Medicina clinica (English ed.)最新文献_第6页

Ventricular extrasystoles secondary to mitral valve prolapse as an initial manifestation of cardiac sarcoidosis 继发于二尖瓣脱垂的室性心动过速是心脏结节病的最初表现

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106976

Javier del Cid Lemus , Carlos Feijoo-Massó , Daniel Valcarcel-Paz

引用次数: 0

Patient and public involvement in registered non-pharmacological non-commercial Spanish trials completed in 2009–2024: A systematic review 2009-2024年完成的西班牙注册非药物非商业试验的患者和公众参与：系统回顾

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106964

Rafael Dal-Ré , Elena García-Méndez

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Kava (Piper methysticum) induced acute skin toxicity 卡瓦（胡椒）引起急性皮肤毒性

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106991

Ishana Dixit , Miguel Mansilla-Polo , Pablo Fernández-Peñas

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GLP-1 receptor agonists in obesity treatment: Effects on cardiometabolic variables and cardiovascular disease GLP-1受体激动剂在肥胖治疗中的作用：对心脏代谢变量和心血管疾病的影响

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106951

Helena Sardà , Idoia Genua , Inka Miñambres

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Diagnostic value of blood coagulation index in obstetric antiphospholipid syndrome and its subtypes 凝血指标对产科抗磷脂综合征及其亚型的诊断价值

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106997

Xuan Qi , Xiaomeng Li , Yan Han , Lingyan Lei , Huifang Guo

{"title":"Diagnostic value of blood coagulation index in obstetric antiphospholipid syndrome and its subtypes","authors":"Xuan Qi , Xiaomeng Li , Yan Han , Lingyan Lei , Huifang Guo","doi":"10.1016/j.medcle.2025.106997","DOIUrl":"10.1016/j.medcle.2025.106997","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize blood coagulation index in obstetric antiphospholipid syndrome (OAPS) and its subtypes, analyzing correlations with immunological indices and diagnostic value.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed on OAPS patients treated at the Department of Rheumatology and Immunology, Second Hospital of Hebei Medical University, from September 2023 to March 2024. Healthy women of the same age range were matched for comparison.</div></div><div><h3>Results</h3><div>A total of 102 OAPS patients and 80 matched healthy controls were included. OAPS patients exhibited significantly lower levels of complement factors C3 and C4, coagulation factors V and VII activities, and protein S activity (<em>p</em>  <0.05). Among OAPS patients, criteria OAPS cases showed significantly higher anti-β2-GPI antibodies and anticardiolipin antibody levels (<em>p</em>  <0.01).</div></div><div><h3>Conclusion</h3><div>Correlations were found between immunological indices (ANA, complement C3, anti-β2-GPI) and coagulation indices (TAT, APTT). ANA, complement C3, anti-β2-GPI antibodies, and TAT were identified as risk factors for predicting OAPS. Blood coagulation and immune indices correlate in OAPS. Detecting these indices may provide diagnostic value for OAPS and its subtypes.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 1","pages":"Article 106997"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixed autoimmune haemolytic anaemia in a patient with Hashimoto's thyroiditis and sarcoidosis 桥本甲状腺炎合并结节病合并自身免疫性溶血性贫血1例

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106979

Isidora Rubezic Lukic , Vesko Vujicic , Enisa Zaric

引用次数: 0

Whipple's disease mimicking systemic lupus erythematosus 类似系统性红斑狼疮的惠普尔氏病

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106960

Laia de Daniel , Xavier Sanjuan , Javier Narváez

引用次数: 0

GLP-1-based medications: Mechanisms involved in obesity treatment 基于glp -1的药物：肥胖治疗的机制

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.107035

Javier Salvador

引用次数: 0

Fabry disease: Importance of genetic counseling in the reclassification of variants of uncertain clinical significance 法布里病：遗传咨询在不确定临床意义的变异重新分类中的重要性

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106965

Elena Colastra Ugena , Ana Peña Cabia , Ismael Calero Paniagua , Sonia Rodríguez Díaz , Begoña Rincón Ruiz , Juan Gómez de Oña

{"title":"Fabry disease: Importance of genetic counseling in the reclassification of variants of uncertain clinical significance","authors":"Elena Colastra Ugena , Ana Peña Cabia , Ismael Calero Paniagua , Sonia Rodríguez Díaz , Begoña Rincón Ruiz , Juan Gómez de Oña","doi":"10.1016/j.medcle.2025.106965","DOIUrl":"10.1016/j.medcle.2025.106965","url":null,"abstract":"<div><h3>Objective</h3><div>Fabry disease (FD) is an X-linked genetic disorder characterized by the deficiency or absence of the enzyme alpha-galactosidase. This leads to intracellular deposits of sphingolipids in vital organs, making it a multisystemic disease.</div><div>The aim ofthis study is to emphasize the importance of genetic diagnosis and multidisciplinary follow-up of patients with FD.</div></div><div><h3>Materials and methods</h3><div>This case presents two patients diagnosed with hypertrophic cardiomyopathy, both carrying the same variant of uncertain clinical significance (VUS) in the GLA gene, with no known relationship between them. Since the genetic counseling consultation, a family segregation study was performed, enabling the redirection of the diagnosis and detection of FD in several symptomatic and asymptomatic relatives.</div></div><div><h3>Results</h3><div>Genetic studies allowed the reclassification of the VUS as probably pathogenic, demonstrating its involvement in the pathology of these patients. Adequate clinical follow-up was provided for these patients, and reproductive genetic counseling was offered to family members.</div></div><div><h3>Discussion</h3><div>Early diagnosis of FD helps improve patient prognosis.</div></div><div><h3>Conclusion</h3><div>Genetic counseling enables early diagnosis and proper follow-up of FD.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 1","pages":"Article 106965"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in self-reported dysexecutive symptomatology in persistent COVID 持续性COVID患者自我报告的执行障碍症状的性别差异

Medicina clinica (English ed.) Pub Date : 2025-07-11 DOI: 10.1016/j.medcle.2025.106953

Juan Antonio Becerra-García, Maëlle Delphine Frédérique Laval

引用次数: 0