Nature mental health最新文献_第9页

Shifting BSMM research paradigms in the context of HIV status-neutral care continuums 在不考虑艾滋病毒感染状况的持续护理背景下转变 BSMM 研究范式

Nature mental health Pub Date : 2024-05-30 DOI: 10.1038/s44220-024-00265-7

John A. Schneider, Darnell N. Motley, L. Philip Schumm, Jade Pagkas-Bather

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Psychedelic-assisted therapy among sexual and gender minority communities 性少数群体和性别少数群体的迷幻辅助疗法

Nature mental health Pub Date : 2024-05-23 DOI: 10.1038/s44220-024-00252-y

Brady D. Hanshaw, Mark Fusunyan, Chase T. M. Anderson, Jack L. Turban

{"title":"Psychedelic-assisted therapy among sexual and gender minority communities","authors":"Brady D. Hanshaw, Mark Fusunyan, Chase T. M. Anderson, Jack L. Turban","doi":"10.1038/s44220-024-00252-y","DOIUrl":"10.1038/s44220-024-00252-y","url":null,"abstract":"Although research on psychedelic-assisted therapy (PAT) is rapidly expanding, the clinical trial literature has been criticized for its underrepresentation of sexual and gender minority (SGM) and racial communities. Accordingly, there is a pressing need to study the outcomes of PAT in minoritized communities and its effects on the mental health disparities among SGM communities. Here we discuss the potential relevance of minority stress theory and its principles as they relate to PAT for SGM communities. Furthermore, we propose a theoretical framework integrating minority stress theory and its extensions with prominent models of psychedelic action, highlighting the potential of PAT to plasticize entrenched cognitive and behavioral patterns associated with minority stress. Future research should explore the mechanisms by which PAT may interact with minority stress processes and the potential benefits of SGM-affirmative adaptations of PAT. The integration of minority stress theory into PAT research may enrich our understanding of its therapeutic mechanisms while tailoring a promising intervention to individuals disproportionately excluded from effective care. This Perspective discusses the importance of increasing access to psychedelic-assisted therapy to sexual and gender minorities and proposes a theoretical framework integrating minority stress theory to inform the research and guide study design.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141104573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anxiety, depression and distress outcomes from the Health4Life intervention for adolescent mental health: a cluster-randomized controlled trial 针对青少年心理健康的 Health4Life 干预措施产生的焦虑、抑郁和苦恼结果：分组随机对照试验

Nature mental health Pub Date : 2024-05-23 DOI: 10.1038/s44220-024-00246-w

S. Smout, K. E. Champion, S. O’Dean, M. Teesson, L. A. Gardner, N. C. Newton

{"title":"Anxiety, depression and distress outcomes from the Health4Life intervention for adolescent mental health: a cluster-randomized controlled trial","authors":"S. Smout, K. E. Champion, S. O’Dean, M. Teesson, L. A. Gardner, N. C. Newton","doi":"10.1038/s44220-024-00246-w","DOIUrl":"10.1038/s44220-024-00246-w","url":null,"abstract":"Mental disorders are a leading cause of disease burden worldwide. As onset typically occurs in adolescence, prevention during this period is critical. The Health4Life-school-based multiple health behavior change (MHBC) intervention targets six lifestyle risk factors: diet, sleep, physical activity, screentime, alcohol use and smoking. Health4Life has been evaluated in a cluster-randomized controlled trial in 71 Australian schools (6,639 grade seven students). This study presents intervention effects on secondary outcomes of depressive, anxiety and psychological distress symptoms. Generalized linear mixed-effect analyses of data from baseline, post-intervention (7 weeks), 12 months and 24 months showed that the Health4Life intervention was no more effective than an active control in reducing depressive, anxiety or psychological distress symptoms at a 24 or 12 month follow-up; however, there were short-term benefits for psychological distress and depressive symptoms immediately post-intervention. This study offers new evidence that multiple health behavior change interventions may improve adolescent mental health, but future research should explore methods to address anxiety and sustain effects over the longer term. A priori ANZCTR trial registration: ACTRN12619000431123. The authors present the secondary outcomes from a cluster-randomized controlled trial of the Health4Life multiple health behavior change intervention. The intervention showed short-term benefits for distress and depressive symptoms but was not more effective than an active control condition.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-024-00246-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141106074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reporting the challenges and negative impacts of lived experience involvement 报告生活经验参与的挑战和负面影响

Nature mental health Pub Date : 2024-05-20 DOI: 10.1038/s44220-024-00254-w

Jamie Morgan

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The potential and perils of generative artificial intelligence in psychiatry and psychology 生成式人工智能在精神病学和心理学中的潜力与危险

Nature mental health Pub Date : 2024-05-17 DOI: 10.1038/s44220-024-00257-7

Arun J. Thirunavukarasu, Jessica O’Logbon

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Exposomic and polygenic contributions to allostatic load in early adolescence 暴露基因组和多基因对青春期早期代谢负荷的影响

Nature mental health Pub Date : 2024-05-14 DOI: 10.1038/s44220-024-00255-9

Kevin W. Hoffman, Kate T. Tran, Tyler M. Moore, Mārtiņš M. Gataviņš, Elina Visoki, Ohyoon Kwon, Grace E. DiDomenico, Barbara H. Chaiyachati, Laura M. Schultz, Laura Almasy, Matthew R. Hayes, Nikolaos P. Daskalakis, Ran Barzilay

{"title":"Exposomic and polygenic contributions to allostatic load in early adolescence","authors":"Kevin W. Hoffman, Kate T. Tran, Tyler M. Moore, Mārtiņš M. Gataviņš, Elina Visoki, Ohyoon Kwon, Grace E. DiDomenico, Barbara H. Chaiyachati, Laura M. Schultz, Laura Almasy, Matthew R. Hayes, Nikolaos P. Daskalakis, Ran Barzilay","doi":"10.1038/s44220-024-00255-9","DOIUrl":"10.1038/s44220-024-00255-9","url":null,"abstract":"Allostatic load (AL) is the cumulative ‘wear and tear’ on the body due to chronic adversity. We tested the poly-environmental (exposomic) and polygenic contributions to AL and their combined contribution to adolescent mental health. In this cohort study of N = 5,036 diverse youth (mean age 12 years) from the Adolescent Brain Cognitive Development Study, we calculated a latent AL score, childhood exposomic risk and genetic risk. We tested the associations of exposomic and polygenic risks with AL using linear mixed-effects models, and tested the mediating role of AL on the pathway from exposomic/polygenic risk to mental health. AL was significantly lower among non-Hispanic white youth compared to Hispanic and non-Hispanic black youth. Childhood exposomic burden was associated with AL in adolescence (β = 0.25, 95% CI 0.22–0.29, P < 0.001). In subset analysis of participants of European-like genetic ancestry (n = 2,928), the type 2 diabetes polygenic risk score (T2D-PRS; β = 0.11, 95% CI 0.07–0.14, P < 0.001) and major depressive disorder (MDD)-PRS (β = 0.05, 95% CI 0.02–0.09, P = 0.003) were associated with AL. Both PRSs showed significant gene–environment interactions such that, with greater polygenic risk, associations between exposome and AL were stronger. AL significantly mediated the indirect path from exposomic risk at age 11 years, and from both MDD-PRS and T2D-PRS to psychopathology at age 12 years. Our findings show that AL can be quantified in youth and is associated with exposomic and polygenic burden, supporting the diathesis–stress model. Using a large US cohort of adolescents, the authors examine exposomic and polygenic contributions to allostatic load and a mediating role of allostatic load on the path from exposomic and polygenic risks to psychopathology.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140980226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurocircuitry basis of motor cortex-related analgesia as an emerging approach for chronic pain management 运动皮层相关镇痛的神经回路基础是慢性疼痛治疗的一种新方法

Nature mental health Pub Date : 2024-05-13 DOI: 10.1038/s44220-024-00235-z

Yang Bai, Kevin Pacheco-Barrios, Niels Pacheco-Barrios, Guobiao Liang, Felipe Fregni

{"title":"Neurocircuitry basis of motor cortex-related analgesia as an emerging approach for chronic pain management","authors":"Yang Bai, Kevin Pacheco-Barrios, Niels Pacheco-Barrios, Guobiao Liang, Felipe Fregni","doi":"10.1038/s44220-024-00235-z","DOIUrl":"10.1038/s44220-024-00235-z","url":null,"abstract":"Aside from movement initiation and control, the primary motor cortex (M1) has been implicated in pain modulation mechanisms. A large body of clinical data has demonstrated that stimulation and behavioural activation of M1 result in clinically important pain relief in patients with specific chronic pain syndromes. However, despite its clinical importance, the full range of circuits for motor cortex-related analgesia (MCRA) remains an enigma. This Review draws on insights from experimental and clinical data and provides an overview of the neurobiological mechanisms of MCRA, with particular emphasis on its neurocircuitry basis. On the basis of structural and functional connections of the M1 within the pain connectome, neural circuits for MCRA are discussed at different levels of the neuroaxis, specifically, the endogenous pain modulation system, the thalamus, the extrapyramidal system, non-noxious somatosensory systems and cortico-limbic pain signatures. We believe that insights from this Review will expedite the understanding of M1-induced pain modulation and offer hope for successful mechanism-based refinements of this interventional approach in chronic pain management. In this Review, the authors discuss the neurobiological mechanisms of motor cortex-related analgesia, drawing insights from both experimental data and clinical data.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140919357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Probing prefrontal-sgACC connectivity using TMS-induced heart–brain coupling 作者更正：利用 TMS 诱导的心脑耦合探测前额叶-sgACC 连接性

Nature mental health Pub Date : 2024-05-13 DOI: 10.1038/s44220-024-00263-9

Eva S. A. Dijkstra, Summer B. Frandsen, Hanneke van Dijk, Felix Duecker, Joseph J. Taylor, Alexander T. Sack, Martijn Arns, Shan H. Siddiqi

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ADHD grows up 多动症的成长

Nature mental health Pub Date : 2024-05-13 DOI: 10.1038/s44220-024-00262-w

引用次数: 0

Emotion dysregulation and right pars orbitalis constitute a neuropsychological pathway to attention deficit hyperactivity disorder 情绪失调和右眶旁构成了注意力缺陷多动障碍的神经心理学途径

Nature mental health Pub Date : 2024-05-13 DOI: 10.1038/s44220-024-00251-z

Wenjie Hou, Barbara J. Sahakian, Christelle Langley, Yuqing Yang, R. A. I. Bethlehem, Qiang Luo

{"title":"Emotion dysregulation and right pars orbitalis constitute a neuropsychological pathway to attention deficit hyperactivity disorder","authors":"Wenjie Hou, Barbara J. Sahakian, Christelle Langley, Yuqing Yang, R. A. I. Bethlehem, Qiang Luo","doi":"10.1038/s44220-024-00251-z","DOIUrl":"10.1038/s44220-024-00251-z","url":null,"abstract":"Emotion dysregulation is common in attention deficit hyperactivity disorder (ADHD), which is known to be clinically heterogeneous. However, it remains unclear whether emotion dysregulation represents a neuropsychological pathway to ADHD. Here, using a large population-based cohort (n = 6,053), we show that emotion dysregulation was associated with ADHD symptoms (partial eta2 = 0.21) and this persisted after controlling for the cognitive and motivational deficits. Emotion dysregulation mediated the association between smaller surface area of the right pars orbitalis and greater ADHD symptoms at 1-year follow-up, indicating an emotion pathway for ADHD. This pathway was associated with immune responses by both transcriptomic analyses and white blood cell markers. In an independent clinical sample for ADHD (n = 672), the emotion pathway improved the case/control classification accuracy. These findings suggest that emotion dysregulation is a core symptom and route to ADHD, which may not respond to the current pharmacological treatments for ADHD. Authors present data supporting a neuropsychological pathway between emotion dysregulation and ADHD symptoms involving morphometry of the right pars orbitalis, transcriptomic, and white blood cell markers.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140983035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0