Medicina clinica (English ed.)最新文献_第9页

Tinea manuum 牛皮癣

Medicina clinica (English ed.) Pub Date : 2024-09-04 DOI: 10.1016/j.medcle.2023.12.029

María Córdoba García-Rayo, Daniel Vírseda González, Luis Jiménez Briones, Noelia Medrano Martínez

引用次数: 0

Percutaneous embolectomy in high-risk acute pulmonary embolism 高危急性肺栓塞的经皮栓子切除术

Medicina clinica (English ed.) Pub Date : 2024-09-04 DOI: 10.1016/j.medcle.2024.01.042

Mercedes Artola Blanco, Jaime Eduardo Pérez Gutiérrez, Elena Bustamante Munguira

引用次数: 0

Meaning and relevance of paper mills 造纸厂的意义和相关性

Medicina clinica (English ed.) Pub Date : 2024-09-04 DOI: 10.1016/j.medcle.2024.02.018

Marta Pulido

引用次数: 0

Identification of NDST1 variant as a cause of intellectual disability 确定 NDST1 变异是导致智力残疾的原因之一

Medicina clinica (English ed.) Pub Date : 2024-09-04 DOI: 10.1016/j.medcle.2024.03.019

Antonio Rosales-Castillo, Antonio Bustos-Merlo, Joaquín Escobar Sevilla

引用次数: 0

Value of the biomarker soluble tyrosine kinase 1 type fms (sFLT-1) in the diagnosis and prognosis of sepsis: a systematic review 生物标志物可溶性酪氨酸激酶1型fms（sFLT-1）在败血症诊断和预后中的价值：系统综述

Medicina clinica (English ed.) Pub Date : 2024-09-02 DOI: 10.1016/j.medcle.2024.03.014

Miguel Javier Ugalde , Alberto Caballero , Marta Martín Fernández , Eduardo Tamayo , Olga de la Varga-Martínez

{"title":"Value of the biomarker soluble tyrosine kinase 1 type fms (sFLT-1) in the diagnosis and prognosis of sepsis: a systematic review","authors":"Miguel Javier Ugalde , Alberto Caballero , Marta Martín Fernández , Eduardo Tamayo , Olga de la Varga-Martínez","doi":"10.1016/j.medcle.2024.03.014","DOIUrl":"10.1016/j.medcle.2024.03.014","url":null,"abstract":"<div><h3>Introduction</h3><p>The present systematic review analyses the role of soluble fms-like tyrosine kinase-1 (sFLT-1) as an indirect biomarCker of endothelial dysfunction in sepsis or septic shock from articles published in Pubmed between 2010 and March 2022.</p></div><div><h3>Materials and methods</h3><p>A systematic review of studies studying sFLT-1 monitoring in intensive care units in adults with sepsis or septic shock vs. controls for sepsis diagnosis and prognosis has been carried out (PROSPERO CRD42023412929 Registry).</p></div><div><h3>Results</h3><p>The endothelial dysfunction of sepsis is one of the keys to the development of the disease. VEGF binds to sFlt-1 acting as a competitive inhibitor of VEGF signalling in endothelial cells and thus neutralizes its pro-inflammatory effects. Endothelial dysfunction is reflected in increased sFLT-1 levels. High values of sFLT-1 were used for the differential diagnosis of sepsis versus other inflammatory pathologies, septic shock versus other types of shock, were elevated over time, estimation of disease prognosis, correlation with sepsis severity, organ dysfunction, and mortality prediction.</p></div><div><h3>Conclusions</h3><p>It is evident that sepsis is based on endothelial dysfunction. sFLT-1 is one of the main biomarkers of microvascular alteration and is a predictive diagnostic and prognostic biomarker.</p></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"163 5","pages":"Pages 224-231"},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2387020624003681/pdfft?md5=0a7d827c91a86fc6a32bc28f3c26914f&pid=1-s2.0-S2387020624003681-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal involvement in adults with cystic fibrosis: Study of 89 patients 成人囊性纤维化患者的肾脏受累情况：对 89 名患者的研究

Medicina clinica (English ed.) Pub Date : 2024-08-31 DOI: 10.1016/j.medcle.2024.03.013

Ester Zamarrón , Layla Diab , Jaime Pavón , Carlos Carpio , Rodolfo Álvarez-Sala , María Concepción Prados

{"title":"Renal involvement in adults with cystic fibrosis: Study of 89 patients","authors":"Ester Zamarrón , Layla Diab , Jaime Pavón , Carlos Carpio , Rodolfo Álvarez-Sala , María Concepción Prados","doi":"10.1016/j.medcle.2024.03.013","DOIUrl":"10.1016/j.medcle.2024.03.013","url":null,"abstract":"<div><h3>Introduction</h3><p>We are assisting to an increase in survival rates among individuals with cystic fibrosis (CF). Until now, renal involvement was a minority issue, but with the rise in life expectancy, we will likely see an increase in its prevalence. Our main objective was to assess renal function in CF and study risk factors associated with its deterioration.</p></div><div><h3>Methods</h3><p>A cross-sectional, retrospective study was conducted, including adults with CF. Clinical, respiratory function, microbiological, blood and urine analysis, and major chronic treatments received were collected.</p></div><div><h3>Results</h3><p>Eighty nine patients with a mean age of 35 ± 12 years were analyzed. Mean serum creatinine levels were 0.8 ± 0.2 mg/dL. 10.6% had a glomerular filtration rate less than 90 ml/min/1.73 m<sup>2</sup>. No patient showed albuminuria. In multivariate model, only age was an independent risk factor for reduced glomerular filtration (OR 0.344, 95% CI 0.004−0.017, p = 0.002).</p></div><div><h3>Conclusions</h3><p>11% of CF adults show decreased glomerular filtration, with age being the sole independent risk factor. Vigilance for this uncommon condition is crucial.</p></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"163 5","pages":"Pages 238-241"},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Polychondritis as a mimicker of challenging-to-manage allergic asthma 复发性多软骨炎是难以控制的过敏性哮喘的模仿者

Medicina clinica (English ed.) Pub Date : 2024-08-31 DOI: 10.1016/j.medcle.2024.03.012

Elena Oliver García, Elena Cañadillas Sánchez, Eva Palero Díaz

引用次数: 0

Perianal basal cell carcinoma 肛周基底细胞癌

Medicina clinica (English ed.) Pub Date : 2024-08-31 DOI: 10.1016/j.medcle.2024.04.010

Marta González Bocanegra , Estefanía Sánchez Sánchez , Alba Manuel-Vázquez

引用次数: 0

Meningitis after prostatic abscess due to hypervirulent Klebsiella pneumoniae 高化脓性肺炎克雷伯菌引起的前列腺脓肿后脑膜炎

Medicina clinica (English ed.) Pub Date : 2024-08-31 DOI: 10.1016/j.medcle.2024.03.011

Leticia Espinosa-del-Barrio , Pedro Jesús Esteve Atiénzar , Elisabet Delgado Sánchez

引用次数: 0

Forensic medicine units in hospitals, a necessary care system 医院法医室，必要的护理系统

Medicina clinica (English ed.) Pub Date : 2024-08-30 DOI: 10.1016/j.medcle.2024.03.009

Andrés Santiago-Sáez , Pilar Pinto Pastor , Bernardo Perea-Pérez

引用次数: 0