Medicina clinica (English ed.)最新文献_第2页

Clinical outcomes of open necrosectomy in patients with infected pancreatic necrosis at a secondary-level hospital 二级医院感染性胰腺坏死开放性坏死切除术的临床效果

Medicina clinica (English ed.) Pub Date : 2026-09-01 Epub Date: 2026-09-11 DOI: 10.1016/j.medcle.2026.107527

Sergio Cruz Contreras, Denisse Becerril Mireles, Adolfo Fuentes Rivas

引用次数: 0

Transient first-degree atrioventricular block following acute vortioxetine overdose 急性沃替西汀过量后短暂的一级房室传导阻滞

Medicina clinica (English ed.) Pub Date : 2026-09-01 Epub Date: 2026-09-25 DOI: 10.1016/j.medcle.2026.107494

A. Cartanyà-Gutiérrez, F. Omiste-Rodrigo, R. Hernández-Vargas

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Full-dose pirfenidone in acute intermittent porphyria: Monitored exposure in a chronic excretor without acute attacks 全剂量吡非尼酮治疗急性间歇性卟啉症：监测无急性发作的慢性排泄者暴露

Medicina clinica (English ed.) Pub Date : 2026-09-01 Epub Date: 2026-09-25 DOI: 10.1016/j.medcle.2026.107533

Manuel Garrido Montes, Marta Pérez Quintana, José Salvador Garcia Morillo

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Prevalence and determinants of long COVID and SARS-CoV-2 reinfection in the Spanish adult population: A nationwide public health survey 西班牙成年人长期COVID和SARS-CoV-2再感染的流行率和决定因素：一项全国性公共卫生调查

Medicina clinica (English ed.) Pub Date : 2026-09-01 Epub Date: 2026-09-25 DOI: 10.1016/j.medcle.2026.107491

Carlos Rescalvo-Casas, Marcos Hernando-Gozalo, Lourdes Lledó-García, Juan Cuadros-González, Ramón Pérez-Tanoira

{"title":"Prevalence and determinants of long COVID and SARS-CoV-2 reinfection in the Spanish adult population: A nationwide public health survey","authors":"Carlos Rescalvo-Casas, Marcos Hernando-Gozalo, Lourdes Lledó-García, Juan Cuadros-González, Ramón Pérez-Tanoira","doi":"10.1016/j.medcle.2026.107491","DOIUrl":"10.1016/j.medcle.2026.107491","url":null,"abstract":"<div><h3>Introduction</h3><div>Long COVID is an emerging public health concern with heterogeneous prevalence. Evidence on the impact of reinfection and vaccination remains limited, especially in Spain.</div></div><div><h3>Methods</h3><div>We conducted a prospective online cohort survey between January 2024 and April 2025, gathering data on demographics, vaccination, symptoms, comorbidities, and reinfection history from Spanish adults (<em>n</em>  =139). Female sex (OR: 1.70; 95% CI: 1.10–2.57; <em>p</em>  =0.018) increased risk. Mixed vaccination schedules raised risk compared to Pfizer-only regimens (OR: 1.30; 95% CI: 1.04–1.62; <em>p</em>  =0.012). Frequent long COVID symptoms included anosmia, dyspnea, pneumonia, and myalgia.</div></div><div><h3>Conclusions</h3><div>This national cohort underscores the persistent burden of long COVID in Spain. Female sex, COPD, reinfection, and mixed vaccination schedules are key associated factors, with implications for targeted prevention strategies and vaccination policies.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 9","pages":"Article 107491"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced serum IL-6 as a potential peripheral marker of amnestic mild cognitive impairment: A pilot study 血清IL-6降低作为健忘轻度认知障碍的潜在外周标志物：一项初步研究

Medicina clinica (English ed.) Pub Date : 2026-09-01 Epub Date: 2026-09-25 DOI: 10.1016/j.medcle.2026.107540

María Micaela Castro, Romina Alejandra Pavón, Alejandro David Moroni, Mario Melcon, Natalia Erica Menite, Gastón Villafañe, Ana María Genaro, María Laura Palumbo

{"title":"Reduced serum IL-6 as a potential peripheral marker of amnestic mild cognitive impairment: A pilot study","authors":"María Micaela Castro, Romina Alejandra Pavón, Alejandro David Moroni, Mario Melcon, Natalia Erica Menite, Gastón Villafañe, Ana María Genaro, María Laura Palumbo","doi":"10.1016/j.medcle.2026.107540","DOIUrl":"10.1016/j.medcle.2026.107540","url":null,"abstract":"<div><h3>Introduction and objective</h3><div>Mild cognitive impairment (MCI) represents an intermediate state between age-related cognitive changes and early stages of dementia. People with amnestic subtype (aMCI) show higher risks of progression to dementia due to Alzheimer's disease. In this pilot study, the aim was to investigate whether cytokines could be potential peripheral markers associated with MCI.</div></div><div><h3>Methods</h3><div>Women were recruited in Junín city, Buenos Aires, Argentina. Their cognitive performance was evaluated using a neuropsychological battery. Serum levels of IFN-γ, IL-1β, IL-2, IL-4 and IL-6 were analyzed by ELISA, and the type 2/type 1 balance was determined. Correlations between both parameters, as well as within-group analysis cytokines levels were evaluated.</div></div><div><h3>Results</h3><div>After cognitive evaluation, participants were classified as healthy controls (HC: <em>n</em>  =7). IL-6 levels were significantly decreased in the aMCI group compared with HC (<em>p</em>  =0.005) and IL-4 (<em>p</em>  <!-->0.052) in aMCI. Several correlations were found between cytokine levels, the type 2/type 1 balance and neurocognitive tests.</div></div><div><h3>Conclusions</h3><div>We concluded that IL-6 decreased levels, altered correlation in cytokine profiles, together with performance on the neuropsychological battery, may serve as potential blood-markers of amnestic mild cognitive impairment.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 9","pages":"Article 107540"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anifrolumab for refractory lupus panniculitis: Sustained remission in a long-standing case 治疗难治性狼疮性睫状体炎的Anifrolumab：长期病例的持续缓解

Medicina clinica (English ed.) Pub Date : 2026-09-01 Epub Date: 2026-09-14 DOI: 10.1016/j.medcle.2026.107526

María Zulaika-Lloret, David Moyano-Bueno, Ricardo Ruiz-Villaverde

引用次数: 0

Secondary alopecia due to semaglutide 西马鲁肽引起的继发性脱发

Medicina clinica (English ed.) Pub Date : 2026-09-01 Epub Date: 2026-09-10 DOI: 10.1016/j.medcle.2026.107507

Javier Obando Pacheco, María Teresa Monserrat-García, Emilio García-García

引用次数: 0

Clinical Trial Registration and Transparency in Europe under Regulation (EU) No 536/2014: Registry Ecosystems and a Five-Country Comparative Analysis (2022–2026) 欧洲临床试验注册和透明度法规（EU） No 536/2014：注册生态系统和五国比较分析（2022-2026）

Medicina clinica (English ed.) Pub Date : 2026-09-01 Epub Date: 2026-09-14 DOI: 10.1016/j.medcle.2026.107544

Rocío Moreno-González, Vanesa Garrido-Rodríguez, Jose Cárdenas-Quesada, Rita Nogueiras-Álvarez, M. Isabel Lucena, Judith Sanabria-Cabrera

引用次数: 0

Medicina clinica (English ed.) Pub Date : 2026-09-01 Epub Date: 2026-09-15 DOI: 10.1016/j.medcle.2026.107534

Enrique Gutiérrez González, María Dolores Perea Aceituno, Vanessa Pachón Olmos, Pilar Soler Crespo, María José Sierra Moros

{"title":"Tobacco-related and tobacco-attributable cancer mortality in Spain, 1999–2023: Trends and gender inequalities","authors":"Enrique Gutiérrez González, María Dolores Perea Aceituno, Vanessa Pachón Olmos, Pilar Soler Crespo, María José Sierra Moros","doi":"10.1016/j.medcle.2026.107534","DOIUrl":"10.1016/j.medcle.2026.107534","url":null,"abstract":"<div><h3>Background</h3><div>Tobacco is the leading risk factor for multiple cancers. Changes in smoking patterns make it essential to assess trends in mortality from tobacco-related cancers in Spain between 1999 and 2023, by sex, age and autonomous community, as well as to estimate tobacco-attributable cancer mortality in individuals aged ≥ 35 years and explore gender inequalities.</div></div><div><h3>Methods</h3><div>Deaths from cancers strongly associated with tobacco use (ICD-10: C00-15; C32-34; C67) were analyzed for the period 1999−2023. Age-adjusted mortality rates were calculated and trends were assessed using joinpoint regression models. Tobacco-attributable mortality was estimated by combining smoking prevalence, relative risks for current and former smokers, and the number of deaths, obtaining population attributable fractions in individuals aged ≥ 35 years.</div></div><div><h3>Results</h3><div>Between 1999 and 2023, mortality decreased among men for all studied cancers (−27.9% for lung cancer; −56.4% for laryngeal cancer). In women, mortality increased for lung cancer (+104.1%), lip-oral cavity-pharynx cancer (+30.0%) and laryngeal cancer (+16.3%), with the greatest increase observed among women aged 55–69 years (+219.1% in lung cancer). Across autonomous communities, men showed widespread declines, whereas increases were observed in most regions among women. Between 2000 and 2023, tobacco use caused more than 600,000 cancer deaths (two-thirds due to lung cancer).</div></div><div><h3>Conclusions</h3><div>Mortality from tobacco-related cancers shows divergent trends by sex, highlighting the need to strengthen tobacco control and prevention policies with a gender perspective, and to continue monitoring smoking patterns and related mortality.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 9","pages":"Article 107534"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of diagnostic delay in COVID-19 index cases on SARS-CoV-2 transmission to household contacts COVID-19指数病例诊断延迟对家庭接触者传播SARS-CoV-2的影响

Medicina clinica (English ed.) Pub Date : 2026-09-01 Epub Date: 2026-09-25 DOI: 10.1016/j.medcle.2026.107499

Jèssica Pardos-Plaza, Manuel Garcia Cenoz, Ignasi Parron, Carme Miret, Diana Toledo, Mònica Carol, Joaquim Ferras, Sofía Godoy, Montserrat Zayas, Iván Martínez-Baz, Inma Sanz, Miquel Alsedà, Joan A. Caylà, Jesús Castilla, Ángela Domínguez, Pere Godoy, SARS-CoV-2 Transmission to Household Contacts Working Group (PI21/01883, ESP22PI01)

{"title":"Impact of diagnostic delay in COVID-19 index cases on SARS-CoV-2 transmission to household contacts","authors":"Jèssica Pardos-Plaza, Manuel Garcia Cenoz, Ignasi Parron, Carme Miret, Diana Toledo, Mònica Carol, Joaquim Ferras, Sofía Godoy, Montserrat Zayas, Iván Martínez-Baz, Inma Sanz, Miquel Alsedà, Joan A. Caylà, Jesús Castilla, Ángela Domínguez, Pere Godoy, SARS-CoV-2 Transmission to Household Contacts Working Group (PI21/01883, ESP22PI01)","doi":"10.1016/j.medcle.2026.107499","DOIUrl":"10.1016/j.medcle.2026.107499","url":null,"abstract":"<div><h3>Introduction</h3><div>Diagnostic delay in COVID-19 index cases may increase household transmission of SARS-CoV-2. A prospective epidemiological study was conducted to analyze SARS-CoV-2 infection among household contacts of confirmed COVID-19 cases.</div></div><div><h3>Methods</h3><div>Recruitment of index cases and their household contacts took place in eight primary care centers. This study included 227 index cases and 329 household contacts and examined the association between the time from symptom onset to index case diagnosis and the household transmission rate of SARS-CoV-2.</div></div><div><h3>Results</h3><div>The prevalence of infection among contacts was 38.9%, increasing with age and reaching 60.6% among individuals aged 65 years or older. Diagnostic delays longer than two days were associated with a higher risk of infection: contacts exposed to index cases diagnosed with a 3–4-day delay had twice the risk compared with those diagnosed earlier (adjusted odds ratio, aOR=2.1; 95% CI: 1.1-3.7). Older age was confirmed as a risk factor (aOR=6.0; 95% CI: 2.3–15.7), while previous SARS-CoV-2 infection and vaccination of the index case were identified as protective factors (aOR=0.5; 95% CI: 0.3–0.9 and 0.3; 95% CI: 0.1–0.6, respectively).</div></div><div><h3>Conclusion</h3><div>These findings demonstrate that diagnostic delay significantly increases household virus transmission, particularly among older adults, highlighting the need to strengthen early detection mechanisms and ensure rapid access to diagnostic testing in all settings.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 9","pages":"Article 107499"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0