Nature mental health最新文献

{"title":"Social identity processes as a vehicle for therapeutic success in psychedelic treatment","authors":"Martha Newson, S. Alexander Haslam, Catherine Haslam, Tegan Cruwys, Leor Roseman","doi":"10.1038/s44220-024-00302-5","DOIUrl":"10.1038/s44220-024-00302-5","url":null,"abstract":"The recent surge in psychedelics research has identified promising therapeutic uses for conditions including anxiety, post-traumatic stress disorder, anorexia, depression, and addiction. However, medicalized forms often lack a vital ingredient: a social group dimension. By integrating psychedelics into group settings and leveraging their capacity to foster social identities, the effects of psychedelic-assisted therapies could be enhanced, echoing their potency in Indigenous and community contexts. We outline the relevance of the ‘social cure’ model, supported by strong empirical evidence in social identity and health literature, emphasizing the importance of group contexts and social identity-based relationships in the theraputic effects of psychedelics. We present practical implications for therapeutic practice and identify future directions and challenges for social cure research, offering an agenda for theory-informed work to investigate the role of social identities and group connections in psychedelic treatment. In this Perspective, authors overview the ‘social cure’ model employing group contexts, identity, and connections and argue for its use as a therapeutic framework for psychedelic treatment.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Found in translation — translational science in mental health research","authors":"","doi":"10.1038/s44220-024-00319-w","DOIUrl":"10.1038/s44220-024-00319-w","url":null,"abstract":"Translational science is often characterized metaphorically, as bridging the gaps among multidisciplinary research areas. However, in reality, translational work is often separate or excluded from clinical research. Integrating elements of translational and clinical work into more general mental health research is key to innovation and progress.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-024-00319-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of workplace managers in protecting and promoting employee mental health","authors":"Leslie B. Hammer","doi":"10.1038/s44220-024-00308-z","DOIUrl":"10.1038/s44220-024-00308-z","url":null,"abstract":"","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping brain and body connections","authors":"Natalia Gass","doi":"10.1038/s44220-024-00304-3","DOIUrl":"10.1038/s44220-024-00304-3","url":null,"abstract":"In this Q&A, we speak to Andrew Zalesky, professor at the University of Melbourne, a co-leader of the Systems Lab and awardee of the prestigious Rebecca L. Cooper Fellowship that provides US$1.35 million over 5 years to study brain networks in health and disease and develop high-tech psychiatric therapies based on brain stimulation. He also led the development of the Melbourne Subcortex Atlas and is recognized for the novel tools he has developed to analyze brain networks.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypocretin receptor antagonists prevent opioid addiction","authors":"Jimmy J. Fraigne, John H. Peever","doi":"10.1038/s44220-024-00300-7","DOIUrl":"10.1038/s44220-024-00300-7","url":null,"abstract":"The opioid abuse epidemic is a major health concern that requires new pain management strategies. Findings now show that suvorexant, a dual hypocretin receptor antagonist, reverses the anatomical and circuit alterations induced by opioids and decreases addictive behavior while maintaining the analgesic properties of the drugs.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain, lifestyle and environmental pathways linking physical and mental health","authors":"Y. E. Tian, James H. Cole, E. Bullmore, Andrew Zalesky","doi":"10.1038/s44220-024-00303-4","DOIUrl":"https://doi.org/10.1038/s44220-024-00303-4","url":null,"abstract":"","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141922104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mood instability metrics to stratify individuals and measure outcomes in bipolar disorder","authors":"Sarah H. Sperry, Anastasia K. Yocum, Melvin G. McInnis","doi":"10.1038/s44220-024-00291-5","DOIUrl":"10.1038/s44220-024-00291-5","url":null,"abstract":"Clinical care for bipolar disorder (BD) has a narrow focus on prevention and remission of episodes with pre-/posttreatment reductions in symptom severity as the ‘gold standard’ for outcomes in clinical trials and measurement-based care strategies. Here the study aim was to provide an innovative method for measuring outcomes in BD that has clinical utility and can stratify individuals with BD based on mood instability. The 603 participants comprised those with a BD (n = 385), other or nonaffective disorder (n = 71) or no psychiatric history (n = 147) enrolled in an longitudinal cohort for at least 10 years that collects patient-reported outcome measures (PROMs) assessing depression, (hypo)mania, anxiety and functioning every 2 months. Mood instability was calculated as the intraindividual s.d. of PROMs over 1-year rolling windows and stratified into low, moderate and high thresholds. Individuals with BD had significantly higher 1-year rolling s.d. for depression, (hypo)mania and anxiety compared with psychiatric comparisons (small–moderate effects) and healthy controls (large effects). A significantly greater proportion of scores for those with BD fell into the moderate (depression 50.6%; anxiety 36.5%; and (hypo)mania 52.1%) and high thresholds (depression 9.4%; anxiety 6.1%; and (hypo)mania 10.1%) compared with psychiatric comparisons (moderate 32.3–42.9% and high 2.6–6.6%) and healthy controls (moderate 11.5–31.7% and high 0.4–5.8%). Being in the high or moderate threshold predicted worse mental health functioning (small to large effects). Mood instability, as measured in commonly used PROMs, characterized the course of illness over time, correlated with functional outcomes and significantly differentiated those with BD from healthy controls and psychiatric comparisons. The results suggest a paradigm shift in monitoring outcomes in BD, by measuring intraindividual s.d. as a primary outcome index. This study introduces a method to measure outcomes in bipolar disorder by quantifying mood instability over time.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141925464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Country and culture, mental health in context","authors":"","doi":"10.1038/s44220-024-00305-2","DOIUrl":"10.1038/s44220-024-00305-2","url":null,"abstract":"Much of psychiatry, psychology and mental health broadly has been dependent on the notion that people are predominantly similar or simply by neglecting diversity. Yet there are powerful influences related to one’s national or country identity, race and ethnicity, community and cultural heritage that speak to a far more complex and dynamic reality. Reflecting on these factors in the context of research is not only a challenge but a profound opportunity to spur future work and to improve care and treatment for individuals.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-024-00305-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141929489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different hierarchical reconfigurations in the brain by psilocybin and escitalopram for depression","authors":"Gustavo Deco, Yonatan Sanz Perl, Samuel Johnson, Niamh Bourke, Robin L. Carhart-Harris, Morten L. Kringelbach","doi":"10.1038/s44220-024-00298-y","DOIUrl":"10.1038/s44220-024-00298-y","url":null,"abstract":"Effective interventions for neuropsychiatric disorders may work by rebalancing the brain’s functional hierarchical organization. Here we directly investigated the effects of two different serotonergic pharmacological interventions on functional brain hierarchy in major depressive disorder in a two-arm double-blind phase II randomized controlled trial comparing psilocybin therapy (22 patients) with escitalopram (20 patients). Patients with major depressive disorder received either 2 × 25 mg of oral psilocybin, three weeks apart, plus six weeks of daily placebo (‘psilocybin arm’) or 2 × 1 mg of oral psilocybin, three weeks apart, plus six weeks of daily escitalopram (10–20 mg; ‘escitalopram arm’). Resting-state functional magnetic resonance imaging scans were acquired at baseline and three weeks after the second psilocybin dose ( NCT03429075 ). The brain mechanisms were captured by generative effective connectivity, estimated from whole-brain modeling of resting state for each session and patient. Hierarchy was determined for each of these sessions using measures of directedness and trophic levels on the effective connectivity, which captures cycle structure, stability and percolation. The results showed that the two pharmacological interventions created significantly different hierarchical reconfigurations of whole-brain dynamics with differential, opposite statistical effect responses. Furthermore, the use of machine learning revealed significant differential reorganization of brain hierarchy before and after the two treatments. Machine learning was also able to predict treatment response with an accuracy of 0.85 ± 0.04. Overall, the results demonstrate that psilocybin and escitalopram work in different ways for rebalancing brain dynamics in depression. This suggests the hypothesis that neuropsychiatric disorders could be closely linked to the breakdown in regions orchestrating brain dynamics from the top of the hierarchy. Psilocybin and escitalopram create significantly different reconfigurations in the global functional hierarchy of brain dynamics with opposite statistical effect responses in people with major depressive disorder.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44220-024-00298-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lessons on targeting family mental health and improving outcomes for children of parents with a mental illness","authors":"Elena Toffol, Markus Stracke, Neele Harlos, Stefanie Lambrecht, Florian Brandt, Sören Friedrich, Sonja Kennard, Lasse Wenzel, Giovanni de Girolamo, Kristin Gilbert, Corinna Reck, Kathleen Otto, Ricarda Steinmayr, Babette Renneberg, Jean L. Paul, Anne A. E. Thorup, Christina Schwenck, Anna-Lena Zietlow, Linda Wirthwein, Hanna Christiansen","doi":"10.1038/s44220-024-00285-3","DOIUrl":"10.1038/s44220-024-00285-3","url":null,"abstract":"Children of parents with a mental illness (COPMI) are at risk of adverse outcomes, as well as of developing a mental illness themselves. Recognition of modifiable risk factors, along with targeted initiatives and interventions have the potential to improve their and their families’ strengths and resilience, and thus effectively interrupt this vicious circle of the transgenerational transmission of mental disorders. Although several international projects have been funded and implemented, their planning, implementation and translation are not free from problems and downsides, and the use of measures specifically targeting COPMI is not yet part of regular clinical practice. Here we illustrate four European projects targeting family mental health, addressing the main problems encountered and the principal focuses for future directions, as learned from live discussions between project team members, participating patients/parents and other stakeholders. Our goal was to summarize those as lessons learned and make them available to the public and research community. Children of parents with a mental illness are at risk of adverse mental health outcomes. This Perspective discusses lessons learned from the European projects targeting family mental health and, on the basis of identified problems and barriers, provides recommendations to guide the development of future projects and facilitate successful implementation of their results.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141968610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}