Nature mental health最新文献

Repurposing semaglutide to treat alcohol use disorder

Nature mental health Pub Date : 2025-03-11 DOI: 10.1038/s44220-025-00400-y

Ana Donnelly

引用次数: 0

GLP-1 receptor agonists: new treatment frontiers

Nature mental health Pub Date : 2025-03-11 DOI: 10.1038/s44220-025-00402-w

引用次数: 0

A network that tracks suicide risk

Nature mental health Pub Date : 2025-03-11 DOI: 10.1038/s44220-025-00401-x

Ioannis Bakoyiannis

引用次数: 0

Transforming the evidence landscape in mental health with platform trials

Nature mental health Pub Date : 2025-03-10 DOI: 10.1038/s44220-025-00391-w

Stefan M. Gold, Fanni-Laura Mäntylä, Kim Donoghue, Jelena Brasanac, Michaela Maria Freitag, Franz König, Martin Posch, J. Antoni Ramos-Quiroga, Francesco Benedetti, Ole Köhler-Forsberg, Nina Grootendorst, Witte Hoogendijk, Carmine M. Pariante, Elyse R. Katz, Steve Webb, Belinda Lennox, Toshi A. Furukawa, Christian Otte

{"title":"Transforming the evidence landscape in mental health with platform trials","authors":"Stefan M. Gold, Fanni-Laura Mäntylä, Kim Donoghue, Jelena Brasanac, Michaela Maria Freitag, Franz König, Martin Posch, J. Antoni Ramos-Quiroga, Francesco Benedetti, Ole Köhler-Forsberg, Nina Grootendorst, Witte Hoogendijk, Carmine M. Pariante, Elyse R. Katz, Steve Webb, Belinda Lennox, Toshi A. Furukawa, Christian Otte","doi":"10.1038/s44220-025-00391-w","DOIUrl":"10.1038/s44220-025-00391-w","url":null,"abstract":"Clinical trials are at the core of evidence-based medicine, but many are underpowered and fail to inform clinical practice. In mental health, the number of regulatory drug approvals has consistently lagged behind other areas of medicine, the effects of established therapies may vary, and comparative effectiveness data for available treatments are scarce. Thus, there is an urgent need for more efficient, faster and more collaborative ways of generating evidence. Traditional approaches of ‘one treatment, one trial’ are slow, inefficient, and limit comparability across trials. In contrast, platform trials use a shared infrastructure for many treatments, shared control group(s) and a master protocol that allows treatments to be added over time and ineffective ones to be dropped early. Here we present examples of platform trials in mental health (M-PACT, EU-PEARLDIVER, PUMA and RESiLIENT) and discuss their potential to increase speed, reduce operational costs and participant burden, and improve statistical power and comparability. This Perspective outlines evidence on existing platform trials in mental health and discusses key challenges and strategies to overcome barriers in order to maximize the potential of platform trials.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 3","pages":"276-285"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurodiversity-informed inclusive understanding of neurological differences

Nature mental health Pub Date : 2025-03-10 DOI: 10.1038/s44220-025-00398-3

Carlos A. Larrauri, Michael Ashley Stein, Anuksha Wickramasinghe, Georgios Ntolkeras, Walid Yassin

引用次数: 0

Group arts interventions for depression and anxiety among older adults: a systematic review and meta-analysis

Nature mental health Pub Date : 2025-03-05 DOI: 10.1038/s44220-024-00368-1

Elizabeth A. Quinn, Emma Millard, Janelle M. Jones

{"title":"Group arts interventions for depression and anxiety among older adults: a systematic review and meta-analysis","authors":"Elizabeth A. Quinn, Emma Millard, Janelle M. Jones","doi":"10.1038/s44220-024-00368-1","DOIUrl":"10.1038/s44220-024-00368-1","url":null,"abstract":"In this systematic review and meta-analysis, we assessed the efficacy of group arts interventions, where individuals engage together in a shared artistic experience (for example, dance or painting), for reducing depression and anxiety among older adults (> 55 yr without dementia). Fifty controlled studies were identified via electronic databases searched to February 2024 (randomised: 42, non-randomised: 8). Thirty-nine studies were included. Thirty-six studies investigated the impact of group arts interventions on depression (n = 3,360) and ten studies investigated anxiety (n = 949). Subgroup analyses assessed whether participant, contextual, intervention and study characteristics moderated the intervention–outcome relationship. Risk of bias was assessed with appropriate tools (RoB-2, ROBINS-1). Group arts interventions were associated with a moderate reduction in depression (Cohen’s d = 0.70, 95% confidence interval (CI) = 0.54–0.87, P < 0.001) and a moderate reduction in anxiety (d = 0.76, 95% CI = 0.37–1.52, P < 0.001), although there was publication bias in the depression studies. After a trim and fill adjustment, the effect for depression remained (d = 0.42; CI = 0.35–0.50; P < 0.001). Context moderated this effect: There was a greater reduction in depression when group arts interventions were delivered in care homes (d = 1.07, 95% CI = 0.72–1.42, P < 0.001) relative to the community (d = 0.51, 95% CI = 0.32–0.70, P < 0.001). Findings indicate that group arts are an effective intervention for addressing depression and anxiety among older adults. In this systematic review and meta-analysis of group arts interventions for older adults, the authors found that participation in shared artistic experience was associated with lower levels of depression and anxiety.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 3","pages":"374-386"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-024-00368-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A network outcome analysis of psychological risk factors driving suicide risk in emergency department patients

Nature mental health Pub Date : 2025-02-20 DOI: 10.1038/s44220-025-00389-4

René Freichel, Matthew K. Nock, Brian A. O’Shea

{"title":"A network outcome analysis of psychological risk factors driving suicide risk in emergency department patients","authors":"René Freichel, Matthew K. Nock, Brian A. O’Shea","doi":"10.1038/s44220-025-00389-4","DOIUrl":"10.1038/s44220-025-00389-4","url":null,"abstract":"Different theories of suicide propose somewhat different psychological factors that lead to suicidal thoughts and behaviors. For example, Beck’s theory highlights hopelessness, while the interpersonal–psychological theory of suicide emphasizes burdensomeness, lack of belonging and fearlessness about death. Surprisingly, few studies have tested which theoretically proposed psychological factors are most predictive of suicidal thoughts and behaviors. We used network outcome analysis to disentangle the effects of these constructs in predicting suicidal ideation, suicide plans and attempts. Participants were 1,412 patients presenting to an emergency department with psychiatric complaints, with follow-up assessments one month and six months (n = 938) later. Here we showed that different psychological factors predicted different parts of the continuum of suicidal thoughts and behaviors. Lack of belongingness was most predictive of suicidal ideation (partial correlation (pcor) = 0.14), acquired capability for death (that is, fearlessness of death) was most predictive of suicide planning (pcor = 0.08), and hopelessness was most predictive of suicide attempts (pcor = 0.12). Individuals’ explicit associations with death (that is, death = me) prospectively predicted all three outcomes (pcor = 0.13–0.23). The occurrence of suicidal thoughts and behaviors is best predicted using constructs from several different theories of suicide. Future theoretical and empirical work should integrate components of existing theories. In this article, the authors share data suggesting that different psychological factors uniquely predict suicidal thoughts and behaviors: lack of belongingness predicts ideation, fearlessness predicts planning, and hopelessness predicts attempts. Further integration of suicide theories is needed.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 3","pages":"346-353"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-025-00389-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct brain network features predict internalizing and externalizing traits in children, adolescents and adults 不同的大脑网络特征可预测儿童、青少年和成年人的内化和外化特征

Nature mental health Pub Date : 2025-02-19 DOI: 10.1038/s44220-025-00388-5

Yueyue Lydia Qu, Jianzhong Chen, Angela Tam, Leon Qi Rong Ooi, Elvisha Dhamala, Carrisa V. Cocuzza, Shaoshi Zhang, Tianchu Zeng, Connor Lawhead, B. T. Thomas Yeo, Avram J. Holmes

{"title":"Distinct brain network features predict internalizing and externalizing traits in children, adolescents and adults","authors":"Yueyue Lydia Qu, Jianzhong Chen, Angela Tam, Leon Qi Rong Ooi, Elvisha Dhamala, Carrisa V. Cocuzza, Shaoshi Zhang, Tianchu Zeng, Connor Lawhead, B. T. Thomas Yeo, Avram J. Holmes","doi":"10.1038/s44220-025-00388-5","DOIUrl":"10.1038/s44220-025-00388-5","url":null,"abstract":"The distinction between externalizing and internalizing traits has been a classic area of study in psychiatry. However, whether shared or unique brain network features predict internalizing and externalizing behaviors remains poorly understood. Using a sample of 5,260 children from the Adolescent Brain Cognitive Development study, 229 adolescents from the Healthy Brain Network and 423 adults from the Human Connectome Project, we show that predictive network features are, at least in part, distinct across internalizing and externalizing behaviors. Across all three samples, behaviors within internalizing and externalizing categories exhibited more similar predictive feature weights than behaviors between categories. These data suggest shared and unique brain network features account for individual variation within broad internalizing and externalizing categories across developmental stages. In this study, the authors present work showing shared and distinct predictive network features associated with internalizing and externalizing behaviors in children, adolescents and adults.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 3","pages":"306-317"},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced mGluR5 availability marks the antidepressant efficacy in major depressive disorder: an [18F]FPEB PET study

Nature mental health Pub Date : 2025-02-18 DOI: 10.1038/s44220-025-00386-7

Bangshan Liu, Aoqian Deng, Chuning Dong, Wentao Chen, Qianqian Zhang, Lianbo Zhou, Feng He, Xin Xiang, Wenwen Ou, Mohan Ma, Jin Liu, Xiaoping Wang, Yumeng Ju, Yunhua Wang, Henry Huang, Xiaowei Ma, Yan Zhang

{"title":"Enhanced mGluR5 availability marks the antidepressant efficacy in major depressive disorder: an [18F]FPEB PET study","authors":"Bangshan Liu, Aoqian Deng, Chuning Dong, Wentao Chen, Qianqian Zhang, Lianbo Zhou, Feng He, Xin Xiang, Wenwen Ou, Mohan Ma, Jin Liu, Xiaoping Wang, Yumeng Ju, Yunhua Wang, Henry Huang, Xiaowei Ma, Yan Zhang","doi":"10.1038/s44220-025-00386-7","DOIUrl":"10.1038/s44220-025-00386-7","url":null,"abstract":"The limited efficacy of antidepressants for major depressive disorder (MDD) underscores the urgent need to explore mechanisms behind treatment heterogeneity and identify new antidepressant targets. This study explores the role of metabotropic glutamate receptor 5 (mGluR5) in MDD, examining mGluR5 availability changes pre- and post-treatment, and their link to clinical outcomes. We studied 25 patients with MDD and 21 healthy controls, with 13 undergoing eight-week vortioxetine treatment (10 mg per day). mGluR5 availability was measured at baseline and follow-up using [18F]3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile positron emission tomography ([18F]FPEB PET) scans, and patients were categorized on the basis of their response. Results showed lower mGluR5 availability in patients with MDD versus the control group at baseline. Post-treatment, the group with MDD exhibited significant increases in mGluR5 availability in the dorsolateral prefrontal cortex and ventromedial prefrontal cortex (N = 13, Cohen’s d = 0.83 and 1.01). The percentage increase in mGluR5 availability correlated with the percentage reduction in scores on the Hamilton rating scale for depression. These findings underscore mGluR5’s key role in MDD pathophysiology and treatment. This study found that mGluR5 availability is lower in patients with MDD and increases after treatment, correlating with symptom improvement, highlighting the role of mGluR5 role in MDD pathophysiology and treatment response.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 3","pages":"298-305"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An analysis on the role of glucagon-like peptide-1 receptor agonists in cognitive and mental health disorders 胰高血糖素样肽-1 受体激动剂在认知和精神疾病中的作用分析

Nature mental health Pub Date : 2025-02-13 DOI: 10.1038/s44220-025-00390-x

Riccardo De Giorgi, Ana Ghenciulescu, Oliwia Dziwisz, Maxime Taquet, Amanda I. Adler, Ivan Koychev, Rachel Upthegrove, Marco Solmi, Robert McCutcheon, Toby Pillinger, Philip J. Cowen, Catherine J. Harmer

{"title":"An analysis on the role of glucagon-like peptide-1 receptor agonists in cognitive and mental health disorders","authors":"Riccardo De Giorgi, Ana Ghenciulescu, Oliwia Dziwisz, Maxime Taquet, Amanda I. Adler, Ivan Koychev, Rachel Upthegrove, Marco Solmi, Robert McCutcheon, Toby Pillinger, Philip J. Cowen, Catherine J. Harmer","doi":"10.1038/s44220-025-00390-x","DOIUrl":"10.1038/s44220-025-00390-x","url":null,"abstract":"Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are novel drugs approved for diabetes and obesity. They are acknowledged as a major scientific breakthrough. In addition to their metabolic effects, these medications act on other bodily systems involved in the physiopathology of various neurological and psychiatric disorders. Several stakeholders are calling for more research to investigate the repurposing potential of GLP-1RAs in cognitive and mental disorders, while others advocate for a better assessment of their safety profile from a neuropsychiatric perspective. In this Analysis, we searched for relevant literature on the effects of GLP-1RAs across a range of illnesses, gathering and describing the available pre-clinical and mechanistic (278 studies) and clinical (96 studies) evidence for cognitive disorders, substance-use disorders, psychotic disorders, mood and anxiety disorders, eating disorders, and others. By leveraging translational insights from these data, we consider potential implications for clinical practice and propose avenues for further research. De Giorgi and colleagues present a comprehensive analysis of pre-clinical and clinical studies examining the role of glucagon-like peptide-1 receptor agonists in mental disorders.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 3","pages":"354-373"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-025-00390-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0