Medicina clinica (English ed.)最新文献

{"title":"Is there new hope for rare diseases?","authors":"Álvaro Hermida Ameijeiras","doi":"10.1016/j.medcle.2025.106949","DOIUrl":"10.1016/j.medcle.2025.106949","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 12","pages":"Article 106949"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric assessment and results of transcatheter aortic valve implantation","authors":"Cristina de la Rubia-Molina ,&nbsp;Andrez Felipe Cubides-Novoa ,&nbsp;María Teresa Madrid-López ,&nbsp;Elisa Patín-González ,&nbsp;Verónica Merchán-Ordoñez ,&nbsp;Martín Negreira-Caamaño ,&nbsp;Javier Gil-Moreno ,&nbsp;Alfonso Freites ,&nbsp;Ignacio Sánchez-Pérez ,&nbsp;Virginia Mazoteras-Muñoz ,&nbsp;Jesús Piqueras-Flores","doi":"10.1016/j.medcle.2025.106936","DOIUrl":"10.1016/j.medcle.2025.106936","url":null,"abstract":"<div><h3>Introduction</h3><div>Comprehensive geriatric assessment (CGA) prior to transcatheter aortic valve replacement (TAVI) implantation for severe aortic stenosis (AS) may improve the selection of patients targeted for this strategy. Despite the fact that VGI includes multiple scales, comparative data among them are limited. Our aim was to evaluate the discriminative capacity of different scales used in CGA on the decision of suitability for TAVI implantation and the influence on prognosis after TAVI implantation.</div></div><div><h3>Methods</h3><div>Single-center prospective observational study including consecutive patients with severe AS referred for TAVI implantation. A CGA was performed in all patients including scales of functionality, frailty, cognitive impairment and comorbidities. The predictive capacity of each of the scales was evaluated. The development of major cardiovascular events (cardiovascular mortality, heart failure and stroke) was analyzed during follow-up.</div></div><div><h3>Results</h3><div>142 patients were selected as candidates for TAVI (80.2%), and 121 were finally implanted. The mean age was 83 ± 4.9 years. Patients who were candidates for TAVI had less valvular area, less atrial fibrillation (AF), less cognitive impairment, more autonomy and less frailty. The SPPB frailty and Barthel functional assessment scales were the main scales of the CGA for the TAVI candidacy decision.</div><div>After TAVI implantation, 21.5% presented a cardiovascular event, with an overall mortality of 19.8% (6.6% cardiovascular). Patients with a higher rate of events and mortality had more AF, HF, renal disease and malnutrition, as well as less family coverage.</div></div><div><h3>Conclusions</h3><div>In elderly patients with severe AS, the CGA is a determining factor in the selection of candidates for TAVI, with frailty and functional assessment being the most important aspects. Family support and nutritional status have a high impact on the prognosis of patients after TAVI.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 12","pages":"Article 106936"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Winds of change are blowing. The care role of internists in hospitals","authors":"Eduardo Montero Ruiz","doi":"10.1016/j.medcle.2025.106942","DOIUrl":"10.1016/j.medcle.2025.106942","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 12","pages":"Article 106942"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal obstruction secondary to distal ileitis caused by anisakiasis","authors":"Santiago Manuel de los Reyes Vázquez ,&nbsp;María del Carmen Palomar Muñoz ,&nbsp;Isabel Murciano Gómez","doi":"10.1016/j.medcle.2025.106946","DOIUrl":"10.1016/j.medcle.2025.106946","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 12","pages":"Article 106946"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of venous thromboembolism in the transgender population on hormone therapy: A systematic review","authors":"Anabel Franco-Moreno ,&nbsp;Pablo Ryan ,&nbsp;Nuria Muñoz-Rivas ,&nbsp;Jorge Valencia ,&nbsp;Juan Torres-Macho ,&nbsp;Susana Bacete-Cebrián","doi":"10.1016/j.medcle.2025.106921","DOIUrl":"10.1016/j.medcle.2025.106921","url":null,"abstract":"<div><h3>Background and objective</h3><div>Hormone therapy is associated with an increased thrombotic risk. The objective of this systematic review is to assess the incidence of venous thromboembolism in the transgender population undergoing gender-affirming hormone therapy and compare it with that in cisgender individuals of the same sex assigned at birth.</div></div><div><h3>Materials and method</h3><div>A literature search was conducted in databases including PubMed, Cochrane Library, Scopus, and EMBASE, encompassing all studies that report data related to the incidence of venous thromboembolism in transgender individuals on hormone therapy.</div></div><div><h3>Results</h3><div>Twenty-one studies were included. Five studies assessed the incidence of thromboembolic events in both populations. The occurrence of thrombosis was higher in transgender women than cisgender men (OR 2.23; 95% CI: 1.93–2.57; <em>p</em> <!-->&lt;<!--> <!-->0.001). No differences between transgender men and cisgender women (OR 0.96; 95% CI: 0.87–2.31; <em>p</em> <!-->=<!--> <!-->0.60) were found.</div></div><div><h3>Conclusion</h3><div>Our systematic review suggests that hormone therapy in transgender women may increase the risk of venous thromboembolism.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 12","pages":"Article 106921"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous nodules on tattoo as the first manifestation of pulmonary sarcoidosis with extrathoracic involvement","authors":"Miguel Antonio Lasheras-Pérez ,&nbsp;Judith González ,&nbsp;Sara Montesinos-González ,&nbsp;Antonio Sahuquillo-Torralba","doi":"10.1016/j.medcle.2025.106934","DOIUrl":"10.1016/j.medcle.2025.106934","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 12","pages":"Article 106934"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmacytoma surrounding a total shoulder prosthesis","authors":"Gökhan Tonkaz ,&nbsp;Esra İbiş ,&nbsp;Duygu Erkal ,&nbsp;Mehmet Tonkaz","doi":"10.1016/j.medcle.2025.106933","DOIUrl":"10.1016/j.medcle.2025.106933","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106933"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eruptive cherry angiomas induced by infliximab in a patient with Crohn's disease","authors":"María López-Pardo Rico ,&nbsp;Carlos Aliste Santos ,&nbsp;María Teresa Rodríguez Granados","doi":"10.1016/j.medcle.2025.106927","DOIUrl":"10.1016/j.medcle.2025.106927","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106927"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of exercise intervention on exercise capacity and cardiopulmonary function in patients with atrial fibrillation: A randomized controlled trial systematic review and meta-analysis","authors":"Zhang Shuai ,&nbsp;Mao Su Jie ,&nbsp;Xiao Kai Wen ,&nbsp;Hong Xu ,&nbsp;Lu Yuan","doi":"10.1016/j.medcle.2025.106908","DOIUrl":"10.1016/j.medcle.2025.106908","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation (AF) is a common cardiac arrhythmia that significantly impacts the cardiopulmonary function and quality of life of patients. Despite various treatment strategies, non-pharmacological interventions, particularly exercise interventions, have gained attention in recent years.</div></div><div><h3>Objective</h3><div>Through systematic review and meta-analysis, this study explores the impact of physical activity on the exercise capacity and quality of life of AF patients. It assesses the safety, clinical outcomes, and physiological mechanisms of exercise intervention in the treatment of AF.</div></div><div><h3>Methods</h3><div>The systematic review and individual patient data (IPD) meta-analysis method were employed, following the PRISMA-IPD guidelines, for literature selection, data extraction, and quality assessment. The analysis focused on the impact of exercise on the cardiopulmonary function and quality of life of AF patients in randomized controlled trials.</div></div><div><h3>Results</h3><div>A total of 12 randomized controlled trials involving 287 AF patients were included. Meta-analysis demonstrated a significant improvement in the 6-minute walk test capacity (SMD<!--> <!-->=<!--> <!-->87.87, 95% CI [42.23, 133.51]), static heart rate improvement (SMD<!--> <!-->=<!--> <!-->−7.63, 95% CI [−11.42, −3.85]), and cardiopulmonary function enhancement (SMD<!--> <!-->=<!--> <!-->2.37, 95% CI [0.96, 3.77]) due to exercise. There was also a significant improvement in the quality of life (SMD<!--> <!-->=<!--> <!-->0.720, 95% CI [0.038, 1.402]).</div></div><div><h3>Conclusion</h3><div>Exercise has a significant effect on improving exercise capacity and cardiopulmonary function in patients with atrial fibrillation. Particularly, high-intensity exercise training has a more significant impact on improving cardiopulmonary function and exercise capacity, emphasizing the importance of personalized exercise plans in enhancing the cardiopulmonary health of AF patients. Further research is needed to explore the effects of exercise on improving the quality of life in the future.</div><div>PROSPERO ID: CRD2023493917.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106908"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scurvy: A call to maintain awareness","authors":"Antoni Riera-Mestre ,&nbsp;Olga Portolà ,&nbsp;Antonio Vidaller","doi":"10.1016/j.medcle.2025.106887","DOIUrl":"10.1016/j.medcle.2025.106887","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106887"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}