Medicina clinica (English ed.)最新文献_第9页

Metabolic index a non-invasive predictive marker of liver steatosis in patients with non-alcoholic fatty liver disease 代谢指数：非酒精性脂肪性肝病患者肝脏脂肪变性的无创预测指标

Medicina clinica (English ed.) Pub Date : 2026-01-01 Epub Date: 2026-02-04 DOI: 10.1016/j.medcle.2026.107268

Julio Lara-Riegos , Luis Alberto Chi-Cervera , Iaarah Montalvo-Gordon , Hugo Azcorra-Pérez , Julio Torres-Romero , Víctor Arana-Argáez , Mario Ramírez-Camacho , María Eugenia Icaza-Chávez

{"title":"Metabolic index a non-invasive predictive marker of liver steatosis in patients with non-alcoholic fatty liver disease","authors":"Julio Lara-Riegos , Luis Alberto Chi-Cervera , Iaarah Montalvo-Gordon , Hugo Azcorra-Pérez , Julio Torres-Romero , Víctor Arana-Argáez , Mario Ramírez-Camacho , María Eugenia Icaza-Chávez","doi":"10.1016/j.medcle.2026.107268","DOIUrl":"10.1016/j.medcle.2026.107268","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Determining insulin resistance (IR) is essential to identify subjects at risk for non-alcoholic fatty liver disease (NAFLD). A particular area of interest is the ability to detect patients with NAFLD using non-invasive biomarkers. This study aimed to evaluate the sensitivity, specificity, and predictive value of the metabolic index for detecting NAFLD.</div></div><div><h3>Materials and methods</h3><div>A retrospective study was conducted in adults of both sexes eligible for inclusion were adults of both sexes aged 18–85 years with and without NAFLD. Liver steatosis was measured using the controlled attenuation parameter (CAP) through FibroScan®. The metabolic index was calculated using the formula: Fasting Glucose × TG/HDL-C2. The study was carried out at the Gastrointestinal and Liver Specialty Clinic in Yucatán, Mexico, between January 2014 and November 2020, using a convenience sampling method. In a total of 138 subjects (32 healthy and 106 patients with NAFLD), anthropometric measures and laboratory tests were obtained to determine levels of triglycerides (TG), glucose (G), total cholesterol (TC), HDL-C, LDL-C, AST, and ALT.</div></div><div><h3>Results</h3><div>The metabolic index showed a specificity of 90,6% (95% CI [80,5–100]), sensitivity of 64.2% (95% CI [55–73,3]), a positive predictive value of 95,8%, a negative predictive value of 43,3%, a positive likelihood ratio of 6,83, and a negative likelihood ratio of 0,40 for detecting NAFLD.</div></div><div><h3>Conclusion</h3><div>The metabolic index showed high specificity for detecting NAFLD and could be used in adult patients with suspected NAFLD seen in primary health care.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 1","pages":"Article 107268"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147409615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastroparesis after lung transplant: An underestimated factor in chronic graft dysfunction 肺移植后胃轻瘫：慢性移植物功能障碍的一个被低估的因素

Medicina clinica (English ed.) Pub Date : 2026-01-01 Epub Date: 2026-01-31 DOI: 10.1016/j.medcle.2026.107253

Myrian González Álvarez , Ana Latorre Díez , Irvin Aníbal Castellanos Girón

引用次数: 0

Challenges of real data studies: Causality, intervention and reproducibility 真实数据研究的挑战：因果关系、干预和可重复性

Medicina clinica (English ed.) Pub Date : 2026-01-01 Epub Date: 2026-02-06 DOI: 10.1016/j.medcle.2026.107292

Inmaculada Arostegui , Josep Roma Millan , Nora Amama-BenHassun , Erik Cobo Valeri

引用次数: 0

Impact of the initiation of flash glucose monitoring (FGM) on glycemic control parameters in adult patients with type 2 diabetes mellitus 启动瞬时血糖监测（FGM）对成人2型糖尿病患者血糖控制参数的影响

Medicina clinica (English ed.) Pub Date : 2026-01-01 Epub Date: 2026-01-31 DOI: 10.1016/j.medcle.2026.107255

Carmela Manrique Mutiozábal , Amaia Legarreta Alday , Zuria Alba Muñoz , Eunate Sánchez Uribe , Ainara Deusto Puertas , Santos Zorrozúa Borja , Maria Luisa Antuñano López , Teresa Ruiz de Azúa Arteche , Estela Benito Martínez , Ester Caballero Renilla , Maite Guimón Bardesi

{"title":"Impact of the initiation of flash glucose monitoring (FGM) on glycemic control parameters in adult patients with type 2 diabetes mellitus","authors":"Carmela Manrique Mutiozábal , Amaia Legarreta Alday , Zuria Alba Muñoz , Eunate Sánchez Uribe , Ainara Deusto Puertas , Santos Zorrozúa Borja , Maria Luisa Antuñano López , Teresa Ruiz de Azúa Arteche , Estela Benito Martínez , Ester Caballero Renilla , Maite Guimón Bardesi","doi":"10.1016/j.medcle.2026.107255","DOIUrl":"10.1016/j.medcle.2026.107255","url":null,"abstract":"<div><h3>Introduction</h3><div>The effective implementation of the FGM contributes to achieving glycemic control, reducing hypoglycemic and hyperglycemic decompensations as well as enhancing patient self-management and improving their perception of quality of life. The aim of our study was to evaluate the glycemic control in type 2 diabetes patients after having implemented FGM in clinical practice.</div></div><div><h3>Material and methods</h3><div>Current patients with type 2 diabetes treated in our unit were monitored (FGM). A Structured Therapeutic Education Program was carried out and glycemic control variables were compared at the start and after 3 months of treatment.</div></div><div><h3>Results</h3><div>A total of 36 patients were included (mean age of 67.8 ± 12.4 years, 36.11% female, diabetes duration 21.5 ± 2.12 years and a previous median glycated hemoglobine of 7.55%). Comparing the baseline data and the measures at 3 months, it was found a decrease in both glucose management indicator (GMI) (0.15% [0.40;0.30], <em>P</em>, 537) and the coefficient of variation (CV) (1,42 ± 4,66%, <em>P</em>, 07), as well as an increase in time in range (TIR) (3,44 ± 14.72%, <em>P</em>, 169). Furthermore, a decrease in time in hyperglycemia > 250 mg/dl was observed (2,00% [−6,50;0,00] <em>P</em>, 001).</div></div><div><h3>Conclusion</h3><div>FGM has led to a favorable advance in the management and glycemic control in patients with type 2 diabetes.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 1","pages":"Article 107255"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147409716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late pulmonary metastasis of pheochromocytoma 嗜铬细胞瘤晚期肺转移

Medicina clinica (English ed.) Pub Date : 2026-01-01 Epub Date: 2026-02-04 DOI: 10.1016/j.medcle.2026.107276

Pablo Andrés Ordóñez Lozano , Olalla García Rodríguez , Andrea Carilla Sanromán

引用次数: 0

Severe hyperglycemia induced by alpelisib in breast cancer: A call for early monitoring alpelisib在乳腺癌中诱导的严重高血糖：早期监测的呼吁

Medicina clinica (English ed.) Pub Date : 2026-01-01 Epub Date: 2026-02-18 DOI: 10.1016/j.medcle.2026.107272

Carolina Peixe , José Vicente Rocha , Maria Inês Alexandre

引用次数: 0

Role of incretin-based therapies in pain management 以肠促胰岛素为基础的治疗在疼痛管理中的作用

Medicina clinica (English ed.) Pub Date : 2026-01-01 Epub Date: 2026-01-31 DOI: 10.1016/j.medcle.2026.107263

Antonio Alcántara Montero, Alfonso Castro Arias

引用次数: 0

Point-of care ultrasound for the diagnosis and management of infections in immunocompromised patients and HIV/AIDS 点护理超声诊断和管理感染免疫功能低下的病人和艾滋病毒/艾滋病

Medicina clinica (English ed.) Pub Date : 2026-01-01 Epub Date: 2026-02-18 DOI: 10.1016/j.medcle.2026.107322

Borja González Muñoz, Carmen Busca Arenzana, Juan María Herrero-Martínez

{"title":"Point-of care ultrasound for the diagnosis and management of infections in immunocompromised patients and HIV/AIDS","authors":"Borja González Muñoz, Carmen Busca Arenzana, Juan María Herrero-Martínez","doi":"10.1016/j.medcle.2026.107322","DOIUrl":"10.1016/j.medcle.2026.107322","url":null,"abstract":"<div><div>Point-of-care ultrasound (POCUS) has become an essential tool in the diagnosis and management of infections in immunocompromised patients, including those with HIV. Despite the existence of several ultrasound protocols, an infection-specific protocol has not yet been developed. In immunocompromised patients, POCUS allows early identification of infectious processes. Ultrasound findings may not differ from those of the general population, but their interpretation does. They are more prone to infection by unusual microorganisms, involvement of unusual territories and formation of abscesses or masses of infectious origin. It is particularly useful for identifying signs of infection, such as consolidations and effusions. In immunocompromised patients, its usefulness varies according to the level of immunosuppression, being especially valuable in the identification of opportunistic infections. Including HIV, transplanted, hematological or autoimmune diseases patients, it facilitates a rapid and accurate assessment, guiding diagnostic and therapeutic procedures.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 1","pages":"Article 107322"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147409501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herpes zoster duplex 带状疱疹双相

Medicina clinica (English ed.) Pub Date : 2026-01-01 Epub Date: 2026-02-18 DOI: 10.1016/j.medcle.2026.107258

Rong Sun, Cheng Tan

引用次数: 0

Inhaled antibiotics: past, Present and future 吸入抗生素：过去，现在和未来

Medicina clinica (English ed.) Pub Date : 2026-01-01 Epub Date: 2026-02-04 DOI: 10.1016/j.medcle.2026.107241

Alberto García-Ortega , Miguel Ángel Martínez-García

引用次数: 0