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Lipid-based nanoparticles for cancer immunotherapy. 用于癌症免疫疗法的脂质基纳米粒子。
Medical review (Berlin, Germany) Pub Date : 2023-08-17 eCollection Date: 2023-06-01 DOI: 10.1515/mr-2023-0020
Shumin Fan, Huize Han, Zhicheng Yan, Yao Lu, Bing He, Qiang Zhang
{"title":"Lipid-based nanoparticles for cancer immunotherapy.","authors":"Shumin Fan, Huize Han, Zhicheng Yan, Yao Lu, Bing He, Qiang Zhang","doi":"10.1515/mr-2023-0020","DOIUrl":"10.1515/mr-2023-0020","url":null,"abstract":"<p><p>As the fourth most important cancer management strategy except surgery, chemotherapy and radiotherapy, cancer immunotherapy has been confirmed to elicit durable antitumor effects in the clinic by leveraging the patient's own immune system to eradicate the cancer cells. However, the limited population of patients who benefit from the current immunotherapies and the immune related adverse events hinder its development. The immunosuppressive microenvironment is the main cause of the failure, which leads to cancer immune evasion and immunity cycle blockade. Encouragingly, nanotechnology has been engineered to enhance the efficacy and reduce off-target toxicity of their therapeutic cargos by spatiotemporally controlling the biodistribution and release kinetics. Among them, lipid-based nanoparticles are the first nanomedicines to make clinical translation, which are now established platforms for diverse areas. In this perspective, we discuss the available lipid-based nanoparticles in research and market here, then describe their application in cancer immunotherapy, with special emphasis on the T cells-activated and macrophages-targeted delivery system. Through perpetuating each step of cancer immunity cycle, lipid-based nanoparticles can reduce immunosuppression and promote drug delivery to trigger robust antitumor response.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 3","pages":"230-269"},"PeriodicalIF":0.0,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ac/54/mr-3-3-mr-2023-0020.PMC10542882.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41164399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence in theranostics of gastric cancer, a review. 人工智能在癌症治疗中的应用综述。
Medical review (Berlin, Germany) Pub Date : 2023-07-27 eCollection Date: 2023-06-01 DOI: 10.1515/mr-2022-0042
Yiqian Zha, Cuili Xue, Yanlei Liu, Jian Ni, Jesus M De La Fuente, Daxiang Cui
{"title":"Artificial intelligence in theranostics of gastric cancer, a review.","authors":"Yiqian Zha, Cuili Xue, Yanlei Liu, Jian Ni, Jesus M De La Fuente, Daxiang Cui","doi":"10.1515/mr-2022-0042","DOIUrl":"10.1515/mr-2022-0042","url":null,"abstract":"<p><p>Gastric cancer (GC) is one of the commonest cancers with high morbidity and mortality in the world. How to realize precise diagnosis and therapy of GC owns great clinical requirement. In recent years, artificial intelligence (AI) has been actively explored to apply to early diagnosis and treatment and prognosis of gastric carcinoma. Herein, we review recent advance of AI in early screening, diagnosis, therapy and prognosis of stomach carcinoma. Especially AI combined with breath screening early GC system improved 97.4 % of early GC diagnosis ratio, AI model on stomach cancer diagnosis system of saliva biomarkers obtained an overall accuracy of 97.18 %, specificity of 97.44 %, and sensitivity of 96.88 %. We also discuss concept, issues, approaches and challenges of AI applied in stomach cancer. This review provides a comprehensive view and roadmap for readers working in this field, with the aim of pushing application of AI in theranostics of stomach cancer to increase the early discovery ratio and curative ratio of GC patients.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 3","pages":"214-229"},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d2/ce/mr-3-3-mr-2022-0042.PMC10542883.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41172050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applications of cutting-edge artificial intelligence technologies in biomedical literature and document mining. 前沿人工智能技术在生物医学文献和文献挖掘中的应用。
Medical review (Berlin, Germany) Pub Date : 2023-06-27 eCollection Date: 2023-06-01 DOI: 10.1515/mr-2023-0011
Fei He, Kai Liu, Zhiyuan Yang, Mark Hannink, Richard D Hammer, Mihail Popescu, Dong Xu
{"title":"Applications of cutting-edge artificial intelligence technologies in biomedical literature and document mining.","authors":"Fei He, Kai Liu, Zhiyuan Yang, Mark Hannink, Richard D Hammer, Mihail Popescu, Dong Xu","doi":"10.1515/mr-2023-0011","DOIUrl":"10.1515/mr-2023-0011","url":null,"abstract":"<p><p>The biomedical literature is a vast and invaluable resource for biomedical research. Integrating knowledge from the literature with biomedical data can help biological studies and the clinical decision-making process. Efforts have been made to gather information from the biomedical literature and create biomedical knowledge bases, such as KEGG and Reactome. However, manual curation remains the primary method to retrieve accurate biomedical entities and relationships. Manual curation becomes increasingly challenging and costly as the volume of biomedical publications quickly grows. Fortunately, recent advancements in Artificial Intelligence (AI) technologies offer the potential to automate the process of curating, updating, and integrating knowledge from the literature. Herein, we highlight the AI capabilities to aid in mining knowledge and building the knowledge base from the biomedical literature.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 3","pages":"200-204"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1e/25/mr-3-3-mr-2023-0011.PMC10542881.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41123814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral microbiome: a doubtful predictor but potential target of cardiovascular diseases. 口腔微生物组：一个值得怀疑的预测因素，但可能成为心血管疾病的靶点。
Medical review (Berlin, Germany) Pub Date : 2023-06-22 eCollection Date: 2023-06-01 DOI: 10.1515/mr-2023-0015
Chak Kwong Cheng, Yu Huang
{"title":"Oral microbiome: a doubtful predictor but potential target of cardiovascular diseases.","authors":"Chak Kwong Cheng, Yu Huang","doi":"10.1515/mr-2023-0015","DOIUrl":"10.1515/mr-2023-0015","url":null,"abstract":"<p><p>Our oral cavity houses various types of microbes including bacteria, protozoa, fungi and viruses, harboring over 700 bacterial species. Oral dysbiosis refers to the imbalance between symbionts and pathobionts in the oral cavity, posing potential threats to host cardiovascular health. Importantly, oral dysbiosis promotes cardiovascular pathophysiology through different mechanisms. Although overgrowth of certain pathogenic bacteria have been indicated in some cardiometabolic diseases, it is still premature to consider oral microbiome as a suitable predictor for non-invasive diagnostic purpose. However, targeting oral microbiome might still provide preventive and therapeutic insights on cardiovascular diseases. Further extensive efforts are needed to deepen our understanding on oral-cardiovascular connection in the context of diagnostic and therapeutic perspectives.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 3","pages":"209-213"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/bd/mr-3-3-mr-2023-0015.PMC10542880.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41164461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two-dimensional layered nanomaterials for tumor diagnosis and treatment. 用于肿瘤诊断和治疗的二维层状纳米材料。
Medical review (Berlin, Germany) Pub Date : 2023-06-14 eCollection Date: 2023-06-01 DOI: 10.1515/mr-2023-0006
Chengyuan Hong, Zhusheng Liu, Tianxiang Chen, Aiguo Wu
{"title":"Two-dimensional layered nanomaterials for tumor diagnosis and treatment.","authors":"Chengyuan Hong, Zhusheng Liu, Tianxiang Chen, Aiguo Wu","doi":"10.1515/mr-2023-0006","DOIUrl":"10.1515/mr-2023-0006","url":null,"abstract":"<p><p>With the evolution of nanomedicine, the past decades witnessed diversified nanomaterials as marvelous anti-tumor tools ushering in a new era of tumor diagnosis and treatment. Among them, two-dimensional layered nanomaterial as an emerging class of nanomaterials has one dimension less than 100 nm, showing a high specific area and the thinnest sheet-like structure (Liu S, Pan X, Liu H. Twodimensional nanomaterials for photothermal therapy. Angew Chem Int Ed 2020;59:5890-900). The discovery of graphene drove the exploration of various new two-dimensional layered nanomaterials for tumor diagnosis and treatment including graphene-based nanomaterials, black phosphorus (BP), transition metal dichalcogenides (TMDs), layered double hydroxides (LDHs), and bismuth oxyhalides (BiOX, X=F, Cl, Br, I) (Ma H, Xue MQ. Recent advances in the photothermal applications of two-dimensional nanomaterial: photothermal therapy and beyond. J Mater Chem 2021;9:17569). On the one hand, they exhibit strong near-infrared (NIR) absorption and the capacity of optimizing corresponding properties by adjusting the crystal structure. On the other hand, they own unique strengths such as fantastic physicochemical properties (graphene-based nanomaterials), high loading capacity (BP), distinct phase-dependent optical properties (TMDs), a specific chemical response to the tumor microenvironment (LDHs), and large X-ray attenuation coefficient (BiOX). Herein, we briefly introduce three typical two-dimensional layered nanomaterials, their prospects and future research priorities in tumor diagnosis and treatment are concluded.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 3","pages":"205-208"},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/06/6a/mr-3-3-mr-2023-0006.PMC10542879.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frontmatter 头版头条
Medical review (Berlin, Germany) Pub Date : 2023-06-01 DOI: 10.1515/mr-2023-frontmatter3
{"title":"Frontmatter","authors":"","doi":"10.1515/mr-2023-frontmatter3","DOIUrl":"https://doi.org/10.1515/mr-2023-frontmatter3","url":null,"abstract":"","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monkeypox scenario in India: a review study. 印度猴痘情况：一项综述研究。
Medical review (Berlin, Germany) Pub Date : 2023-05-26 eCollection Date: 2023-06-01 DOI: 10.1515/mr-2023-0004
Ashish William, Molly Madan
{"title":"Monkeypox scenario in India: a review study.","authors":"Ashish William, Molly Madan","doi":"10.1515/mr-2023-0004","DOIUrl":"10.1515/mr-2023-0004","url":null,"abstract":"<p><p>The monkeypox virus, which causes the viral zoonotic disease, is known as the most significant orthopoxvirus infection following the elimination of smallpox. The monkeypox virus, which was previously exclusive to West and Central African nations and caused endemic diseases in monkeys and people, has recently been linked to human infections in non-endemic areas including the United States of America (USA) and more than 30 additional countries. Guidelines for the diagnosis and treatment of monkeypox have also recently been made available by the Ministry of Health and Family Welfare of India and the Indian Government. The monkeypox outbreak continues to be a worldwide health emergency, the highest degree of alert recognised by the World Health Organization. The Centers for Disease Control and Prevention (CDC) advises vaccination for those who have been exposed to the disease as well as those who may be at higher risk of contracting it, such as those who have been identified by public health officials as a contact of someone who has the disease.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 3","pages":"270-276"},"PeriodicalIF":0.0,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/82/9b/mr-3-3-mr-2023-0004.PMC10542878.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"One-for-All" approach: a black technology for nanomedicine development? “一个为所有人”的方法：纳米医学发展的黑技术？
Medical review (Berlin, Germany) Pub Date : 2023-04-26 eCollection Date: 2023-04-01 DOI: 10.1515/mr-2023-0003
Jiajia Xiang, Shiqun Shao, Zhuxian Zhou, Youqing Shen
{"title":"\"One-for-All\" approach: a black technology for nanomedicine development?","authors":"Jiajia Xiang, Shiqun Shao, Zhuxian Zhou, Youqing Shen","doi":"10.1515/mr-2023-0003","DOIUrl":"10.1515/mr-2023-0003","url":null,"abstract":"<p><p>Cancer nanomedicines require different, even opposite, properties to voyage the cascade drug delivery process involving a series of biological barriers. Currently-approved nanomedicines can only alleviate adverse effects but cannot improve patient survival because they fail to meet all the requirements. Therefore, nanocarriers with synchronized functions are highly requisite to capacitate efficient drug delivery and enhanced therapeutic efficacies. This perspective article summarizes recent advances in the two main strategies for nanomedicine design, the All-in-One approach (integration of all the functions in one system) and the One-for-All approach (one functional group with proper affinity enables all the functions), and presents our views on future nanomedicine development.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 2","pages":"184-187"},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/6e/mr-3-2-mr-2023-0003.PMC10471114.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10311379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of macrophage polarization by iron-based nanoparticles. 铁基纳米颗粒对巨噬细胞极化的调节。
Medical review (Berlin, Germany) Pub Date : 2023-04-18 eCollection Date: 2023-04-01 DOI: 10.1515/mr-2023-0002
He Ding, Yuxin Zhang, Yu Mao, Yan Li, Yan Shen, Jingyi Sheng, Ning Gu
{"title":"Modulation of macrophage polarization by iron-based nanoparticles.","authors":"He Ding, Yuxin Zhang, Yu Mao, Yan Li, Yan Shen, Jingyi Sheng, Ning Gu","doi":"10.1515/mr-2023-0002","DOIUrl":"10.1515/mr-2023-0002","url":null,"abstract":"<p><p>Macrophage polarization is an essential process involved in immune regulation. In response to different microenvironmental stimulation, macrophages polarize into cells with different phenotypes and functions, most typically M1 (pro-inflammatory) and M2 (anti-inflammatory) macrophages. Iron-based nanoparticles have been widely explored and reported to regulate macrophage polarization for various biomedical applications. However, the influence factors and modulation mechanisms behind are complicated and not clear. In this review, we systemically summarized different iron-based nanoparticles that regulate macrophage polarization and function and discussed the influence factors and mechanisms underlying the modulation process. This review aims to deepen the understanding of the modulation of macrophage polarization by iron-based nanoparticles and expects to provide evidence and guidance for subsequent design and application of iron-based nanoparticles with specific macrophage modulation functions.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 2","pages":"105-122"},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/d2/mr-3-2-mr-2023-0002.PMC10471121.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10311382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Nanomedicine sheds new light on cancer immunotherapy. 纳米医学为癌症免疫疗法提供了新的思路。
Medical review (Berlin, Germany) Pub Date : 2023-04-17 eCollection Date: 2023-04-01 DOI: 10.1515/mr-2023-0005
Yingying Yu, Liangzhu Feng, Zhuang Liu
{"title":"Nanomedicine sheds new light on cancer immunotherapy.","authors":"Yingying Yu, Liangzhu Feng, Zhuang Liu","doi":"10.1515/mr-2023-0005","DOIUrl":"10.1515/mr-2023-0005","url":null,"abstract":"<p><p>Cancer immunotherapy comprising of immune checkpoint blockade (ICB) therapy, immune cell therapies, cancer vaccines and many others represents a profound arsenal in the fight against different types of cancers. However, their overall clinical objective response rates, particularly against most solid tumors, are still not sufficient owing to a variety of reasons including the heterogenous expression of tumor antigens, limited tumor infiltration of effector immune cells, acquired tumor immunosuppression and some other factors. In recent years, various nanomedicine strategies have been proposed to assist cancer immunotherapy via distinct mechanisms, presenting new promises in many published studies. This perspective will thus provide a brief overview regarding the development of nanomedicine platforms for improving cancer immunotherapy.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 2","pages":"188-192"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/78/44/mr-3-2-mr-2023-0005.PMC10471084.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10674620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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