Medicina clinica (English ed.)最新文献

{"title":"Polyangiitis overlap syndrome with granulomatosis and systemic sclerosis","authors":"Alejandra Montserrat Cervantes González , María Alcocer León , Gilberto de Hoyos Rodríguez","doi":"10.1016/j.medcle.2025.107052","DOIUrl":"10.1016/j.medcle.2025.107052","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107052"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of relapsed multiple myeloma presenting as testicular plasmacytoma with stable bone marrow disease","authors":"Rita González-Resina , Robert R. Rodríguez-Carpio , Ana C. Godoy-Molias","doi":"10.1016/j.medcle.2025.107049","DOIUrl":"10.1016/j.medcle.2025.107049","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107049"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute organophosphorus pesticide poisoning with hepatic portal venous gas","authors":"Xinsen Chen , Ting Jiang , Lu Zhang","doi":"10.1016/j.medcle.2025.106967","DOIUrl":"10.1016/j.medcle.2025.106967","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 106967"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of anticoagulation with vitamin K antagonists in Spain: A systematic review with meta-analysis of national registries","authors":"José Miguel Rivera-Caravaca ,&nbsp;Danilo Menichelli ,&nbsp;Daniele Pastori ,&nbsp;Eva Soler-Espejo ,&nbsp;María Asunción Esteve-Pastor ,&nbsp;David Vivas ,&nbsp;Inmaculada Roldán ,&nbsp;Manuel Anguita ,&nbsp;José Luis Ferreiro ,&nbsp;Vanessa Roldán ,&nbsp;Francisco Marín ,&nbsp;on behalf of the Working Group on Cardiovascular Thrombosis of the Spanish Society of Cardiology","doi":"10.1016/j.medcle.2025.107031","DOIUrl":"10.1016/j.medcle.2025.107031","url":null,"abstract":"<div><h3>Background</h3><div>Vitamin K antagonists (VKAs) depend on appropriate time in therapeutic range (TTR). We reviewed studies in Spain providing data on the quality of oral anticoagulation with VKA in atrial fibrillation (AF) patients, to present an overview of the quality of this therapy in our country.</div></div><div><h3>Methods</h3><div>Systematic review and meta-analysis of national studies. We searched PubMed, Web of Science and Google Scholar databases for studies published in the last 10 years, until June 2024. We reported the mean pooled TTR and proportion of international normalized ratios (INRs) in range (PINRR), as well as the pooled prevalence of poor quality of VKA therapy.</div></div><div><h3>Results</h3><div>Seven studies were included in the analysis, for an overall cohort of 6953 patients (mean age 73.6–83 years). The pooled analysis gave a mean TTR of 63.22% (95% confidence interval [CI] 46.55–79.89) and a mean PINRR of 60.53% (95% CI 44.40–76.65). Accordingly, the pooled prevalence of a TTR &lt;65% was 50.01% (95% CI 45.36–54.65), and the pooled prevalence of a PINRR &lt;60% was 46.90% (95% CI 41.56–52.31). Similar results were observed in a sensitivity analysis performed including only those studies fulfilling very similar inclusion/exclusion criteria (<em>n</em> <!-->=<!--> <!-->5).</div></div><div><h3>Conclusion</h3><div>The mean TTR and PINRR of AF patients on VKAs in Spain were below the recommended standards. Nearly 50% of patients showed poor anticoagulation control, remaining exposed to low-quality therapy and complications related to AF.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107031"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial phosphate transporter (PiC) deficiency due to mutation in SLC25A3 in a Spanish family","authors":"Carmen Rodríguez-Barrios ,&nbsp;Irene Gutierrez-Rosa ,&nbsp;Moises Rodriguez-Gonzalez","doi":"10.1016/j.medcle.2025.107051","DOIUrl":"10.1016/j.medcle.2025.107051","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107051"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic significance of carcinoembryonic antigen and anti-MDA5 antibodies in polymyositis/dermatomyositis-associated rapidly progressive interstitial lung disease","authors":"Pengfang Tang,&nbsp;Wengting Hong,&nbsp;Binbin Chen,&nbsp;Hongying Shi","doi":"10.1016/j.medcle.2025.107048","DOIUrl":"10.1016/j.medcle.2025.107048","url":null,"abstract":"<div><h3>Objectives</h3><div>To explore relationship between lung cancer-related biomarkers and polymyositis/dermatomyositis (PM/DM) complicated with interstitial pneumonia, so as to identify serological markers for PM/DM rapidly progressing interstitial pneumonia (RP-ILD).</div></div><div><h3>Methods</h3><div>This study was a control study in which clinical and laboratory data were collected from the Fujian Medical University Affiliated Second Hospital between August 2019 and January 2024. The tumor markers assessed included carcinoembryonic antigen (CEA), cytokeratin-19 fragment (CYFRA21-1), and neuron-specific enolase (NSE). The study aimed to compare clinical indicators and lung cancer biomarker differences among patients with PM/DM exhibiting varying characteristics. Data analysis was conducted using Spearman's rank correlation, logistic regression analysis, and receiver operating characteristic (ROC) curve analysis.</div></div><div><h3>Results</h3><div>The study included a total of 130 patients, of whom 99 (76.15%) were diagnosed with interstitial lung disease (ILD). Among these, 73 patients had chronic ILD, while 26 exhibited RP-ILD. The remaining 31 individuals (23.85%) did not have ILD. In terms of clinical symptoms, the incidence of Gottron's sign and shortness of breath was significantly higher in the RP-ILD group compared to the chronic ILD and non-ILD groups. In terms of clinical markers, RP-ILD patients had much higher levels of serum ferritin, CEA, and CYFRA21-1 than those with chronic ILD (C-ILD) and non-ILD (N-ILD). Conversely, the RP-ILD group showed significantly reduced values for the oxygenation index, forced vital capacity, carbon monoxide diffusion capacity, and CD3⁺CD4⁺ T cell counts compared to the other groups. A significant correlation was observed between the presence of anti-melanoma differentiation-associated gene 5 (MDA5) antibodies, serum CEA levels, CD3⁺CD4⁺ T cell ratio, and oxygenation index with PM/DM complicated by RP-ILD. The combination of serum CEA levels and anti-MDA5 antibodies demonstrated the highest diagnostic value for PM/DM-RPILD, demonstrating a sensitivity of 88.9% and a specificity of 81.6%, with an area under the curve of 0.923 (<em>P</em> <!-->&lt;<!--> <!-->0.001).</div></div><div><h3>Conclusions</h3><div>Elevated serum concentrations of lung cancer-associated biomarkers, notably CEA, alongside the presence of anti-MDA5 antibodies, exhibit a significant correlation with PM/DM complicated by RP-ILD. This combination of biomarkers could enhance the identification of RP-ILD subtypes in PM/DM patients.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107048"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with in-hospital and 12-month mortality in patients undergoing hip arthroplasty for femoral neck fracture","authors":"Julieta Passini-Sánchez ,&nbsp;Juan Miguel Gómez-Palomo ,&nbsp;Ana Martínez-Crespo ,&nbsp;Plácido Zamora-Navas","doi":"10.1016/j.medcle.2025.107021","DOIUrl":"10.1016/j.medcle.2025.107021","url":null,"abstract":"<div><h3>Introduction</h3><div>The increase in the incidence of hip fractures in elderly patients is associated with higher mortality, with rates as high as 30% per year. The aim of this study was to identify the factors associated with in-hospital and 12-month mortality in patients undergoing hip arthroplasty for femoral neck fracture. While the type of procedure (HA vs. THA) was analysed, the primary focus was on clinical and perioperative variables influencing mortality.</div></div><div><h3>Material and methods</h3><div>A retrospective case–control study was conducted with a sample of 476 patients treated with THA or HA between 2016 and 2018. A multivariate analysis was performed, to identify the variables with the most significant impact on in-hospital mortality and mortality within the first year of follow-up.</div></div><div><h3>Results</h3><div>In-hospital mortality was 6.8%, while 12-month mortality reached 10.9%. The variables associated with higher mortality were age, respiratory disease, renal insufficiency, chronic anaemia, use of antiplatelet or anticoagulant medications, and being bedridden or chair-bound. No statistically significant differences were observed regarding the type of procedure (THA or HA).</div></div><div><h3>Conclusions</h3><div>The use of antiplatelet or anticoagulant medications, chronic renal insufficiency, and being bedridden or chair-bound were associated with higher in-hospital mortality. Chronic anaemia, respiratory disease, chronic renal insufficiency, and being bedridden or chair-bound correlated with an increase in mortality during the first year.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107021"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid remission of SAPHO syndrome with secukinumab","authors":"Guangliang Wei,&nbsp;Huidong Chen,&nbsp;Jie Chen","doi":"10.1016/j.medcle.2025.107050","DOIUrl":"10.1016/j.medcle.2025.107050","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107050"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glufosinate-ammonium poisoning: A clinical case","authors":"Junwei Luo,&nbsp;Lingjun Kong,&nbsp;Yuanyuan Kuang","doi":"10.1016/j.medcle.2025.107072","DOIUrl":"10.1016/j.medcle.2025.107072","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107072"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small fiber neuropathy","authors":"Teresa Sevilla ,&nbsp;Lucía Galán Dávila","doi":"10.1016/j.medcle.2025.106950","DOIUrl":"10.1016/j.medcle.2025.106950","url":null,"abstract":"<div><div>Small fiber neuropathy (SFN) are a frequent cause of consultation in neurology. The estimated prevalence is of minimum 53 cases/100.000 inhabitants. The most frequent symptoms are neuropathic pain and dysautonomic disfunction. Symptoms, examination, neurophysologic test and skin biopsy are the pillars in its diagnosis. In the last years new causes of SFN has been described as for example mutations in sodium channel or immune causes as TS-HDS, FGFR-3 y plexina D1. Nowadays the treatment of SFN is mainly symptomatic including antidepressives and antiepileptics in a essay-mistake approach. However this new knowledge in the field may lead to a better definition of phenotype and genotype and a more personalized treatment.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 106950"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}