Medicina clinica (English ed.)最新文献_第9页

Plasmacytoma surrounding a total shoulder prosthesis 全肩假体周围的浆细胞瘤

Medicina clinica (English ed.) Pub Date : 2025-06-09 DOI: 10.1016/j.medcle.2025.106933

Gökhan Tonkaz , Esra İbiş , Duygu Erkal , Mehmet Tonkaz

引用次数: 0

Eruptive cherry angiomas induced by infliximab in a patient with Crohn's disease 英夫利昔单抗在克罗恩病患者中诱发的爆发性樱桃血管瘤

Medicina clinica (English ed.) Pub Date : 2025-06-09 DOI: 10.1016/j.medcle.2025.106927

María López-Pardo Rico , Carlos Aliste Santos , María Teresa Rodríguez Granados

引用次数: 0

Effects of exercise intervention on exercise capacity and cardiopulmonary function in patients with atrial fibrillation: A randomized controlled trial systematic review and meta-analysis 运动干预对房颤患者运动能力和心肺功能的影响：一项随机对照试验、系统评价和荟萃分析

Medicina clinica (English ed.) Pub Date : 2025-06-09 DOI: 10.1016/j.medcle.2025.106908

Zhang Shuai , Mao Su Jie , Xiao Kai Wen , Hong Xu , Lu Yuan

{"title":"Effects of exercise intervention on exercise capacity and cardiopulmonary function in patients with atrial fibrillation: A randomized controlled trial systematic review and meta-analysis","authors":"Zhang Shuai , Mao Su Jie , Xiao Kai Wen , Hong Xu , Lu Yuan","doi":"10.1016/j.medcle.2025.106908","DOIUrl":"10.1016/j.medcle.2025.106908","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation (AF) is a common cardiac arrhythmia that significantly impacts the cardiopulmonary function and quality of life of patients. Despite various treatment strategies, non-pharmacological interventions, particularly exercise interventions, have gained attention in recent years.</div></div><div><h3>Objective</h3><div>Through systematic review and meta-analysis, this study explores the impact of physical activity on the exercise capacity and quality of life of AF patients. It assesses the safety, clinical outcomes, and physiological mechanisms of exercise intervention in the treatment of AF.</div></div><div><h3>Methods</h3><div>The systematic review and individual patient data (IPD) meta-analysis method were employed, following the PRISMA-IPD guidelines, for literature selection, data extraction, and quality assessment. The analysis focused on the impact of exercise on the cardiopulmonary function and quality of life of AF patients in randomized controlled trials.</div></div><div><h3>Results</h3><div>A total of 12 randomized controlled trials involving 287 AF patients were included. Meta-analysis demonstrated a significant improvement in the 6-minute walk test capacity (SMD=87.87, 95% CI [42.23, 133.51]), static heart rate improvement (SMD=−7.63, 95% CI [−11.42, −3.85]), and cardiopulmonary function enhancement (SMD=2.37, 95% CI [0.96, 3.77]) due to exercise. There was also a significant improvement in the quality of life (SMD=0.720, 95% CI [0.038, 1.402]).</div></div><div><h3>Conclusion</h3><div>Exercise has a significant effect on improving exercise capacity and cardiopulmonary function in patients with atrial fibrillation. Particularly, high-intensity exercise training has a more significant impact on improving cardiopulmonary function and exercise capacity, emphasizing the importance of personalized exercise plans in enhancing the cardiopulmonary health of AF patients. Further research is needed to explore the effects of exercise on improving the quality of life in the future.</div><div>PROSPERO ID: CRD2023493917.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106908"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extensive lichen planus after initiation of durvalumab for cholangiocarcinoma 胆管癌开始使用杜伐单抗后出现大面积扁平苔藓

Medicina clinica (English ed.) Pub Date : 2025-06-09 DOI: 10.1016/j.medcle.2025.106926

Miguel Mansilla-Polo , Rafael Fayos-Gregori , Gonzalo Alonso-Fernández

引用次数: 0

Mirror image in double superior vena cava 双上腔静脉镜像

Medicina clinica (English ed.) Pub Date : 2025-06-09 DOI: 10.1016/j.medcle.2025.106923

Hayri Ogul

引用次数: 0

Comparison of the efficacy of pharmacological interventions for the prevention of delirium: A systematic review and network meta-analysis 预防谵妄的药物干预效果比较：系统综述和网络荟萃分析

Medicina clinica (English ed.) Pub Date : 2025-06-09 DOI: 10.1016/j.medcle.2025.106918

Xiangwu Zhou , Chengguo Yin

{"title":"Comparison of the efficacy of pharmacological interventions for the prevention of delirium: A systematic review and network meta-analysis","authors":"Xiangwu Zhou , Chengguo Yin","doi":"10.1016/j.medcle.2025.106918","DOIUrl":"10.1016/j.medcle.2025.106918","url":null,"abstract":"<div><h3>Background</h3><div>In recent years, many pharmacological agents for the prevention of delirium have emerged; however, the efficacy of these agents in preventing delirium remains unclear.</div></div><div><h3>Objective</h3><div>To compare and rank the efficacy of different pharmacological interventions for the prevention of delirium.</div></div><div><h3>Design</h3><div>A systematic review and network meta-analysis.</div></div><div><h3>Methods</h3><div>Relevant randomized controlled trials on drug prevention of delirium were extracted from three electronic databases. A network meta-analysis was then conducted to assess the relative efficacy of drug interventions in preventing delirium. The quality of the data was evaluated using the Cochrane Risk of Bias tool.</div></div><div><h3>Results</h3><div>A total of 80 randomized controlled trials on drug interventions were included in the final analysis. Treatment with dexmedetomidine can prevent delirium.</div></div><div><h3>Conclusion</h3><div>Dexmedetomidine treatment can prevent delirium and reduce patient suffering. Healthcare professionals should be encouraged to use dexmedetomidine for delirium prevention.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106918"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scurvy: A call to maintain awareness 坏血病：呼吁保持警惕

Medicina clinica (English ed.) Pub Date : 2025-06-09 DOI: 10.1016/j.medcle.2025.106887

Antoni Riera-Mestre , Olga Portolà , Antonio Vidaller

引用次数: 0

Effects of six months treatment with liraglutide among patients with psoriasis and obesity, beyond metabolic control? 利拉鲁肽治疗6个月对代谢无法控制的银屑病和肥胖患者的影响？

Medicina clinica (English ed.) Pub Date : 2025-06-09 DOI: 10.1016/j.medcle.2025.106941

Joana Nicolau , Antoni Nadal , Pilar Sanchís , Antelm Pujol , María Isabel Tamayo , Cristina Nadal , Lluís Masmiquel

{"title":"Effects of six months treatment with liraglutide among patients with psoriasis and obesity, beyond metabolic control?","authors":"Joana Nicolau , Antoni Nadal , Pilar Sanchís , Antelm Pujol , María Isabel Tamayo , Cristina Nadal , Lluís Masmiquel","doi":"10.1016/j.medcle.2025.106941","DOIUrl":"10.1016/j.medcle.2025.106941","url":null,"abstract":"<div><h3>Introduction</h3><div>Obesity and psoriasis are two closely related chronic diseases and share multiple comorbidities. The common etiopathogenic basis would be a low-grade chronic inflammation, with a cross talk between adipose tissue and the skin. Obesity in patients with psoriasis results in a worse prognosis of the lesions and reduces the effectiveness of treatment.</div></div><div><h3>Objectives</h3><div>To assess the mid-term effect of liraglutide 3mg on anthropometric and morphofunctional, biochemical, and dermatological parameters in patients with psoriasis and obesity.</div></div><div><h3>Material and methods</h3><div>48 patients were included (52.1%♀, age 48.7±11.8 years, BMI 37.9±5.6kg/m<sup>2</sup>, psoriasis duration 17.8±11.1 years). The severity of the lesions was evaluated with the PASI (Psoriasis Area Severity Index) and the VAS (pain visual analog scale), and DLQI (Dermatology Quality Index) and the Beck depression test (BDI). Also, biochemical and anthropometric determinations were performed baseline and after 6 months.</div></div><div><h3>Results</h3><div>There was a reduction in BMI (37.9±5.6 vs 35±4.9; <em>p</em>       =0.001) and preperitoneal fat (1.6±0.6 vs 1.2±0.6cm; <em>p</em>      <0.0001), VAS (4.4±1.9 vs 2.2±1.6; <em>p</em>      <0.0001) and BDI (15.5±3.6 vs 7.6±2.5; <em>p</em>       <0.0001), homocysteine (13±3.3 vs 9.6±2.5μmol/L; <em>p</em>       =0.001). In multiple regression analysis, dermatological improvement was independent of weight loss.</div></div><div><h3>Conclusions</h3><div>Liraglutide exerts beneficial effects not only on BMI and visceral fat, but also reduces inflammatory parameters in patients with psoriasis and obesity, improving skin lesions and quality of life.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106941"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a machine learning model for predicting cardiovascular risk factors and major adverse cardiovascular events in young adults with glucose metabolism disorders 开发用于预测年轻成人糖代谢紊乱的心血管危险因素和主要不良心血管事件的机器学习模型

Medicina clinica (English ed.) Pub Date : 2025-06-09 DOI: 10.1016/j.medcle.2025.106911

Yangyang Zhao , Wenjing Zhang , Jiecheng Peng

{"title":"Development of a machine learning model for predicting cardiovascular risk factors and major adverse cardiovascular events in young adults with glucose metabolism disorders","authors":"Yangyang Zhao , Wenjing Zhang , Jiecheng Peng","doi":"10.1016/j.medcle.2025.106911","DOIUrl":"10.1016/j.medcle.2025.106911","url":null,"abstract":"<div><h3>Background</h3><div>Glucose metabolism disorders (GMDs) are a serious global public health issue, characterized by a high incidence rate and youthfulness. GMDs contribute to the occurrence of major adverse cardiovascular events (MACEs), meanwhile with the rest of the remaining cardiovascular risk factors (CVRFs) act synergistically to influence MACEs. Although numerous studies have explored CVRFs and their prognostic role in cardiovascular diseases, there is a lack of predictive models for novel cardiovascular risk factors and MACEs in the young population, particularly among patients with GMDS. This study aims to investigate important CVRFs affecting MACEs in young patients with GMDs by means of LASSO regression, randomized forest, and XGBoost, providing new evidence to support the early adoption of proactive and comprehensive interventions and management.</div></div><div><h3>Methods</h3><div>The study included 411 young patients with GMDs who visit the First People's Hospital of Anqing Affiliated to Anhui Medical University, between September 2022 and June 2023. The patients were randomly divided into a training set and a testing set in a 7:3. Comprehensive analysis was performed using LASSO regression, random forest, and XGBoost methods. The performance of the models was evaluated and validated, and the important cardiovascular risk factors identified by the three models were compared.</div></div><div><h3>Results</h3><div>After one year of follow-up, the incidence of events was higher in men compared to women (85.2% vs. 14.8%). LASSO regression analysis identified BP, TYg, BMI, FBG, and Tg/HDL as significant variables associated with MACEs. The random forest method highlighted BMI, TYg, Tg/HDL, Tg, and FBG as key factors related to MACEs. The XGBoost model also emphasized the important roles of BMI, TYg, TG, and BP. Combining the results from all three models, BMI, TYg, and BP consistently demonstrated significant importance across all models.</div></div><div><h3>Conclusions</h3><div>To some extent, males are more likely to experience adverse cardiovascular events compared to females. Combining the three major predictive models suggests that traditional CVRFs (BP, BMI) and novel CVRFs (TYg) play an important role in the development of distant MACEs in young GMDs, and that interventions for them may have implications for preventing DM transformation.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106911"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allergic rhinitis 过敏性鼻炎

Medicina clinica (English ed.) Pub Date : 2025-05-27 DOI: 10.1016/j.medcle.2025.106916

Victoria Cardona, Arnau Salvany-Pijuan, Javier Pereira-González

引用次数: 0