Nature mental health最新文献

{"title":"The stomach’s turn: elucidating the gut–brain axis","authors":"","doi":"10.1038/s44220-025-00489-1","DOIUrl":"10.1038/s44220-025-00489-1","url":null,"abstract":"Philosophers and scientists have debated for centuries about how cognition and emotions are produced and the causal roles the body and brain serve. The advent of more sophisticated models of gut–brain axis communication have contributed substantially to the understanding of these key pathways and have identified functional differences associated with depression and anxiety. New work highlights the potential importance of stomach–brain coupling in interpreting interoceptive states in mental health conditions.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 8","pages":"853-854"},"PeriodicalIF":8.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44220-025-00489-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional enhancement of memory in Alzheimer’s disease dementia: a systematic review","authors":"Arunima Kapoor, Mara Mather, Daniel A. Nation","doi":"10.1038/s44220-025-00470-y","DOIUrl":"10.1038/s44220-025-00470-y","url":null,"abstract":"Progressive decline in episodic memory is a hallmark of Alzheimer’s disease (AD). Emotional arousal is known to enhance memory. Enhanced encoding of emotionally arousing stimuli or events may improve memory in patients with AD; however, whether this effect is present in patients with AD remains unclear. Here we conducted a systematic search of the literature to identify relevant literature on emotional enhancement of memory in AD. Inclusion criteria were studies that (1) included individuals with Alzheimer’s disease and (2) assessed emotional memory, particularly episodic memory. Thirty-five studies were included. Twelve out of 35 studies (34.3%) showed clear emotional enhancement of memory for episodic memory among participants with mild AD, while 13 studies (37.1%) found no effect. Ten studies (28.6%) found that emotional enhancement of memory was influenced by stimuli type, valence of emotion, level of encoding or intensity of emotion. Studies including brain imaging showed that amygdala and hippocampus volume are strong predictors of emotional enhancement of memory in AD, regardless of level of cognitive impairment. Evaluating volumes or networks of brain regions known to be involved in emotional memory processing may be a key factor influencing the preservation of enhanced encoding of emotional information. Future studies are needed to confirm whether atrophy of memory-related brain regions diminishes emotional enhancement of memory in AD. Alzheimer’s disease (AD) is characterized by a decline in episodic memory, yet the potential for emotional arousal to enhance memory in patients with AD remains uncertain. Here the authors systematically review 35 studies, revealing that emotional enhancement of memory in AD is influenced by factors such as stimulus type and brain region volumes, suggesting potential therapeutic targets.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 9","pages":"1078-1087"},"PeriodicalIF":8.7,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical implementation of pre-emptive pharmacogenomics in patients with anxiety disorders","authors":"Maria-Theodora Pandi, Μaria Skokou, Margarita-Ioanna Koufaki, Kariofyllis Karamperis, Federico Melograna, Christina Mitropoulou, George P. Patrinos","doi":"10.1038/s44220-025-00466-8","DOIUrl":"10.1038/s44220-025-00466-8","url":null,"abstract":"Anxiety disorder is a typically chronic psychiatric condition with relapsing phases, affecting millions of individuals globally. Medication and psychotherapy are the primary interventions that can alleviate the symptoms in the short term. However, considerable interindividual variability in drug treatment response is observed, which can be attributed to genetic factors, mainly related to CYP2D6 and CYP2C19 genetic variants affecting antidepressant pharmacokinetics. Here we present our findings from the first and largest prospective clinical study focusing exclusively on outpatient adult anxiety patients, following the ICD-10 definitions. Our data indicate a lower incidence of psychiatric adverse drug reactions in the pharmacogenomics (PGx)-guided arm compared with the control arm. Furthermore, no hospitalizations were reported for the PGx-guided arm, unlike the control arm. In addition, participants in the control arm received more concomitant medications in total compared with the PGx-guided arm (P = 0.047). Our findings demonstrate that genome-guided therapeutics may substantially benefit anxiety patients and should be considered in routine clinical practice. In this study, Pandi and colleagues analyze the relevance of pharmacogenomic testing in the occurrence of adverse drug reactions in patients with a diagnosis of anxiety disorders from the PREPARE study.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 8","pages":"909-917"},"PeriodicalIF":8.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing youth co-design of ethical guidelines for AI-powered digital mental health tools","authors":"C. A. Figueroa, G. Ramos, A. M. Psihogios, E. Ekuban, P. Bansie, M. de Haas, N. S. Karnik, O. Ajilore, E. E. Anderson, C. Stiles-Shields","doi":"10.1038/s44220-025-00467-7","DOIUrl":"10.1038/s44220-025-00467-7","url":null,"abstract":"Adolescents and young adults (AYA) often face mental health challenges and are heavily influenced by technology. Digital health interventions (DHIs), leveraging smartphone data and artificial intelligence, offer immense potential for personalized and accessible mental health support. However, ethical guidelines for DHI research fail to address AYA’s unique developmental and technological needs and leave crucial ethical questions unanswered. This gap creates risks of either over- or under-protecting AYA in DHI research, slowing progress and causing harm. This Perspective examines ethical gaps in DHI research for AYA, focusing on three critical domains: challenges of passive data collection and artificial intelligence, consent practices, and risks of exacerbating inequities. We propose an agenda for ethical guidance based on bioethical principles autonomy, respect for persons, beneficence and justice, developed through participatory research with AYA, particularly marginalized groups. We discuss methodologies to achieve this agenda, ensuring ethical, youth-focused and equitable DHI research for the mental health of AYA. Adolescents and young adults face unique ethical challenges in digital health interventions due to their developmental and technological needs. Here the authors identify critical ethical gaps in digital health interventions research for this population and emphasize the need to co-design ethical guidelines with youth, particularly those from marginalized backgrounds, rooted in core principles, such as autonomy, beneficence and justice.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 8","pages":"870-878"},"PeriodicalIF":8.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Blunted stress reactivity as a mechanism linking early psychosocial deprivation to psychopathology during adolescence","authors":"Mark Wade, Margaret A. Sheridan, Stacy S. Drury, Florin Tibu, Charles H. Zeanah, Nathan A. Fox, Charles A. Nelson, Katie A. McLaughlin","doi":"10.1038/s44220-025-00473-9","DOIUrl":"10.1038/s44220-025-00473-9","url":null,"abstract":"","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 9","pages":"1100-1100"},"PeriodicalIF":8.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44220-025-00473-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stomach–brain coupling indexes a dimensional signature of mental health","authors":"Leah Banellis, Ignacio Rebollo, Niia Nikolova, Micah Allen","doi":"10.1038/s44220-025-00468-6","DOIUrl":"10.1038/s44220-025-00468-6","url":null,"abstract":"Visceral rhythms orchestrate the physiological states underlying human emotion. Chronic aberrations in these brain–body interactions are implicated in a broad spectrum of mental health disorders. However, the relationship between gastric–brain coupling and affective symptoms remains poorly understood. Here we investigated the relationship between this novel interoceptive axis and mental health in 243 participants, using a cross-validated machine learning approach. We find that increased frontoparietal brain coupling to the gastric rhythm indexes a dimensional signature of poorer mental health, spanning anxiety, depression, stress and well-being. Control analyses confirm the specificity of these interactions to the gastric–brain axis. Our study proposes coupling between the stomach and brain as a factor in mental health and offers potential new targets for interventions remediating aberrant brain–body coupling. Using a relatively large and diverse sample of mostly young adults, this study by Banellis, Rebollo and colleagues examines associations between regional stomach–brain coupling and mental health and identifies brain–body dynamics as a potential target for intervention.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 8","pages":"899-908"},"PeriodicalIF":8.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeled estimates of the health outcomes and economic value of improving the social determinants of mental health","authors":"Paul Crosland, Nicholas Ho, Kim-Huong Nguyen, Kristen Tran, Seyed Hossein Hosseini, Catherine Vacher, Adam Skinner, Jordan van Rosmalen, Sebastian Rosenberg, Frank Iorfino, Victoria Loblay, Olivia Iannelli, Sarah Piper, Yun Ju Christine Song, Sophie Morson, Judith M. G. Piccone, Adam Connell, Deborah A. Marshall, Ian B. Hickie, Jo-An Occhipinti","doi":"10.1038/s44220-025-00459-7","DOIUrl":"10.1038/s44220-025-00459-7","url":null,"abstract":"The prevalence and burden of mental disorders have worsened despite increased community awareness. Enhanced access to treatments alone is unlikely to deliver improvements in population mental health, so more attention needs to be paid to social and environmental influences. Here we estimate the health benefits and economic value of improving the social determinants of mental health within Brisbane South, a diverse population of 1.2 million people, in Australia. The incremental net monetary benefit (combining costs and monetized health outcomes) derived from 5% improvements in the average yearly change of social cohesion, childhood difficulties, substance misuse and unemployment over 11 years from 2024 to 2034 was projected to be AUD$146.64 million, AUD$234.50 million, AUD$281.67 million and AUD$100.43 million, respectively. Quality-adjusted life years, suicide deaths, emergency department presentations and self-harm hospitalizations were also improved. This study demonstrates the health and economic value of investing in the social determinants of mental health. This Analysis estimates the health benefits and economic value of enhancing social determinants of mental health in Brisbane South, Australia, home to 1.2 million people. Crosland et al. analyze the impact of a 5% improvement in social cohesion, childhood difficulties, substance misuse, unemployment, underemployment, homelessness and staying engaged with education over 11 years.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 8","pages":"943-956"},"PeriodicalIF":8.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44220-025-00459-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnesium–ibogaine therapy effects on cortical oscillations and neural complexity in veterans with traumatic brain injury","authors":"Jennifer I. Lissemore, Anna Chaiken, Kirsten N. Cherian, Derrick Buchanan, Flint Espil, Jackob N. Keynan, Malvika Sridhar, Camarin E. Rolle, Manish Saggar, Corey J. Keller, Nolan R. Williams","doi":"10.1038/s44220-025-00463-x","DOIUrl":"10.1038/s44220-025-00463-x","url":null,"abstract":"Traumatic brain injury can lead to chronic psychiatric and cognitive symptoms, coupled with changes to the nature of cortical oscillations and neural complexity. Treatment with magnesium–ibogaine was recently found to improve the sequelae of traumatic brain injury, yet the effects of ibogaine on human cortical oscillations and complexity are unknown. Resting-state electroencephalography was performed prospectively before, 3.5 days after and 1 month after magnesium–ibogaine therapy in an observational, open-label study of 30 combat veterans. We assessed the effects of ibogaine on cortical oscillations and complexity and how these neurophysiological effects relate to psychiatric and cognitive outcomes of ibogaine treatment. After treatment, slower oscillations (theta–alpha) increased in power, and power at higher frequencies (beta–gamma) decreased. Accordingly, the theta/beta ratio increased post-treatment, which correlated with improved cognitive inhibition. Peak alpha frequency and neural complexity were lower after treatment, which persisted at 1-month follow-up. These neurophysiological markers correlated with improved executive function, post-traumatic stress disorder and anxiety after ibogaine. Altogether, these findings suggest reduced spatiotemporal complexity of brain activity and ‘slowing’ of cortical oscillations in the brain at rest after magnesium–ibogaine therapy, which may relate to psychiatric and cognitive improvements after ibogaine, thus providing key insight into the effects of ibogaine on brain function in humans. Follow-up controlled clinical trials are needed to confirm the findings from this initial single-arm trial. A single treatment with magnesium–ibogaine results in enhanced power of cortical theta and alpha oscillations, reduced beta and gamma power and reduced neural complexity in veterans with traumatic brain injury.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 8","pages":"918-931"},"PeriodicalIF":8.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial electrophysiological biomarkers of compulsivity in obsessive–compulsive disorder","authors":"Tara Arbab, Melisse N. Bais, Martijn Figee, Isidoor O. Bergfeld, P. Richard Schuurman, Pepijn van den Munckhof, Ingo Willuhn, Damiaan Denys","doi":"10.1038/s44220-025-00457-9","DOIUrl":"10.1038/s44220-025-00457-9","url":null,"abstract":"There is an emerging need for objective neural biomarkers of obsessive–compulsive disorder (OCD) to improve the efficacy of neuromodulatory interventions, most notably deep-brain stimulation (DBS), and develop closed-loop stimulation paradigms. Preliminary data suggest that such biomarkers may be derived from local field potentials (LFPs) recorded in individual patients implanted with sensing DBS devices. However, reliable LFP signatures that are generalizable across OCD patients have yet to be identified. Here, we relate LFPs recorded from sensing DBS electrodes in different basal-ganglia structures to core symptoms of OCD in 11 patients during personalized provocation of obsessions and compulsions. We identify two general markers of compulsion: delta and alpha LFP power was significantly increased during all compulsions in the external globus pallidus (GPe), nucleus accumbens, anterior limb of the internal capsule (ALIC) and anterior lateral anterior commissure. In mental compulsion subtypes, similar low-frequency increases were observed only in GPe (delta/alpha) and ALIC (alpha), suggesting that these signals possibly reflect more universal biomarkers of compulsivity unconfounded by motor function. GPe delta power correlated with OCD symptom severity, establishing a meaningful connection between subcortical sensing DBS readout and patient experience. ALIC alpha power was modulated by the phase of theta oscillations during compulsions, possibly reflecting pathological coupling of cortical networks in OCD. Our results demonstrate unique, group-level LFP correlates of core OCD symptoms across disease-relevant basal-ganglia structures. These electrophysiological signatures help pave the way toward the development of biomarker-targeted neuromodulatory intervention for OCD. Netherlands Trial Register ID: NL7486 . This research identifies local field potential markers associated with obsessive–compulsive disorder symptoms in patients during provocation. Key findings reveal increased delta and alpha power in specific brain regions, correlating with symptom severity and suggesting potential biomarkers for targeted interventions.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 8","pages":"889-898"},"PeriodicalIF":8.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44220-025-00457-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of computational modeling of interpersonal dynamics in psychopathology","authors":"Orestis Zavlis, Giles Story, Claire Friedrich, Peter Fonagy, Michael Moutoussis","doi":"10.1038/s44220-025-00465-9","DOIUrl":"10.1038/s44220-025-00465-9","url":null,"abstract":"Interpersonal dynamics have long been acknowledged as critical for the development and treatment of mental health problems. While recent computational approaches have been argued to be uniquely suited for investigating such dynamics, no systematic assessment has been made to scrutinize this claim. Here we conduct a systematic review to assess the utility of computational modeling in the field of interpersonal psychopathology. Candidate studies (k = 4,208), including preprints and conference manuscripts, were derived from five databases (MEDLINE, Embase, PsycINFO, Web of Science and Google Scholar) up to May 2025. A total of 58 studies met inclusion criteria and were assessed in terms of the validity, performance and transparency of their computational modeling. Bayesian modeling was the most common approach (k = 18), followed by machine learning (k = 17), dynamical systems modeling (k = 13) and reinforcement learning (k = 10). These approaches revealed several interpersonal disruptions across various mental health conditions, including rigid social learning in mood conditions, hypo- versus hyper-mentalizing in autism versus psychotic conditions and polarized relational dynamics in personality conditions. Despite these insights, critical challenges persist, with few studies reporting comprehensive performance metrics (16%) or adopting open science practices (20%). We discuss these challenges and conclude with more optimistic messages by suggesting that when rigorously and transparently conducted, computational approaches have the potential to advance our understanding of psychopathology by highlighting the social underpinnings of both mental health and disorder. This systematic review provides insights into interpersonal dynamics of psychopathology when using various computational approaches and highlights the key challenges in the field of social computational psychiatry, including the need to standardize computational tasks, apply diverse computational models to the same datasets, report more comprehensive performance metrics and adopt open science practices to enhance transparency.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 8","pages":"932-942"},"PeriodicalIF":8.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44220-025-00465-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}