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US-guided ablation of tumors – where is it used and how did we get there 美国引导的肿瘤消融术-在哪里使用以及我们是如何到达那里的
Med-X Pub Date : 2023-07-11 DOI: 10.1007/s44258-023-00002-2
Jia-peng Wu, Jie Yu, J. Fowlkes, P. Liang, C. Nolsøe
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引用次数: 0
Non-viral approaches for gene therapy and therapeutic genome editing across the blood-brain barrier. 跨血脑屏障的基因治疗和治疗性基因组编辑的非病毒方法。
Med-X Pub Date : 2023-01-01 Epub Date: 2023-07-11 DOI: 10.1007/s44258-023-00004-0
Ruosen Xie, Yuyuan Wang, Jacobus C Burger, Dongdong Li, Min Zhu, Shaoqin Gong
{"title":"Non-viral approaches for gene therapy and therapeutic genome editing across the blood-brain barrier.","authors":"Ruosen Xie, Yuyuan Wang, Jacobus C Burger, Dongdong Li, Min Zhu, Shaoqin Gong","doi":"10.1007/s44258-023-00004-0","DOIUrl":"10.1007/s44258-023-00004-0","url":null,"abstract":"<p><p>The success of brain-targeted gene therapy and therapeutic genome editing hinges on the efficient delivery of biologics bypassing the blood-brain barrier (BBB), which presents a significant challenge in the development of treatments for central nervous system disorders. This is particularly the case for nucleic acids and genome editors that are naturally excluded by the BBB and have poor chemical stability in the bloodstream and poor cellular uptake capability, thereby requiring judiciously designed nanovectors administered systemically for intracellular delivery to brain cells such as neurons. To overcome this obstacle, various strategies for bypassing the BBB have been developed in recent years to deliver biologics to the brain via intravenous administration using non-viral vectors. This review summarizes various brain targeting strategies and recent representative reports on brain-targeted non-viral delivery systems that allow gene therapy and therapeutic genome editing via intravenous administration, and highlights ongoing challenges and future perspectives for systemic delivery of biologics to the brain via non-viral vectors.</p>","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10241591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Material design for oral insulin delivery. 口服胰岛素输送的材料设计。
Med-X Pub Date : 2023-01-01 Epub Date: 2023-07-11 DOI: 10.1007/s44258-023-00006-y
Kangfan Ji, Yuejun Yao, Xinwei Wei, Wei Liu, Juan Zhang, Yun Liu, Yang Zhang, Jinqiang Wang, Zhen Gu
{"title":"Material design for oral insulin delivery.","authors":"Kangfan Ji,&nbsp;Yuejun Yao,&nbsp;Xinwei Wei,&nbsp;Wei Liu,&nbsp;Juan Zhang,&nbsp;Yun Liu,&nbsp;Yang Zhang,&nbsp;Jinqiang Wang,&nbsp;Zhen Gu","doi":"10.1007/s44258-023-00006-y","DOIUrl":"10.1007/s44258-023-00006-y","url":null,"abstract":"<p><p>Frequent insulin injections remain the primary method for controlling the blood glucose level of individuals with diabetes mellitus but are associated with low compliance. Accordingly, oral administration has been identified as a highly desirable alternative due to its non-invasive nature. However, the harsh gastrointestinal environment and physical intestinal barriers pose significant challenges to achieving optimal pharmacological bioavailability of insulin. As a result, researchers have developed a range of materials to improve the efficiency of oral insulin delivery over the past few decades. In this review, we summarize the latest advances in material design that aim to enhance insulin protection, permeability, and glucose-responsive release. We also explore the opportunities and challenges of using these materials for oral insulin delivery.</p>","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10241592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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