Medicina clinica (English ed.)最新文献_第5页

Prognostic value of extreme NT-proBNP levels in patients hospitalized for heart failure 极端NT-proBNP水平对心力衰竭住院患者的预后价值

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106990

Miguel Yebra Yebra , Alejandro Sáenz de Urturi Rodríguez , Sergio González García , Paula de Peralta García , Maria Asenjo Martínez , Jose Antonio Rueda Camino , Raquel Barba Martín

{"title":"Prognostic value of extreme NT-proBNP levels in patients hospitalized for heart failure","authors":"Miguel Yebra Yebra , Alejandro Sáenz de Urturi Rodríguez , Sergio González García , Paula de Peralta García , Maria Asenjo Martínez , Jose Antonio Rueda Camino , Raquel Barba Martín","doi":"10.1016/j.medcle.2025.106990","DOIUrl":"10.1016/j.medcle.2025.106990","url":null,"abstract":"<div><h3>Background and objective</h3><div>To evaluate the prognostic value of extreme levels of the N-terminal pro-B-type natriuretic peptide (NT-proBNP) measured at any time during hospitalization for heart failure (HF).</div></div><div><h3>Materials and methods</h3><div>A retrospective cohort study including patients hospitalized for HF in a secondary-level hospital with at least one NT-proBNP measurement. Two groups were defined: patients with extreme NT-proBNP levels (>50,000 pg/ml) and those with elevated NT-proBNP levels (>1800 pg/ml and <20,000 pg/ml). The primary outcome was a composite of (1) in-hospital mortality, (2) HF readmission, and (3) six-month mortality. Cox survival models were used for analysis.</div></div><div><h3>Results</h3><div>A total of 83 patients with extreme NT-proBNP levels and 100 with elevated NT-proBNP levels were included; 61% were women, with a median age of 87 years. Comorbidity burden was high and similar between groups (median Charlson index: 8). The primary outcome was more frequent in patients with extreme NT-proBNP levels: 25.02 vs. 10.53 events per 100 patient-months (HR 2.07; 95% CI: 1.37–3.14). Both in-hospital and six-month mortality were significantly higher in the extreme NT-proBNP group, while HF readmissions were numerically higher but not statistically significant. These results remained consistent after multivariable adjustment.</div></div><div><h3>Conclusions</h3><div>Patients hospitalized for HF with NT-proBNP levels > 50,000 pg/ml have a worse prognosis than those with NT-proBNP < 20,000 pg/ml, representing a high-risk subgroup with short-term mortality.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 1","pages":"Article 106990"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and prognostic differences in diabetic ketoacidosis between type 2 and type 1 diabetes 2型和1型糖尿病酮症酸中毒的临床和预后差异

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106973

Maria Sara Tapia Sanchiz, Victor Navas Moreno, Marta Lopez Ruano, Carmen Martínez Otero, Elena Carrillo López, Carolina Sager La Ganga, Juan José Raposo López, Selma Amar, Sara González Castañar, Jose Alfonso Arranz Martín, Mónica Marazuela, Fernando Sebastian-Valles

{"title":"Clinical and prognostic differences in diabetic ketoacidosis between type 2 and type 1 diabetes","authors":"Maria Sara Tapia Sanchiz, Victor Navas Moreno, Marta Lopez Ruano, Carmen Martínez Otero, Elena Carrillo López, Carolina Sager La Ganga, Juan José Raposo López, Selma Amar, Sara González Castañar, Jose Alfonso Arranz Martín, Mónica Marazuela, Fernando Sebastian-Valles","doi":"10.1016/j.medcle.2025.106973","DOIUrl":"10.1016/j.medcle.2025.106973","url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this study was to analyse the differences in diabetic ketoacidosis (DKA) between type 2 diabetes (T2D) and type 1 diabetes (T1D) in a Spanish cohort.</div></div><div><h3>Materials and methods</h3><div>This retrospective cohort study included all cases of DKA between 2010 and 2024 in a Spanish tertiary hospital. Clinical and laboratory variables were collected to identify differences between DKA in T2D and T1D. Logistic regression models were used to evaluate 30-day mortality following a DKA event.</div></div><div><h3>Results</h3><div>A total of 249 subjects (52.2% female) with a mean age of 50.2±19.9 years were included. Eighty-nine patients (35.7%) had T2D, and 160 (64.3%) had T1D. A higher proportion of cardiovascular precipitating events was observed in the T2D group (12.5% vs. 3.2%, <em>p</em>  <0.05). However, 30-day mortality was 13.5% in T2D and 1.3% in T1D (<em>p</em>  <0.05), independent of age and diabetes type.</div></div><div><h3>Conclusion</h3><div>DKA in T2D is associated with a higher risk of mortality due to the severity of precipitating factors, despite a more favorable blood gas profile compared to T1D. Early identification of episodes is essential to prevent complications.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 1","pages":"Article 106973"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in clinical profile between men and women with obstructive sleep apnoeas 男性和女性阻塞性睡眠呼吸暂停的临床特征差异

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106975

Nuria Roger-Casals , Ana Maria Muñoz-Fernández , Cristina Muñoz-Pindado

引用次数: 0

Role of emergent transcatheter aortic valve implantation in the treatment of cardiogenic shock secondary to severe aortic stenosis 急诊经导管主动脉瓣植入术在治疗严重主动脉狭窄继发心源性休克中的作用

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106978

María Mendoza-Prieto , Isabel Espinosa-Rueda , Luis Martín-Villén

引用次数: 0

Eribulin-induced pulmonary toxicity mimicking metastatic lung disease 艾力布林诱导的肺毒性模拟转移性肺疾病

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.1069930

Luis Gorospe , Cristina Saavedra-Serrano , Noelia Martínez-Jáñez

引用次数: 0

Intestinal occlusion due to endometriosis 子宫内膜异位症引起的肠道阻塞

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106984

Coro Velasco Gametxogoikoetxea, Iñigo Arana Iñiguez, Teresa Esther Santa Cruz Sarasqueta

引用次数: 0

Duodenal Burkitt’s lymphoma 十二指肠伯基特淋巴瘤

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106954

Marc Lleixà Rioboo , Guillem Soy , Eva C. Vaquero , Gerard Frigola Quintana , Ignacio Iborra Chaqués

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Behçet syndrome 摘要综合症

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106983

Gerard Espinosa

引用次数: 0

Efgartigimod for the treatment of Guillain–Barré syndrome with concurrent posterior reversible encephalopathy syndrome 艾夫加替莫德治疗吉兰-巴罗综合征并发后部可逆性脑病综合征

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106935

Weiwei Tao , Hui Liang , Weijun Hong

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Lineage switch in acute lymphoblastic leukemia following anti-CD19 therapy 抗cd19治疗后急性淋巴细胞白血病的谱系转换

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106995

Itziar de Aguirre , Vitor Botafogo , José Tomás Navarro

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