Med-X Pub Date : 2023-12-30 DOI: 10.1007/s44258-023-00014-y

Jiayu Liao

引用次数: 0

Correction: Fluorescence imaging deformability cytometry: integrating nuclear structure with mechanical phenotyping 校正:荧光成像变形细胞术:将核结构与机械表型相结合

Med-X Pub Date : 2023-11-06 DOI: 10.1007/s44258-023-00012-0

Hector E. Muñoz, Jonathan Lin, Bonnie G. Yeh, Tridib Biswas, Dino Di Carlo

引用次数: 0

Recent advances in cancer-on-a-chip tissue models to dissect the tumour microenvironment 肿瘤芯片组织模型解剖肿瘤微环境的最新进展

Med-X Pub Date : 2023-10-13 DOI: 10.1007/s44258-023-00011-1

Kimberly Seaman, Yu Sun, Lidan You

{"title":"Recent advances in cancer-on-a-chip tissue models to dissect the tumour microenvironment","authors":"Kimberly Seaman, Yu Sun, Lidan You","doi":"10.1007/s44258-023-00011-1","DOIUrl":"https://doi.org/10.1007/s44258-023-00011-1","url":null,"abstract":"Abstract Three-dimensional cancer-on-a-chip tissue models aim to replicate the key hallmarks of the tumour microenvironment and allow for the study of dynamic interactions that occur during tumour progression. Recently, complex cancer-on-a-chip models incorporating multiple cell types and biomimetic extracellular matrices have been developed. These models have generated new research directions in engineering and medicine by allowing for the real-time observation of cancer-host cell interactions in a physiologically relevant microenvironment. However, these cancer-on-a-chip models have yet to overcome limitations including the complexity of device manufacturing, the selection of optimal materials for preclinical drug screening studies, long-term microfluidic cell culture as well as associated challenges, and the technical robustness or difficulty in the use of these microfluidic platforms. In this review, an overview of the tumour microenvironment, its unique characteristics, and the recent advances of cancer-on-a-chip models that recapitulate native features of the tumour microenvironment are presented. The current challenges that cancer-on-a-chip models face and the future directions of research that are expected to be seen are also discussed. Graphical Abstract","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135918402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescence imaging deformability cytometry: integrating nuclear structure with mechanical phenotyping 荧光成像变形细胞术:将核结构与机械表型相结合

Med-X Pub Date : 2023-09-15 DOI: 10.1007/s44258-023-00008-w

Hector E. Muñoz, Jonathan Lin, Bonnie G. Yeh, Tridib Biswas, Dino Di Carlo

{"title":"Fluorescence imaging deformability cytometry: integrating nuclear structure with mechanical phenotyping","authors":"Hector E. Muñoz, Jonathan Lin, Bonnie G. Yeh, Tridib Biswas, Dino Di Carlo","doi":"10.1007/s44258-023-00008-w","DOIUrl":"https://doi.org/10.1007/s44258-023-00008-w","url":null,"abstract":"Abstract Mechanical measurements of cells can provide unique insights into cell state and disease processes. The overall mechanical properties of cells can be heavily affected by the stiffest organelle, the nucleus. However, it is challenging to fully characterize internal nuclear structures in most cell mechanical measurement platforms. Here, we demonstrate single-cell deformability measurements of whole cells and stained nuclei in a fluorescence imaging flow cytometry platform. We also introduce bending energy derived metrics as a way to normalize measurements of cytoskeletal cortex and nuclear shape changes of cells and demonstrate the utility of relative deformability distributions to characterize populations of cells. We apply the platform to measure changes in cell biophysical properties during the process of NETosis, whereby neutrophils undergo drastic nuclear restructuring. We characterize cell size, deformability, and nuclear structure changes and their correlations in thousands of neutrophils undergoing NETosis, a process implicated in development of critical disease states, such as sepsis. This platform can aid in understanding heterogeneity in deformability in cell populations and how this may be influenced by nuclear or internal structure changes. Graphical Abstract","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135352894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Direct and quantitative assessments of near-infrared light attenuation and spectroscopic detection depth in biological tissues using surface-enhanced Raman scattering 使用表面增强拉曼散射直接定量评估生物组织中的近红外光衰减和光谱检测深度

Med-X Pub Date : 2023-08-24 DOI: 10.1007/s44258-023-00010-2

Li Lin, Haoqi He, Ruiyang Xue, Yumin Zhang, Ziwen Wang, S. Nie, Jian Ye

引用次数: 1

Hyperactivity of platelets and increased megakaryopoiesis in COVID-19 patients with acute respiratory distress syndrome COVID-19合并急性呼吸窘迫综合征患者血小板过度活跃和巨核生成增加

Med-X Pub Date : 2023-08-22 DOI: 10.1007/s44258-023-00009-9

Lingna Wang, Huicong Liu, Jiaqing Liu, Haitao Yuan, Chen Wu, Xiyang Li, Kaikai Xu, Jiang Hong, Guoyan Wu, Fangfang Zhu

引用次数: 0

Noninvasive and affordable type 2 diabetes screening by deep learning-based risk assessment and detection using ophthalmic images inspired by traditional Chinese medicine 基于深度学习的2型糖尿病风险评估和检测:基于中医眼科图像的无创和可负担的2型糖尿病筛查

Med-X Pub Date : 2023-07-11 DOI: 10.1007/s44258-023-00005-z

Zhi Zhang, Han Wang, Lei Chen, Chensi Cao, Tengwen Liu, Ruifang Ren, Ruixing Zhou, Rudan Huang, D. Hu, Chenxing Zhu, Chong Lu, Yunsheng Xu, Zhaohui Fang, Fuer Lu, Huimin Pan, Yanjin Su, Nanlin Fu, Huixia Zhan, Qin Si, Chenze Bai, Ri Le Ge, Hongmei Cao, Wei Dong, Guohui Yang, Lan Wu, Jiao‐yang Guo, Jing Cheng

引用次数: 0

MRI-guided robot intervention—current state-of-the-art and new challenges 核磁共振引导的机器人干预——当前最先进的技术和新的挑战

Med-X Pub Date : 2023-07-11 DOI: 10.1007/s44258-023-00003-1

Shaoping Huang, Chuqian Lou, Ying Zhou, Zhao He, Xuejun Jin, Yuan Feng, A. Gao, Guang-zhong Yang

引用次数: 1

X for medicine: exploration and innovation in biomedical engineering X代表医学:生物医学工程的探索与创新

Med-X Pub Date : 2023-07-11 DOI: 10.1007/s44258-023-00007-x

Song Li, L. Xu

引用次数: 0

Smart textiles for self-powered biomonitoring 用于自供电生物监测的智能纺织品

Med-X Pub Date : 2023-07-11 DOI: 10.1007/s44258-023-00001-3

Junyi Yin, Shaolei Wang, Aiden Di Carlo, A. Chang, Xiao Wan, Jing Xu, Xiao Xiao, Jun Chen

引用次数: 18

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