Nature mental health最新文献_第10页

Opioid-induced neuroanatomical, microglial and behavioral changes are blocked by suvorexant without diminishing opioid analgesia 舒伐沙坦可阻断阿片类药物诱导的神经解剖学、小胶质细胞和行为变化，但不会降低阿片类药物的镇痛效果

Nature mental health Pub Date : 2024-07-09 DOI: 10.1038/s44220-024-00278-2

Ronald McGregor, Ming-Fung Wu, Thomas C. Thannickal, Songlin Li, Jerome M. Siegel

{"title":"Opioid-induced neuroanatomical, microglial and behavioral changes are blocked by suvorexant without diminishing opioid analgesia","authors":"Ronald McGregor, Ming-Fung Wu, Thomas C. Thannickal, Songlin Li, Jerome M. Siegel","doi":"10.1038/s44220-024-00278-2","DOIUrl":"10.1038/s44220-024-00278-2","url":null,"abstract":"Heroin use disorder in humans and chronic opioid administration to mice result in an increase in the number and a decrease in the size of detected hypocretin (Hcrt, or orexin) neurons. Chronic morphine administration to mice increases Hcrt axonal projections to the ventral tegmental area (VTA), the level of tyrosine hydroxylase (TH) in VTA and the number of detected TH+ cells in VTA, and activates VTA and hypothalamic microglia. Co-administration of morphine with the dual Hcrt receptor antagonist suvorexant prevents morphine-induced changes in the number and size of Hcrt neurons, the increase in Hcrt projections to the VTA and microglial activation in the VTA and hypothalamus. Co-administration of suvorexant with morphine also prevents morphine anticipatory behavior and reduces opioid withdrawal symptoms. However, suvorexant does not diminish morphine analgesia. Here we show that combined administration of opioids and suvorexant may reduce the addiction potential of opioid use for pain relief in humans while maintaining the analgesic effects of opioids. The authors demonstrate that, in a mouse model of heroin use disorder, co-administration of morphine and suvorexant prevented both morphine-induced anatomical changes in hypocretin neurons and morphine anticipation and reduced morphine withdrawal behavior but spared analgesia, suggesting applications for reducing opioid addiction potential in humans.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 9","pages":"1018-1031"},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141664442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Publisher Correction: Characterizing the phenotypic and genetic structure of psychopathology in UK Biobank 出版商更正：英国生物数据库中精神病理学的表型和遗传结构特征

Nature mental health Pub Date : 2024-07-09 DOI: 10.1038/s44220-024-00293-3

Camille M. Williams, Hugo Peyre, Tobias Wolfram, Younga H. Lee, Jakob Seidlitz, Tian Ge, Jordan W. Smoller, Travis T. Mallard, Franck Ramus

引用次数: 0

A cognitive neural circuit biotype of depression showing functional and behavioral improvement after transcranial magnetic stimulation in the B-SMART-fMRI trial 在 B-SMART-fMRI 试验中，经颅磁刺激后抑郁症认知神经回路生物型的功能和行为得到改善

Nature mental health Pub Date : 2024-07-05 DOI: 10.1038/s44220-024-00271-9

Leonardo Tozzi, Claire Bertrand, Laura Michele Hack, Timothy Lyons, Alisa Marie Olmsted, Divya Rajasekharan, TeChieh Chen, Yosef A. Berlow, Jerome A. Yesavage, Kelvin Lim, Michelle R. Madore, Noah S. Philip, Paul Holtzheimer, Leanne Maree Williams

{"title":"A cognitive neural circuit biotype of depression showing functional and behavioral improvement after transcranial magnetic stimulation in the B-SMART-fMRI trial","authors":"Leonardo Tozzi, Claire Bertrand, Laura Michele Hack, Timothy Lyons, Alisa Marie Olmsted, Divya Rajasekharan, TeChieh Chen, Yosef A. Berlow, Jerome A. Yesavage, Kelvin Lim, Michelle R. Madore, Noah S. Philip, Paul Holtzheimer, Leanne Maree Williams","doi":"10.1038/s44220-024-00271-9","DOIUrl":"10.1038/s44220-024-00271-9","url":null,"abstract":"We previously identified a cognitive biotype of depression characterized by treatment resistance, impaired cognitive control behavioral performance and dysfunction in the cognitive control circuit, comprising the dorsolateral prefrontal cortex (dLPFC) and dorsal anterior cingulate cortex (dACC). Therapeutic transcranial magnetic stimulation (TMS) to the left dLPFC is a promising option for individuals whose depression does not respond to pharmacotherapy. Here, 43 veterans with treatment-resistant depression were assessed before TMS, after early TMS and post-TMS using functional magnetic resonance imaging during a Go–NoGo paradigm, behavioral cognitive control tests and symptom questionnaires. Stratifying veterans at baseline based on task-evoked dLPFC–dACC connectivity, we demonstrate that TMS-related improvement in cognitive control circuit connectivity and behavioral performance is specific to individuals with reduced connectivity at baseline (cognitive biotype +), whereas individuals with intact connectivity at baseline (cognitive biotype −) did not demonstrate significant changes. Our findings show that dLPFC–dACC connectivity during cognitive control is both a promising diagnostic biomarker for a cognitive biotype of depression and a response biomarker for cognitive improvement after TMS applied to the dLPFC. The authors investigate functional connectivity before and after transcranial magnetic stimulation in veterans with treatment-resistant depression stratified by cognitive biotype, demonstrating associated brain connectivity-mediated improvement in cognitive behavioral task performance.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 8","pages":"987-998"},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-024-00271-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal cannabis exposure, the brain, and psychopathology during early adolescence 产前接触大麻、大脑和青春期早期的精神病理学

Nature mental health Pub Date : 2024-07-04 DOI: 10.1038/s44220-024-00281-7

David A. A. Baranger, Alex P. Miller, Aaron J. Gorelik, Sarah E. Paul, Alexander S. Hatoum, Emma C. Johnson, Sarah M. C. Colbert, Christopher D. Smyser, Cynthia E. Rogers, Janine D. Bijsterbosch, Arpana Agrawal, Ryan Bogdan

{"title":"Prenatal cannabis exposure, the brain, and psychopathology during early adolescence","authors":"David A. A. Baranger, Alex P. Miller, Aaron J. Gorelik, Sarah E. Paul, Alexander S. Hatoum, Emma C. Johnson, Sarah M. C. Colbert, Christopher D. Smyser, Cynthia E. Rogers, Janine D. Bijsterbosch, Arpana Agrawal, Ryan Bogdan","doi":"10.1038/s44220-024-00281-7","DOIUrl":"10.1038/s44220-024-00281-7","url":null,"abstract":"Prenatal cannabis exposure (PCE) is associated with mental health problems in early adolescence, but the possible neurobiological mechanisms remain unknown. In a large longitudinal sample of adolescents (ages 9–12 years, n = 9,322–10,186), we find that PCE is associated with localized differences in gray and white matter of the frontal and parietal cortices, their associated white matter tracts, and striatal resting-state connectivity, even after accounting for potential pregnancy, familial, and child confounds. Variability in forceps minor and pars triangularis diffusion metrics partially longitudinally mediate associations of PCE with attention problems and attention deficit hyperactivity disorder symptoms. PCE-related differences in brain development may confer vulnerability to worse mental health in early adolescence. The authors used data from the ABCD Study to examine the effects of prenatal cannabis exposure on neuroimaging metrics and mental health in adolescents.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 8","pages":"975-986"},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing the phenotypic and genetic structure of psychopathology in UK Biobank 英国生物数据库中精神病理学的表型和遗传结构特征

Nature mental health Pub Date : 2024-07-04 DOI: 10.1038/s44220-024-00272-8

Camille M. Williams, Hugo Peyre, Tobias Wolfram, Younga H. Lee, Jakob Seidlitz, Tian Ge, Jordan W. Smoller, Travis T. Mallard, Franck Ramus

{"title":"Characterizing the phenotypic and genetic structure of psychopathology in UK Biobank","authors":"Camille M. Williams, Hugo Peyre, Tobias Wolfram, Younga H. Lee, Jakob Seidlitz, Tian Ge, Jordan W. Smoller, Travis T. Mallard, Franck Ramus","doi":"10.1038/s44220-024-00272-8","DOIUrl":"10.1038/s44220-024-00272-8","url":null,"abstract":"Mental health conditions are characterized by higher-order transdiagnostic factor structures, which may contribute to the high levels of comorbidity observed in psychopathology. However, the phenotypic and genetic structures of various psychopathology diagnoses may differ, raising questions about the validity and utility of these factors. Here we study the phenotypic and genetic factor structures of ten psychiatric conditions using UK Biobank and public genomic data. Although the factor structure of psychopathology was generally genetically and phenotypically consistent, conditions related to externalizing (for example, alcohol use disorder) and compulsivity (for example, eating disorders) exhibited cross-level disparities in their relationships with other conditions, possibly due to environmental influences. Domain-level factors, especially thought disorder and internalizing factors, were more informative than a general psychopathology factor in genome-wide association and polygenic index analyses. Collectively, our findings enhance the understanding of comorbidity and shared etiology, highlight the intricate interplay between genes and environment, and offer guidance for psychiatric research using polygenic indices. In this study using UK Biobank and genomic data, the phenotypic and genetic factor structures across ten psychiatric conditions are analyzed, finding general genetic and phenotypic consistency but greater potential gene and environment disparities in conditions associated with externalizing disorders.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 8","pages":"960-974"},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141968558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting risk of postpartum depression using neurophysiological measures 利用神经生理指标预测产后抑郁风险

Nature mental health Pub Date : 2024-07-04 DOI: 10.1038/s44220-024-00288-0

引用次数: 0

The role of prepulse inhibition in predicting new-onset postpartum depression 冲动抑制在预测新发产后抑郁症中的作用

Nature mental health Pub Date : 2024-07-01 DOI: 10.1038/s44220-024-00279-1

Allison Eriksson, Richelle D. Björvang, Ebba Ancker, Fotios C. Papadopoulos, Inger Sundström Poromaa, Emma Fransson, Alkistis Skalkidou

引用次数: 0

Prevalence and patterns of methamphetamine use and mental health disparity in the United States 美国使用甲基苯丙胺的流行率和模式以及心理健康差异

Nature mental health Pub Date : 2024-06-26 DOI: 10.1038/s44220-024-00282-6

Diensn G. Xing, Farhan Mohiuddin, Md. Shenuarin Bhuiyan, Md. Ismail Hossain, Zaki Al-Yafeai, Abu Saleh Mosa Faisal, Nicholas E. Goeders, Steven A. Conrad, John A. Vanchiere, James C. Patterson, Christopher G. Kevil, Mohammad Alfrad Nobel Bhuiyan

{"title":"Prevalence and patterns of methamphetamine use and mental health disparity in the United States","authors":"Diensn G. Xing, Farhan Mohiuddin, Md. Shenuarin Bhuiyan, Md. Ismail Hossain, Zaki Al-Yafeai, Abu Saleh Mosa Faisal, Nicholas E. Goeders, Steven A. Conrad, John A. Vanchiere, James C. Patterson, Christopher G. Kevil, Mohammad Alfrad Nobel Bhuiyan","doi":"10.1038/s44220-024-00282-6","DOIUrl":"10.1038/s44220-024-00282-6","url":null,"abstract":"Methamphetamine is a growing health problem, as is mental health illness. However, no studies have investigated the combinatory effects of both diseases or characterized national trends over a period of time greater than 10 years. We evaluated US trends in mental health disorder-related hospital admissions (MHD-HAs) and compared them with those with concurrent methamphetamine use (MHD-HA-MUs), comparing the demographic characteristics from 2008 to 2020. Our findings reveal a significant increase in MHD-HA-MUs, increasing 10.5-fold, compared with a 1.4-fold increase in MHD-HAs. We also found a 1.53 times higher adjusted prevalence ratio of MHD-HA-MUs compared with MHD-HAs, even when adjusted for confounding factors. MHD-HA-MUs increased significantly among male patients (13-fold), non-Hispanic Black patients (39-fold), those aged 41–64 years (16-fold), and the South (24-fold). Overall, the data suggest that there are synergistic effects with methamphetamine use and mental health disorder, highlighting this patient group’s unique needs, requiring distinct action. Investigating the influence of using methamphetamine on the rate of admissions for mental health disorders, this study finds that concurrent methamphetamine use increased mental health-related hospital admissions 10.5-fold. Increased prevalence was also found for men, non-Hispanic Black people, middle-aged adults, and people living in the South.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 8","pages":"951-959"},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141968557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the maternal brain in the context of the mental load of motherhood 从母亲的精神负担角度了解母性大脑

Nature mental health Pub Date : 2024-06-25 DOI: 10.1038/s44220-024-00268-4

Bridget L. Callaghan, Clare McCormack, Pilyoung Kim, Jodi L. Pawluski

{"title":"Understanding the maternal brain in the context of the mental load of motherhood","authors":"Bridget L. Callaghan, Clare McCormack, Pilyoung Kim, Jodi L. Pawluski","doi":"10.1038/s44220-024-00268-4","DOIUrl":"10.1038/s44220-024-00268-4","url":null,"abstract":"The transition to motherhood is a time when nearly all aspects of a female’s existence are modified—from her biological processes to her social role. In recent years we have substantially increased our interest in this developmental period of a woman’s life (matrescence), with a focus on the neurobiology of motherhood and maternal mental health. However, one potential set of factors that is likely driving maternal vulnerability to mental illness is the growing burden of the mental load of motherhood. This mental load is part and parcel of bearing and parenting a young child, but its impact on mothers is undeniable. Here, we review how this mental load may impact the maternal brain and outline how it may be especially pronounced in the modern day, as mothers are dealing with additional pressures such as poverty, single parenthood, lack of institutional policies for parents, and the rise of intensive mothering ideologies. We contextualize the mental load of motherhood within the framework of maternal brain plasticity, and we urge future researchers to consider this framework when studying maternal mental health more broadly. There is an urgent need to approach research with an understanding of what the majority of mothers experience to make advances in supporting a healthy transition to motherhood. This Review discusses the key factors that comprise the mental load of motherhood and the need to provide support for a healthy transition to motherhood.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 7","pages":"764-772"},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141608127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gamma oscillations of visual cortex underlying emotion and cognition deficits associated with suicide attempt in major depressive disorder 视觉皮层的伽马振荡是与重度抑郁障碍患者自杀未遂相关的情绪和认知障碍的基础

Nature mental health Pub Date : 2024-06-21 DOI: 10.1038/s44220-024-00269-3

Zhongpeng Dai, Wei Zhang, Hongliang Zhou, Siqi Zhang, Zhilu Chen, Zhijian Yao, Qing Lu

{"title":"Gamma oscillations of visual cortex underlying emotion and cognition deficits associated with suicide attempt in major depressive disorder","authors":"Zhongpeng Dai, Wei Zhang, Hongliang Zhou, Siqi Zhang, Zhilu Chen, Zhijian Yao, Qing Lu","doi":"10.1038/s44220-024-00269-3","DOIUrl":"10.1038/s44220-024-00269-3","url":null,"abstract":"Altered neural oscillations in response to negative or positive emotional stimuli may be related to severe clinical symptoms in patients with major depressive disorder, particularly high suicidality. However, the underlying neurobiological mechanisms of this aberrant oscillatory activity and its potential emotional and cognitive functions remain unclear. Here we conducted a cross-sectional study of 107 participants, including 40 healthy controls and 67 patients with major depressive disorder (33 with suicide attempts and 34 without). All participants underwent an emotional expression recognition task during the magnetoencephalography scanning and completed neurocognitive assessments. Time–frequency characteristics and phase connections were analysed and compared between groups in sensor and source space using cluster-based permutation tests. The association between abnormal oscillatory features and neurocognitive performance was also evaluated. We found that increased gamma oscillations (50–70 Hz) of the visual cortices were considerably associated with suicide attempts in depression. Moreover, gamma-band source power in happy or sad conditions could predict individualized suicide risk. Gamma-band phase connections under the happy or sad condition were related to deficits in large-scale cognitive functions. Overall, gamma oscillations of the visual areas induced by the emotional stimuli were reliable biomarkers for identifying suicide attempts in depressive patients. Abnormal gamma-band connection involving visual cortex under both happy and sad expressions were significantly correlated with broad cognitive deficits. The authors investigate neural oscillations, measured by magnetoencephalography, in response to emotionally valenced stimuli as a potential biomarker characterizing individuals with major depressive disorder who had previously made a suicide attempt.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"2 8","pages":"924-934"},"PeriodicalIF":0.0,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141968608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0