Association of the Ratio of Second to Fourth Digit Length and Phthalate Exposure With Sexual Function in Japanese Men Seeking Fertility Treatment.

IF 2.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
American Journal of Men's Health Pub Date : 2025-05-01 Epub Date: 2025-07-01 DOI:10.1177/15579883251352972
Kazumitsu Yamasaki, Masahiro Uchida, Yuki Mizuno, Teruaki Iwamoto, Shoko Konishi
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引用次数: 0

Abstract

Sexual dysfunction, which is increasingly recognized as a cause of male infertility, may be influenced by environmental factors such as phthalic acid diesters (phthalates) and prenatal androgen exposure. This study aimed to investigate the association between male sexual function and recent exposure to phthalates and prenatal testosterone. The cross-sectional study included 177 males seeking fertility treatment. The index-to-ring-finger length ratio (2D:4D) was calculated as a measure of prenatal androgen exposure. To evaluate recent phthalate exposure, urinary concentrations of seven phthalate metabolites were measured. Their associations with International Index of Erectile Function (IIEF) scores were analyzed using generalized linear models. One standard deviation increase of mono-methyl phthalate was negatively associated with IIEF domains A (erectile function; exponentiated coefficient, 0.95; exponentiated 95% confidence interval, CI, [0.91, 0.98]) and D (intercourse satisfaction; exponentiated coefficient, 0.91; exponentiated [0.85, 0.97]). While mono-butyl phthalate was positively associated with domain A, mono-ethyl phthalate, monobenzyl phthalate, and the molar sum of di (2-ethylhexyl) phthalate metabolites showed no significant association with IIEF domain scores. When the serum testosterone concentration was included as an exposure variable, the overall association between urinary phthalates and IIEF domain scores remained similar. The left- and right-hand 2D:4D ratios did not show significant associations with any IIEF domain scores. Recent phthalate exposure may affect male sexual function by decreasing testosterone levels and other potential mechanisms.

在寻求生育治疗的日本男性中,第二到第四手指长度的比例和邻苯二甲酸盐暴露与性功能的关系。
性功能障碍越来越被认为是男性不育的一个原因,它可能受到诸如邻苯二甲酸二酯(邻苯二甲酸酯)和产前雄激素暴露等环境因素的影响。本研究旨在探讨男性性功能与近期接触邻苯二甲酸酯和产前睾酮之间的关系。横断面研究包括177名寻求生育治疗的男性。计算食指与无名指长度比(2D:4D)作为产前雄激素暴露的衡量标准。为了评估最近的邻苯二甲酸盐暴露,测量了尿中七种邻苯二甲酸盐代谢物的浓度。使用广义线性模型分析其与国际勃起功能指数(IIEF)评分的关系。邻苯二甲酸一甲酯增加一个标准差与IIEF结构域A(勃起功能;指数系数,0.95;指数95%置信区间(CI,[0.91, 0.98])和D(性交满意度;指数系数为0.91;指数[0.85,0.97])。邻苯二甲酸一丁酯与结构域A呈正相关,邻苯二甲酸一乙酯、邻苯二甲酸一苯酯和邻苯二甲酸二(2-乙基己基)代谢产物的摩尔数与IIEF结构域得分无显著关联。当将血清睾酮浓度作为暴露变量时,尿邻苯二甲酸酯和IIEF结构域评分之间的总体关联仍然相似。左侧和右侧的2D:4D比值与任何IIEF域分数没有显着关联。最近的邻苯二甲酸盐暴露可能通过降低睾丸激素水平和其他潜在机制影响男性性功能。
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来源期刊
American Journal of Men's Health
American Journal of Men's Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
3.70
自引率
4.30%
发文量
107
审稿时长
15 weeks
期刊介绍: American Journal of Men"s Health will be a core resource for cutting-edge information regarding men"s health and illness. The Journal will publish papers from all health, behavioral and social disciplines, including but not limited to medicine, nursing, allied health, public health, health psychology/behavioral medicine, and medical sociology and anthropology.
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