Comparison of the efficacy of pharmacological interventions for the prevention of delirium: A systematic review and network meta-analysis

Medicina clinica (English ed.) Pub Date : 2025-06-09 DOI:10.1016/j.medcle.2025.106918

Xiangwu Zhou , Chengguo Yin

{"title":"Comparison of the efficacy of pharmacological interventions for the prevention of delirium: A systematic review and network meta-analysis","authors":"Xiangwu Zhou , Chengguo Yin","doi":"10.1016/j.medcle.2025.106918","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>In recent years, many pharmacological agents for the prevention of delirium have emerged; however, the efficacy of these agents in preventing delirium remains unclear.</div></div><div><h3>Objective</h3><div>To compare and rank the efficacy of different pharmacological interventions for the prevention of delirium.</div></div><div><h3>Design</h3><div>A systematic review and network meta-analysis.</div></div><div><h3>Methods</h3><div>Relevant randomized controlled trials on drug prevention of delirium were extracted from three electronic databases. A network meta-analysis was then conducted to assess the relative efficacy of drug interventions in preventing delirium. The quality of the data was evaluated using the Cochrane Risk of Bias tool.</div></div><div><h3>Results</h3><div>A total of 80 randomized controlled trials on drug interventions were included in the final analysis. Treatment with dexmedetomidine can prevent delirium.</div></div><div><h3>Conclusion</h3><div>Dexmedetomidine treatment can prevent delirium and reduce patient suffering. Healthcare professionals should be encouraged to use dexmedetomidine for delirium prevention.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106918"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina clinica (English ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2387020625002451","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background

In recent years, many pharmacological agents for the prevention of delirium have emerged; however, the efficacy of these agents in preventing delirium remains unclear.

Objective

To compare and rank the efficacy of different pharmacological interventions for the prevention of delirium.

Design

A systematic review and network meta-analysis.

Methods

Relevant randomized controlled trials on drug prevention of delirium were extracted from three electronic databases. A network meta-analysis was then conducted to assess the relative efficacy of drug interventions in preventing delirium. The quality of the data was evaluated using the Cochrane Risk of Bias tool.

Results

A total of 80 randomized controlled trials on drug interventions were included in the final analysis. Treatment with dexmedetomidine can prevent delirium.

Conclusion

Dexmedetomidine treatment can prevent delirium and reduce patient suffering. Healthcare professionals should be encouraged to use dexmedetomidine for delirium prevention.

查看原文本刊更多论文

预防谵妄的药物干预效果比较：系统综述和网络荟萃分析

近年来，出现了许多预防谵妄的药物；然而，这些药物在预防谵妄方面的功效尚不清楚。目的比较不同药物干预措施预防谵妄的疗效并进行排序。设计系统评价和网络荟萃分析。方法从3个电子数据库中提取药物预防谵妄的相关随机对照试验。然后进行网络荟萃分析，以评估药物干预在预防谵妄方面的相对疗效。使用Cochrane偏倚风险工具评估数据质量。结果共纳入80项药物干预随机对照试验。右美托咪定治疗可预防谵妄。结论右美托咪定治疗可预防谵妄，减轻患者痛苦。应鼓励医疗保健专业人员使用右美托咪定预防谵妄。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Medicina clinica (English ed.)

自引率

0.00%

发文量