Medicina clinica (English ed.)最新文献

{"title":"Cutaneous rash and cholestatic hepatitis induced by methimazole","authors":"Antonio Bustos-Merlo , Antonio Rosales-Castillo , Carlos Javier García Calvente","doi":"10.1016/j.medcle.2025.106884","DOIUrl":"10.1016/j.medcle.2025.106884","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106884"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crohn's disease in patients with systemic lupus erythematosus","authors":"Doryan José García Olivas , Judith Hernández Sánchez , Javier Cabrera Valencia","doi":"10.1016/j.medcle.2025.106928","DOIUrl":"10.1016/j.medcle.2025.106928","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106928"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of the prevalence of alcohol consumption and characterization of hazardous consumption in Spain: 2005–2022","authors":"Ana González-Moreno ,&nbsp;Mónica Pérez-Ríos ,&nbsp;Carla Guerra-Tort ,&nbsp;María Isolina Santiago-Pérez ,&nbsp;Ana Teijeiro ,&nbsp;Lucía Martin-Gisbert ,&nbsp;Guadalupe García ,&nbsp;Cristina Candal-Pedreira ,&nbsp;Julia Rey-Brandariz","doi":"10.1016/j.medcle.2025.106909","DOIUrl":"10.1016/j.medcle.2025.106909","url":null,"abstract":"<div><h3>Background and objective</h3><div>The objectives of this study were to analyze the evolution of the prevalence of alcohol consumption between 2005 and 2022, to estimate the prevalence of hazardous alcohol consumption in 2022, and to characterize hazardous consumers.</div></div><div><h3>Materials and methods</h3><div>Microdata from 9 editions of the EDADES survey were used. Prevalences of alcohol consumption were estimated overall, by sex and age group between 2005 and 2022. Additionally, the prevalence of hazardous alcohol consumption at the national level and in the autonomous communities was determined in 2022. Trend analysis was performed by applying joinpoint regression models and a multivariate logistic regression model was fitted to characterize hazardousconsumers.</div></div><div><h3>Results</h3><div>The trend in the prevalence of alcohol consumption was found to be stable for lifetime, past 12 months, and past 30 days consumption, while a decreasing trend was observed for daily consumption. In 2022, 6.5% (95%CI: 6.1–6.9) of the Spanish population aged 15–64 years had risky alcohol consumption. This prevalence ranged from 13.1% (95%CI: 11.2–15.3) in the Region of Murcia to 2.9% (95%CI: 1.9–4.3) in Cantabria. The use of cannabis in the last year was the variable with the highest OR for hazardous alcohol consumption overall, in men and in women (OR &gt; 2.7).</div></div><div><h3>Conclusions</h3><div>The prevalence of alcohol consumption in Spain is high and its trend is stable. The use of other drugs such as tobacco or cannabis increases the odds of having a hazardous alcohol consumption.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106909"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spirometric alterations and their risk factors in young ambulatory population","authors":"Marc Vila ,&nbsp;Sandra Casas-Recasens ,&nbsp;Rosa Faner ,&nbsp;Vinicius Rosa Oliveira ,&nbsp;Alvar Agustí","doi":"10.1016/j.medcle.2025.106910","DOIUrl":"10.1016/j.medcle.2025.106910","url":null,"abstract":"<div><h3>Introduction</h3><div>Recent studies have shown that about 10% of adults aged 20–40 years in the general population have reduced spirometric values, and that this is associated with a greater risk of respiratory and non-respiratory diseases and early mortality at 20 years of follow-up. Thirty years ago, the IBERPOC study identified a very high prevalence (18%) of chronic obstructive pulmonary disease (COPD) in the Osona region (Catalonia, Spain) in people older than 40 years of age.</div></div><div><h3>Objective</h3><div>To investigate the current prevalence of spirometric alterations, clinical manifestations and risk factors in adults aged 18–50 years in Osona.</div></div><div><h3>Methods</h3><div>241 participants living in Osona were prospectively included (149 women (61,8%) and 92 men (38,2%)), with a mean age of 34,2 ± 10,3 years, living in Osona.</div></div><div><h3>Results</h3><div>Results showed that: (1) the prevalence of spirometric abnormalities before bronchodilation (&lt;lower limit of normal; LLN) in the population studied was 20.7% (14,5% FEV₁, 10,8% FVC and 7,9% FEV₁/FVC), particularly in males who also smoked more and more often worked in potentially risk labours; (2) 20–30% of participants referred respiratory symptoms, particularly in females; (3) the comparison between participants with normal or abnormal spirometry showed that the latter did not have a higher smoking exposure or early life-events but had been diagnosed of COPD, asthma or diabetes more frequently.</div></div><div><h3>Conclusions</h3><div>20.7% of young adults in Osona have abnormal spirometric values, similarly to the results of the IBERPOC study more than 30 years ago. The investigation of its origin merits a larger study that includes environmental, genetic and epigenetic measurements.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106910"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of ocular ultrasound for monitoring acute retinal arterial ischemia","authors":"Luis Castilla-Guerra ,&nbsp;Antonio Gómez-Escobar ,&nbsp;Estanislao Gutiérrez Sánchez ,&nbsp;María del Carmen Fernández-Moreno","doi":"10.1016/j.medcle.2025.106863","DOIUrl":"10.1016/j.medcle.2025.106863","url":null,"abstract":"<div><h3>Introduction</h3><div>The ocular ultrasound spot sign negatively predicts the success of thrombolytic treatment in retinal arterial occlusions. We evaluated the presence of the spot sign in these patients.</div></div><div><h3>Material and methods</h3><div>Retrospective study of patients with acute central retinal artery occlusion (CRAO) or its branches (BRAO). An ocular ultrasound was performed to assess the presence of spot sign.</div></div><div><h3>Results</h3><div>Twenty patients were included, 13 CRAO and 7 BRAO. Carotid stenosis was the most common etiology, in 50%, 7 CRAO and 3 BRAO. A spot sign was observed in 9 patients (45%), 7 CRAO and 2 BRAO. We did not observe significant differences between patients with CRAO and BRAO. Patients with the spot sign were significantly older, 73 (± 9) vs 66 (± 6) years (p = 0.028).</div></div><div><h3>Conclusions</h3><div>Ocular ultrasound is very useful in the evaluation of patients with acute retinal ischemia. More than fifty percent of CRAOs and one in four with BRAOs have the spot sign and would not benefit from systemic thrombolysis.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106863"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular profile of systemic lupus erythematosus patients hospitalized for COVID-19 in Spain: Analysis of the SEMI-COVID-19 Registry","authors":"Halbert Hernández-Negrín ,&nbsp;María Rosa Bernal-López ,&nbsp;Almudena López-Sampalo ,&nbsp;Manuel Rubio-Rivas ,&nbsp;Josefa Andrea Aguilar-García ,&nbsp;Angie Gómez-Uranga ,&nbsp;María Carnevali ,&nbsp;María Luisa Taboada-Martínez ,&nbsp;José-Manuel Ramos-Rincón ,&nbsp;Ricardo Gómez-Huelgas ,&nbsp;list of members of the SEMI-COVID-19 Network ,&nbsp;Appendix A. List of members of the SEMI-COVID-19 Network,&nbsp;Halbert Hernández-Negrín ,&nbsp;María Rosa Bernal-López ,&nbsp;Almudena López-Sampalo ,&nbsp;Manuel Rubio-Rivas ,&nbsp;Josefa Andrea Aguilar-García ,&nbsp;Angie Gómez-Uranga ,&nbsp;María Carnevali ,&nbsp;María Luisa Taboada-Martínez ,&nbsp;Ricardo Gómez-Huelgas","doi":"10.1016/j.medcle.2025.106889","DOIUrl":"10.1016/j.medcle.2025.106889","url":null,"abstract":"<div><h3>Background</h3><div>Despite advancements in understanding the interplay between systemic lupus erythematosus (SLE), cardiovascular disease and COVID-19, challenges and knowledge gaps persist. This study aimed to characterize the cardiovascular profiles of SLE patients hospitalized with COVID-19 and to evaluate the influence of SLE on the development of cardiovascular complications.</div></div><div><h3>Methods</h3><div>This was a multicentre, nationwide observational study in which data were sourced from the SEMI-COVID-19 Registry between March 1, 2020, and March 31, 2021, involving 150 Spanish hospitals. SLE patients were matched with non-SLE patients based on sex, age, and hospitalization date.</div></div><div><h3>Results</h3><div>Of the 20,970 patients included in the SEMI-COVID-19 Registry, 38 were previously diagnosed with SLE. The non-SLE group was composed of 103 patients. The mean age of the SLE patients was 63 years, with 81.6% females and 21.1% non-European patients. SLE patients exhibited a significantly higher frequency of chronic kidney disease (14.4% vs 2.9%; <em>p</em> <!-->=<!--> <!-->0.004), stroke (23.7% vs 2.9%; <em>p</em> <!-->&lt;<!--> <!-->0.001), and increased use of cardiovascular medications. SLE demonstrated an independent association with the occurrence of major cardiovascular events (MACE) (OR: 3.934; 95% CI: 1.247–12.432).</div></div><div><h3>Conclusions</h3><div>SLE patients hospitalized for COVID-19 are at high risk of having an unfavorable baseline cardiovascular profile and are more prone to MACEs and adverse noncardiovascular outcomes during hospitalization.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106889"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep dermatophytosis caused by Trichophyton rubrum","authors":"Borja González Rodríguez,&nbsp;Christian Gutiérrez Collar,&nbsp;An Wang,&nbsp;Lorena Calderón Lozano,&nbsp;Alba Calleja Algarra","doi":"10.1016/j.medcle.2025.106886","DOIUrl":"10.1016/j.medcle.2025.106886","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106886"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult Pompe disease: Analysis of 13 patients","authors":"Paloma Martín-Jiménez ,&nbsp;Laura Bermejo-Guerrero ,&nbsp;Ana Hernandez-Voth ,&nbsp;Ana Arteche-López ,&nbsp;Aurelio Hernández-Lain ,&nbsp;María Rabasa ,&nbsp;Cristina Domínguez-González","doi":"10.1016/j.medcle.2025.106729","DOIUrl":"10.1016/j.medcle.2025.106729","url":null,"abstract":"<div><h3>Introduction</h3><div>Pompe Disease (PD) is a lysosomal disorder caused by a deficiency of the enzyme acid alpha-glucosidase (GAA), primarily manifesting as a progressive myopathy with early respiratory involvement. Since 2006, enzyme replacement therapy (ERT) has been available.</div></div><div><h3>Materials and methods</h3><div>We describe 13 patients with partial GAA deficiency, followed at Hospital 12 de Octubre, 8 of whom were receiving treatment.</div></div><div><h3>Results</h3><div>8 patients exhibit symptoms, all with late onset. They display axial and proximal weakness predominantly in the lower limbs but maintain autonomous gait. Five patients require non-invasive mechanical ventilation due to respiratory insufficiency. All symptomatic patients receive ERT, and in 7/8 (87.5%), there is a decline in motor and pulmonary function after an average of 8.25 years of treatment (baseline and post-treatment FVC and 6MWT mean 86.6% vs 70.8% and 498 vs 430 m, respectively).</div></div><div><h3>Conclusion</h3><div>Not all patients with partial GAA deficiency experience symptoms of PD, and symptomatic patients, despite ERT with recombinant alpha-glucosidase, mostly experience a gradual decline in motor and respiratory function.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106729"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pompe disease","authors":"José César Milisenda,&nbsp;Ana Matas-García","doi":"10.1016/j.medcle.2025.106922","DOIUrl":"10.1016/j.medcle.2025.106922","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106922"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycotic aneurysm, a rare complication of urothelial carcinoma treatment","authors":"Julián Tejero Cobos,&nbsp;Antonio Torres Gómez,&nbsp;Haylen José Marín Gómez,&nbsp;Ramez Constantino Chahin","doi":"10.1016/j.medcle.2025.106871","DOIUrl":"10.1016/j.medcle.2025.106871","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106871"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}