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Medicina clinica (English ed.)最新文献

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Increased TLR9 protein level and upregulated serum cytokines IL-10 and IFN1A in systemic lupus erythematous patients 系统性红斑狼疮患者TLR9蛋白水平升高，血清细胞因子IL-10和IFN1A上调
Medicina clinica (English ed.) Pub Date : 2026-07-01 Epub Date: 2026-07-24 DOI: 10.1016/j.medcle.2026.107447
Elena Grau García, Samuel Leal Rodríguez, Luis Gómez-Lechón Quirós, Jose Andrés Román Ivorra
{"title":"Increased TLR9 protein level and upregulated serum cytokines IL-10 and IFN1A in systemic lupus erythematous patients","authors":"Elena Grau García,&nbsp;Samuel Leal Rodríguez,&nbsp;Luis Gómez-Lechón Quirós,&nbsp;Jose Andrés Román Ivorra","doi":"10.1016/j.medcle.2026.107447","DOIUrl":"10.1016/j.medcle.2026.107447","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association between serum TLR7 and TLR9 levels and previous viral infections, disease activity, and proinflammatory cytokine levels in SLE patients.</div></div><div><h3>Methods</h3><div>A cross-sectional observational study was conducted in patients with SLE and healthy controls. Data on previous infections, disease activity, and clinical parameters were collected. Serum TLR7, TLR9, interleukin-10 (IL-10), and interferon-α (IFN-α) levels were measured by ELISA.</div></div><div><h3>Results</h3><div>TLR9 levels were significantly higher in SLE patients than in controls (<em>P</em> <!-->&lt;<!--> <!-->0.001). TLR7 levels did not differ between groups but showed a positive association with age (<em>P</em> <!-->&lt;<!--> <!-->0.001). No associations were found between TLR7 or TLR9 levels and CRP, ESR, anti-dsDNA, ENAs, antiphospholipid antibodies, disease activity, previous infections, or disease duration. Lower TLR7 levels were observed in patients with antiphospholipid syndrome (<em>P</em> <!-->=<!--> <!-->0.001). Elevated TLR9 levels were significantly associated with increased IL-10 and IFN-α (<em>P</em> <!-->&lt;<!--> <!-->0.001). TLR7 was not associated with IFN-α, although a trend toward higher levels was observed with elevated IL-10.</div></div><div><h3>Conclusion</h3><div>TLR9 is elevated in SLE and correlates with IL-10 and IFN-α, while TLR7 increases with age.</div><div>.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107447"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ischemic priapism: A rare complication of severe methanol intoxication 缺血性阴茎勃起：严重甲醇中毒的罕见并发症
Medicina clinica (English ed.) Pub Date : 2026-07-01 Epub Date: 2026-07-24 DOI: 10.1016/j.medcle.2026.107467
Tzu-Ching Sung, Tzu-Yuan Yang, Hsin-I. Shih, Hsiang-Chin Hsu
{"title":"Ischemic priapism: A rare complication of severe methanol intoxication","authors":"Tzu-Ching Sung,&nbsp;Tzu-Yuan Yang,&nbsp;Hsin-I. Shih,&nbsp;Hsiang-Chin Hsu","doi":"10.1016/j.medcle.2026.107467","DOIUrl":"10.1016/j.medcle.2026.107467","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107467"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Life threatening excoriated acne 危及生命的去角质痤疮
Medicina clinica (English ed.) Pub Date : 2026-07-01 Epub Date: 2026-07-24 DOI: 10.1016/j.medcle.2026.107456
Noelia Muñoz-Domínguez, Pablo Balado-Simó, José M. Mascaró Jr., Jesús Aibar
{"title":"Life threatening excoriated acne","authors":"Noelia Muñoz-Domínguez,&nbsp;Pablo Balado-Simó,&nbsp;José M. Mascaró Jr.,&nbsp;Jesús Aibar","doi":"10.1016/j.medcle.2026.107456","DOIUrl":"10.1016/j.medcle.2026.107456","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107456"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sacroiliitis as an atypical presentation of a late relapse of Whipple’s disease 骶髂炎是惠普尔病晚期复发的非典型表现
Medicina clinica (English ed.) Pub Date : 2026-07-01 Epub Date: 2026-07-17 DOI: 10.1016/j.medcle.2026.107481
Antonio Rosales-Castillo
{"title":"Sacroiliitis as an atypical presentation of a late relapse of Whipple’s disease","authors":"Antonio Rosales-Castillo","doi":"10.1016/j.medcle.2026.107481","DOIUrl":"10.1016/j.medcle.2026.107481","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107481"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The nuclear accident of Chernobyl. A review 40 years later 切尔诺贝利核事故。40年后的回顾
Medicina clinica (English ed.) Pub Date : 2026-07-01 Epub Date: 2026-07-16 DOI: 10.1016/j.medcle.2026.107463
Alberto Biete Solà
{"title":"The nuclear accident of Chernobyl. A review 40 years later","authors":"Alberto Biete Solà","doi":"10.1016/j.medcle.2026.107463","DOIUrl":"10.1016/j.medcle.2026.107463","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107463"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social responsibility and commitment in the context of artificial intelligence in healthcare 医疗领域人工智能的社会责任与承诺
Medicina clinica (English ed.) Pub Date : 2026-07-01 Epub Date: 2026-07-17 DOI: 10.1016/j.medcle.2026.107446
Laureano Fernández-Cruz Pérez, Eduardo M. Targarona Soler, José Ibeas López
{"title":"Social responsibility and commitment in the context of artificial intelligence in healthcare","authors":"Laureano Fernández-Cruz Pérez,&nbsp;Eduardo M. Targarona Soler,&nbsp;José Ibeas López","doi":"10.1016/j.medcle.2026.107446","DOIUrl":"10.1016/j.medcle.2026.107446","url":null,"abstract":"<div><div>Artificial intelligence in healthcare represents a conceptual and cultural revolution. AI is transforming evidence-based medicine into data-driven medicine, enabling personalized and real-time clinical decisions. However, this progress requires prudence and ethical commitment, since healthcare is a complex domain due to the sensitivity of data and the need to safeguard patients’ privacy, autonomy, and dignity. In addition, technical, ethical, and organizational challenges arise when implementing AI in healthcare systems. Robust infrastructures, professional training, and collaborative governance are needed to ensure equity and sustainability. Responsibility in the use of AI in healthcare must be shared among professionals, academic institutions, industry, public administration and obviously, the patients. Medical leadership is essential to guide technological development, and ensure that innovation benefits patients and society. The future of AI in healthcare depends on the ethical and social commitment, turning technology into an opportunity to strengthen healthcare system.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107446"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148660546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amiodarone today 胺碘酮今天
Medicina clinica (English ed.) Pub Date : 2026-07-01 Epub Date: 2026-07-16 DOI: 10.1016/j.medcle.2026.107417
Juan Tamargo, Eva Delpón
{"title":"Amiodarone today","authors":"Juan Tamargo,&nbsp;Eva Delpón","doi":"10.1016/j.medcle.2026.107417","DOIUrl":"10.1016/j.medcle.2026.107417","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107417"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pruritus sine materia as the prodrome of bullous pemphigoid associated with renal carcinoma 肾癌伴大疱性类天疱疮的前驱症状：皮肤瘙痒
Medicina clinica (English ed.) Pub Date : 2026-07-01 Epub Date: 2026-07-17 DOI: 10.1016/j.medcle.2026.107477
Marta Sánchez Díaz, Alberto Andamoyo Castañeda, Enrique Herrera Acosta
{"title":"Pruritus sine materia as the prodrome of bullous pemphigoid associated with renal carcinoma","authors":"Marta Sánchez Díaz,&nbsp;Alberto Andamoyo Castañeda,&nbsp;Enrique Herrera Acosta","doi":"10.1016/j.medcle.2026.107477","DOIUrl":"10.1016/j.medcle.2026.107477","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107477"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New evidence in the pharmacological treatment of gastrointestinal angiodysplasias 胃肠道血管发育不良的药理治疗新证据
Medicina clinica (English ed.) Pub Date : 2026-06-01 Epub Date: 2026-05-22 DOI: 10.1016/j.medcle.2026.107430
Luis Angel Sánchez Muñoz
{"title":"New evidence in the pharmacological treatment of gastrointestinal angiodysplasias","authors":"Luis Angel Sánchez Muñoz","doi":"10.1016/j.medcle.2026.107430","DOIUrl":"10.1016/j.medcle.2026.107430","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 6","pages":"Article 107430"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148241335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nebulised antifungal therapy in allergic bronchopulmonary aspergillosis in a patient with treatment-limiting comorbidities 雾化抗真菌治疗过敏性支气管肺曲霉病患者的治疗限制合并症
Medicina clinica (English ed.) Pub Date : 2026-06-01 Epub Date: 2026-06-13 DOI: 10.1016/j.medcle.2026.107397
Mercedes Carrasco Sánchez , Estefanía Llopis Pastor , Mercedes García-Salmones Martín
{"title":"Nebulised antifungal therapy in allergic bronchopulmonary aspergillosis in a patient with treatment-limiting comorbidities","authors":"Mercedes Carrasco Sánchez ,&nbsp;Estefanía Llopis Pastor ,&nbsp;Mercedes García-Salmones Martín","doi":"10.1016/j.medcle.2026.107397","DOIUrl":"10.1016/j.medcle.2026.107397","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 6","pages":"Article 107397"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148244466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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