{"title":"Osteoporosis in premenopausal women","authors":"Pilar Peris","doi":"10.1016/j.medcle.2025.106940","DOIUrl":"10.1016/j.medcle.2025.106940","url":null,"abstract":"<div><div>The development of osteoporosis and fractures in young premenopausal women is infrequent and is usually associated with secondary causes of osteoporosis. Therefore, it is recommendable to perform a clinical evaluation and a thorough laboratory study searching for possible causes of bone loss in these patients. Treatment depends on the cause of osteoporosis and the associated processes as well as the future gestational desire of the patient, all of which should be taken into account when evaluating the most adequate diagnostic and the therapeutic approach in these patients.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106940"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Arnés-García, Elena Zamorano-García, Isabel Gallego-Romero
{"title":"Beri-beri: A rare and reversible cause of heart failure","authors":"Daniel Arnés-García, Elena Zamorano-García, Isabel Gallego-Romero","doi":"10.1016/j.medcle.2025.106893","DOIUrl":"10.1016/j.medcle.2025.106893","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106893"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francisco Larrosa , Laura Pujol , Elena Hernández-Montero
{"title":"Chronic otitis media","authors":"Francisco Larrosa , Laura Pujol , Elena Hernández-Montero","doi":"10.1016/j.medcle.2025.106915","DOIUrl":"10.1016/j.medcle.2025.106915","url":null,"abstract":"<div><div>Chronic otitis media, defined as persistent or recurrent inflammation of the middle ear mucosa, is a frequent entity in primary and secondary care. This disease causes otorrhea and hearing loss that significantly affect the quality of life of patients.</div><div>In recent years, there have been new developments in its diagnosis, prevention and treatment. In this last aspect, pharmacological treatment, surgical techniques and hearing rehabilitation through implants have shown significant advances. On the other hand, chronic otitis media complications continue to occur in emergency services and have to be kept in mind because of their potential seriousness.</div><div>The objective of this work is to offer the reader an update in chronic otitis media, so it may help improving the care of affected patients.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 10","pages":"Article 106915"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pau Riera , Berta Martín-Cullell , Anna de Dios , Anna C. Virgili , Lucía Ramírez , David Páez
{"title":"Monitoring of adverse effects and quality of life during chemotherapy treatment through the EMMA Salud mobile App in patients with colorectal cancer","authors":"Pau Riera , Berta Martín-Cullell , Anna de Dios , Anna C. Virgili , Lucía Ramírez , David Páez","doi":"10.1016/j.medcle.2025.106895","DOIUrl":"10.1016/j.medcle.2025.106895","url":null,"abstract":"<div><h3>Background and aim</h3><div>One third of patients with colorectal cancer (CRC) undergoing chemotherapy develop serious adverse effects. The aim was to monitor toxicities, evaluate quality of life and the usefulness of the EMMA Salud mobile App in these patients.</div></div><div><h3>Patients and methods</h3><div>Prospective single-center study including patients with CRC who started fluoropyrimidine-based chemotherapy treatment between 02/2022 and 02/2023. Through the mobile application, patients could record adverse effects, interact with healthcare professionals and answer quality of life (EORTC-CRC) and anxiety/depression (HADS) questionnaires.</div></div><div><h3>Results</h3><div>A total of 31 patients were included. Regarding the use of the App, 10 patients (32.2%) recorded variables of interest, 11 (35.5%) recorded toxicities and 10 (32.2%) sent direct messages to healthcare professionals. Many patients (48%) also used the telephone consultation from the nurse case manager. The response rate to HADS and EORTC-CRC was 30% at baseline and 10% at approximately 6 months.</div></div><div><h3>Conclusions</h3><div>Monitoring toxicities through a mobile application can improve communication in motivated patients who adhere to new technologies. However, the role of the nurse case manager continues to be a valuable resource.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106895"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of cardiovascular risk factors on glomerular filtration rate and on morbidity and mortality after renal donation","authors":"Pilar Fraile Gómez , Nina Duarte Duarte , Alexandra Lizarazo , Alejandro Martín Parada , Celia Rodriguez-Tudero , Fernanda Lorenzo Gómez","doi":"10.1016/j.medcle.2025.106913","DOIUrl":"10.1016/j.medcle.2025.106913","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Living donor kidney transplantation increases recipient and graft survival compared with cadaveric donor transplantation. Correct donor selection is essential to optimize transplant outcomes as well as post-donation safety. The aim of this study is to analyze the influence of baseline characteristics of living kidney donors on renal function, morbidity and mortality after nephrectomy.</div></div><div><h3>Patients and methods</h3><div>An observational, descriptive, cross-sectional study was designed that included living kidney donors followed up at the Salamanca University Hospital between 2011 and January 2023. Statistical significance was considered if <em>P</em> <!-->≤<!--> <!-->.05.</div></div><div><h3>Results</h3><div>Ninety-one donors were included, 63% women, with a mean age of 52<!--> <!-->±<!--> <!-->10.8 years. 52.1% were overweight or obese, 9.9% had hypertension and 22% were dyslipidemic. Mortality was 0% and 84.3% had no complications. GFR (CKD-EPI) dropped from 92 to 57.1<!--> <!-->ml/min/1.73<!--> <!-->m<sup>2</sup> at 1 month after nephrectomy. There was a significant increase in proteinuria at 1 month and 2 years. After nephrectomy, BMI, MAP, HbA1c, uric acid, total cholesterol, LDL and triglycerides increased (<em>P</em> <!-->≤<!--> <!-->.05).</div></div><div><h3>Conclusions</h3><div>The mean GFR of donors as well as its compensation after nephrectomy was lower and slower than the figures reported in the literature, probably due to the higher mean age of our donors. The increased prevalence of obesity, dyslipidemia and hyperuricemia postdonation and worsening of HbA1c and MAP levels make strict monitoring of donors necessary. In our experience, kidney donation is a safe process with low morbidity and mortality.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"164 11","pages":"Article 106913"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}