Medicina clinica (English ed.)最新文献

{"title":"Biomarkers in transthyretin amyloidosis. Present and future","authors":"Fernando Martínez Valle,&nbsp;Carmen Pérez Bocanegra","doi":"10.1016/j.medcle.2025.106939","DOIUrl":"10.1016/j.medcle.2025.106939","url":null,"abstract":"<div><div>The appearance of new treatments for the different forms of ATTR has highlighted the importance of early diagnosis, since most of these treatments are highly effective in the initial phases of the disease. Currently, the diagnosis of ATTR is fundamentally based on clinical findings, cardiac imaging and neurophysiological parameters, and it is common a delay in diagnosis, and this occurs very frequently in advanced phases of the disease. The appearance of different biomarkers attempts to promote early diagnosis, as well as stratify into different risk groups, which can benefit from specific treatments, as well as obtain prognostic data from patients. This article reviews the different biomarkers currently available in ATTR and potential future biomarkers.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106939"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Institutional or personal e-mail address in manuscripts submitted to biomedical journals: The case of retired physicians","authors":"José Berciano","doi":"10.1016/j.medcle.2025.106944","DOIUrl":"10.1016/j.medcle.2025.106944","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106944"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Science and Medicine: Allies to apply the best evidence to clinical practice","authors":"Tomás Cobo Castro ,&nbsp;María Rosa Arroyo Castillo ,&nbsp;José Ramón Repullo Labrador","doi":"10.1016/j.medcle.2025.106938","DOIUrl":"10.1016/j.medcle.2025.106938","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106938"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tarui disease and rhabdomyolysis without renal failure","authors":"Roberto Hurtado-García ,&nbsp;Javier Martínez Elvira ,&nbsp;Inmaculada González-Cuello","doi":"10.1016/j.medcle.2025.106931","DOIUrl":"10.1016/j.medcle.2025.106931","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106931"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palliative sedation","authors":"Cristina Lojo-Cruz,&nbsp;Juan Mora-Delgado","doi":"10.1016/j.medcle.2025.106937","DOIUrl":"10.1016/j.medcle.2025.106937","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106937"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Professional situation of physicians trained outside the EU in Barcelona","authors":"Gustavo Andrés Tolchinsky Wiesen ,&nbsp;Ana Graciela Angulo Menéndez ,&nbsp;Carles Martin-Fumadó","doi":"10.1016/j.medcle.2025.106930","DOIUrl":"10.1016/j.medcle.2025.106930","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106930"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous rash and cholestatic hepatitis induced by methimazole","authors":"Antonio Bustos-Merlo ,&nbsp;Antonio Rosales-Castillo ,&nbsp;Carlos Javier García Calvente","doi":"10.1016/j.medcle.2025.106884","DOIUrl":"10.1016/j.medcle.2025.106884","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106884"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crohn's disease in patients with systemic lupus erythematosus","authors":"Doryan José García Olivas ,&nbsp;Judith Hernández Sánchez ,&nbsp;Javier Cabrera Valencia","doi":"10.1016/j.medcle.2025.106928","DOIUrl":"10.1016/j.medcle.2025.106928","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106928"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of the prevalence of alcohol consumption and characterization of hazardous consumption in Spain: 2005–2022","authors":"Ana González-Moreno ,&nbsp;Mónica Pérez-Ríos ,&nbsp;Carla Guerra-Tort ,&nbsp;María Isolina Santiago-Pérez ,&nbsp;Ana Teijeiro ,&nbsp;Lucía Martin-Gisbert ,&nbsp;Guadalupe García ,&nbsp;Cristina Candal-Pedreira ,&nbsp;Julia Rey-Brandariz","doi":"10.1016/j.medcle.2025.106909","DOIUrl":"10.1016/j.medcle.2025.106909","url":null,"abstract":"<div><h3>Background and objective</h3><div>The objectives of this study were to analyze the evolution of the prevalence of alcohol consumption between 2005 and 2022, to estimate the prevalence of hazardous alcohol consumption in 2022, and to characterize hazardous consumers.</div></div><div><h3>Materials and methods</h3><div>Microdata from 9 editions of the EDADES survey were used. Prevalences of alcohol consumption were estimated overall, by sex and age group between 2005 and 2022. Additionally, the prevalence of hazardous alcohol consumption at the national level and in the autonomous communities was determined in 2022. Trend analysis was performed by applying joinpoint regression models and a multivariate logistic regression model was fitted to characterize hazardousconsumers.</div></div><div><h3>Results</h3><div>The trend in the prevalence of alcohol consumption was found to be stable for lifetime, past 12 months, and past 30 days consumption, while a decreasing trend was observed for daily consumption. In 2022, 6.5% (95%CI: 6.1–6.9) of the Spanish population aged 15–64 years had risky alcohol consumption. This prevalence ranged from 13.1% (95%CI: 11.2–15.3) in the Region of Murcia to 2.9% (95%CI: 1.9–4.3) in Cantabria. The use of cannabis in the last year was the variable with the highest OR for hazardous alcohol consumption overall, in men and in women (OR &gt; 2.7).</div></div><div><h3>Conclusions</h3><div>The prevalence of alcohol consumption in Spain is high and its trend is stable. The use of other drugs such as tobacco or cannabis increases the odds of having a hazardous alcohol consumption.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106909"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular profile of systemic lupus erythematosus patients hospitalized for COVID-19 in Spain: Analysis of the SEMI-COVID-19 Registry","authors":"Halbert Hernández-Negrín ,&nbsp;María Rosa Bernal-López ,&nbsp;Almudena López-Sampalo ,&nbsp;Manuel Rubio-Rivas ,&nbsp;Josefa Andrea Aguilar-García ,&nbsp;Angie Gómez-Uranga ,&nbsp;María Carnevali ,&nbsp;María Luisa Taboada-Martínez ,&nbsp;José-Manuel Ramos-Rincón ,&nbsp;Ricardo Gómez-Huelgas ,&nbsp;list of members of the SEMI-COVID-19 Network ,&nbsp;Appendix A. List of members of the SEMI-COVID-19 Network,&nbsp;Halbert Hernández-Negrín ,&nbsp;María Rosa Bernal-López ,&nbsp;Almudena López-Sampalo ,&nbsp;Manuel Rubio-Rivas ,&nbsp;Josefa Andrea Aguilar-García ,&nbsp;Angie Gómez-Uranga ,&nbsp;María Carnevali ,&nbsp;María Luisa Taboada-Martínez ,&nbsp;Ricardo Gómez-Huelgas","doi":"10.1016/j.medcle.2025.106889","DOIUrl":"10.1016/j.medcle.2025.106889","url":null,"abstract":"<div><h3>Background</h3><div>Despite advancements in understanding the interplay between systemic lupus erythematosus (SLE), cardiovascular disease and COVID-19, challenges and knowledge gaps persist. This study aimed to characterize the cardiovascular profiles of SLE patients hospitalized with COVID-19 and to evaluate the influence of SLE on the development of cardiovascular complications.</div></div><div><h3>Methods</h3><div>This was a multicentre, nationwide observational study in which data were sourced from the SEMI-COVID-19 Registry between March 1, 2020, and March 31, 2021, involving 150 Spanish hospitals. SLE patients were matched with non-SLE patients based on sex, age, and hospitalization date.</div></div><div><h3>Results</h3><div>Of the 20,970 patients included in the SEMI-COVID-19 Registry, 38 were previously diagnosed with SLE. The non-SLE group was composed of 103 patients. The mean age of the SLE patients was 63 years, with 81.6% females and 21.1% non-European patients. SLE patients exhibited a significantly higher frequency of chronic kidney disease (14.4% vs 2.9%; <em>p</em> <!-->=<!--> <!-->0.004), stroke (23.7% vs 2.9%; <em>p</em> <!-->&lt;<!--> <!-->0.001), and increased use of cardiovascular medications. SLE demonstrated an independent association with the occurrence of major cardiovascular events (MACE) (OR: 3.934; 95% CI: 1.247–12.432).</div></div><div><h3>Conclusions</h3><div>SLE patients hospitalized for COVID-19 are at high risk of having an unfavorable baseline cardiovascular profile and are more prone to MACEs and adverse noncardiovascular outcomes during hospitalization.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106889"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}