American Journal of Men's Health最新文献_第4页

Psychosocial Factors and Andropause Symptoms Among Japanese Men: An Internet-Based Cross-Sectional Study.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241312836

Fumiya Tanji, Hirohito Nanbu, Daisaku Nishimoto, Maiko Kawajiri

{"title":"Psychosocial Factors and Andropause Symptoms Among Japanese Men: An Internet-Based Cross-Sectional Study.","authors":"Fumiya Tanji, Hirohito Nanbu, Daisaku Nishimoto, Maiko Kawajiri","doi":"10.1177/15579883241312836","DOIUrl":"10.1177/15579883241312836","url":null,"abstract":"This study aimed to investigate the relationship between psychosocial factors and andropause symptoms among Japanese men in an internet-based cross-sectional study. We conducted an internet-based cross-sectional study in 2024, named Japanese Men's health and Andropause Related Symptoms (J-MARS) study. Data on demographics, medical history, andropause symptoms, lifestyles (physical activity, insomnia, height, weight, and smoking and drinking habits), and psychological distress were collected from 1,489 men aged 20-69 years who participated in the J-MARS study. Andropause symptoms were measured using the Aging Males' Symptoms (AMS) rating scale, which was included in the analysis. We conducted a multivariate logistic regression analysis, and estimated odds ratios and 95% confidence intervals to examine the associated factors with severe andropause symptoms. Severe andropause symptoms according to the AMS score were noted in 125 men (8.4%). Severe andropause symptoms were associated with former smoking, current smoking, strength training (≥1.0 hr/day), probable insomnia, moderate psychological distress, and severe psychological distress. After excluding 289 participants with cardiovascular disease, cerebrovascular disease, cancer, or depression, severe andropause symptoms were associated with age, absence of a spouse, and suspected insomnia in addition to the above factors. Age, insomnia, and psychological distress were also significantly associated with all AMS subdomains (somatic, psychological, and sexual symptoms). Psychological stress, insomnia, and smoking habits are strongly associated with severe andropause symptoms. These findings may be useful for the prevention of andropause and for patient education.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241312836"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Women, Men, and Cancer Survivorship: A Commentary on Current Data and Possible Underlying Issues.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241309039

Michael J Rovito, Sydney Martinez, Kamalie Thomas, Khushi Chauhan, Samantha Gibson

{"title":"Women, Men, and Cancer Survivorship: A Commentary on Current Data and Possible Underlying Issues.","authors":"Michael J Rovito, Sydney Martinez, Kamalie Thomas, Khushi Chauhan, Samantha Gibson","doi":"10.1177/15579883241309039","DOIUrl":"10.1177/15579883241309039","url":null,"abstract":"Tonorezos et al.'s recent analysis of U.S. cancer survivorship prevalence provides insightful commentary on the dramatic increase of those surviving the disease over the last 50 years. This growth is reflective of improvements in cancer detection, treatment, and the effects of an aging population. While survival rates have seen a significant increase, more focus is needed on the long term and postsurvivorship health care. What Tonorezos et al.'s piece also indicates is that survivorship trends reveal disparities based on several variables, such as age, sex, and cancer type. Women tend to be diagnosed earlier and have higher survival rates when compared to men, arguably due to more frequent screenings vis-a-vis a sequela of increased utilization of care. Men have higher cancer incidence rates among the aging population, accompanied by lower survival rates, frequently linked to late diagnosis and less utilization of preventive care. Addressing sex-specific disparities is pivotal to developing future treatment plans among cancer survivors. Health care providers must adjust to the multifaceted demands of the population. Public health movements should focus on increasing awareness and promotion of early detection in the male population, taking note of the successful initiatives seen in women's health. It is imperative that these disparities and long-term needs are assimilated into the comprehensive conversation about cancer care to improve outcomes for all survivors.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241309039"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The HIV Testing and Health Care Intervention: Insights into Promoting HIV Testing Among Middle-Aged and Older Men Who Have Sex With Men.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241312388

Alex Siu Wing Chan

引用次数: 0

Impact of Ramadan Intermittent Fasting on Salivary pH, Flow Rate, and Electrolyte Levels in Healthy Adult Men.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241312396

Sinda Yacoub, Mehdi Khemiss, Amira Besbes, Helmi Ben Saad

{"title":"Impact of Ramadan Intermittent Fasting on Salivary pH, Flow Rate, and Electrolyte Levels in Healthy Adult Men.","authors":"Sinda Yacoub, Mehdi Khemiss, Amira Besbes, Helmi Ben Saad","doi":"10.1177/15579883241312396","DOIUrl":"10.1177/15579883241312396","url":null,"abstract":"This before-and-after design study, which was conducted during Ramadan 2023, aimed to compare salivary flow rate (SFR), potential hydrogen (pH), and electrolyte concentrations before Ramadan (BR), at the end of Ramadan (ER), and after Ramadan (AR). Men aged 20 to 30 years who were fasting during Ramadan were recruited from the University of Monastir (Tunisia). Unstimulated saliva was collected over a 5-minute period between 10 and 11 a.m. at BR, ER, and AR. After recording the SFR, the pH was measured immediately using a pH meter. Concentrations of several salivary electrolytes (e.g., calcium, potassium, sodium, chloride, and phosphate) were determined using inductively coupled plasma-optical emission spectroscopy. Twenty-seven participants completed all three sessions. Ramadan intermittent fasting (RIF) caused significant changes only in calcium levels and pH. The mean (M)±standard deviation (SD) salivary calcium concentration decreased during ER compared to BR and AR (0.10 ± 0.08 vs. 0.21 ± 0.18 [p = .041] vs. 0.22 ± 0.20 [p = .026], respectively). The M±SD salivary pH increased during ER compared to BR (6.88 ± 0.23 vs. 6.69 ± 0.35 [p = .049], respectively). To conclude, RIF decreased salivary calcium, increased salivary pH, and did not significantly affect potassium, sodium, chloride, or phosphate. The pH change, although statistically significant, was clinically insignificant, as values remained normal. The lack of reference values for salivary calcium limits assessment of its clinical impact. There is a need for further research on the effects of RIF on saliva secretion.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241312396"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concentration of Selected Serum Trace Elements in Male Patients With Diabetic Erectile Dysfunction: A Case-Control Study.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241307526

Zhe Yu, Zhenliang Pan, Rongbo Cai, Yuanzhi Xie, Xiaolan Huang, Jinxiang Wu, Jianyu Zhang

{"title":"Concentration of Selected Serum Trace Elements in Male Patients With Diabetic Erectile Dysfunction: A Case-Control Study.","authors":"Zhe Yu, Zhenliang Pan, Rongbo Cai, Yuanzhi Xie, Xiaolan Huang, Jinxiang Wu, Jianyu Zhang","doi":"10.1177/15579883241307526","DOIUrl":"10.1177/15579883241307526","url":null,"abstract":"Identifying novel risk factors for erectile dysfunction (ED) is crucial for developing targeted intervention. This study aimed to investigate the potential impacts of serum trace elements (TEs) concentration on the risk of diabetic ED. A retrospective case-control study was conducted involving 51 patients with diabetic ED and 51 control subjects. Serum levels of copper (Cu), zinc (Zn), magnesium (Mg), iron (Fe), and calcium (Ca) were measured using inductively coupled plasma-mass spectrometry (ICP-MS). While most selected TEs showed no significant differences, Cu levels were notably higher in patients with diabetic ED. In addition, the Cu/Zn ratio (CZr) was significantly elevated in the diabetic ED group compared to controls (1.3 vs. 1.2 mg/L, p < .001), reflecting its potential relevance to oxidative stress. Receiver operating characteristic curve analysis revealed that CZr exhibited better diagnostic performance for ED than the single parameter. These findings suggest disruptions in Cu homeostasis and a high probability of elevated CZr in diabetic ED. Further studies are warranted to validate our findings and elucidate the underlying mechanisms.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241307526"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Scoping Review of Preferences of Men Who Experienced Sexual Assault: Implications for Adaptation of Trauma-Focused Cognitive Behavioral Therapies.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883241260512

Lydia Gamache, Laurence Dubé, Geneviève Belleville

{"title":"A Scoping Review of Preferences of Men Who Experienced Sexual Assault: Implications for Adaptation of Trauma-Focused Cognitive Behavioral Therapies.","authors":"Lydia Gamache, Laurence Dubé, Geneviève Belleville","doi":"10.1177/15579883241260512","DOIUrl":"10.1177/15579883241260512","url":null,"abstract":"About 1 in 10 men experiences sexual assault, resulting in various difficulties most frequently associated with post-traumatic stress disorder. However, trauma-focused cognitive behavioral therapies (TF-CBT) seem less effective for men who experienced sexual assault compared to women. Efficacy of TF-CBT could be improved by adapting interventions according to the empirical data detailing men's preferences regarding psychological services. This scoping review aimed to document preferences of men who experienced sexual assault regarding psychological services, and to explore barriers and motivators to help-seeking for this population. A systematic approach was used to gather literature describing preferences regarding psychological services, and barriers and motivators to help-seeking. Thirty-five peer-reviewed studies and two non-peer reviewed reports met inclusion criteria. Data from included articles were extracted using a systematic extraction grid. A thematic content analysis was conducted to synthesize and present the results from the 37 studies. The number of empirical studies on preferences regarding psychological services was limited as only five documented preferences, all related to the clinician's characteristics (e.g., clinician's gender) and the type of intervention (e.g., action-oriented). Most studies reviewed barriers to help-seeking. The barriers most frequently identified were adherence to masculine norms and to myths about male sexual assault. Injury or substance abuse following sexual assault often act as motivators to help-seeking for men. To adapt TF-CBT to men who experienced sexual assault, researchers and clinicians should accommodate and further study these men's preferences, consider their motivators regarding help-seeking and alleviate barriers to help-seeking, notably by deconstructing masculine norms.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883241260512"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Hepatitis C Infection on Semen Parameters of Men From Rawalpindi and Islamabad, Punjab, Pakistan.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883251316564

Jamal Uddin, Shamim Akhter, Muhammad Javaid Asad, Muhammad Irfan, Mazhar Qayyum, Majid Aijaz, Shahzad Aslam

{"title":"Effect of Hepatitis C Infection on Semen Parameters of Men From Rawalpindi and Islamabad, Punjab, Pakistan.","authors":"Jamal Uddin, Shamim Akhter, Muhammad Javaid Asad, Muhammad Irfan, Mazhar Qayyum, Majid Aijaz, Shahzad Aslam","doi":"10.1177/15579883251316564","DOIUrl":"10.1177/15579883251316564","url":null,"abstract":"Hepatitis C virus (HCV) poses a global health challenge, especially due to its genetic diversity and capacity to infect 71 million people worldwide. This infection is prevalent in Pakistan, with 15% of the population affected, with varying rates across provinces. HCV primarily targets liver cells but can also impact other bodily systems, including the reproductive system. Liver infection, oxidative stress, and inflammation may directly or indirectly affect the production, transport, and functions of reproductive hormones and sperm. This study hypothesized that HCV infection may reduce male fertility in the patients. In this case-control study, 74 HCV-infected men and 12 healthy controls from Rawalpindi and Islamabad were compared for semen quality. Participants provided semen samples following strict guidelines, ensuring the reliability of results. The semen analysis, conducted using manual and computer-assisted techniques, revealed significant (p < .05) reductions in volume, concentration, motility, and morphology among HCV-infected men compared to the control group. In addition, a weak negative correlation between virus load and semen parameters was observed. These findings reveal broader health implications of HCV beyond liver damage, highlighting the need for targeted reproductive health interventions for affected men. Improved fertility preservation options and informed reproductive guidance for HCV-infected men could significantly benefit those undergoing treatment.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883251316564"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Commercial Determinants of Nonalcoholic Beer: Redemption, Revenue, or Men's Harm Reduction?

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883251317096

John L Oliffe, Nina Gao, Mary T Kelly, Trevor Goodyear, Murray Drummond, Christine Levesque, Katherine White

{"title":"The Commercial Determinants of Nonalcoholic Beer: Redemption, Revenue, or Men's Harm Reduction?","authors":"John L Oliffe, Nina Gao, Mary T Kelly, Trevor Goodyear, Murray Drummond, Christine Levesque, Katherine White","doi":"10.1177/15579883251317096","DOIUrl":"10.1177/15579883251317096","url":null,"abstract":"Public awareness about the connections between men's alcohol use and poor health outcomes, including increased male suicide risk, has led to reduced consumption and increased use of nonalcoholic beverages-most prominently nonalcoholic beer (NAB). Marketed as a healthy substitution option (i.e., periodically switching to an NAB rather than abstaining from alcoholic beer), the rapidly growing NAB sector might be somewhat redemptive, wherein the alcoholic beer industry (as the predominant producers of NAB) is selling harm reduction to men, albeit for profit. The commercial determinants of NAB are, however, complex and have significant implications for legislation and policy. For example, in Canada, NAB is exempt from alcoholic beer excise duty but considered beer for the goods and services and harmonized sales taxes. Coupled with industry production costs and profit margins, these taxes contribute to NAB and alcoholic beer retail price parity. From a public health perspective, there are also concerns about increasing alcoholic beer brand recognition and sales revenue by extending NAB visibility in more places (e.g., supermarkets), contexts (e.g., taking medication), and activities (e.g., driving). The current article highlights (1) the connections between men's alcohol use and health risks, ahead of discussing, (2) the rise of NAB, and mapping (3) NAB legislation and policy implications. We conclude with a discussion about the redemption, revenue, and men's harm reduction potentials, pragmatically arguing the need to both regulate and incentivize NAB. Proposed are promising directions for future research with the goal of reducing men's alcohol use and associated harms.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883251317096"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Race, Age, and Allostatic Load Among Men in the Nashville Stress and Health Study.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883251317095

Roland J Thorpe, Ángela Gutiérrez, Paul Archibald, Amy D Thierry, Marino Bruce, Corina Mills, Keith Norris, Courtney S Thomas Tobin

{"title":"Race, Age, and Allostatic Load Among Men in the Nashville Stress and Health Study.","authors":"Roland J Thorpe, Ángela Gutiérrez, Paul Archibald, Amy D Thierry, Marino Bruce, Corina Mills, Keith Norris, Courtney S Thomas Tobin","doi":"10.1177/15579883251317095","DOIUrl":"10.1177/15579883251317095","url":null,"abstract":"High allostatic load (AL), a measure of physiological dysregulation, has been linked with premature morbidity and mortality. There is a paucity of research assessing AL among non-Hispanic Black (NHB) and non-Hispanic White (NHW) American men of various age groups. This study investigated racial differences in AL among NHB and NHW adult men and assessed whether racial differences in AL varied by age. Data were drawn from NHB (n = 232) and NHW (n = 246) men in the Nashville Stress and Health Study. AL was based on the sum of 10 biomarkers that was dichotomized as high AL (four or more high-risk biomarkers) or low AL (fewer than four high-risk biomarkers). Modified Poisson regression models were estimated to assess race differences in AL, adjusting for age, socioeconomic status (SES), and health behaviors. Interactions assessed whether racial differences in AL varied between young (22-49 years) and older (50-69) men. NHB men had a higher prevalence of being in the high AL group (prevalence ratio [PR] = 1.54, confidence interval [CI] = [1.09, 2.18]), relative to NHW men in the total sample. Among young men ages 22 to 49 years, NHB men had a higher prevalence of being in the high AL group (PR = 2.09, CI = [1.25, 3.49]), relative to NHW men. Among older men ages 50 to 69 years, there were no racial differences in AL. Findings underscore the importance of identifying factors that are associated with high AL, which is critical to mitigate premature morbidity and mortality, among NHB men.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883251317095"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of ESR1 Xba1 (rs9340799) With Male Infertility: A Systematic Review and Meta-Analysis.

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2025-01-01 DOI: 10.1177/15579883251319134

Hania Qamar, Sadia Bibi, Zeeshan Qadeer, Faiza Muzammil, Masooma Batool, Shaista Aslam, Ayesha Akram, Adina Arshad, Muhammad Irfan

{"title":"Association of ESR1 Xba1 (rs9340799) With Male Infertility: A Systematic Review and Meta-Analysis.","authors":"Hania Qamar, Sadia Bibi, Zeeshan Qadeer, Faiza Muzammil, Masooma Batool, Shaista Aslam, Ayesha Akram, Adina Arshad, Muhammad Irfan","doi":"10.1177/15579883251319134","DOIUrl":"10.1177/15579883251319134","url":null,"abstract":"Variations in the estrogen receptor genes, particularly the Xba1 (rs9340799) SNP in the ESR1 gene, may influence the effects of estrogen on male fertility. Results from previous studies on this SNP for male infertility have been inconclusive. This review aimed to determine the association of ESR1 Xba1 (rs9340799) with male infertility. Relevant case-control studies published in English were searched from Google Scholar, Embase, Scopus, Web of Science, Cochrane Library, and PubMed using keywords of ESR, polymorphism, and male infertility. Studies on animals, reviews, and abstracts were excluded. Pooled odds ratios (ORs) were calculated for four genetic models, with heterogeneity assessed by I2. A fixed or random effect model was applied based on I2, and trial sequential analysis (TSA) was conducted with 5% significance for type I error and 95% power. ESR1 expression levels were examined in testes, hypothalamus, prostate, and pituitary using GTEx Analysis. Nine studies (four Asian, four Caucasian, one African) met the criteria. The G allele was protective against infertility overall (OR: 0.80; 95% confidence interval [CI] = [0.70, 0.92]) and in Caucasian men (OR: 0.71; 95% CI = [0.54, 0.92]). Lower infertility risk was observed in Asian (AA vs. GG OR: 0.65; 95% CI = [0.43, 0.98]) and Caucasian men (OR: 0.49; 95% CI = [0.28, 0.83]). TSA indicated no further studies are likely to change these results. No significant change in expression of ESR1 was observed due to this SNP. The present meta-analysis suggests that the SNP Xba1 (rs9340799) in ESR1 is protective against male infertility, with current data sufficient to confirm these findings.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 1","pages":"15579883251319134"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0