Medicina clinica (English ed.)最新文献

{"title":"Comparison of the efficacy of pharmacological interventions for the prevention of delirium: A systematic review and network meta-analysis","authors":"Xiangwu Zhou ,&nbsp;Chengguo Yin","doi":"10.1016/j.medcle.2025.106918","DOIUrl":"10.1016/j.medcle.2025.106918","url":null,"abstract":"<div><h3>Background</h3><div>In recent years, many pharmacological agents for the prevention of delirium have emerged; however, the efficacy of these agents in preventing delirium remains unclear.</div></div><div><h3>Objective</h3><div>To compare and rank the efficacy of different pharmacological interventions for the prevention of delirium.</div></div><div><h3>Design</h3><div>A systematic review and network meta-analysis.</div></div><div><h3>Methods</h3><div>Relevant randomized controlled trials on drug prevention of delirium were extracted from three electronic databases. A network meta-analysis was then conducted to assess the relative efficacy of drug interventions in preventing delirium. The quality of the data was evaluated using the Cochrane Risk of Bias tool.</div></div><div><h3>Results</h3><div>A total of 80 randomized controlled trials on drug interventions were included in the final analysis. Treatment with dexmedetomidine can prevent delirium.</div></div><div><h3>Conclusion</h3><div>Dexmedetomidine treatment can prevent delirium and reduce patient suffering. Healthcare professionals should be encouraged to use dexmedetomidine for delirium prevention.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106918"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensive lichen planus after initiation of durvalumab for cholangiocarcinoma","authors":"Miguel Mansilla-Polo ,&nbsp;Rafael Fayos-Gregori ,&nbsp;Gonzalo Alonso-Fernández","doi":"10.1016/j.medcle.2025.106926","DOIUrl":"10.1016/j.medcle.2025.106926","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106926"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mirror image in double superior vena cava","authors":"Hayri Ogul","doi":"10.1016/j.medcle.2025.106923","DOIUrl":"10.1016/j.medcle.2025.106923","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106923"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of six months treatment with liraglutide among patients with psoriasis and obesity, beyond metabolic control?","authors":"Joana Nicolau ,&nbsp;Antoni Nadal ,&nbsp;Pilar Sanchís ,&nbsp;Antelm Pujol ,&nbsp;María Isabel Tamayo ,&nbsp;Cristina Nadal ,&nbsp;Lluís Masmiquel","doi":"10.1016/j.medcle.2025.106941","DOIUrl":"10.1016/j.medcle.2025.106941","url":null,"abstract":"<div><h3>Introduction</h3><div>Obesity and psoriasis are two closely related chronic diseases and share multiple comorbidities. The common etiopathogenic basis would be a low-grade chronic inflammation, with a cross talk between adipose tissue and the skin. Obesity in patients with psoriasis results in a worse prognosis of the lesions and reduces the effectiveness of treatment.</div></div><div><h3>Objectives</h3><div>To assess the mid-term effect of liraglutide 3<!--> <!-->mg on anthropometric and morphofunctional, biochemical, and dermatological parameters in patients with psoriasis and obesity.</div></div><div><h3>Material and methods</h3><div>48 patients were included (52.1%♀, age 48.7<!--> <!-->±<!--> <!-->11.8 years, BMI 37.9<!--> <!-->±<!--> <!-->5.6<!--> <!-->kg/m², psoriasis duration 17.8<!--> <!-->±<!--> <!-->11.1 years). The severity of the lesions was evaluated with the PASI (Psoriasis Area Severity Index) and the VAS (pain visual analog scale), and DLQI (Dermatology Quality Index) and the Beck depression test (BDI). Also, biochemical and anthropometric determinations were performed baseline and after 6 months.</div></div><div><h3>Results</h3><div>There was a reduction in BMI (37.9<!--> <!-->±<!--> <!-->5.6 vs 35<!--> <!-->±<!--> <!-->4.9; <em>p</em> <!-->&lt;<!--> <!-->0.001), waist circumference (111.6<!--> <!-->±<!--> <!-->7 vs 104.7<!--> <!-->±<!--> <!-->9.3<!--> <!-->cm; <em>p</em> <!-->=<!--> <!-->0.001) and preperitoneal fat (1.6<!--> <!-->±<!--> <!-->0.6 vs 1.2<!--> <!-->±<!--> <!-->0.6<!--> <!-->cm; <em>p</em> <!-->&lt;<!--> <!-->0.0001). PASI (12<!--> <!-->±<!--> <!-->8.4 to 4.3<!--> <!-->±<!--> <!-->2.9; <em>p</em> <!-->&lt;<!--> <!-->0.0001), VAS (4.4<!--> <!-->±<!--> <!-->1.9 vs 2.2<!--> <!-->±<!--> <!-->1.6; <em>p</em> <!-->=<!--> <!-->0.003), DLQI (11.9<!--> <!-->±<!--> <!-->6.2 vs 4.8<!--> <!-->±<!--> <!-->3.4; <em>p</em> <!-->&lt;<!--> <!-->0.0001) and BDI (15.5<!--> <!-->±<!--> <!-->3.6 vs 7.6<!--> <!-->±<!--> <!-->2.5; <em>p</em> <!-->&lt;<!--> <!-->0.0001) improved significantly. C-reactive protein (3.9<!--> <!-->±<!--> <!-->3.1 vs 1.8<!--> <!-->±<!--> <!-->3.2<!--> <!-->mg/L; <em>p</em> <!-->&lt;<!--> <!-->0.0001), homocysteine (13<!--> <!-->±<!--> <!-->3.3 vs 9.6<!--> <!-->±<!--> <!-->2.5<!--> <!-->μmol/L; <em>p</em> <!-->&lt;<!--> <!-->0.0001), and plasma cortisol (12.5<!--> <!-->±<!--> <!-->4 vs 8.9<!--> <!-->±<!--> <!-->3.7<!--> <!-->μg/dL; <em>p</em> <!-->=<!--> <!-->0.001). In multiple regression analysis, dermatological improvement was independent of weight loss.</div></div><div><h3>Conclusions</h3><div>Liraglutide exerts beneficial effects not only on BMI and visceral fat, but also reduces inflammatory parameters in patients with psoriasis and obesity, improving skin lesions and quality of life.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106941"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a machine learning model for predicting cardiovascular risk factors and major adverse cardiovascular events in young adults with glucose metabolism disorders","authors":"Yangyang Zhao ,&nbsp;Wenjing Zhang ,&nbsp;Jiecheng Peng","doi":"10.1016/j.medcle.2025.106911","DOIUrl":"10.1016/j.medcle.2025.106911","url":null,"abstract":"<div><h3>Background</h3><div>Glucose metabolism disorders (GMDs) are a serious global public health issue, characterized by a high incidence rate and youthfulness. GMDs contribute to the occurrence of major adverse cardiovascular events (MACEs), meanwhile with the rest of the remaining cardiovascular risk factors (CVRFs) act synergistically to influence MACEs. Although numerous studies have explored CVRFs and their prognostic role in cardiovascular diseases, there is a lack of predictive models for novel cardiovascular risk factors and MACEs in the young population, particularly among patients with GMDS. This study aims to investigate important CVRFs affecting MACEs in young patients with GMDs by means of LASSO regression, randomized forest, and XGBoost, providing new evidence to support the early adoption of proactive and comprehensive interventions and management.</div></div><div><h3>Methods</h3><div>The study included 411 young patients with GMDs who visit the First People's Hospital of Anqing Affiliated to Anhui Medical University, between September 2022 and June 2023. The patients were randomly divided into a training set and a testing set in a 7:3. Comprehensive analysis was performed using LASSO regression, random forest, and XGBoost methods. The performance of the models was evaluated and validated, and the important cardiovascular risk factors identified by the three models were compared.</div></div><div><h3>Results</h3><div>After one year of follow-up, the incidence of events was higher in men compared to women (85.2% vs. 14.8%). LASSO regression analysis identified BP, TYg, BMI, FBG, and Tg/HDL as significant variables associated with MACEs. The random forest method highlighted BMI, TYg, Tg/HDL, Tg, and FBG as key factors related to MACEs. The XGBoost model also emphasized the important roles of BMI, TYg, TG, and BP. Combining the results from all three models, BMI, TYg, and BP consistently demonstrated significant importance across all models.</div></div><div><h3>Conclusions</h3><div>To some extent, males are more likely to experience adverse cardiovascular events compared to females. Combining the three major predictive models suggests that traditional CVRFs (BP, BMI) and novel CVRFs (TYg) play an important role in the development of distant MACEs in young GMDs, and that interventions for them may have implications for preventing DM transformation.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106911"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic rhinitis","authors":"Victoria Cardona,&nbsp;Arnau Salvany-Pijuan,&nbsp;Javier Pereira-González","doi":"10.1016/j.medcle.2025.106916","DOIUrl":"10.1016/j.medcle.2025.106916","url":null,"abstract":"<div><div>Allergic rhinitis is an inflammation of the nasal mucosa caused by immunoglobulin E, presenting with symptoms such as sneezing, nasal itching, congestion, and rhinorrhea. It is often associated with conjunctivitis and asthma, significantly impacting quality of life. An integrated care approach is recommended, spanning from pharmacy and primary care to specialized care for severe or poorly controlled cases. Treatment includes avoiding allergens and using medications like antihistamines and intranasal corticosteroids. Combinations of these medications in a single intranasal spray have shown greater efficacy. In severe cases, immunotherapy is effective if tailored to the causing allergen. Tools like visual analogue scales and mobile applications facilitate monitoring and management of rhinitis, optimizing care and improving patient self management. In this narrative review, all these aspects will be addressed.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106916"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers in transthyretin amyloidosis. Present and future","authors":"Fernando Martínez Valle,&nbsp;Carmen Pérez Bocanegra","doi":"10.1016/j.medcle.2025.106939","DOIUrl":"10.1016/j.medcle.2025.106939","url":null,"abstract":"<div><div>The appearance of new treatments for the different forms of ATTR has highlighted the importance of early diagnosis, since most of these treatments are highly effective in the initial phases of the disease. Currently, the diagnosis of ATTR is fundamentally based on clinical findings, cardiac imaging and neurophysiological parameters, and it is common a delay in diagnosis, and this occurs very frequently in advanced phases of the disease. The appearance of different biomarkers attempts to promote early diagnosis, as well as stratify into different risk groups, which can benefit from specific treatments, as well as obtain prognostic data from patients. This article reviews the different biomarkers currently available in ATTR and potential future biomarkers.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106939"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Institutional or personal e-mail address in manuscripts submitted to biomedical journals: The case of retired physicians","authors":"José Berciano","doi":"10.1016/j.medcle.2025.106944","DOIUrl":"10.1016/j.medcle.2025.106944","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106944"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Science and Medicine: Allies to apply the best evidence to clinical practice","authors":"Tomás Cobo Castro ,&nbsp;María Rosa Arroyo Castillo ,&nbsp;José Ramón Repullo Labrador","doi":"10.1016/j.medcle.2025.106938","DOIUrl":"10.1016/j.medcle.2025.106938","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106938"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tarui disease and rhabdomyolysis without renal failure","authors":"Roberto Hurtado-García ,&nbsp;Javier Martínez Elvira ,&nbsp;Inmaculada González-Cuello","doi":"10.1016/j.medcle.2025.106931","DOIUrl":"10.1016/j.medcle.2025.106931","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106931"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}