Medicina clinica (English ed.)最新文献

{"title":"Fibrolipomatous hamartoma involving median and ulnar nerves associated with macrodactyly","authors":"Raquel Maroto-Rodríguez, María Dolores Gimeno Garcia-Andrade, Carmen Ferrete Ferrer, Gloria Dargallo Carbonell","doi":"10.1016/j.medcle.2026.107457","DOIUrl":"10.1016/j.medcle.2026.107457","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107457"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148660545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrotendinous xanthomatosis","authors":"Antonio Rosales-Castillo, Blanca Sánchez Checa, Lucía Triguero Cuerva","doi":"10.1016/j.medcle.2026.107476","DOIUrl":"10.1016/j.medcle.2026.107476","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107476"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colonic perforation and cardiac tamponade: Two rare complications of cerebrospinal fluid shunting","authors":"Daniel Arnés-García, Celia Gómez-Gordo, Purificación Fernández-Morales","doi":"10.1016/j.medcle.2026.107474","DOIUrl":"10.1016/j.medcle.2026.107474","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107474"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superior vena cava syndrome: A real-world analysis of 91 cases","authors":"Aurora Gómez-Tórtola,&nbsp;Olaya Huergo-Fernández,&nbsp;Laura Plaza-Martínez,&nbsp;Lucía Ordieres-Ortega,&nbsp;Crhistian-Mario Oblitas,&nbsp;Francisco Galeano-Valle,&nbsp;Pablo Demelo-Rodríguez","doi":"10.1016/j.medcle.2026.107431","DOIUrl":"10.1016/j.medcle.2026.107431","url":null,"abstract":"<div><h3>Background</h3><div>Superior vena cava (SVCS) is an uncommon but potentially life-threatening condition caused by partial or complete obstruction of venous return through the superior vena cava, most commonly due to malignancy or catheter-related thrombosis. While SVCS is clinically relevant, contemporary data describing its presentation, management, and outcomes remain limited. The primary objective of this study was to describe the clinical characteristics, treatments, and outcomes of this population, and the secondary objective was to identify factors associated with mortality.</div></div><div><h3>Method</h3><div>Retrospective, single-center observational study including patients over 18 years of age diagnosed with SVCS between 2012 and 2023. Data were collected from electronic medical records. SVCS was confirmed by imaging. Life-threatening presentations were defined by the presence of cerebral or laryngeal edema, hemodynamic instability, or ICU admission.</div></div><div><h3>Results</h3><div>Ninety-one patients were included (mean age 59.5 years; 51.6% women). Most cases were malignancy-related (90.1%), primarily lung cancer (50.5%). At diagnosis, 26.4% had life-threatening symptoms and 19.8% had concurrent venous thromboembolism. Interventional treatment was required in 38.4%, with stenting being the most common procedure. During follow-up (median 124 days), 82.4% of patients died, mainly from cancer progression. Mortality was associated with older age, corticosteroid use, and malignancy. Thrombotic etiology and incidental diagnosis were linked to better outcomes. In multivariate analysis, lung cancer remained an independent predictor of mortality (OR 4.67; 95% CI: 1.05–23.4).</div></div><div><h3>Conclusion</h3><div>In this cohort, SVCS was predominantly associated with malignancy, mainly lung cancer, and carried a high mortality rate. Catheter-related and thrombotic SVCS showed more favorable outcomes, emphasizing the prognostic importance of the underlying etiology.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107431"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse events associated with the use of flumazenil","authors":"Santiago Nogué-Xarau,&nbsp;Montserrat Amigó-Tadin","doi":"10.1016/j.medcle.2026.107428","DOIUrl":"10.1016/j.medcle.2026.107428","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107428"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraneoplastic spinal myoclonus as the presenting manifestation of papillary thyroid carcinoma","authors":"Antonio Torres Gómez,&nbsp;Raquel Ríos Fernández,&nbsp;José Antonio Sáez Moreno","doi":"10.1016/j.medcle.2026.107472","DOIUrl":"10.1016/j.medcle.2026.107472","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107472"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red eye: Diagnostic criteria, signs of alert and therapeutic approach","authors":"Esther Arranz-Marquez,&nbsp;Montserrat Garcia-Gonzalez,&nbsp;Miguel A. Teus","doi":"10.1016/j.medcle.2026.107433","DOIUrl":"10.1016/j.medcle.2026.107433","url":null,"abstract":"<div><div>“Red eye” is one of the main reasons of urgent consultation in Primary Care and in Ophthalmologic Emergencies. In many cases, the underlying cause is a benign condition that can be managed by the Primary Care Physician. However, not every red eye is a conjunctivitis, so it is important to recognize the warning signs and symptoms associated with potentially serious conditions. Causes of red eye include diseases of the ocular surface (conjunctivitis), which are generally benign; internal eye diseases (uveitis, glaucoma, scleritis, trauma) and extraocular diseases (cavernous sinus thrombosis, orbital cellulitis), which are generally ophthalmic and systemically severe, respectively. In this expert review, we aim to provide a practical approach to the differential diagnosis of red eye in general practice, defining the criteria of severity and urgency for referral to a specialized Ophthalmology consultation.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107433"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eclampsia-related posterior reversible encephalopathy syndrome: A classic imaging presentation","authors":"Xinsen Chen,&nbsp;Meng Shao,&nbsp;Shuo Fan,&nbsp;Ting Jiang","doi":"10.1016/j.medcle.2026.107461","DOIUrl":"10.1016/j.medcle.2026.107461","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107461"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary artery intimal sarcoma mimicking pulmonary embolism","authors":"Enmanuel A. Leiva-Murillo,&nbsp;Rosanel Amaro-Rodríguez","doi":"10.1016/j.medcle.2026.107458","DOIUrl":"10.1016/j.medcle.2026.107458","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107458"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and therapeutic characteristics of a Spanish systemic lupus erythematosus cohort: Comparison with the RELESSER registry","authors":"Isabel Sánchez Berná,&nbsp;María Martín Armada,&nbsp;Mónica Zamora Pasadas,&nbsp;Antonio Manuel Martín Belmonte,&nbsp;Nuria Navarrete Navarrete","doi":"10.1016/j.medcle.2026.107453","DOIUrl":"10.1016/j.medcle.2026.107453","url":null,"abstract":"<div><h3>Introduction</h3><div>Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterised by marked clinical and therapeutic heterogeneity. In Spain, patient care is primarily shared between Rheumatology and Internal Medicine departments. The characterization of local patients series and their comparison with national registries allows clinical profiles and management patterns to be contextualized across different healthcare settings.</div></div><div><h3>Methods</h3><div>A retrospective cross-sectional study was conducted including all patients with SLE under active follow-up in a specialised autoimmune diseases unit within the Department of Internal Medicine at a Spanish tertiary hospital between 2024 and 2025. Demographic, clinical, immunological, and therapeutic variables were analyzed. Findings were compared with previously published data from the Spanish Society of Rheumatology’s Systemic Lupus Erythematosus Registry (RELESSER).</div></div><div><h3>Results</h3><div>A total of 305 patients were included, predominantly women (89.8%), with a mean age at diagnosis of 34.2 ± 15.4 years and a mean disease duration of 15.7 ± 11.8 years. Musculoskeletal (83.3%) and mucocutaneous manifestations (79.3%) were the most frequent, followed by haematological (38.4%) and renal involvement (29.5%). Disease activity and accumulated damage were low [SLEDAI 2 (0–4), SLEDAIc 0 (0–1), SDI 0 (0–1)]. Compared with RELESSER, our series showed longer disease duration, higher use of antimalarials, lower exposure to corticosteroids and conventional immunosuppressive agents, and a higher use of biologic therapies.</div></div><div><h3>Conclusions</h3><div>This single-center registry shows overall clinical characteristics comparable to those reported in RELESSER, with relevant differences in treatment patterns, reflecting the variability in SLE management in real-world clinical practice.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 7","pages":"Article 107453"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}