Nature mental health最新文献

{"title":"An analysis on the role of glucagon-like peptide-1 receptor agonists in cognitive and mental health disorders","authors":"Riccardo De Giorgi, Ana Ghenciulescu, Oliwia Dziwisz, Maxime Taquet, Amanda I. Adler, Ivan Koychev, Rachel Upthegrove, Marco Solmi, Robert McCutcheon, Toby Pillinger, Philip J. Cowen, Catherine J. Harmer","doi":"10.1038/s44220-025-00390-x","DOIUrl":"10.1038/s44220-025-00390-x","url":null,"abstract":"Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are novel drugs approved for diabetes and obesity. They are acknowledged as a major scientific breakthrough. In addition to their metabolic effects, these medications act on other bodily systems involved in the physiopathology of various neurological and psychiatric disorders. Several stakeholders are calling for more research to investigate the repurposing potential of GLP-1RAs in cognitive and mental disorders, while others advocate for a better assessment of their safety profile from a neuropsychiatric perspective. In this Analysis, we searched for relevant literature on the effects of GLP-1RAs across a range of illnesses, gathering and describing the available pre-clinical and mechanistic (278 studies) and clinical (96 studies) evidence for cognitive disorders, substance-use disorders, psychotic disorders, mood and anxiety disorders, eating disorders, and others. By leveraging translational insights from these data, we consider potential implications for clinical practice and propose avenues for further research. De Giorgi and colleagues present a comprehensive analysis of pre-clinical and clinical studies examining the role of glucagon-like peptide-1 receptor agonists in mental disorders.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 3","pages":"354-373"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-025-00390-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wellbeing: more than being well","authors":"","doi":"10.1038/s44220-025-00392-9","DOIUrl":"10.1038/s44220-025-00392-9","url":null,"abstract":"Alongside mental health, the term wellbeing is often included to describe influences that bear on a person’s quality of life, such as social or economic factors, or to a person’s subjective assessment of satisfaction or fulfillment. Competing concepts have proliferated, providing an important area in which increased clarity may help refine mental health research that includes wellbeing.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 2","pages":"159-159"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-025-00392-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing well-being in clinical research and treatment","authors":"Fallon R. Goodman","doi":"10.1038/s44220-024-00381-4","DOIUrl":"10.1038/s44220-024-00381-4","url":null,"abstract":"People with higher well-being fare better on important life outcomes from financial stability to mortality risk. Enhancing well-being is important to patients and clinicians, and changes in well-being during and after a treatment may indicate meaningful improvement. Despite strong incentives for well-being measurement, well-being remains understudied in scientific literature on the course and treatment of psychopathology. To catalyze new inquiry, this Perspective illustrates ways that assessing well-being can enhance observational and treatment studies of psychopathology and provides recommendations to address measurement challenges that researchers face when targeting well-being. This Perspective equips researchers to test critical questions concerning resilience and recovery, optimize clinical interventions and enhance population mental health. This Perspective discusses methodological and theoretical challenges for measuring well-being in clinical research and the importance of including well-being measures in clinical studies.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 2","pages":"167-174"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic divergence between individuals with self-reported autistic traits and clinically ascertained autism","authors":"Sarah M. Banker, Miles Harrington, Matthew Schafer, Soojung Na, Matthew Heflin, Sarah Barkley, Jadyn Trayvick, Arabella W. Peters, Abigaël A. Thinakaran, Daniela Schiller, Jennifer H. Foss-Feig, Xiaosi Gu","doi":"10.1038/s44220-025-00385-8","DOIUrl":"10.1038/s44220-025-00385-8","url":null,"abstract":"While allowing for rapid recruitment of large samples, online research relies heavily on participants’ self-reports of neuropsychiatric traits, foregoing the clinical characterizations available in laboratory settings. Autism spectrum disorder (ASD) research is one example for which the clinical validity of such an approach remains elusive. Here we compared 56 adults with ASD recruited in person and evaluated by clinicians to matched samples of adults recruited through an online platform (Prolific; 56 with high autistic traits and 56 with low autistic traits) and evaluated via self-reported surveys. Despite having comparable self-reported autistic traits, the online high-trait group reported significantly more social anxiety and avoidant symptoms than in-person ASD participants. Within the in-person sample, there was no relationship between self-rated and clinician-rated autistic traits, suggesting they may capture different aspects of ASD. The groups also differed in their social tendencies during two decision-making tasks; the in-person ASD group was less perceptive of opportunities for social influence and acted less affiliative toward virtual characters. These findings highlight the need for a differentiation between clinically ascertained and trait-defined samples in autism research. Comparing clinically diagnosed adults with autism spectrum disorder (ASD) with online participants with self-reported high autistic traits, this study detected higher rates of social anxiety and avoidance symptoms in online participants, emphasizing the potential distinctions between clinically ascertained autism and self-reported trait-based samples.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 3","pages":"286-297"},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-025-00385-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of maternal blood biomarkers of prenatal APAP exposure with placental gene expression and child attention deficit hyperactivity disorder","authors":"Brennan H. Baker, Theo K. Bammler, Emily S. Barrett, Nicole R. Bush, Brent R. Collett, Karen J. Derefinko, Daniel A. Enquobahrie, Catherine J. Karr, Kaja Z. LeWinn, Jiawang Liu, Christine T. Loftus, James W. MacDonald, Shanna H. Swan, Qi Zhao, Alison G. Paquette, Sheela Sathyanarayana","doi":"10.1038/s44220-025-00387-6","DOIUrl":"10.1038/s44220-025-00387-6","url":null,"abstract":"Despite evidence linking prenatal acetaminophen (APAP) exposure and adverse neurodevelopment in humans and animals, over half of pregnant women in most populations use APAP. Prior studies could be biased by inaccurate self-reported APAP use, and the molecular mechanisms linking prenatal APAP with adverse neurodevelopment are unknown. Here we estimated associations between maternal plasma biomarkers of APAP exposure, child attention deficit hyperactivity disorder (ADHD) and placental gene expression in 307 African American mother–child pairs. Overall, detection of APAP in second trimester plasma was associated with higher odds for child ADHD diagnosis (odds ratio of 3.15 (95% confidence interval 1.20 to 8.29)). Prenatal APAP exposure and ADHD were associated with placental upregulation of immune system pathways in females and downregulation of oxidative phosphorylation in both sexes. In females only, prenatal APAP was associated with 5.22% higher odds (0.0456–13.1%) of ADHD statistically, mediated through increased immunoglobulin heavy constant gamma 1 (IGHG1) expression. These results highlight placental molecular mechanisms that may underlie developmental toxicity of prenatal APAP exposure. In this study, the authors report that maternal plasma biomarkers of acetaminophen exposure during pregnancy were associated with an increased risk of a diagnosis of child attention deficit hyperactivity disorder. The findings suggest that acetaminophen exposure impacts immune pathways and oxidative phosphorylation, potentially mediating neurodevelopmental risks.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 3","pages":"318-331"},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ethical imperative of self-directed tools in crisis helplines to prevent suicide at scale","authors":"Jonah Meyerhoff, Daniel D. L. Coppersmith, Kathryn R. Fox","doi":"10.1038/s44220-025-00384-9","DOIUrl":"10.1038/s44220-025-00384-9","url":null,"abstract":"Using the US National Suicide and Crisis Lifeline as a case example, we discuss the tacit requirement that users of helplines disclose suicide-related thoughts and behaviors as a central barrier to suicide prevention interventions. This Comment outlines the need for self-guided digital suicide prevention interventions within helpline infrastructure.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 3","pages":"269-270"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why loneliness requires a multidimensional approach: a critical narrative review","authors":"Brendan E. Walsh, Jonathan Rottenberg, Robert C. Schlauch","doi":"10.1038/s44220-024-00382-3","DOIUrl":"10.1038/s44220-024-00382-3","url":null,"abstract":"An immense corpus of work documents deleterious effects of loneliness on physical health, cognition, psychological symptoms, and wellbeing. In this Review, we argue that the widespread assumption that loneliness is unidimensional may lead to imprecise interpretations of findings and hamper intervention efforts. We critically revisit a longstanding multidimensional loneliness framework that posits two distinct dimensions: emotional loneliness (perceived lack of intimate connections) and social loneliness (perceived deficits in social networks). We demonstrate how distinguishing loneliness dimensions may provide a clearer picture of the nature of loneliness and its correlates, risk factors and consequences. For instance, emotional loneliness appears to be a more severe typology that overlaps greatly with pathology, whereas social loneliness is more reflective of deficits in social connectedness and social support. We additionally evaluate the utility of this multidimensional framework in the domains of clinical practice and public health and provide suggestions to stimulate further research. This Review discusses the multidimensional conceptualization of loneliness and the utility of this framework for clinical practice and public health.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 2","pages":"175-184"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recovering wellbeing from the diseases of despair: integrating neuroscience, evidence-based practice and policy to heal the opioid crisis","authors":"Eric L. Garland","doi":"10.1038/s44220-024-00378-z","DOIUrl":"10.1038/s44220-024-00378-z","url":null,"abstract":"Developing a robust approach to mitigating the current opioid crisis in the USA will require translating novel evidence-based, neuroscience-informed treatments into clinical care and public policy.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 2","pages":"162-163"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain dynamics reflecting an intra-network brain state are associated with increased post-traumatic stress symptoms in the early aftermath of trauma","authors":"Mohammad S. E. Sendi, Zening Fu, Nathaniel G. Harnett, Sanne J. H. van Rooij, Victor Vergara, Diego A. Pizzagalli, Nikolaos P. Daskalakis, Stacey L. House, Francesca L. Beaudoin, Xinming An, Thomas C. Neylan, Gari D. Clifford, Tanja Jovanovic, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul I. Musey Jr., Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Robert A. Swor, Nina T. Gentile, Vishnu P. Murty, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Erica Harris, Anna M. Chang, Claire Pearson, David A. Peak, Roland C. Merchant, Robert M. Domeier, Niels K. Rathlev, Brian J. O’Neil, Paulina Sergot, Leon D. Sanchez, Steven E. Bruce, John F. Sheridan, Steven E. Harte, Ronald C. Kessler, Karestan C. Koenen, Samuel A. McLean, Jennifer S. Stevens, Vince D. Calhoun, Kerry J. Ressler","doi":"10.1038/s44220-024-00377-0","DOIUrl":"10.1038/s44220-024-00377-0","url":null,"abstract":"Post-traumatic stress (PTS) encompasses a range of psychological responses following trauma, which may lead to more severe outcomes such as post-traumatic-stress disorder (PTSD). Identifying early neuroimaging biomarkers that link brain function to PTS outcomes is critical for understanding PTSD risk. This longitudinal study examines the association between brain dynamic functional network connectivity and current/future PTS symptom severity, and the impact of sex on this relationship. By analyzing 275 participants’ dynamic functional network connectivity data obtained ~2 weeks after trauma exposure, we noted that brain dynamics of an inter-network brain state link negatively with current (r = −0.197, Pcorrected = 0.0079) and future (r = –0.176, Pcorrected = 0.0176) PTS symptom severity. In addition, dynamics of an intra-network brain state correlated with future symptom intensity (r = 0.205, Pcorrected = 0.0079). We additionally observed that the association between the network dynamics of the inter-network and intra-network brain state with symptom severity is more pronounced in the female group. Our findings highlight a potential link between brain network dynamics in the aftermath of trauma with current and future PTSD outcomes, with a stronger effect in the female group, underscoring the importance of sex differences. This multisite study detects a link between brain dynamic functional network connectivity and current and future post-traumatic stress symptom severity with a stronger effect in the female group.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 2","pages":"185-198"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression symptom-specific genetic associations in clinically diagnosed and proxy case Alzheimer’s disease","authors":"Lachlan Gilchrist, Thomas P. Spargo, Rebecca E. Green, Jonathan R. I. Coleman, David M. Howard, Jackson G. Thorp, Brett N. Adey, Jodie Lord, Helena L. Davies, Jessica Mundy, Abigail R. ter Kuile, Molly R. Davies, Christopher Hübel, Shannon Bristow, Sang Hyuck Lee, Henry Rogers, Charles Curtis, Saakshi Kakar, Chelsea M. Malouf, Gursharan Kalsi, Ryan Arathimos, Anne Corbett, Clive Ballard, Helen Brooker, Byron Creese, Dag Aarsland, Adam Hampshire, Latha Velayudhan, Thalia C. Eley, Gerome Breen, Alfredo Iacoangeli, Sulev Kõks, Cathryn M. Lewis, Petroula Proitsi","doi":"10.1038/s44220-024-00369-0","DOIUrl":"10.1038/s44220-024-00369-0","url":null,"abstract":"Depression is a risk factor for the later development of Alzheimer’s disease (AD), but evidence for the genetic relationship is mixed. Assessing depression symptom-specific genetic associations may better clarify this relationship. To address this, we conducted genome-wide meta-analysis (a genome-wide association study, GWAS) of the nine depression symptom items, plus their sum score, on the Patient Health Questionnaire (PHQ-9) (GWAS-equivalent N: 224,535–308,421) using data from UK Biobank, the GLAD study and PROTECT, identifying 37 genomic risk loci. Using six AD GWASs with varying proportions of clinical and proxy (family history) case ascertainment, we identified 20 significant genetic correlations with depression/depression symptoms. However, only one of these was identified with a clinical AD GWAS. Local genetic correlations were detected in 14 regions. No statistical colocalization was identified in these regions. However, the region of the transmembrane protein 106B gene (TMEM106B) showed colocalization between multiple depression phenotypes and both clinical-only and clinical + proxy AD. Mendelian randomization and polygenic risk score analyses did not yield significant results after multiple testing correction in either direction. Our findings do not demonstrate a causal role of depression/depression symptoms on AD and suggest that previous evidence of genetic overlap between depression and AD may be driven by the inclusion of family history-based proxy cases/controls. However, colocalization at TMEM106B warrants further investigation. Using genome-wide meta-analyses of clinical measures of depression and biobank data, the authors investigate symptom-specific genetic associations between depression and subsequent risk for Alzheimer’s disease, finding an absence of a putative genetic overlap between disorders.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 2","pages":"212-228"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-024-00369-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}