西班牙人群动脉僵硬度的演变及其与心血管危险因素的关系EVA的后续研究

David González Falcón , Leticia Gómez-Sánchez , Marta Gómez-Sánchez , Emiliano Rodríguez-Sánchez , Olaya Tamayo-Morales , Cristina Lugones-Sánchez , Susana González-Sánchez , Moises Diaz , Manuel A. Gómez-Marcos , on behalf of the EVA Study Investigators
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引用次数: 0

摘要

前言和目的分析西班牙无心血管疾病人群5年期间动脉僵硬度的增加及其与心血管危险因素的关系和性别差异。MethodsLongitudinal研究。通过年龄和性别分层随机抽样,平均年龄55.9岁,女性50.3%,基线评估纳入501名受试者,其中480名受试者随访5年,用sphygmoor和Vasera评估动脉僵硬度的增加情况。结果颈-股脉波速度(cf-PWV)为0.22 (SD 0.36) m/sec,臂-踝脉波速度(ba-PWV)为0.18 (SD 0.30) m/sec,心-踝血管指数(CAVI)为0.04 (SD 0.18),中枢增强指数(CAI)为0.38 (SD 2.66)。多元回归显示,cf-PWV和ba-PWV的升高与全球平均动脉压相关(β = 0.02;β =−0.02),男性(β = 0.02;β =−0.03)。在女性中,ba-PWV和CAVI的增加与BMI呈负相关(β = - 0.06;β =−0.03)。结论:在全球范围内,按性别划分,RA的四项指标在五年内均有所增加。这些增加根据所使用的测量方法、年龄、性别和相关的CRF而有所不同。高血压患者的ba-PWV在全球和性别上都有较大的增加。在全球和男性中,平均血压与cf-PWV和ba-PWV升高有关。BMI与女性ba-PWV和CAVI的增加呈负相关。在ClinicalTrials.gov注册的研究。(NCT02623894)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evolution of arterial stiffness and association with cardiovascular risk factors in the Spanish population. Follow-up to the study EVA

Introduction and objectives

To analyse the increase of arterial stiffness over a five-year period and its relationship with cardiovascular risk factors and sex-based differences in a Spanish population without cardiovascular disease.

Methods

Longitudinal study. Analysis of the increase in arterial stiffness measures evaluated with SphygmoCor and Vasera of 480 subjects followed for 5 years of the 501 subjects included in the baseline evaluation, selected through random sampling stratified by age and sex, mean age of 55.9 years, 50.3% women.

Results

Increases per year: carotid-femoral pulse wave velocity (cf-PWV), 0.22 (SD 0.36) m/sec, brachial-ankle pulse wave velocity (ba-PWV), 0.18 (SD 0.30) m/sec, Cardio-Ankle Vascular Index (CAVI), 0.04 (SD 0.18) and Central Augmentation Index (CAI), 0.38 (SD 2.66). Multiple regression, increases in cf-PWV and ba-PWV showed an association with mean arterial pressure in global (β = 0.02; β = −0.02) and in men (β = 0.02; β = −0.03). In women, increases in ba-PWV and CAVI showed a negative association with BMI (β = −0.06; β = −0.03).

Conclusions

The four measures of RA increase over five years globally and by sex. These increases differ according to the measure used, age, sex and associated CRF. Hypertensive people has greater increases in ba-PWV in global and by sex. The average blood pressure is associated with increases in cf-PWV and ba-PWV in global and in men. BMI is negatively associated with increases in ba-PWV and CAVI in women.
Study registered at ClinicalTrials.gov. (NCT02623894).
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