Medicina clinica (English ed.)最新文献

{"title":"Artificial intelligence in surgical training and education: A narrative review","authors":"Julio Mayol","doi":"10.1016/j.medcle.2026.107505","DOIUrl":"10.1016/j.medcle.2026.107505","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 9","pages":"Article 107505"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in pharmacogenomics","authors":"José A.G. Agúndez, Elena García-Martín","doi":"10.1016/j.medcle.2026.107464","DOIUrl":"10.1016/j.medcle.2026.107464","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 8","pages":"Article 107464"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colchicine in cardiovascular disease: A systematic review and meta-analysis of randomized controlled trials","authors":"Luis E. Cueva-Cañola,&nbsp;Christiany Tapia,&nbsp;Ariadna P. Torres Castro,&nbsp;Carlos E. Espinosa-Temaxte,&nbsp;Victor A. Castillo Bringas,&nbsp;Karoly P. Zuñiga-Montaño,&nbsp;Jose R. Aguilar González,&nbsp;Arath Josué Campos-Muñoz,&nbsp;Abraham Zenteno-Aguilar,&nbsp;Sergio Morales Acosta,&nbsp;Aline Pérez Carrada,&nbsp;Wagner Rios-Garcia,&nbsp;Gabriel Ramirez,&nbsp;Diego Araiza-Garaygordobil,&nbsp;Ricardo Allende-Carrera","doi":"10.1016/j.medcle.2026.107498","DOIUrl":"10.1016/j.medcle.2026.107498","url":null,"abstract":"<div><h3>Objective</h3><div>Residual inflammatory risk contributes to recurrent cardiovascular events despite optimal medical therapy. Colchicine has been evaluated in multiple randomized controlled trials (RCTs) across diverse cardiovascular settings; however, results regarding efficacy and safety have been variable. This meta-analysis aimed to comprehensively assess the impact of colchicine on cardiovascular efficacy outcomes and adverse events (AEs) in adult patients with high cardiovascular risk or established cardiovascular disease.</div></div><div><h3>Methods</h3><div>PubMed, Embase, Cochrane CENTRAL, and Web of Science were systematically searched from inception to August 29, 2024. RCTs comparing colchicine with placebo or standard therapy were included. Risk ratios (RR) and mean differences with 95% confidence intervals (CI) were pooled using random-effects models. Risk of bias was assessed using RoB 2, and certainty of evidence was evaluated with GRADE.</div></div><div><h3>Results</h3><div>Thirty-nine RCTs including 37,812 participants were analyzed. Colchicine reduced acute myocardial infarction (RR<!--> <!-->=<!--> <!-->0.81, 95% CI 0.71–0.92), atrial fibrillation (RR<!--> <!-->=<!--> <!-->0.74, 95% CI 0.66–0.84), pericarditis (RR<!--> <!-->=<!--> <!-->0.48, 95% CI 0.39–0.59), acute coronary syndrome (RR<!--> <!-->=<!--> <!-->0.39, 95% CI 0.23–0.65), and hospitalization (RR<!--> <!-->=<!--> <!-->0.52, 95% CI 0.38–0.70). No reduction was observed for all-cause mortality. The certainty of evidence was high for all assessed outcomes according to GRADE. Gastrointestinal AEs were more frequent, particularly at higher doses, without an increase in serious AEs.</div></div><div><h3>Conclusion</h3><div>Colchicine reduces recurrent cardiovascular events with an acceptable safety profile but does not affect all-cause mortality.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 8","pages":"Article 107498"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of prolonged hospitalization and inadequate anticoagulation on cognitive decline in older patients with atrial fibrillation","authors":"Natalie Burgos Bencosme,&nbsp;Jorge Eduardo Herrera Parra,&nbsp;Lucia Antuña Montes,&nbsp;Sarah Elisabeth Rodríguez Santiago,&nbsp;Monserrat González Delgado,&nbsp;Jose Gutiérrez Rodríguez","doi":"10.1016/j.medcle.2026.107515","DOIUrl":"10.1016/j.medcle.2026.107515","url":null,"abstract":"<div><h3>Background and objective</h3><div>Atrial fibrillation (AF) and prolonged hospitalization are known risk factors for cognitive decline (CD). However, whether anticoagulation quality during admission is associated with differences in CD risk among geriatric patients remains unknown. The objective is to evaluate the association between anticoagulation profile and the frequency of new-onset CD in older hospitalized patients with AF.</div></div><div><h3>Material and methods</h3><div>Ambispective observational study including 254 patients aged ≥80 years with AF admitted to an acute geriatric unit (2019–2022). The retrospective phase included the collection of baseline clinical variables from electronic health records; the prospective phase comprised scheduled cognitive follow-up at 6 and 12 months after discharge. Hospital length of stay and anticoagulation quality (Adequate, Inadequate/Underdosing, or No treatment) were analyzed. The primary outcome was the cumulative frequency of new-onset CD at 12 months.</div></div><div><h3>Results</h3><div>The cumulative frequency of CD was 18.9%. Patients with adequate anticoagulation had a lower frequency (13.5%; 95%CI 8.3–18.7) compared with those with inadequate dosing (27.9%; 95%CI 18.2–37.6) and no treatment (33.9%; 95%CI 21.4–46.4). In multivariable analysis, inadequate anticoagulation (HR 1.78; 95%CI 1.15–2.85) and absence of treatment (HR 2.25; 95%CI 1.35–3.65) were independently associated with CD, as was very prolonged hospital stay (HR 2.41; 95%CI 1.45–3.95). Adequate anticoagulation was associated with greater deterioration-free survival even among patients with prolonged stays.</div></div><div><h3>Conclusions</h3><div>Prolonged hospitalization and inadequate or absent anticoagulation were associated with a higher frequency of new-onset cognitive decline. Optimizing anticoagulation represents a recommended and timely strategy associated with cognitive preservation in older hospitalized patients.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 8","pages":"Article 107515"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Strongyloides stercoralis in rheumatic patients undergoing immunosuppression screening","authors":"Cristina Calomarde-Gomez,&nbsp;Mercè López de Recalde,&nbsp;Sara Jonàs,&nbsp;Sonia Mínguez","doi":"10.1016/j.medcle.2026.107466","DOIUrl":"10.1016/j.medcle.2026.107466","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 8","pages":"Article 107466"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sea fan neovascularization in ischemic retinopathy as the initial manifestation of antiphospholipid syndrome","authors":"Mariam Cernichiaro-Espinosa,&nbsp;Irving A. Domínguez-Varela,&nbsp;Pablo Baquero-Ospina","doi":"10.1016/j.medcle.2026.107469","DOIUrl":"10.1016/j.medcle.2026.107469","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 8","pages":"Article 107469"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambient AI scribe in pediatric outpatient visits: Documentation burden, quality, and scale-up limits","authors":"Violeta Vallejo,&nbsp;Jordi Farreras,&nbsp;Laura Valero,&nbsp;Carla González-Grado,&nbsp;Irene Peral,&nbsp;Iván Cano,&nbsp;Cristian Launes,&nbsp;EMIA-DOC Study Group","doi":"10.1016/j.medcle.2026.107541","DOIUrl":"10.1016/j.medcle.2026.107541","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 8","pages":"Article 107541"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-islet cell tumor hypoglycemia due to recurrent pleural solitary fibrous tumor: Control with low-dose prednisone","authors":"Gema Villa López,&nbsp;María Calatayud Gutiérrez","doi":"10.1016/j.medcle.2026.107480","DOIUrl":"10.1016/j.medcle.2026.107480","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 8","pages":"Article 107480"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgG4-related sclerosing cholangitis","authors":"Mateo Eduardo Belando Pardo,&nbsp;María Dolores Lizán Ballesta,&nbsp;Eva María Noguera López,&nbsp;Jesús M. de la Peña Moral","doi":"10.1016/j.medcle.2026.107462","DOIUrl":"10.1016/j.medcle.2026.107462","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 8","pages":"Article 107462"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central nervous system-limited Epstein–Barr virus-associated lymphomatoid granulomatosis in an immunosuppressed patient","authors":"Juan Francisco Muñoz-Osuna,&nbsp;Fernando Leiva-Cepas,&nbsp;Ana Isabel Pérez-Caballero","doi":"10.1016/j.medcle.2026.107479","DOIUrl":"10.1016/j.medcle.2026.107479","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"166 8","pages":"Article 107479"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}