Nature mental health最新文献

{"title":"A safer option for treating schizophrenia in teens","authors":"Natalia Gass","doi":"10.1038/s44220-025-00438-y","DOIUrl":"10.1038/s44220-025-00438-y","url":null,"abstract":"","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 5","pages":"484-484"},"PeriodicalIF":8.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therabot for the treatment of mental disorders","authors":"Ioannis Bakoyiannis","doi":"10.1038/s44220-025-00439-x","DOIUrl":"10.1038/s44220-025-00439-x","url":null,"abstract":"","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 5","pages":"485-485"},"PeriodicalIF":8.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women’s brain health and brain capital","authors":"Laura Castro-Aldrete, Megan Greenfield, Erin Smith, Harris A. Eyre, Mariapaola Barbato, Lucy Pérez, Antonella Santuccione Chadha","doi":"10.1038/s44220-025-00406-6","DOIUrl":"10.1038/s44220-025-00406-6","url":null,"abstract":"Brain capital, broadly defined as a form of capital that prioritizes brain skills and brain health, is urgently required. Integrating social, emotional and cognitive brain resources is a great asset for a wealthy and healthy society. Nevertheless, there is little investment in women’s brain health on a global scale. Women, on average, spend nine additional years in poor health compared with men, which hinders their participation in education, the workforce and society at large. This Perspective highlights the crucial intersection between investing in women’s brain health and the concept of ‘brain capital.’ Here we argue that addressing the women’s health gap could potentially increase the global economy by US $1 trillion in annual incremental gross domestic product. Furthermore, we hope this article will serve as a springboard to stimulate discussion and concrete stakeholder actions toward closing the women’s brain health gap and will add to the growing discourse on sex- and gender-specific healthcare and its impact on global community well-being. In this Perspective, the authors discuss the need to address the women’s brain health gap and its link to the concept of brain capital.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 5","pages":"488-497"},"PeriodicalIF":8.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44220-025-00406-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking the measurement of physical neglect in research and practice","authors":"Julia Ditzer, Jana Ray, Myriam V. Thoma, Rahel Bachem, Andreas Maercker, Anna-Lena Zietlow","doi":"10.1038/s44220-025-00425-3","DOIUrl":"10.1038/s44220-025-00425-3","url":null,"abstract":"Physical neglect is a frequently overlooked form of child maltreatment in both research and practice. Here, we summarize the complexities of measuring physical neglect, and provide recommendations to guide future research and facilitate a deeper understanding of the effects of physical neglect on children’s development and wellbeing.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 7","pages":"750-752"},"PeriodicalIF":8.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal brain imaging of insomnia, depression and anxiety symptoms indicates transdiagnostic commonalities and differences","authors":"Siemon C. de Lange, Elleke Tissink, Tom Bresser, Jeanne E. Savage, Danielle Posthuma, Martijn P. van den Heuvel, Eus J. W. van Someren","doi":"10.1038/s44220-025-00412-8","DOIUrl":"10.1038/s44220-025-00412-8","url":null,"abstract":"Insomnia disorder, major depressive disorder and anxiety disorders are the most common mental health conditions, often co-occurring and sharing genetic risk factors, suggesting possible common brain mechanisms. Here we analyzed multimodal magnetic resonance imaging data from over 25,604 UK Biobank participants to identify shared versus symptom-specific brain features associated with symptom severity of these disorders. Smaller total cortical surface area, smaller thalamic volumes and weaker functional connectivity were linked to more severe symptoms of all three disorders. Disorder-specific symptom severity associations were also observed: smaller reward-related subcortical regions were associated with more severe insomnia symptoms; thinner cortices in language, reward and limbic regions with more severe depressive symptoms; and weaker amygdala reactivity and functional connectivity of dopamine-, glutamate- and histamine-enriched regions with more severe anxiety symptoms. These symptom-specific associations were often in parts of the amygdala–hippocampal–medial prefrontal circuit, highlighting the interconnectedness of these disorders and suggesting new pathways for research and treatment. The authors used data from the UK Biobank to identify associations of self-rated symptoms of insomnia, depression and anxiety with cortical area, cortical thickness, subcortical volume, structural connectivity, functional connectivity, cognitive–emotional domains and neurochemical receptor distribution.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 5","pages":"517-529"},"PeriodicalIF":8.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Global Flourishing Study: Study Profile and Initial Results on Flourishing","authors":"Tyler J. VanderWeele, Byron R. Johnson, Piotr T. Bialowolski, Rebecca Bonhag, Matt Bradshaw, Thomas Breedlove, Brendan Case, Ying Chen, Zhuo Job Chen, Victor Counted, Richard G. Cowden, Pedro Antonio de la Rosa, Chris Felton, Alex Fogleman, Cristina Gibson, Nikolitsa Grigoropoulou, Craig Gundersen, Sung Joon Jang, Kathryn A. Johnson, Blake Victor Kent, Eric S. Kim, Young-Il Kim, Hayami K. Koga, Matthew T. Lee, Noemi Le Pertel, Tim Lomas, Katelyn N. G. Long, Lucía Macchia, Christos A. Makridis, Lesley Markham, Julia S. Nakamura, Nicholas Norman-Krause, Chukwuemeka N. Okafor, Sakurako S. Okuzono, Suzanne T. Ouyang, R. Noah Padgett, Jason Paltzer, James L. Ritchie-Dunham, Zacc Ritter, Koichiro Shiba, Rajesh Srinivasan, John Ssozi, Dorota Weziak-Bialowolska, Renae Wilkinson, Robert D. Woodberry, Jennifer Wortham, George Yancey","doi":"10.1038/s44220-025-00423-5","DOIUrl":"10.1038/s44220-025-00423-5","url":null,"abstract":"The Global Flourishing Study is a longitudinal panel study of over 200,000 participants in 22 geographically and culturally diverse countries, spanning all six populated continents, with nationally representative sampling and intended annual survey data collection for 5 years to assess numerous aspects of flourishing and its possible determinants. The study is intended to expand our knowledge of the distribution and determinants of flourishing around the world. Relations between a composite flourishing index and numerous demographic characteristics are reported. Participants were also surveyed about their childhood experiences, which were analyzed to determine their associations with subsequent adult flourishing. Analyses are presented both across and within countries, and discussion is given as to how the demographic and childhood relationships vary by country and which patterns appear to be universal versus culturally specific. Brief comment is also given on the results of a whole series of papers in the Global Flourishing Study Special Collection, employing similar analyses, but with more-specific aspects of well-being. The Global Flourishing Study expands our knowledge of the distribution and determinants of well-being and provides foundational knowledge for the promotion of societal flourishing. The Global Flourishing Study provides a comprehensive view of the distribution and determinants of well-being by assessing domains such as health, happiness, meaning, character, relationships and financial security. Initial findings reveal significant variations in flourishing across countries and demographic groups, with factors such as age, marital status and religious service attendance showing strong associations with well-being.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 6","pages":"636-653"},"PeriodicalIF":8.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal thinness is associated with genetic risk of schizophrenia","authors":"","doi":"10.1038/s44220-025-00421-7","DOIUrl":"10.1038/s44220-025-00421-7","url":null,"abstract":"Greater genetic susceptibility to schizophrenia is associated with thinner retinal structures — the macula, as well as both the outer retina and the inner retina. Biological pathways associated with neuroinflammation, which play a part in schizophrenia, might be involved in retinal thinning mechanisms.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 5","pages":"486-487"},"PeriodicalIF":8.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network temperature as a metric of stability in depression symptoms across adolescence","authors":"Poppy Z. Grimes, Aja L. Murray, Keith Smith, Andrea G. Allegrini, Giulia G. Piazza, Henrik Larsson, Sacha Epskamp, Heather C. Whalley, Alex S. F. Kwong","doi":"10.1038/s44220-025-00415-5","DOIUrl":"10.1038/s44220-025-00415-5","url":null,"abstract":"Depression is characterized by diverse symptom combinations that can be represented as dynamic networks. While previous research has focused on central symptoms for targeted interventions, less attention has been given to whole-network properties. Here we show that ‘network temperature’, a novel measure of psychological network stability, captures symptom alignment across adolescence—a critical period for depression onset. Network temperature reflects system stability, with higher values indicating less symptom alignment and greater variability. In three large longitudinal adolescent cohorts (total N = 35,901), we found that network temperature decreases across adolescence, with the steepest decline during early adolescence, particularly in males. This suggests that depression symptom networks stabilize throughout development via increased symptom alignment, potentially explaining why adolescence is a crucial period for depression onset. These findings highlight early adolescence as a key intervention window and underscore the importance of sex-specific and personalized interventions. This study explores the dynamics of adolescent depression through the lens of network temperature, a novel concept in psychological symptom networks. Researchers observed a decrease in network temperature across adolescence, indicating increased stability and decreased variability of depressive symptoms as adolescents age and with distinct patterns between sexes. This work emphasizes the importance of understanding network dynamics over static measures, offering new insights into the stability and variability of depression symptoms.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 5","pages":"548-557"},"PeriodicalIF":8.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The risk of social isolation and loneliness on progression from incident cardiovascular disease to subsequent depression","authors":"Xin Qi, Shiqiang Cheng, Jin Yang, Li Liu, Jingcan Hao, Wenming Wei, Chuyu Pan, Meijuan Kang, Yan Wen, Bolun Cheng, Feng Zhang","doi":"10.1038/s44220-025-00418-2","DOIUrl":"10.1038/s44220-025-00418-2","url":null,"abstract":"Loneliness and social isolation are crucial triggers in the development of cardiovascular disease (CVD) and depression. This study aimed to explore the associations of loneliness and social isolation with the transition from incident CVD to subsequent depression. Multistate models were constructed to investigate the effects of loneliness and social isolation on the transitions from a healthy state to incident CVD, further to subsequent depression and to death in the UK Biobank cohort (N = 265,794). Participants in the loneliness group had a greater risk for the transition from incident CVD to subsequent depression (hazard ratio = 2.008; 95% confidence interval 1.751–2.351). The hazard ratios of the transition from incident CVD to subsequent depression were 1.148 (1.036–1.274) in the moderately isolated group and 1.173 (1.020–1.348) in the most isolated group. These findings highlight the need for interventions targeting loneliness and social isolation to mitigate the risk of CVD and depression. Using multistate models, the authors examine the effects of loneliness and social isolation on the transition from a healthy state to cardiovascular disease, subsequent depression and death.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 5","pages":"558-566"},"PeriodicalIF":8.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health consequences of exposure to mass and non-mass shootings in a national sample of US adults","authors":"Jillian K. Peterson, James A. Densley, David C. Pyrooz","doi":"10.1038/s44220-025-00413-7","DOIUrl":"10.1038/s44220-025-00413-7","url":null,"abstract":"Gun violence exposure is a major public health issue in the United States, yet its mental health consequences remain insufficiently examined. This study investigates the short- and long-term psychological self-reported impacts of lifetime gun violence exposure using a cross-sectional survey of 10,000 respondents designed to be representative of US adults administered online by YouGov in January 2024. Findings revealed that 20.1% of respondents reported a mass shooting in their community, 18.3% had been threatened with a firearm, and 2.2% and 2.4% were injured in mass and non-mass shootings, respectively. Between 58.6% and 94.4% reported mental health consequences across exposure types, with younger individuals and women particularly vulnerable. While mass shootings corresponded with greater psychological distress, the long-term impacts, including post-traumatic stress, were reported at a higher rate following non-mass shootings. These findings promote trauma-informed public health interventions tailored to both individual and community-level needs in the aftermath of gun violence. This study reports short-term and long-term mental health outcomes across several forms of firearm violence exposure using data from an online survey of 10,000 US respondents administered by YouGov and identifies vulnerable groups.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 5","pages":"530-537"},"PeriodicalIF":8.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44220-025-00413-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}