian Critelli, Brittney K Chong, Karolina Sadowska, Kevin Pain, Christopher J Gonzalez","doi":"10.1177/15579883241290344","DOIUrl":"10.1177/15579883241290344","url":null,"abstract":"Hispanic men have the highest prevalence of obesity relative to other racial and ethnic subgroups; however, this population is consistently underrepresented in weight management interventions. This systematic review aims to provide an overview of behavioral weight management interventions adapted for Hispanic men and describe their tailoring strategies and efficacy. Six online databases were selected for their abundant collection of high-quality, peer-reviewed literature and searched for studies which evaluated and reported weight outcomes for a cohort of adult (>18 years) Hispanic men. Of 6,508 unique publications screened, 12 interventions met inclusion criteria, the majority of which were published in the past 10 years. Only one study regarding an intervention tailored for Hispanic men was a randomized controlled trial adequately powered to assess a weight-based outcome; the remaining assessed feasibility or utilized quasi-experimental methods. Intervention characteristics and tailoring strategies varied considerably, but content was most frequently based on the Diabetes Prevention Program. Tailoring strategies commonly focused on improving linguistic access and incorporating social or family support. Follow-up varied from 1 month to 30 months and mean change in weight, the most common outcome, ranged from 0.6 to -6.3 kg. Our findings reveal a need for more fully powered randomized controlled trials evaluating the efficacy of interventions systematically tailored specifically for Hispanic men. Although the majority were not fully powered, these interventions showed some efficacy among their small cohorts for short-term weight loss. Future directions include exploring how to tailor goals, concepts, and metaphors included in interventions and comparing individual to group delivery settings.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241290344"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health Care Engagement in Disease Prevention and Management: Factors Influencing Chronic Disease Program Referral Adherence Among Non-Hispanic Black and Hispanic Men With Chronic Conditions. 医疗保健参与疾病预防和管理：影响非西班牙裔黑人和西班牙裔男性慢性病患者坚持慢性病计划的因素。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241288978

Caroline D Bergeron, Cynthia L Cisneros Franco, Ledric D Sherman, Kristin Pullyblank, Wendy Brunner, Arica A Brandford, Chung Lin Kew, Matthew Lee Smith

{"title":"Health Care Engagement in Disease Prevention and Management: Factors Influencing Chronic Disease Program Referral Adherence Among Non-Hispanic Black and Hispanic Men With Chronic Conditions.","authors":"Caroline D Bergeron, Cynthia L Cisneros Franco, Ledric D Sherman, Kristin Pullyblank, Wendy Brunner, Arica A Brandford, Chung Lin Kew, Matthew Lee Smith","doi":"10.1177/15579883241288978","DOIUrl":"10.1177/15579883241288978","url":null,"abstract":"This study aimed to identify factors associated with being referred to an evidence-based disease prevention and management program by a health care provider and adherence to such referrals by non-Hispanic Black and Hispanic men. Utilizing a cross-sectional design, data were collected via an internet-based questionnaire from a national sample of 1,679 non-Hispanic Black and Hispanic men ages 40 years and older with one or more chronic diseases. A 105-item survey assessed program referral and attendance, chronic conditions and medications, disease symptoms, support, communication during physician visit, health care frustrations, disease self-management efficacy, barriers to self-care, helpfulness of learning from others for self-care, and sociodemographics. Binary logistic regression models were fitted to assess factors associated with referrals to a disease prevention and management program and attendance. Results indicated that approximately 23% of participants were referred to a program, and 19.2% reported attendance. Factors associated with being referred to and attending a program included being younger, having more chronic conditions, taking more medications daily, having higher pain scores, reporting more health care frustrations, and reporting better communication with physicians during visits. Men referred to attend a chronic disease program by a health care provider were 16.86 times more likely to attend a chronic disease program (p < .001). These findings suggest the importance of health care engagement for non-clinical disease prevention and management programs, particularly among non-Hispanic Black and Hispanic men with complex disease profiles.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241288978"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening of the Combined Risk of Genetics and Epidemiology on Infertility Among Indian Men: Synergistic Effect of AZFc Partial Deletions and Habits of Smokeless Chewing Tobacco. 印度男性不育症遗传学和流行病学综合风险筛查：AZFc 部分缺失与无烟咀嚼烟草习惯的协同效应。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241279195

Saurav Dutta, Pranab Paladhi, Samudra Pal, Souvik Srimani, Gunja Bose, Papiya Ghosh, Ratna Chattopadhyay, Sujay Ghosh

{"title":"Screening of the Combined Risk of Genetics and Epidemiology on Infertility Among Indian Men: Synergistic Effect of AZFc Partial Deletions and Habits of Smokeless Chewing Tobacco.","authors":"Saurav Dutta, Pranab Paladhi, Samudra Pal, Souvik Srimani, Gunja Bose, Papiya Ghosh, Ratna Chattopadhyay, Sujay Ghosh","doi":"10.1177/15579883241279195","DOIUrl":"10.1177/15579883241279195","url":null,"abstract":"The AZFc partial deletions of Y chromosome and lifestyle/epidemiological factors such as the use of smokeless chewing tobacco (SCT) exhibit intriguing variations in their association with male infertility across the population, ethnicity, and genetic background. Here, a pioneering attempt has been made to elucidate the interactions of such deletions with the habits of SCT consumption among the participating individuals, using their large epidemiological data. This screening program was conducted among Bengali-speaking men in West Bengal, India. We screened the prevalence and association of distinct partial deletions (gr/gr, b1/b3, and b2/b3) of the AZFc region using locus-specific sequence-tagged site (STS) markers among 728 case subjects and compared them with 264 ethnicity- and age-matched proven-fertile control men. The recorded epidemiological data of the study group and the outcome of partial deletion analysis were compiled to frame the plausible Gene × Epidemiological factor (G × E) interactions. The gr/gr deletion was reported to be significantly associated with azoospermic (p = .0015, odds ratio [OR] = 3.413) and oligozoospermic (p = .0382, OR = 3.012) case subgroups, and b1/b3 deletions were also detected among the infertile persons only. The G × E model revealed that men who carried microdeletions as well as were SCT users had an elevated risk of infertility (p = .002, OR = 6.38). The study highlights the fact that AZFc partial deletions and SCT, when co-occurred, synergistically increase the risk of infertility among men. This work helps to get more insight into the etiology of male infertility in the light of gene-environmental interaction.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241279195"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11437552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0