Nature mental health最新文献_第10页

A call for a formal diagnosis for childbirth-related PTSD 呼吁对分娩相关创伤后应激障碍进行正式诊断

Nature mental health Pub Date : 2024-02-23 DOI: 10.1038/s44220-024-00213-5

Sharon Dekel

引用次数: 0

Sex differences in prenatal development of neural complexity in the human brain 人脑神经复杂性产前发育的性别差异

Nature mental health Pub Date : 2024-02-23 DOI: 10.1038/s44220-024-00206-4

Joel Frohlich, Julia Moser, Katrin Sippel, Pedro A. M. Mediano, Hubert Preissl, Alireza Gharabaghi

{"title":"Sex differences in prenatal development of neural complexity in the human brain","authors":"Joel Frohlich, Julia Moser, Katrin Sippel, Pedro A. M. Mediano, Hubert Preissl, Alireza Gharabaghi","doi":"10.1038/s44220-024-00206-4","DOIUrl":"10.1038/s44220-024-00206-4","url":null,"abstract":"The complexity of neural activity is a commonly used readout of healthy functioning in cortical circuits. Previous work has linked neural complexity to the level of maternal care in preterm infants at risk for developing mental disorders, yet the evolution of neural complexity in early human development is largely unknown. We hypothesized that cortical dynamics would evolve to optimize information processing as birth approaches, thereby increasing the complexity of cortical activity. To test this hypothesis, we conducted a cohort study relating prenatal neural complexity to maturation. Magnetoencephalography (MEG) recordings were obtained from a sample of fetuses and newborns, including longitudinal data before and after birth. Using cortical responses to auditory irregularities, we computed several entropy measures that reflect the complexity of the MEG signal. Despite our hypothesis, neural complexity decreased significantly with maturation in both fetuses and newborns. Furthermore, we found that complexity decreased significantly faster in male fetuses for most entropy measures. Our surprising results chart the evolution of neural complexity in perinatal human development and may lay a foundation for future work that would relate fetal neural complexity to developmental phenotypes, especially in the area of perinatal risk where biomarkers are greatly needed. A magnetoencephalography study provides evidence that neural signal complexity declines with brain maturation in human fetuses and newborns and the decline occurs faster in male fetuses.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140546904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disentangling direct and indirect genetic effects from partners and offspring on maternal depression using trio-GCTA 利用三重遗传效应分析法（Trio-GCTA）区分伴侣和后代对母亲抑郁的直接和间接遗传效应

Nature mental health Pub Date : 2024-02-20 DOI: 10.1038/s44220-024-00207-3

Ludvig Daae Bjørndal, Espen Moen Eilertsen, Ziada Ayorech, Rosa Cheesman, Yasmin I. Ahmadzadeh, Jessie R. Baldwin, Helga Ask, Laurie John Hannigan, Tom A. McAdams, Alexandra Havdahl, Ragnhild Bang Nes, Espen Røysamb, Eivind Ystrom

{"title":"Disentangling direct and indirect genetic effects from partners and offspring on maternal depression using trio-GCTA","authors":"Ludvig Daae Bjørndal, Espen Moen Eilertsen, Ziada Ayorech, Rosa Cheesman, Yasmin I. Ahmadzadeh, Jessie R. Baldwin, Helga Ask, Laurie John Hannigan, Tom A. McAdams, Alexandra Havdahl, Ragnhild Bang Nes, Espen Røysamb, Eivind Ystrom","doi":"10.1038/s44220-024-00207-3","DOIUrl":"10.1038/s44220-024-00207-3","url":null,"abstract":"Maternal depressive symptoms are highly prevalent and can negatively impact affected individuals and family members. Understanding etiological influences on maternal depression, such as genetic liability, is key to inform treatment and prevention efforts. Here we quantified direct and indirect genetic effects (that is, when genetic variants in other individuals influence risk of maternal depression through the environment) from partners and offspring on maternal depressive symptoms at multiple time points using genome-wide complex trait analysis with parent–offspring trios. We used data from the Norwegian Mother, Father and Child cohort study, including up to 21,000 genotyped parent–offspring trios. Models with indirect genetic effects had best fit at three out of five time points (3, 5 and 8 years after birth). The variance in maternal depressive symptoms explained by direct genetic effects ranged from 5% to 14%, whereas indirect genetic effects explained 0–14% of variance across time points. Heritable traits in family members contribute to maternal depressive symptoms through the environment at several time points after birth. The authors used a large sample of trios from the MoBa cohort study to estimate direct and indirect genetic effects on maternal depression at various time points using trio-GCTA.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140447961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical activity compensates affective downsides of daily life aloneness 体育锻炼能弥补日常生活中孤独带来的情感缺憾

Nature mental health Pub Date : 2024-02-19 DOI: 10.1038/s44220-024-00205-5

引用次数: 0

Real-life behavioral and neural circuit markers of physical activity as a compensatory mechanism for social isolation 体育活动作为社会隔离补偿机制的真实行为和神经回路标记

Nature mental health Pub Date : 2024-02-19 DOI: 10.1038/s44220-024-00204-6

Anastasia Benedyk, Markus Reichert, Marco Giurgiu, Irina Timm, Iris Reinhard, Carina Nigg, Oksana Berhe, Alexander Moldavski, Christoph von der Goltz, Urs Braun, Ulrich Ebner-Priemer, Andreas Meyer-Lindenberg, Heike Tost

{"title":"Real-life behavioral and neural circuit markers of physical activity as a compensatory mechanism for social isolation","authors":"Anastasia Benedyk, Markus Reichert, Marco Giurgiu, Irina Timm, Iris Reinhard, Carina Nigg, Oksana Berhe, Alexander Moldavski, Christoph von der Goltz, Urs Braun, Ulrich Ebner-Priemer, Andreas Meyer-Lindenberg, Heike Tost","doi":"10.1038/s44220-024-00204-6","DOIUrl":"10.1038/s44220-024-00204-6","url":null,"abstract":"Social isolation and loneliness pose major societal challenges accelerated by the coronavirus disease 2019 pandemic, especially for mental health. In this cohort study using accelerometry, electronic diaries and neuroimaging in a community-based sample of 317 young adults, we show that people felt affectively worse when lacking social contact, but less so when engaging in physical activity. This putative compensatory mechanism was present even at small physical activity doses and was pronounced in individuals with higher brain functional connectivity within the default mode network signaling risk for depression. Social-affective benefits of movement were higher in people showing exacerbated loneliness and were replicated throughout the pandemic. These findings extend the state of knowledge on the dynamic interplay of social contact and physical activity in daily life identifying an accessible protective strategy to mitigate the negative effects of social isolation, particularly among at-risk individuals, which comes with the potential to improve public health in the post-pandemic world. Physical activity has the potential to combat the negative mental health effects of social isolation. Its benefit is particularly high in people at increased neural and psychological risk for affective disorders.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-024-00204-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140104554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discriminative functional connectivity signature of cocaine use disorder links to rTMS treatment response 可卡因使用障碍的判别性功能连接特征与经颅磁刺激治疗反应的联系

Nature mental health Pub Date : 2024-02-16 DOI: 10.1038/s44220-024-00209-1

Kanhao Zhao, Gregory A. Fonzo, Hua Xie, Desmond J. Oathes, Corey J. Keller, Nancy B. Carlisle, Amit Etkin, Eduardo A. Garza-Villarreal, Yu Zhang

{"title":"Discriminative functional connectivity signature of cocaine use disorder links to rTMS treatment response","authors":"Kanhao Zhao, Gregory A. Fonzo, Hua Xie, Desmond J. Oathes, Corey J. Keller, Nancy B. Carlisle, Amit Etkin, Eduardo A. Garza-Villarreal, Yu Zhang","doi":"10.1038/s44220-024-00209-1","DOIUrl":"10.1038/s44220-024-00209-1","url":null,"abstract":"Cocaine use disorder (CUD) is prevalent, and repetitive transcranial magnetic stimulation (rTMS) shows promise in reducing cravings. However, the association between a consistent CUD-specific functional connectivity signature and treatment response remains unclear. Here we identify a validated functional connectivity signature from functional magnetic resonance imaging to discriminate CUD, with successful independent replication. We found increased connectivity within the visual and dorsal attention networks and between the frontoparietal control and ventral attention networks, alongside reduced connectivity between the default mode and limbic networks in patients with CUD. These connections were associated with drug use history and cognitive impairments. Using data from a randomized clinical trial, we also established the prognostic value of these functional connectivities for rTMS treatment outcomes in CUD, especially involving the frontoparietal control and default mode networks. Our findings reveal insights into the neurobiological mechanisms of CUD and link functional connectivity biomarkers with rTMS treatment response, offering potential targets for future therapeutic development. The authors used a machine learning model to distinguish patients with cocaine use disorder and polysubstance use history from healthy controls, using resting-state functional magnetic resonance imaging functional connectivity data.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140454623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The dynamic process of hyperfocusing and hyperfiltering in schizophrenia 精神分裂症患者过度聚焦和过度过滤的动态过程

Nature mental health Pub Date : 2024-02-16 DOI: 10.1038/s44220-024-00211-7

Jian Li, Bao-liang Zhong, Dongsheng Zhou, Yingtao Fu, Xiaoqi Huang, Luo Chen, Huiying Liu, Jiewei Zheng, Enze Tang, Yongqi Li, Chenxiao Guan, Mowei Shen, Hui Chen

{"title":"The dynamic process of hyperfocusing and hyperfiltering in schizophrenia","authors":"Jian Li, Bao-liang Zhong, Dongsheng Zhou, Yingtao Fu, Xiaoqi Huang, Luo Chen, Huiying Liu, Jiewei Zheng, Enze Tang, Yongqi Li, Chenxiao Guan, Mowei Shen, Hui Chen","doi":"10.1038/s44220-024-00211-7","DOIUrl":"10.1038/s44220-024-00211-7","url":null,"abstract":"Schizophrenia is typically characterized by impairments in selective attention. However, recent evidence seems to counterintuitively show that people with schizophrenia (PSZ) exhibit superior attentional selection compared with healthy control subjects, an intriguing phenomenon known as hyperfocusing. Such supranormal attention is believed to underlie multiple kinds of cognitive impairments observed in PSZ, and thus exploring this remarkable phenomenon holds promise for inspiring innovative treatments aimed at addressing cognitive deficits in PSZ. Here, in this case–control study comprising four independent experiments, we aimed to investigate two central questions regarding this phenomenon. First, we sought to investigate whether hyperfocusing on the relevant information would be accompanied with hyperfiltering on irrelevant information, by adopting tasks wherein participants were asked to focus on one feature (that is, color) of an object while ignoring another (that is, shape). Another important objective is to understand how such supranormal attention unfolds over the course of cognitive processing by manipulating the time course. Our research reveals that hyperfocusing on relevant information coincides with greater filtering (that is, hyperfiltering) of irrelevant information from the same object. Additionally, our research shows that hyperfocusing develops through continuously enhancing the relevant information and progressively weakening the irrelevant information over time. Crucially, these key findings are replicated and generalized across different designs and research paradigms, underscoring the robustness and replicability of our study. These convincing findings extend our understanding of cognitive mechanisms behind hyperfocusing. Hyperfocusing in schizophrenia is accompanied with hyperfiltering of irrelevant information over time.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140454550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wildfires are associated with increased emergency department visits for anxiety disorders in the western United States 野火与美国西部焦虑症急诊就诊人数增加有关

Nature mental health Pub Date : 2024-02-15 DOI: 10.1038/s44220-024-00210-8

Qingyang Zhu, Danlu Zhang, Wenhao Wang, Rohan Richard D’Souza, Haisu Zhang, Binyu Yang, Kyle Steenland, Noah Scovronick, Stefanie Ebelt, Howard H. Chang, Yang Liu

{"title":"Wildfires are associated with increased emergency department visits for anxiety disorders in the western United States","authors":"Qingyang Zhu, Danlu Zhang, Wenhao Wang, Rohan Richard D’Souza, Haisu Zhang, Binyu Yang, Kyle Steenland, Noah Scovronick, Stefanie Ebelt, Howard H. Chang, Yang Liu","doi":"10.1038/s44220-024-00210-8","DOIUrl":"10.1038/s44220-024-00210-8","url":null,"abstract":"As wildfires increasingly impact the global economy and public health, understanding their effects is crucial. Particularly, the relationship between wildfires and anxiety disorders remains unclear. In this study, we explore this association by analyzing 1,897,865 emergency department visits for anxiety disorders in the western United States. We examined records from 2007 to 2018, using a case-crossover design and conditional logistic regression to assess the impact of wildfire-related exposures on these visits. Here we show that exposure to wildfire smoke PM2.5 is positively linked with emergency department visits for anxiety disorders. This effect is more pronounced in women and girls and in older adults, highlighting their vulnerability. Notably, major smoke events (smoke PM2.5 contributed ≥75% of the total PM2.5) significantly amplify this risk. These findings underscore the psychological impacts of wildfires and their smoke, suggesting a need for targeted disaster risk reduction and climate risk management strategies, especially for vulnerable groups such as older adults and women. Our results call for increased climate awareness and tailored risk communication to mitigate these emerging health challenges. In this paper, authors examine the impact of wildfire-related exposures on emergency department visits for anxiety disorders in the western United States, finding that women and older adults were the most vulnerable.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139774998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental health inequality in young LGBT+ people demands early universal interventions LGBT+ 青年的心理健康不平等要求尽早采取普遍干预措施

Nature mental health Pub Date : 2024-02-15 DOI: 10.1038/s44220-024-00201-9

Elizabeth Ingram, M. Schlief, J. Pachankis, Grace Levy, T. Stefanidou, Talen Wright, Gemma Lewis

引用次数: 0

Wildfires are associated with increased emergency department visits for anxiety disorders in the western United States 野火与美国西部焦虑症急诊就诊人数增加有关

Nature mental health Pub Date : 2024-02-15 DOI: 10.1038/s44220-024-00210-8

Qingyang Zhu, Danlu Zhang, Wenhao Wang, R. D'souza, Haisu Zhang, Binyu Yang, Kyle Steenland, N. Scovronick, S. Ebelt, Howard H. Chang, Yang Liu

引用次数: 0