Nature mental health最新文献

{"title":"Addressing the oversight of hemispheric differences in psychiatry research","authors":"Annakarina Mundorf, Sebastian Ocklenburg","doi":"10.1038/s44220-025-00405-7","DOIUrl":"10.1038/s44220-025-00405-7","url":null,"abstract":"","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 4","pages":"389-390"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subgroup-specific brain connectivity alterations in early stages of psychosis","authors":"Ludovica Mana, Ane López-González, Yasser Alemán-Gómez, Philipp S. Baumann, Raoul Jenni, Luis Alameda, Lilith Abrahamyan Empson, Paul Klauser, Philippe Conus, Patric Hagmann, Manel Vila-Vidal, Gustavo Deco","doi":"10.1038/s44220-025-00394-7","DOIUrl":"10.1038/s44220-025-00394-7","url":null,"abstract":"Functional brain scans have shown that connectivity alterations are strongly associated with the first episode of psychosis, yet it is not well understood whether these alterations vary with the clinical status of patients at the time of scanning. This cross-sectional study aimed to identify brain connectivity properties that differentiate remitting and non-remitting early psychosis (EP) patients from healthy controls and to explore the mechanisms underlying these differences. To this end, we analyzed resting-state fMRI and DSI data from 88 EP patients categorized by their remission ability after the first episode of psychosis. We focused on differences between stage III remitting–relapsing (EP3R) and stage III non-remitting (EP3NR) patients. Opposing functional connectivity (FC) alterations were observed: EP3NR patients exhibited lower FC compared with controls, while EP3R patients showed higher FC, possibly reflecting compensatory mechanisms. Whole-brain network modeling revealed lower local stability affecting the ability to regulate the flow of stimuli across the network in stage III patients, particularly in EP3R, which may indicate an adaptation to impaired network conductivity. These findings highlight subgroup-specific brain alterations and underscore the importance of considering this source of heterogeneity in psychosis research. This magnetic resonance imaging study identified distinct brain connectivity profiles for different clinical remission trajectories after a first episode of psychosis.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 4","pages":"408-420"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotions and individual differences shape human foraging under threat","authors":"Hailey A. Trier, Jill X. O’Reilly, Lisa Spiering, Sandy Ma Yishan, Nils Kolling, Matthew F. S. Rushworth, Jacqueline Scholl","doi":"10.1038/s44220-025-00393-8","DOIUrl":"10.1038/s44220-025-00393-8","url":null,"abstract":"A common behavior in natural environments is foraging for rewards. However, this is often in the presence of predators. Therefore, one of the most fundamental decisions for humans, as for other animals, is how to apportion time between reward-motivated pursuit behavior and threat-motivated checking behavior. To understand what affects how people strike this balance, we developed an ecologically inspired task and looked at both within-participant dynamics (moods) and between-participant individual differences (questionnaires about real-life behaviors) in two large internet samples (n = 374 and n = 702) in a cross-sectional design. For the within-participant dynamics, we found that people regulate task-evoked stress homeostatically by changing behavior (increasing foraging and hiding). Individual differences, even in superficially related traits (apathy–anhedonia and anxiety–compulsive checking) reliably mapped onto unique behaviors. Worse task performance, due to maladaptive checking, was linked to gender (women checked excessively) and specific anxiety-related traits: somatic anxiety (reduced self-reported checking due to worry) and compulsivity (self-reported disorganized checking). While anhedonia decreased self-reported task engagement, apathy, strikingly, improved overall task performance by reducing excessive checking. In summary, we provide a multifaceted paradigm for assessment of checking for threat in a naturalistic task that is sensitive to both moods as they change throughout the task and clinical dimensions. Thus, it could serve as an objective measurement tool for future clinical studies interested in threat, vigilance or behavior–emotion interactions in contexts requiring both reward seeking and threat avoidance. This study explores the impact of mood and individual differences on trading off between possible rewards and checking for the presence for threat and escaping to safety in a gamified foraging task.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 4","pages":"444-465"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-025-00393-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repurposing semaglutide to treat alcohol use disorder","authors":"Ana Donnelly","doi":"10.1038/s44220-025-00400-y","DOIUrl":"10.1038/s44220-025-00400-y","url":null,"abstract":"","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 3","pages":"274-274"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1 receptor agonists: new treatment frontiers","authors":"","doi":"10.1038/s44220-025-00402-w","DOIUrl":"10.1038/s44220-025-00402-w","url":null,"abstract":"Given the early success of treating diabetes and obesity with glucagon-like peptide-1 receptor agonists (GLP-1RAs) and their neurobiological effects, interest is mounting in identifying new clinical applications and repurposing of these drugs for the treatment of neuropsychiatric conditions. A growing body of evidence points to the potential of GLP-1RA medications for the treatment of specific mental disorders, which will open the door for continued development and refinement of this class of drugs.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 3","pages":"267-268"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-025-00402-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A network that tracks suicide risk","authors":"Ioannis Bakoyiannis","doi":"10.1038/s44220-025-00401-x","DOIUrl":"10.1038/s44220-025-00401-x","url":null,"abstract":"","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 3","pages":"275-275"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming the evidence landscape in mental health with platform trials","authors":"Stefan M. Gold, Fanni-Laura Mäntylä, Kim Donoghue, Jelena Brasanac, Michaela Maria Freitag, Franz König, Martin Posch, J. Antoni Ramos-Quiroga, Francesco Benedetti, Ole Köhler-Forsberg, Nina Grootendorst, Witte Hoogendijk, Carmine M. Pariante, Elyse R. Katz, Steve Webb, Belinda Lennox, Toshi A. Furukawa, Christian Otte","doi":"10.1038/s44220-025-00391-w","DOIUrl":"10.1038/s44220-025-00391-w","url":null,"abstract":"Clinical trials are at the core of evidence-based medicine, but many are underpowered and fail to inform clinical practice. In mental health, the number of regulatory drug approvals has consistently lagged behind other areas of medicine, the effects of established therapies may vary, and comparative effectiveness data for available treatments are scarce. Thus, there is an urgent need for more efficient, faster and more collaborative ways of generating evidence. Traditional approaches of ‘one treatment, one trial’ are slow, inefficient, and limit comparability across trials. In contrast, platform trials use a shared infrastructure for many treatments, shared control group(s) and a master protocol that allows treatments to be added over time and ineffective ones to be dropped early. Here we present examples of platform trials in mental health (M-PACT, EU-PEARLDIVER, PUMA and RESiLIENT) and discuss their potential to increase speed, reduce operational costs and participant burden, and improve statistical power and comparability. This Perspective outlines evidence on existing platform trials in mental health and discusses key challenges and strategies to overcome barriers in order to maximize the potential of platform trials.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 3","pages":"276-285"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodiversity-informed inclusive understanding of neurological differences","authors":"Carlos A. Larrauri, Michael Ashley Stein, Anuksha Wickramasinghe, Georgios Ntolkeras, Walid Yassin","doi":"10.1038/s44220-025-00398-3","DOIUrl":"10.1038/s44220-025-00398-3","url":null,"abstract":"Neurodiversity is a concept that acknowledges the wide range of neurological differences, yet societal norms rooted in neurotypical standards often stigmatize these differences. We propose adopting a ‘big tent’ approach to neurodiversity that embraces a broad spectrum of neurodevelopmental and mental health conditions in identity and advocacy.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 3","pages":"271-273"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Group arts interventions for depression and anxiety among older adults: a systematic review and meta-analysis","authors":"Elizabeth A. Quinn, Emma Millard, Janelle M. Jones","doi":"10.1038/s44220-024-00368-1","DOIUrl":"10.1038/s44220-024-00368-1","url":null,"abstract":"In this systematic review and meta-analysis, we assessed the efficacy of group arts interventions, where individuals engage together in a shared artistic experience (for example, dance or painting), for reducing depression and anxiety among older adults (> 55 yr without dementia). Fifty controlled studies were identified via electronic databases searched to February 2024 (randomised: 42, non-randomised: 8). Thirty-nine studies were included. Thirty-six studies investigated the impact of group arts interventions on depression (n = 3,360) and ten studies investigated anxiety (n = 949). Subgroup analyses assessed whether participant, contextual, intervention and study characteristics moderated the intervention–outcome relationship. Risk of bias was assessed with appropriate tools (RoB-2, ROBINS-1). Group arts interventions were associated with a moderate reduction in depression (Cohen’s d = 0.70, 95% confidence interval (CI) = 0.54–0.87, P < 0.001) and a moderate reduction in anxiety (d = 0.76, 95% CI = 0.37–1.52, P < 0.001), although there was publication bias in the depression studies. After a trim and fill adjustment, the effect for depression remained (d = 0.42; CI = 0.35–0.50; P < 0.001). Context moderated this effect: There was a greater reduction in depression when group arts interventions were delivered in care homes (d = 1.07, 95% CI = 0.72–1.42, P < 0.001) relative to the community (d = 0.51, 95% CI = 0.32–0.70, P < 0.001). Findings indicate that group arts are an effective intervention for addressing depression and anxiety among older adults. In this systematic review and meta-analysis of group arts interventions for older adults, the authors found that participation in shared artistic experience was associated with lower levels of depression and anxiety.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 3","pages":"374-386"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-024-00368-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Divergent biological pathways linking short and long sleep durations to mental and physical health","authors":"Yuzhu Li, Weikang Gong, Barbara J. Sahakian, Shuyi Huang, Wei Zhang, Yujie Zhao, Liang Ma, Sharon Naismith, Jintai Yu, Tianye Jia, Wei Cheng, Jianfeng Feng","doi":"10.1038/s44220-025-00395-6","DOIUrl":"10.1038/s44220-025-00395-6","url":null,"abstract":"Short and long sleep durations are associated with multiple physical, psychiatric and neurodegenerative diseases, yet their potentially shared and distinct biological mechanisms remain unclear. Here, using data from UK Biobank participants aged 38–73 years, we have characterized the in-depth genetic architecture of short (≤7 h) and long (≥7 h) sleep groups, along with their associations with behaviors, neuroimaging and blood biomarkers. The two sleep groups exhibited independent genetic architectures and distinct immunometabolic and proteomic profiles. Notably, long sleep showed more significant associations with cardiovascular-related biomarkers (for example, cholesterol), brain structures (for example, hippocampus) and plasma proteins (for example, GDF15), whereas short sleep demonstrated greater genetic overlap with psychiatric conditions, particularly depression. Mendelian randomization further supported this dissociation by showing that long sleep duration is probably a consequence of multiple brain disorders and cardiovascular diseases, whereas short sleep duration has a potential causal effect on various brain and physical illnesses. Our findings advance our understanding of the relationship between sleep and health conditions by revealing distinct biological origins and genetic mechanisms underlying short and long sleep duration. Using data from the UK Biobank, the authors investigate the differences between short and long sleep duration regarding genetics, biomarkers and phenotypic implications.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 4","pages":"429-443"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-025-00395-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}