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Strategic reuse of rapid antigen tests for coagulation status assessment: an integrated machine learning approach 凝血状态评估中快速抗原检测的战略性重复使用：一种综合机器学习方法
Med-X Pub Date : 2024-07-18 DOI: 10.1007/s44258-024-00025-3
Allan Sun, Arian Nasser, Chaohao Chen, Y. Zhao, Haimei Zhao, Zihao Wang, Wenlong Cheng, Pierre Qian, L. Ju
{"title":"Strategic reuse of rapid antigen tests for coagulation status assessment: an integrated machine learning approach","authors":"Allan Sun, Arian Nasser, Chaohao Chen, Y. Zhao, Haimei Zhao, Zihao Wang, Wenlong Cheng, Pierre Qian, L. Ju","doi":"10.1007/s44258-024-00025-3","DOIUrl":"https://doi.org/10.1007/s44258-024-00025-3","url":null,"abstract":"","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141827717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atomic force microscopy in the characterization and clinical evaluation of neurological disorders: current and emerging technologies 原子力显微镜在神经系统疾病的表征和临床评估中的应用：现有技术和新兴技术
Med-X Pub Date : 2024-06-03 DOI: 10.1007/s44258-024-00022-6
David T. She, M. Nai, C. T. Lim
{"title":"Atomic force microscopy in the characterization and clinical evaluation of neurological disorders: current and emerging technologies","authors":"David T. She, M. Nai, C. T. Lim","doi":"10.1007/s44258-024-00022-6","DOIUrl":"https://doi.org/10.1007/s44258-024-00022-6","url":null,"abstract":"","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141272197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomaterials-enabled electrical stimulation for tissue healing and regeneration 利用生物材料电刺激促进组织愈合和再生
Med-X Pub Date : 2024-05-21 DOI: 10.1007/s44258-024-00020-8
Han-Sem Kim, Tanza Baby, Jung-Hwan Lee, U. Shin, Hae-Won Kim
{"title":"Biomaterials-enabled electrical stimulation for tissue healing and regeneration","authors":"Han-Sem Kim, Tanza Baby, Jung-Hwan Lee, U. Shin, Hae-Won Kim","doi":"10.1007/s44258-024-00020-8","DOIUrl":"https://doi.org/10.1007/s44258-024-00020-8","url":null,"abstract":"","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141114692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancement in modulation of brain extracellular space and unlocking its potential for intervention of neurological diseases 调控脑细胞外空间并挖掘其干预神经系统疾病的潜力方面的进展
Med-X Pub Date : 2024-05-03 DOI: 10.1007/s44258-024-00021-7
Yu Yong, Yicong Cai, Jiawei Lin, Lin Ma, HongBin Han, Fenfang Li
{"title":"Advancement in modulation of brain extracellular space and unlocking its potential for intervention of neurological diseases","authors":"Yu Yong, Yicong Cai, Jiawei Lin, Lin Ma, HongBin Han, Fenfang Li","doi":"10.1007/s44258-024-00021-7","DOIUrl":"https://doi.org/10.1007/s44258-024-00021-7","url":null,"abstract":"","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shear wave ultrasound elastography for estimating cartilage stiffness: implications for early detection of osteoarthritis 用于估算软骨硬度的剪切波超声弹性成像技术：对早期检测骨关节炎的意义
Med-X Pub Date : 2024-04-12 DOI: 10.1007/s44258-024-00018-2
Elias Georgas, Adnan Rayes, Junhang Zhang, Qifa Zhou, Yi-Xian Qin
{"title":"Shear wave ultrasound elastography for estimating cartilage stiffness: implications for early detection of osteoarthritis","authors":"Elias Georgas, Adnan Rayes, Junhang Zhang, Qifa Zhou, Yi-Xian Qin","doi":"10.1007/s44258-024-00018-2","DOIUrl":"https://doi.org/10.1007/s44258-024-00018-2","url":null,"abstract":"","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140710535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining multi-mode thermal therapy with IL-6 and IL-17A neutralization amplifies antitumor immunity to facilitate long-term survival in LLC1-bearing mice 将多模式热疗法与 IL-6 和 IL-17A 中和疗法相结合，可增强抗肿瘤免疫力，促进 LLC1 携带小鼠的长期存活
Med-X Pub Date : 2024-04-03 DOI: 10.1007/s44258-024-00016-4
Jiamin Zheng, Jincheng Zou, Yue Lou, Shicheng Wang, Zelun Zhang, Junjun Wang, Peishan Du, Yongxin Zhu, Jiaqi You, Yichen Yao, Yuankai Hao, Aili Zhang, Ping Liu
{"title":"Combining multi-mode thermal therapy with IL-6 and IL-17A neutralization amplifies antitumor immunity to facilitate long-term survival in LLC1-bearing mice","authors":"Jiamin Zheng, Jincheng Zou, Yue Lou, Shicheng Wang, Zelun Zhang, Junjun Wang, Peishan Du, Yongxin Zhu, Jiaqi You, Yichen Yao, Yuankai Hao, Aili Zhang, Ping Liu","doi":"10.1007/s44258-024-00016-4","DOIUrl":"https://doi.org/10.1007/s44258-024-00016-4","url":null,"abstract":"","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140750101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping the distribution of tension across paxillin upon shear stress with FRET-based biosensor 利用基于 FRET 的生物传感器绘制剪切应力作用下 paxillin 的张力分布图
Med-X Pub Date : 2024-03-18 DOI: 10.1007/s44258-024-00017-3
Shuai Shao, Sha Deng, Na Li, Zheng-Zhu Zhang, Hangyu Zhang, Bo Liu
{"title":"Mapping the distribution of tension across paxillin upon shear stress with FRET-based biosensor","authors":"Shuai Shao, Sha Deng, Na Li, Zheng-Zhu Zhang, Hangyu Zhang, Bo Liu","doi":"10.1007/s44258-024-00017-3","DOIUrl":"https://doi.org/10.1007/s44258-024-00017-3","url":null,"abstract":"","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140233205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Employing toehold-mediated DNA strand displacement reactions for biomedical applications 在生物医学应用中采用脚趾介导的 DNA 链置换反应
Med-X Pub Date : 2024-01-29 DOI: 10.1007/s44258-024-00015-5
Keziah Jacob Souza, Deepak K. Agrawal
{"title":"Employing toehold-mediated DNA strand displacement reactions for biomedical applications","authors":"Keziah Jacob Souza, Deepak K. Agrawal","doi":"10.1007/s44258-024-00015-5","DOIUrl":"https://doi.org/10.1007/s44258-024-00015-5","url":null,"abstract":"","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140486913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering biomaterials by inkjet printing of hydrogels with functional particulates. 通过喷墨打印带有功能微粒的水凝胶来制造生物材料。
Med-X Pub Date : 2024-01-01 Epub Date: 2024-07-03 DOI: 10.1007/s44258-024-00024-4
Cih Cheng, Eric J Williamson, George T-C Chiu, Bumsoo Han
{"title":"Engineering biomaterials by inkjet printing of hydrogels with functional particulates.","authors":"Cih Cheng, Eric J Williamson, George T-C Chiu, Bumsoo Han","doi":"10.1007/s44258-024-00024-4","DOIUrl":"10.1007/s44258-024-00024-4","url":null,"abstract":"<p><p>Hydrogels with particulates, including proteins, drugs, nanoparticles, and cells, enable the development of new and innovative biomaterials. Precise control of the spatial distribution of these particulates is crucial to produce advanced biomaterials. Thus, there is a high demand for manufacturing methods for particle-laden hydrogels. In this context, 3D printing of hydrogels is emerging as a promising method to create numerous innovative biomaterials. Among the 3D printing methods, inkjet printing, so-called drop-on-demand (DOD) printing, stands out for its ability to construct biomaterials with superior spatial resolutions. However, its printing processes are still designed by trial and error due to a limited understanding of the ink behavior during the printing processes. This review discusses the current understanding of transport processes and hydrogel behaviors during inkjet printing for particulate-laden hydrogels. Specifically, we review the transport processes of water and particulates within hydrogel during ink formulation, jetting, and curing. Additionally, we examine current inkjet printing applications in fabricating engineered tissues, drug delivery devices, and advanced bioelectronics components. Finally, the challenges and opportunities for next-generation inkjet printing are also discussed.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microneedle sensors for dermal interstitial fluid analysis. 用于皮肤间液分析的微针传感器。
Med-X Pub Date : 2024-01-01 Epub Date: 2024-10-01 DOI: 10.1007/s44258-024-00028-0
Gwangmook Kim, Hyunah Ahn, Joshua Chaj Ulloa, Wei Gao
{"title":"Microneedle sensors for dermal interstitial fluid analysis.","authors":"Gwangmook Kim, Hyunah Ahn, Joshua Chaj Ulloa, Wei Gao","doi":"10.1007/s44258-024-00028-0","DOIUrl":"10.1007/s44258-024-00028-0","url":null,"abstract":"<p><p>The rapid advancement in personalized healthcare has driven the development of wearable biomedical devices for real-time biomarker monitoring and diagnosis. Traditional invasive blood-based diagnostics are painful and limited to sporadic health snapshots. To address these limitations, microneedle-based sensing platforms have emerged, utilizing interstitial fluid (ISF) as an alternative biofluid for continuous health monitoring in a minimally invasive and painless manner. This review aims to provide a comprehensive overview of microneedle sensor technology, covering microneedle design, fabrication methods, and sensing strategy. Additionally, it explores the integration of monitoring electronics for continuous on-body monitoring. Representative applications of microneedle sensing platforms for both monitoring and therapeutic purposes are introduced, highlighting their potential to revolutionize personalized healthcare. Finally, the review discusses the remaining challenges and future prospects of microneedle technology.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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