Medicina clinica (English ed.)最新文献

{"title":"Efficacy of once-weekly semaglutide in patients with heart failure with preserved ejection fraction, obesity and type 2 diabetes","authors":"Miguel A. Pérez-Velasco ,&nbsp;Maria-Rosa Bernal-López ,&nbsp;Alicia Trenas ,&nbsp;Michele Ricci ,&nbsp;María-Dolores López-Carmona ,&nbsp;María-Dolores García de Lucas ,&nbsp;Ricardo Gómez-Huelgas ,&nbsp;Luis M. Pérez-Belmonte","doi":"10.1016/j.medcle.2025.107019","DOIUrl":"10.1016/j.medcle.2025.107019","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>There is still limited evidence on the role of glucagon-like peptide-1 receptor agonists in heart failure. We analyzed the efficacy in terms of health status, and the change in body weight of once-weekly semaglutide in patients with heart failure with preserved ejection fraction, obesity and type 2 diabetes.</div></div><div><h3>Patients and methods</h3><div>This prospective, real-world study included patients with heart heart failure with preserved ejection fraction, obesity and type 2 diabetes treated with once-weekly 1.00<!--> <!-->mg semaglutide (Sema-Preserved Group) and patients not treated with glucagon-like peptide-1 receptor agonists (Control-Preserved Group). A 1:1 propensity score matching analysis was performed. The primary outcome was the heart failure status defined as the ≥5 point difference in the Spanish version of the Kansas City Cardiomyopathy Questionnaire total symptom score, and the change of body weight at 24 months.</div></div><div><h3>Results</h3><div>After matching, 203 patients were included in each group. A primary outcome event occurred in 123 patients (60.6%) in the Sema-Preserved Group and 36 (17.7%) in the Control-Preserved Group (odds ratio: 3.99; 95% confidence interval: 1.69–6.28; <em>p</em> <!-->&lt;<!--> <!-->0.01), and the mean change in body weight was −12.9<!--> <!-->±<!--> <!-->4.2<!--> <!-->kg in patients with semaglutide and −2.5<!--> <!-->±<!--> <!-->1.1<!--> <!-->kg in control patients (<em>p</em> <!-->&lt;<!--> <!-->0.01). There were also significant declines in the heart failure events, and in all-cause hospitalizations.</div></div><div><h3>Conclusions</h3><div>Once-weekly 1.00<!--> <!-->mg semaglutide was associated with improved heart failure health status, and weight loss in patients with heart failure with preserved ejection fraction, obesity, and type 2 diabetes. Further research on glucagon-like peptide-1 receptor agonists in heart failure is needed.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107019"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of anti-p200 pemphigoid without immunoblot: Usefulness of collagen IV immunohistochemistry","authors":"Marta Cebolla-Verdugo ,&nbsp;David Moyano-Bueno ,&nbsp;Ricardo Ruiz-Villaverde","doi":"10.1016/j.medcle.2025.107068","DOIUrl":"10.1016/j.medcle.2025.107068","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107068"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three years of assisted dying in Spain: Data, controversies and challenges","authors":"Luis Espericueta","doi":"10.1016/j.medcle.2025.107037","DOIUrl":"10.1016/j.medcle.2025.107037","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107037"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative cardiac abnormalities associated with one-year mortality in elderly patients undergoing hip fracture surgery: role of focused transthoracic echocardiography","authors":"Kaihua Fan ,&nbsp;Jianwei Zhang ,&nbsp;Ying Gao,&nbsp;Weimei Li","doi":"10.1016/j.medcle.2025.107013","DOIUrl":"10.1016/j.medcle.2025.107013","url":null,"abstract":"<div><h3>Purpose</h3><div>We sought to identify preoperative cardiac abnormalities with routine preoperative transthoracic echocardiography (TTE) associated with postoperative mortality in elderly patients undergoing hip fractures surgery, in order to provide reference for focused TTE.</div></div><div><h3>Methods</h3><div>In this retrospective study, a total of 669 elderly patients (age over 65 years) undergoing hip fractures surgery were included, of which 58 (8.7%) died within one-year after discharge. Cox regression analysis models were used to identify the prognostic cardiac abnormalities of postoperative mortality.</div></div><div><h3>Results</h3><div>Univariate analysis showed that age (HR 1.065, 95%CI 1.030–1.101; <em>P</em> <!-->&lt;<!--> <!-->0.001), ASA score (III, IV vs. I, II) (HR 1.855, 95%CI 1.098–3.067; <em>P</em> <!-->=<!--> <!-->0.022), history of chronic obstructive pulmonary disease (COPD) (HR 4.446, 95%CI 1.909–10.355; <em>P</em> <!-->=<!--> <!-->0.001) and atrial fibrillation (AF) (HR 3.803, 95%CI 1.803–8.024; <em>P</em> <!-->&lt;<!--> <!-->0.001), presence of left ventricular ejection fraction (LVEF)<!--> <!-->&lt;<!--> <!-->50% (HR 5.009, 95%CI 2.151–11.665; <em>P</em> <!-->&lt;<!--> <!-->0.001), left ventricular dilatation (HR 3.813, 95%CI 1.730–8.403; <em>P</em> <!-->=<!--> <!-->0.001), pulmonary arterial systolic pressure (PASP)<!--> <!-->&gt;<!--> <!-->25<!--> <!-->mmHg (HR 4.388, 95%CI 2.492–7.725; <em>P</em> <!-->&lt;<!--> <!-->0.001), moderate–severe aortic valve stenosis (AS) (HR 4.702, 95%CI 1.471–15.035; <em>P</em> <!-->=<!--> <!-->0.009) were the dominant predictors of mortality within one-year. The presence of LVEF<!--> <!-->&lt;<!--> <!-->50%, left ventricular dilatation and elevated PASP were proved to be the independent predictors of one-year mortality in elderly patients in multivariate analysis.</div></div><div><h3>Conclusion</h3><div>Cardiac abnormalities derived from preoperative TTE, namely LVEF<!--> <!-->&lt;<!--> <!-->50%, AS, left ventricular dilatation and elevated PASP had prognostic value for elderly patients undergoing hip fracture surgery. We consider that these indices would be clinically important regarding the preoperative cardiac risk assessment of elderly hip fracture, which may be assessed in the focused TTE.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107013"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body packer","authors":"Mehmet Tonkaz,&nbsp;Duygu Erkal,&nbsp;Gökhan Tonkaz","doi":"10.1016/j.medcle.2025.106970","DOIUrl":"10.1016/j.medcle.2025.106970","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 106970"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Livedo racemosa secondary to genicular artery embolization in a patient with knee osteoarthritis","authors":"Lula María Nieto Benito,&nbsp;Pablo Fonda Pascual,&nbsp;Loreto Carrasco Santos","doi":"10.1016/j.medcle.2025.107071","DOIUrl":"10.1016/j.medcle.2025.107071","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107071"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid response to anifrolumab in refractory systemic lupus erythematosus","authors":"Diego López-Martínez ,&nbsp;Nuria Lozano-Rivas ,&nbsp;Paloma Sánchez-Pedreño-Guillen","doi":"10.1016/j.medcle.2025.107007","DOIUrl":"10.1016/j.medcle.2025.107007","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107007"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of Kikuchi-Fujimoto disease initially presented as aseptic meningitis","authors":"Jinliang Deng ,&nbsp;Lin Shen ,&nbsp;Jingzhe Han","doi":"10.1016/j.medcle.2025.107039","DOIUrl":"10.1016/j.medcle.2025.107039","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107039"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyspnea and hemoptysis caused by leech infestation","authors":"Makram Tbini ,&nbsp;Sarra Bouziri ,&nbsp;Houssem Eddine Kamel ,&nbsp;Chaima Ben Ammar ,&nbsp;Mamia Ben Salah","doi":"10.1016/j.medcle.2025.107018","DOIUrl":"10.1016/j.medcle.2025.107018","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107018"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ganglioneuroma: A rare disease that simulates malignancy","authors":"Verónica Vallejo Herrera ,&nbsp;María José Vallejo Herrera ,&nbsp;Juan Sebastián Rodríguez Moncada","doi":"10.1016/j.medcle.2025.107109","DOIUrl":"10.1016/j.medcle.2025.107109","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 3","pages":"Article 107109"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}