Med-X最新文献_第2页

Optical strategies for in vivo retinal ganglion cell imaging. 体内视网膜神经节细胞成像的光学策略。

Med-X Pub Date : 2025-01-01 Epub Date: 2025-11-17 DOI: 10.1007/s44258-025-00066-2

Justin Chen, Raymond Fang, Xiaorong Liu, Hao F Zhang

{"title":"Optical strategies for in vivo retinal ganglion cell imaging.","authors":"Justin Chen, Raymond Fang, Xiaorong Liu, Hao F Zhang","doi":"10.1007/s44258-025-00066-2","DOIUrl":"10.1007/s44258-025-00066-2","url":null,"abstract":"Retinal ganglion cells (RGCs) are essential in transmitting visual information from the retina to the brain, and their impairment has been linked to glaucoma and various neuro-ophthalmic diseases. In vivo imaging of RGC morphology and functionality is crucial for understanding the pathophysiology of retinal disease caused by RGC degeneration and their responses to treatments. This review provides a comprehensive overview of optical technologies suitable for in vivo RGC imaging. First, we compare scanning laser ophthalmoscopy, optical coherence tomography, and two-photon imaging and discuss their effectiveness in quantifying RGC damage in retinal disorders. Then, we discuss how functional vascular imaging techniques and specialized fluorophores, such as capQ and GCaMP, can be exploited to provide deeper insights into the physiology of RGCs. Lastly, we highlight the clinical translation of these imaging modalities, emphasizing handheld devices and clinical workflows to improve the image acquisition process. We also highlight the emerging role of machine learning, which automates tasks such as segmentation and disease classification to improve the efficiency of large data analysis.Graphical abstract: ","PeriodicalId":74169,"journal":{"name":"Med-X","volume":"3 1","pages":"21"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12628489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145566565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frontiers in mechanobiology and mechanomedicine. 机械生物学和机械医学的前沿。

Med-X Pub Date : 2025-01-01 Epub Date: 2025-11-28 DOI: 10.1007/s44258-025-00071-5

Priscilla Y Hwang, Panagiotis Mistriotis, Haogang Cai, Longwei Liu, Bo Zhang, Quinton Smith, Jacopo Ferruzzi, Peter Yingxiao Wang, Song Li

引用次数: 0

A review of light-field imaging in biomedical sciences. 光场成像在生物医学中的研究进展。

Med-X Pub Date : 2025-01-01 Epub Date: 2025-12-16 DOI: 10.1007/s44258-025-00070-6

Ruixuan Zhao, Xuanwen Hua, Woongjae Baek, Zhaoqiang Wang, Shu Jia, Liang Gao

{"title":"A review of light-field imaging in biomedical sciences.","authors":"Ruixuan Zhao, Xuanwen Hua, Woongjae Baek, Zhaoqiang Wang, Shu Jia, Liang Gao","doi":"10.1007/s44258-025-00070-6","DOIUrl":"10.1007/s44258-025-00070-6","url":null,"abstract":"Light-field imaging is an emerging paradigm in biomedical optics, offering the unique ability to capture volumetric information in a single snapshot by encoding both the spatial and angular components of light. Unlike conventional three-dimensional (3D) imaging modalities that rely on mechanical or optical scanning, light-field imaging enables high-speed volumetric acquisition, making it particularly well-suited for capturing rapid biological dynamics. This review outlines the theoretical foundations of light-field imaging and surveys its core implementations across microscopy, mesoscopy, and endoscopy. Special attention is given to the fundamental trade-offs between imaging speed, spatial resolution, and depth of field, as well as recent advances that address these limitations through compressive sensing, deep learning, and meta-optics. By positioning light-field imaging within the broader landscape of biomedical imaging technologies, we highlight its unique strengths, existing challenges, and future potential as a scalable and versatile tool for biological discovery and clinical applications.Graphical abstract: ","PeriodicalId":74169,"journal":{"name":"Med-X","volume":"3 1","pages":"25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12705775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspectives on non-genetic optoelectronic modulation biointerfaces for advancing healthcare. 推进医疗保健的非遗传光电调制生物接口展望。

Med-X Pub Date : 2024-12-01 Epub Date: 2024-10-21 DOI: 10.1007/s44258-024-00030-6

Aman Majmudar, Saehyun Kim, Pengju Li, Bozhi Tian

{"title":"Perspectives on non-genetic optoelectronic modulation biointerfaces for advancing healthcare.","authors":"Aman Majmudar, Saehyun Kim, Pengju Li, Bozhi Tian","doi":"10.1007/s44258-024-00030-6","DOIUrl":"10.1007/s44258-024-00030-6","url":null,"abstract":"Advancements in optoelectronic biointerfaces have revolutionized healthcare by enabling targeted stimulation and monitoring of cells, tissues, and organs. Photostimulation, a key application, offers precise control over biological processes, surpassing traditional modulation methods with increased spatial resolution and reduced invasiveness. This perspective highlights three approaches in non-genetic optoelectronic photostimulation: nanostructured phototransducers for cellular stimulation, micropatterned photoelectrode arrays for tissue stimulation, and thin-film flexible photoelectrodes for multiscale stimulation. Nanostructured phototransducers provide localized stimulation at the cellular or subcellular level, facilitating cellular therapy and regenerative medicine. Micropatterned photoelectrode arrays offer precise tissue stimulation, critical for targeted therapeutic interventions. Thin-film flexible photoelectrodes combine flexibility and biocompatibility for scalable medical applications. Beyond neuromodulation, optoelectronic biointerfaces hold promise in cardiology, oncology, wound healing, and endocrine and respiratory therapies. Future directions include integrating these devices with advanced imaging and feedback systems, developing wireless and biocompatible devices for long-term use, and creating multifunctional devices that combine photostimulation with other therapies. The integration of light and electronics through these biointerfaces paves the way for innovative, less invasive, and more accurate medical treatments, promising a transformative impact on patient care across various medical fields.","PeriodicalId":74169,"journal":{"name":"Med-X","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategic reuse of rapid antigen tests for coagulation status assessment: an integrated machine learning approach 凝血状态评估中快速抗原检测的战略性重复使用：一种综合机器学习方法

Med-X Pub Date : 2024-07-18 DOI: 10.1007/s44258-024-00025-3

Allan Sun, Arian Nasser, Chaohao Chen, Y. Zhao, Haimei Zhao, Zihao Wang, Wenlong Cheng, Pierre Qian, L. Ju

引用次数: 0

Atomic force microscopy in the characterization and clinical evaluation of neurological disorders: current and emerging technologies 原子力显微镜在神经系统疾病的表征和临床评估中的应用：现有技术和新兴技术

Med-X Pub Date : 2024-06-03 DOI: 10.1007/s44258-024-00022-6

David T. She, M. Nai, C. T. Lim

引用次数: 0

Biomaterials-enabled electrical stimulation for tissue healing and regeneration 利用生物材料电刺激促进组织愈合和再生

Med-X Pub Date : 2024-05-21 DOI: 10.1007/s44258-024-00020-8

Han-Sem Kim, Tanza Baby, Jung-Hwan Lee, U. Shin, Hae-Won Kim

引用次数: 0

Advancement in modulation of brain extracellular space and unlocking its potential for intervention of neurological diseases 调控脑细胞外空间并挖掘其干预神经系统疾病的潜力方面的进展

Med-X Pub Date : 2024-05-03 DOI: 10.1007/s44258-024-00021-7

Yu Yong, Yicong Cai, Jiawei Lin, Lin Ma, HongBin Han, Fenfang Li

引用次数: 0

Shear wave ultrasound elastography for estimating cartilage stiffness: implications for early detection of osteoarthritis 用于估算软骨硬度的剪切波超声弹性成像技术：对早期检测骨关节炎的意义

Med-X Pub Date : 2024-04-12 DOI: 10.1007/s44258-024-00018-2

Elias Georgas, Adnan Rayes, Junhang Zhang, Qifa Zhou, Yi-Xian Qin

引用次数: 0

Combining multi-mode thermal therapy with IL-6 and IL-17A neutralization amplifies antitumor immunity to facilitate long-term survival in LLC1-bearing mice 将多模式热疗法与 IL-6 和 IL-17A 中和疗法相结合，可增强抗肿瘤免疫力，促进 LLC1 携带小鼠的长期存活

Med-X Pub Date : 2024-04-03 DOI: 10.1007/s44258-024-00016-4

Jiamin Zheng, Jincheng Zou, Yue Lou, Shicheng Wang, Zelun Zhang, Junjun Wang, Peishan Du, Yongxin Zhu, Jiaqi You, Yichen Yao, Yuankai Hao, Aili Zhang, Ping Liu

引用次数: 0