Med-X Pub Date : 2024-03-18 DOI: 10.1007/s44258-024-00017-3

Shuai Shao, Sha Deng, Na Li, Zheng-Zhu Zhang, Hangyu Zhang, Bo Liu

引用次数: 0

Employing toehold-mediated DNA strand displacement reactions for biomedical applications 在生物医学应用中采用脚趾介导的 DNA 链置换反应

Med-X Pub Date : 2024-01-29 DOI: 10.1007/s44258-024-00015-5

Keziah Jacob Souza, Deepak K. Agrawal

引用次数: 0

Hydrogels in wearable neural interfaces. 可穿戴神经界面中的水凝胶。

Med-X Pub Date : 2024-01-01 Epub Date: 2024-12-09 DOI: 10.1007/s44258-024-00040-4

Mengmeng Yao, Ju-Chun Hsieh, Kai Wing Kevin Tang, Huiliang Wang

{"title":"Hydrogels in wearable neural interfaces.","authors":"Mengmeng Yao, Ju-Chun Hsieh, Kai Wing Kevin Tang, Huiliang Wang","doi":"10.1007/s44258-024-00040-4","DOIUrl":"10.1007/s44258-024-00040-4","url":null,"abstract":"The integration of wearable neural interfaces (WNIs) with the human nervous system has marked a significant progression, enabling progress in medical treatments and technology integration. Hydrogels, distinguished by their high-water content, low interfacial impedance, conductivity, adhesion, and mechanical compliance, effectively address the rigidity and biocompatibility issues common in traditional materials. This review highlights their important parameters-biocompatibility, interfacial impedance, conductivity, and adhesiveness-that are integral to their function in WNIs. The applications of hydrogels in wearable neural recording and neurostimulation are discussed in detail. Finally, the opportunities and challenges faced by hydrogels for WNIs are summarized and prospected. This review aims to offer a thorough examination of hydrogel technology's present landscape and to encourage continued exploration and innovation. As developments progress, hydrogels are poised to revolutionize wearable neural interfaces, offering significant enhancements in healthcare and technological applications.Graphical abstract: ","PeriodicalId":74169,"journal":{"name":"Med-X","volume":"2 1","pages":"23"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering biomaterials by inkjet printing of hydrogels with functional particulates. 通过喷墨打印带有功能微粒的水凝胶来制造生物材料。

Med-X Pub Date : 2024-01-01 Epub Date: 2024-07-03 DOI: 10.1007/s44258-024-00024-4

Cih Cheng, Eric J Williamson, George T-C Chiu, Bumsoo Han

{"title":"Engineering biomaterials by inkjet printing of hydrogels with functional particulates.","authors":"Cih Cheng, Eric J Williamson, George T-C Chiu, Bumsoo Han","doi":"10.1007/s44258-024-00024-4","DOIUrl":"10.1007/s44258-024-00024-4","url":null,"abstract":"Hydrogels with particulates, including proteins, drugs, nanoparticles, and cells, enable the development of new and innovative biomaterials. Precise control of the spatial distribution of these particulates is crucial to produce advanced biomaterials. Thus, there is a high demand for manufacturing methods for particle-laden hydrogels. In this context, 3D printing of hydrogels is emerging as a promising method to create numerous innovative biomaterials. Among the 3D printing methods, inkjet printing, so-called drop-on-demand (DOD) printing, stands out for its ability to construct biomaterials with superior spatial resolutions. However, its printing processes are still designed by trial and error due to a limited understanding of the ink behavior during the printing processes. This review discusses the current understanding of transport processes and hydrogel behaviors during inkjet printing for particulate-laden hydrogels. Specifically, we review the transport processes of water and particulates within hydrogel during ink formulation, jetting, and curing. Additionally, we examine current inkjet printing applications in fabricating engineered tissues, drug delivery devices, and advanced bioelectronics components. Finally, the challenges and opportunities for next-generation inkjet printing are also discussed.Graphical abstract: ","PeriodicalId":74169,"journal":{"name":"Med-X","volume":"2 1","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microneedle sensors for dermal interstitial fluid analysis. 用于皮肤间液分析的微针传感器。

Med-X Pub Date : 2024-01-01 Epub Date: 2024-10-01 DOI: 10.1007/s44258-024-00028-0

Gwangmook Kim, Hyunah Ahn, Joshua Chaj Ulloa, Wei Gao

引用次数: 0

Develop quantitative FRET (qFRET) technology as a high-throughput universal assay platform for basic quantitative biomedical and translational research and development 开发定量 FRET（qFRET）技术，作为基础定量生物医学和转化研发的高通量通用检测平台

Med-X Pub Date : 2023-12-30 DOI: 10.1007/s44258-023-00014-y

Jiayu Liao

引用次数: 0

Correction: Fluorescence imaging deformability cytometry: integrating nuclear structure with mechanical phenotyping 校正:荧光成像变形细胞术:将核结构与机械表型相结合

Med-X Pub Date : 2023-11-06 DOI: 10.1007/s44258-023-00012-0

Hector E. Muñoz, Jonathan Lin, Bonnie G. Yeh, Tridib Biswas, Dino Di Carlo

引用次数: 0

Recent advances in cancer-on-a-chip tissue models to dissect the tumour microenvironment 肿瘤芯片组织模型解剖肿瘤微环境的最新进展

Med-X Pub Date : 2023-10-13 DOI: 10.1007/s44258-023-00011-1

Kimberly Seaman, Yu Sun, Lidan You

{"title":"Recent advances in cancer-on-a-chip tissue models to dissect the tumour microenvironment","authors":"Kimberly Seaman, Yu Sun, Lidan You","doi":"10.1007/s44258-023-00011-1","DOIUrl":"https://doi.org/10.1007/s44258-023-00011-1","url":null,"abstract":"Abstract Three-dimensional cancer-on-a-chip tissue models aim to replicate the key hallmarks of the tumour microenvironment and allow for the study of dynamic interactions that occur during tumour progression. Recently, complex cancer-on-a-chip models incorporating multiple cell types and biomimetic extracellular matrices have been developed. These models have generated new research directions in engineering and medicine by allowing for the real-time observation of cancer-host cell interactions in a physiologically relevant microenvironment. However, these cancer-on-a-chip models have yet to overcome limitations including the complexity of device manufacturing, the selection of optimal materials for preclinical drug screening studies, long-term microfluidic cell culture as well as associated challenges, and the technical robustness or difficulty in the use of these microfluidic platforms. In this review, an overview of the tumour microenvironment, its unique characteristics, and the recent advances of cancer-on-a-chip models that recapitulate native features of the tumour microenvironment are presented. The current challenges that cancer-on-a-chip models face and the future directions of research that are expected to be seen are also discussed. Graphical Abstract","PeriodicalId":74169,"journal":{"name":"Med-X","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135918402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescence imaging deformability cytometry: integrating nuclear structure with mechanical phenotyping 荧光成像变形细胞术:将核结构与机械表型相结合

Med-X Pub Date : 2023-09-15 DOI: 10.1007/s44258-023-00008-w

Hector E. Muñoz, Jonathan Lin, Bonnie G. Yeh, Tridib Biswas, Dino Di Carlo

{"title":"Fluorescence imaging deformability cytometry: integrating nuclear structure with mechanical phenotyping","authors":"Hector E. Muñoz, Jonathan Lin, Bonnie G. Yeh, Tridib Biswas, Dino Di Carlo","doi":"10.1007/s44258-023-00008-w","DOIUrl":"https://doi.org/10.1007/s44258-023-00008-w","url":null,"abstract":"Abstract Mechanical measurements of cells can provide unique insights into cell state and disease processes. The overall mechanical properties of cells can be heavily affected by the stiffest organelle, the nucleus. However, it is challenging to fully characterize internal nuclear structures in most cell mechanical measurement platforms. Here, we demonstrate single-cell deformability measurements of whole cells and stained nuclei in a fluorescence imaging flow cytometry platform. We also introduce bending energy derived metrics as a way to normalize measurements of cytoskeletal cortex and nuclear shape changes of cells and demonstrate the utility of relative deformability distributions to characterize populations of cells. We apply the platform to measure changes in cell biophysical properties during the process of NETosis, whereby neutrophils undergo drastic nuclear restructuring. We characterize cell size, deformability, and nuclear structure changes and their correlations in thousands of neutrophils undergoing NETosis, a process implicated in development of critical disease states, such as sepsis. This platform can aid in understanding heterogeneity in deformability in cell populations and how this may be influenced by nuclear or internal structure changes. Graphical Abstract","PeriodicalId":74169,"journal":{"name":"Med-X","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135352894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Direct and quantitative assessments of near-infrared light attenuation and spectroscopic detection depth in biological tissues using surface-enhanced Raman scattering 使用表面增强拉曼散射直接定量评估生物组织中的近红外光衰减和光谱检测深度

Med-X Pub Date : 2023-08-24 DOI: 10.1007/s44258-023-00010-2

Li Lin, Haoqi He, Ruiyang Xue, Yumin Zhang, Ziwen Wang, S. Nie, Jian Ye

引用次数: 1

Med-X最新文献