Nature mental health最新文献_第4页

Proteogenomic signature of Alzheimer’s disease and related dementia risk in individuals with major depressive disorder 重度抑郁症患者阿尔茨海默病和相关痴呆风险的蛋白质基因组特征

IF 8.7

Nature mental health Pub Date : 2025-07-14 DOI: 10.1038/s44220-025-00460-0

Breno Satler Diniz, Zhiduo Chen, David C. Steffens, Luke Pilling, Yuliya Nikolova, Kevan Clifford, Richard H. Fortinsky, George A. Kuchel, Chia-Ling Kuo

{"title":"Proteogenomic signature of Alzheimer’s disease and related dementia risk in individuals with major depressive disorder","authors":"Breno Satler Diniz, Zhiduo Chen, David C. Steffens, Luke Pilling, Yuliya Nikolova, Kevan Clifford, Richard H. Fortinsky, George A. Kuchel, Chia-Ling Kuo","doi":"10.1038/s44220-025-00460-0","DOIUrl":"10.1038/s44220-025-00460-0","url":null,"abstract":"The mechanisms linking a history of major depressive disorder (MDD) to an increased risk of Alzheimer’s disease and related dementia (ADRD) are not fully understood. Using the UK Biobank, we evaluated the biological mechanisms linking the conditions. In participants without history of MDD, 493 proteins were significantly associated with the risk of ADRD. By contrast, in participants with a history of MDD at baseline, a smaller set of six proteins were significantly associated with ADRD risk (NfL, GFAP, PSG1, VGF, GET3 and HPGDS), with GET3 being specifically associated with ADRD risk in the latter group. Two-sample Mendelian randomization analysis showed that the apolipoprotein E and IL-10 receptor subunit B genes were causally linked to incident ADRD. Finally, we developed a proteomic risk score (PrRSMDD-ADRD), which showed strong discriminative power (C statistic = 0.84) to identify participants with MDD who developed ADRD on follow-up. Here we show that plasma proteins associated with inflammation and amyloid-β metabolism are causally linked to a higher ADRD risk in individuals with MDD. Moreover, the PrRSMDD-ADRD can be useful to identify individuals with the highest risk of developing ADRD in a highly vulnerable population. This study investigates biological mechanisms connecting major depressive disorder to Alzheimer’s disease risk, identifying six key proteins and establishing a proteomic risk score with strong predictive power for identifying vulnerable individuals at risk of developing dementia.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 8","pages":"879-888"},"PeriodicalIF":8.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Illuminating posterior targets for transcranial magnetic stimulation beyond the prefrontal cortex 前额叶皮层以外经颅磁刺激的后靶照明

IF 8.7

Nature mental health Pub Date : 2025-07-14 DOI: 10.1038/s44220-025-00433-3

Daniel M. McCalley, Lauren L. Sanderson, Logan T. Dowdle, Claudia B. Padula, Shan H. Siddiqi, Kristen K. Ellard, Joseph J. Taylor

{"title":"Illuminating posterior targets for transcranial magnetic stimulation beyond the prefrontal cortex","authors":"Daniel M. McCalley, Lauren L. Sanderson, Logan T. Dowdle, Claudia B. Padula, Shan H. Siddiqi, Kristen K. Ellard, Joseph J. Taylor","doi":"10.1038/s44220-025-00433-3","DOIUrl":"10.1038/s44220-025-00433-3","url":null,"abstract":"Transcranial magnetic stimulation (TMS) is rapidly developing as a therapeutic tool for multiple psychiatric disorders. All current US Food and Drug Administration-cleared TMS indications for psychiatric illness target the frontal lobes. Historically, TMS target selection was based on reports of brain lesion locations that cause illness or functional neuroimaging correlates within the prefrontal cortex. In addition to prefrontal targets, however, these neuroimaging studies have consistently implicated posterior brain regions in a variety of psychiatric disorders. Thus far, these posterior regions have rarely been tested in TMS clinical trials. In this Perspective, we consider the role in psychiatric disorders of posterior regions such as the occipital cortex, precuneus, inferior parietal lobules and cerebellum. We synthesize preliminary evidence across the few existing TMS trials targeting posterior regions and consider the risks and benefits of stimulating posterior targets for the treatment of psychiatric illness. In this Perspective, the authors review evidence suggesting that stimulating posterior regions such as the occipital cortex and cerebellum could offer new therapeutic avenues, potentially enhancing TMS efficacy across various psychiatric conditions.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 8","pages":"859-869"},"PeriodicalIF":8.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suicide rates among US medical residents 美国住院医生的自杀率

IF 8.7

Nature mental health Pub Date : 2025-07-09 DOI: 10.1038/s44220-025-00462-y

Natalia Gass

引用次数: 0

Physician, heal thyself? Supporting physician mental health 医生，你能治好吗？辅助医生心理健康

IF 8.7

Nature mental health Pub Date : 2025-07-09 DOI: 10.1038/s44220-025-00464-w

引用次数: 0

A systematic review and meta-analysis of interventions to reduce or prevent symptoms of common mental disorders and suicidality in physicians 减少或预防医生常见精神障碍和自杀症状的干预措施的系统回顾和荟萃分析

IF 8.7

Nature mental health Pub Date : 2025-07-09 DOI: 10.1038/s44220-025-00450-2

Katherine Petrie, Mikayla Gregory, Daniel A. J. Collins, Aimee Gayed, Samineh Sanatkar, Kimberlie Dean, Mark Deady, Samuel B. Harvey

{"title":"A systematic review and meta-analysis of interventions to reduce or prevent symptoms of common mental disorders and suicidality in physicians","authors":"Katherine Petrie, Mikayla Gregory, Daniel A. J. Collins, Aimee Gayed, Samineh Sanatkar, Kimberlie Dean, Mark Deady, Samuel B. Harvey","doi":"10.1038/s44220-025-00450-2","DOIUrl":"10.1038/s44220-025-00450-2","url":null,"abstract":"We conducted an updated systematic review and meta-analysis on the effectiveness of interventions for reducing or preventing symptoms of common mental disorder (CMD) and suicidality among physicians. Databases were searched for randomized and non-randomized controlled trials of interventions to reduce or prevent depression, anxiety, general psychological distress or suicidality among physicians. The primary outcome was differences in symptoms of CMD following intervention. Random-effects meta-analyses and subgroup and sensitivity analyses were conducted. Twenty-four studies were included in the qualitative synthesis, of which 21 were included in the meta-analysis. Compared with controls, physician-directed interventions significantly reduced symptoms of CMD among physicians at post-intervention (standardized mean difference 0.45; 95% confidence interval 0.26–0.65; P < 0.001; moderate heterogeneity) and follow-up with a small to moderate effect size. Preliminary findings suggest that group-based, face-to-face and skills-based interventions show promise for reducing symptoms of CMD among physicians. Research regarding organizational-level interventions is urgently required. Systematic review registration: PROSPERO CRD42018091646 . Physicians face high rates of common mental disorders (CMDs) and suicidality, yet effective interventions remain underexplored. This systematic review and meta-analysis synthesizing the latest evidence on interventions finds that a range of physician-directed interventions reduces symptoms of CMD and that these moderate effects are maintained over time.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 7","pages":"838-851"},"PeriodicalIF":8.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44220-025-00450-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A meta-analytic review of child maltreatment and interoception 儿童虐待与间感受的元分析综述

IF 8.7

Nature mental health Pub Date : 2025-07-07 DOI: 10.1038/s44220-025-00456-w

Julia Ditzer, Christian Franz Joseph Woll, Clara Burger, Alisa Ernst, Ilka Böhm, Susan Garthus-Niegel, Anna-Lena Zietlow

{"title":"A meta-analytic review of child maltreatment and interoception","authors":"Julia Ditzer, Christian Franz Joseph Woll, Clara Burger, Alisa Ernst, Ilka Böhm, Susan Garthus-Niegel, Anna-Lena Zietlow","doi":"10.1038/s44220-025-00456-w","DOIUrl":"10.1038/s44220-025-00456-w","url":null,"abstract":"Interoception—the ability to sense internal bodily signals such as heartbeat or breathing—plays a central role in both mental and physical health. Disruptions in interoception are increasingly recognized as important contributors to various psychological and medical conditions, yet the origins remain unclear. One possible risk factor is exposure to childhood maltreatment. Here we present a meta-analytic review examining the association between child maltreatment and different aspects of interoception. In this Analysis, we use meta-analytic methods to examine the relationship between childhood maltreatment and interoception across 17 studies. We found no consistent association between childhood maltreatment and interoceptive accuracy, sensibility, or awareness. However, a history of childhood maltreatment—particularly emotional maltreatment—was associated with lower body trust, a dimension of interoception reflecting confidence in bodily signals. These findings suggest that early adverse experiences may undermine the foundational sense of trust in one’s body, with potential long-term consequences for mental and physical health. Interoception, the perception of internal bodily signals, is crucial for mental and physical well-being, yet the origins of disruptions in interoception are not well understood. Here the authors conduct a meta-analysis of 17 studies, revealing that childhood maltreatment, particularly emotional maltreatment, is linked to reduced body trust, potentially impacting long-term health outcomes.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 7","pages":"821-837"},"PeriodicalIF":8.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards a mechanistic framework for understanding early-onset restrictive eating disorders 建立理解早发性限制性饮食失调的机制框架

IF 8.7

Nature mental health Pub Date : 2025-07-02 DOI: 10.1038/s44220-025-00458-8

引用次数: 0

Neuroimaging insights into adolescent depression risk and development 神经影像学对青少年抑郁风险和发展的洞察

IF 8.7

Nature mental health Pub Date : 2025-07-01 DOI: 10.1038/s44220-025-00453-z

Niamh MacSweeney, Yara J. Toenders, Christian K. Tamnes

{"title":"Neuroimaging insights into adolescent depression risk and development","authors":"Niamh MacSweeney, Yara J. Toenders, Christian K. Tamnes","doi":"10.1038/s44220-025-00453-z","DOIUrl":"10.1038/s44220-025-00453-z","url":null,"abstract":"Adolescence is a period of increased risk for the onset of depression. However, the neurobiological mechanisms underlying this vulnerability remain poorly understood despite substantial investment and efforts in this research area. In this Perspective, we review existing literature on the links between the adolescent brain and depression risk and development, and discuss methodological and conceptual challenges related to quantifying brain features and measuring depression. We highlight the importance of considering both large-scale longitudinal cohort studies and smaller focused investigator-led studies with deep phenotyping to advance our understanding of the neural basis of depression in adolescence. Emphasizing the need to embrace the developmental context and refine our methodologies, we propose several considerations to help current and future researchers advance our understanding of how the developing brain influences depression risk in today’s youth. Adolescence marks a critical period for the onset of depression, yet the neurobiological mechanisms remain unclear. Here the authors review literature linking adolescent brain development to depression risk, emphasizing the need for both large-scale and focused studies to refine methodologies and enhance understanding of neural influences on youth depression.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 7","pages":"772-779"},"PeriodicalIF":8.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Partner status and partner mental health and the risk of postpartum depression 伴侣状况、伴侣心理健康和产后抑郁症的风险

IF 8.7

Nature mental health Pub Date : 2025-07-01 DOI: 10.1038/s44220-025-00461-z

Mette-Marie Zacher Kjeldsen, Xiaoqin Liu, Kathrine Bang Madsen, Anja Friis Elliott, Simon Zacher Kjeldsen, Merete Lund Mægbæk, Veerle Bergink, Vibe G. Frokjaer, Trine Munk-Olsen

{"title":"Partner status and partner mental health and the risk of postpartum depression","authors":"Mette-Marie Zacher Kjeldsen, Xiaoqin Liu, Kathrine Bang Madsen, Anja Friis Elliott, Simon Zacher Kjeldsen, Merete Lund Mægbæk, Veerle Bergink, Vibe G. Frokjaer, Trine Munk-Olsen","doi":"10.1038/s44220-025-00461-z","DOIUrl":"10.1038/s44220-025-00461-z","url":null,"abstract":"Although the association between partner status and postpartum depression (PPD) is well studied, less is known about how a partner’s psychiatric history affects PPD risk in partnered mothers. Here, using maternal PPD screenings merged with Danish registers from 149,383 childbirths, we examined the influence of partner status and partner mental health on PPD risk. Exposures were partner status and partner psychiatric history, and outcomes were PPD (positive screening) and severe PPD (antidepressants or diagnosis). In total, 14.7% were unpartnered mothers, with a higher risk of PPD (absolute risk (AR) 8.9% versus 7.0%; relative risk (RR) 1.11 (95% confidence interval (CI) 1.05–1.16)) and severe PPD (AR 1.1% versus 0.9%; RR 0.99 (95% CI 0.86–1.14)) compared with partnered mothers. Among partnered mothers, 19.7% had partners with psychiatric history. Recent psychiatric history increased the risk of PPD (AR 8.3%; RR 1.10 (95% CI 1.02–1.18)) and severe PPD (AR 1.5%; RR 1.42 (95% CI 1.18–1.69)), compared with no psychiatric history. We show that unpartnered mothers face a slightly increased PPD risk, while recent partner psychiatric episodes markedly increase risk in partnered mothers. In this study, Zacher Kjeldsen and colleagues examine the role of partner mental health in maternal postpartum depression risk.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 7","pages":"814-820"},"PeriodicalIF":8.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The promise and challenges of psychedelic-assisted therapy: lessons from Canada’s Special Access Program 迷幻药辅助治疗的前景与挑战：来自加拿大特殊准入计划的经验教训

IF 8.7

Nature mental health Pub Date : 2025-06-27 DOI: 10.1038/s44220-025-00446-y

Nicolas Garel, Louis Plourde, Kyle T. Greenway, Michel Dorval

引用次数: 0