Nature mental health最新文献

{"title":"Magnetoencephalography oscillation-based functional connectivity identifies clinically relevant depression phenotypes","authors":"Wenya Liu \u0000 (, ), Maria Vesterinen, Alexandra Andersson, Paula Partanen, Samanta Knapič, Joonas J. Juvonen, Felix Siebenhühner, Antti Salonen, Hanna Renvall, Risto J. Ilmoniemi, Eero Castrén, Erkki Isometsä, Dimitri Van De Ville, J. Matias Palva, Satu Palva","doi":"10.1038/s44220-026-00723-4","DOIUrl":"10.1038/s44220-026-00723-4","url":null,"abstract":"Heterogeneity in clinical presentation and mechanisms of major depressive disorder (MDD) probably contributes to limited responses to current treatments in many patients. Identifying biologically meaningful phenotypes would constitute a major step towards the development of personalized treatment approaches. Brain-activity-based phenotyping offers a promising route toward this goal. In particular, brain oscillations—rhythmic patterns of neural activity that support information processing—have been implicated in depression but have not previously been used to define biological phenotypes of the disorder. Yet, no studies have used brain oscillations to identify biological depression phenotypes. Here we report data-driven identification of oscillation phenotypes for MDD. We conducted a cross-sectional study and collected resting-state magnetoencephalography (MEG), structural magnetic resonance imaging and clinical symptom data from 263 patients with MDD and 75 healthy controls. We assessed oscillation-based functional connectivity from source-reconstructed MEG data with two coupling-mode measures and computed their low-dimensional brain–symptom associations to obtain latent components. Using clustering methods on these components, we identified five depression phenotypes that were characterized by distinct spectral and spatial patterns and differentiated clinically unique symptom profiles. These findings suggest that MEG-based oscillatory connectivity captures clinically relevant heterogeneity in MDD and provides candidate mechanistic phenotypes for future validation and treatment-stratification studies. Using magnetoencephalography, structural magnetic resonance imaging and clinical symptom data from patients with major depressive disorder, the authors identify five depression phenotypes with distinct neural and symptom profiles.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"4 10","pages":"1534-1547"},"PeriodicalIF":9.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44220-026-00723-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149100823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Representativeness and inclusivity in pharmacological and nutraceutical interventions in youth mental health disorders: a systematic review and meta-analysis","authors":"Claudia Aymerich, Javier Torres-Cortés, Antonio Melillo, Borja Pedruzo, Ana Catalan, Olatz Ibarretxe, Chiara Nosarti, Katya Rubia, Celso Arango, Philip Shaw, Cornelius Ani, Hannah Chu-Han Huang, Bernadka Dubicka, Ian Kelleher, Paolo Fusar-Poli, Samuele Cortese, Gonzalo Salazar de Pablo","doi":"10.1038/s44220-026-00722-5","DOIUrl":"10.1038/s44220-026-00722-5","url":null,"abstract":"Randomized controlled trials (RCTs) guide treatment decisions in youth with mental health disorders, yet concerns remain about their generalizability. Here we conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant systematic review and meta-analysis (CRD42024629137) to assess the inclusivity and representativeness of RCTs on pharmacological and nutraceutical interventions in children and adolescents with Diagnostic and Statistical Manual of Mental Disorders and/or International Classification of Diseases-defined mental disorders. Random-effects meta-analyses were conducted by disorder, and temporal trends were assessed. Primary outcomes were the representativeness of RCTs with respect to sex (pooled proportion of female participants) and race/ethnicity (distribution of racial and ethnic groups); secondary outcomes included the exclusion of key clinical populations (for example, autistic individuals, those with intellectual disability and those with suicide risk). A total of 397 RCTs (46,989 participants; mean age 10.2 ± 3.1 years) were included, mostly targeting attention deficit hyperactivity disorder (34.5%) or autism spectrum disorder (29.7%). Female participants represented 28.3%. Only 53.7% of RCTs reported racial data; 75.0% were white, 10.1% Black, 6.2% Hispanic and 2.0% Asian. Autistic individuals and those with learning disabilities were excluded in 56.5% and 44.3% of trials, respectively; 76.0% of depression RCTs excluded participants at suicide risk. There is a persistent mismatch between the youth most affected by mental health disorders and those included in RCTs. Some vulnerable populations including people of colour, women and special populations seem to be under-represented, requiring more inclusive practice to support equitable and effective care. This systematic review and meta-analysis of 397 randomized controlled trials identifies an under-representation of women, people of colour and vulnerable youth populations in mental health research, highlighting the need for more inclusive methodologies in clinical trials.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"4 10","pages":"1592-1603"},"PeriodicalIF":9.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44220-026-00722-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149100811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term cardiorenal illness trajectories after initiation of antihypertensive medications in adults with and without ADHD: a nationwide cohort study","authors":"Yiling Zhou, Douwe Postmus, Sheyu Li, Anne van Lammeren, Casper F. M. Franssen, Harold Snieder, Catharina A. Hartman","doi":"10.1038/s44220-026-00718-1","DOIUrl":"10.1038/s44220-026-00718-1","url":null,"abstract":"Adults with attention deficit hyperactivity disorder (ADHD) have a higher prevalence and incidence of hypertension, but whether long-term cardiorenal trajectories after the initiation of antihypertensive medications differ by ADHD status is unclear. Here, in this nationwide retrospective cohort study using Dutch register data, we included 706,414 new users (52.2% female, aged 18–90 years) of antihypertensive medications without prior cardiovascular disease or chronic kidney disease (CKD); 10,689 had ADHD. Multistate modelling was used to characterize long-term cardiorenal illness trajectories and compare transition-specific rates between adults with and without ADHD. Adults with ADHD had higher adjusted rates of heart failure hospitalization (HHF; hazard ratio (HR), 1.46; 95% confidence interval (CI), 1.12–1.90) and stroke (HR, 1.19; 95% CI, 1.03–1.38) after antihypertensive medication initiation. They also had higher adjusted rates of cardiorenal death after HHF (HR, 1.79; 95% CI, 1.01–3.17) or CKD (HR, 2.57; 95% CI, 1.33–4.97) onset. Ten-year trajectories through HHF or CKD to cardiorenal death were more common in adults with ADHD. This research investigates long-term cardiorenal outcomes in adults initiating antihypertensive medications, revealing that those with ADHD experience significantly higher rates of heart failure hospitalization, stroke and cardiorenal death than counterparts without ADHD, using multistate modelling for analysis.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"4 10","pages":"1502-1510"},"PeriodicalIF":9.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149100821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Brain morphological pattern is associated with the presence, severity and transition of transdiagnostic psychiatric disorders in preadolescents","authors":"Nanyu Kuang, Christopher J. Hammond, Betty Jo Salmeron, Xiang Xiao, Danni Wang, Laura Murray, Hong Gu, Tianye Zhai, Hui Zheng, Justine Hill, Maria Scavnicky, Hanbing Lu, Amy Janes, Thomas J. Ross, Yihong Yang","doi":"10.1038/s44220-026-00732-3","DOIUrl":"10.1038/s44220-026-00732-3","url":null,"abstract":"","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"4 9","pages":"1463-1463"},"PeriodicalIF":9.3,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44220-026-00732-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vision science and oculomics in psychiatry: retinal biomarkers, visual circuits, and field consolidation","authors":"Paulo Lizano, Katharine N. Thakkar, Sonia Bansal, Michel Maziade, Robert M. G. Reinhart, Halide Bilge Turkozer, Siegfried Wagner, Steven Silverstein","doi":"10.1038/s44220-026-00724-3","DOIUrl":"10.1038/s44220-026-00724-3","url":null,"abstract":"In this Comment, we discuss how visual system abnormalities in schizophrenia can provide mechanistic insights and aid prognosis. We also highlight the importance of coordinated efforts to harmonize the field of vision and oculomics in psychiatry.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"4 10","pages":"1480-1482"},"PeriodicalIF":9.3,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149100863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal biomarker assessments in psychiatric disorders: perspective and roadmap from a data and methods sharing initiative","authors":"Cemal Demirlek, Ali S. Raza, Finn Rabe, Florian J. Raabe, Kaitlyn Kaiser, Erik Velez-Perez, Daman P. Dhunna, Chelsea Kiely, Steve Silverstein, Halide Bilge Turkozer, Siegfried K. Wagner, Paulo Lizano","doi":"10.1038/s44220-026-00719-0","DOIUrl":"10.1038/s44220-026-00719-0","url":null,"abstract":"The retina offers a noninvasive, high-resolution window into brain and systemic pathology by capturing neurostructural, vascular and functional changes, positioning oculomics as a promising avenue for psychiatric biomarker discovery. However, progress has been limited by small, single-site samples, device heterogeneity, proprietary software and fragmented analytic pipelines. The Consortium for Vision and Oculomics in Psychiatry–Data and Methods Sharing Initiative aims to address these gaps by building a collaborative framework for data and methods sharing in retinal imaging across psychiatric populations. We summarize key modalities (fundus photography, optical coherence tomography (OCT), OCT–angiography, and electroretinography), highlighting their relevance to psychotic, mood and neurodevelopmental disorders, as well as recurring challenges in acquisition, segmentation, quality control and cross-device comparability. This roadmap aims to accelerate validation and clinical translation of retinal biomarkers for risk, monitoring, prognosis and treatment stratification in psychiatry, and to foster transparent, reproducible and scalable oculomics research across sites and platforms. This Perspective addresses limitations in oculomics for psychiatric biomarker discovery by establishing a collaborative framework for data sharing. Key methods include fundus photography, OCT, OCT-A, and ERG, enhancing retinal imaging’s role in understanding various psychiatric disorders and improving clinical applications.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"4 10","pages":"1491-1501"},"PeriodicalIF":9.3,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149100818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrical vestibular system stimulation versus sham for treatment of post-traumatic stress disorder: a double-blind, randomized clinical trial","authors":"Peter J. Colvonen, Christopher Hunt, Jane Park, Kira Clare, Erik Viirre, Shengjia Tu, Xin M. Tu, Dhakshin Ramanathan","doi":"10.1038/s44220-026-00714-5","DOIUrl":"10.1038/s44220-026-00714-5","url":null,"abstract":"In-home electrical vestibular system stimulation (VSS) represents a promising and underexplored approach to address core physiological dysregulation and arousal symptoms in post-traumatic stress disorder (PTSD). We conducted a fully remote, double-blind, placebo-controlled, nationally recruited 12-week superiority trial investigating the effects of a noninvasive VSS headset compared with a sham control headset in reducing PTSD symptoms. Participants were ≥22 years and ≤74 years old, diagnosed with PTSD and had at least current moderate severity of PTSD. The primary outcome was the PTSD Checklist for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (PCL-5; mean 51.83, s.d. 12.91). Secondary outcomes were insomnia severity, quality of life and generalized anxiety. Overall, 383 participants were consented and randomized to an active VSS headset or sham (mean age 45.88 years, s.d. 10.67 years; 56.70% female). Both groups were advised to use the headset at home for 30 min per day for 12 weeks. The headsets are like headphones, with two self-adhesive electrode pads placed over the mastoid processes (VSS headset delivers participant-controlled 0.0–1.5 mA; sham delivers a 1-min ramp-up to 1.0 mA and back down to 0.0 mA). Mixed-effects models showed that the VSS group at 12 weeks had a larger decrease in PCL-5, with a 23.5-point decrease (12-week PCL-5 mean 27.3, s.d. 5.7), while the sham group had a 12.1-point decrease on the PCL-5 (12-week PCL-5 mean 35.7, s.d. 5.7). The VSS group had larger gains across all secondary outcomes. There were equal discontinuation rates between groups. There were minimal adverse events reported (9% had mild dizziness) with no differences between groups. Together, 12 weeks of in-home VSS is effective and safe, and shows strong potential as an accessible intervention that may reach a broad population seeking support for PTSD. ClinicalTrials.gov NCT05242367 . In-home electrical vestibular system stimulation offers a novel approach to mitigate physiological dysregulation and arousal symptoms in post-traumatic stress disorder (PTSD). Here the authors demonstrate that a 12-week regimen of noninvasive vestibular system stimulation significantly reduces PTSD symptoms and improves secondary outcomes, highlighting its potential as a safe, accessible intervention for widespread PTSD treatment.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"4 10","pages":"1524-1533"},"PeriodicalIF":9.3,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149100822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain morphological pattern is associated with the presence, severity and transition of transdiagnostic psychiatric disorders in preadolescents","authors":"Nanyu Kuang, Christopher J. Hammond, Betty Jo Salmeron, Xiang Xiao, Danni Wang, Laura Murray, Hong Gu, Tianye Zhai, Hui Zheng, Justine Hill, Maria Scavnicky, Hanbing Lu, Amy Janes, Thomas J. Ross, Yihong Yang","doi":"10.1038/s44220-026-00704-7","DOIUrl":"10.1038/s44220-026-00704-7","url":null,"abstract":"Cognitive function, psychological processes, mental states and behaviors are key dimensions of mental disorders across diagnostic categories, but whether they are linked to common or distinct brain morphological patterns underlying risk or resilience remains unclear. The current study is a longitudinal investigation of 8,672 youths from the Adolescent Brain Cognitive Development (ABCD) study aged 9–10 years at baseline (4,412 male; 4,260 female). A machine learning approach based on canonical correlation analysis was used to identify latent dimensional associations of cortical morphology (surface area, cortical and subcortical volume, cortical thickness and sulcal/gyral depth) with multidomain behavioral assessments, including cognitive scores and psychological measures indexing motivation, impulse control, mental states and behaviors across a continuum from healthy to pathological. We identified a robust latent brain structural variate across morphological measures that correlated positively with cognitive performance and negatively with psychological measures indexing greater psychopathology. Higher scores on this brain variate reflected larger cortical surface area and cortical volume, especially in the temporal gyri, together with a posterior–anterior gradient in cortical thickness, showing greater thickness in occipital, parietal and temporal cortices and lower thickness in cingulate and frontal regions. This brain variate and the related cognitive–psychological–behavioral variate remained stable and showed a dose-dependent relationship with cumulative psychiatric diagnoses assessed concurrently and at the 2-year follow-up, with lower brain variate scores associated with higher numbers of comorbid diagnoses. Brain scores were also associated with longitudinal transitions between healthy and diagnosed states: lower baseline scores associated with persistent psychiatric diagnoses and higher baseline scores associated with persistent healthy states, suggesting a vulnerability–resilience continuum for psychopathology. These findings advance the neurodevelopmental understanding of psychiatric disorders and highlight the potential utility of morphology-informed approaches for early screening and intervention in youth. This study investigates the relationship of brain morphology with cognitive and psychological dimensions in 8,672 youths, using machine learning to reveal significant correlations between cortical metrics and behavioral assessments, indicating a continuum of vulnerability and resilience for psychiatric disorders.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"4 9","pages":"1404-1415"},"PeriodicalIF":9.3,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychedelic therapy and the current and future roles for psychiatric pharmacists in the USA","authors":"Jayme Jenkins, Samantha Catanzano, Nina Vadiei, Madeline Brendle, Rana Zalmai, M. Lynn Crismon, Anton L. V. Avanceña","doi":"10.1038/s44220-026-00709-2","DOIUrl":"10.1038/s44220-026-00709-2","url":null,"abstract":"This Comment reviews pharmacists’ current contributions to psychiatric care in the USA and explains how their expertise, especially that of Board-Certified Psychiatric Pharmacists (BCPPs), positions them to have a key role in the safe, effective delivery of psychedelic therapies. Despite regulatory, reimbursement and training barriers, integrating BCPPs into this emerging field could improve patient safety, address workforce shortages and expand access to care.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"4 10","pages":"1483-1485"},"PeriodicalIF":9.3,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149100816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binge-eating behavior and anorexia nervosa have shared and distinct genetic components","authors":"","doi":"10.1038/s44220-026-00697-3","DOIUrl":"10.1038/s44220-026-00697-3","url":null,"abstract":"Genome-wide association studies of individuals with binge-eating behavior, anorexia nervosa or neither identify distinct genetic associations with each phenotype. Although both eating disorder phenotypes correlate genetically with other psychiatric conditions, binge eating also correlates with impulsivity, earlier age at first menstrual cycle and increased body mass, whereas anorexia nervosa shares genetics with metabolic traits.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"4 9","pages":"1359-1360"},"PeriodicalIF":9.3,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}