自然杀伤细胞治疗癌症的研究现状及展望

Xiangyu Zhao, Minghao Lin, Xiaojun Huang
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引用次数: 0

摘要

自然杀伤细胞(Natural killer, NK)天生具有有效消灭癌细胞的能力。然而,由于NK细胞治疗后在肿瘤环境下不易增殖,容易诱导功能障碍,因此NK细胞输注的疗效受到限制,未能在临床中得到广泛应用。生物技术的快速发展促进了NK细胞治疗癌症的发展。在这篇综述中,我们将全面分析NK细胞治疗癌症的现状和未来前景,重点介绍NK细胞的生物学特性,以及在微环境中增强其靶向能力和克服肿瘤免疫抑制的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current status and future perspective of natural killer cell therapy for cancer
Abstract Natural killer (NK) cells possess innate abilities to effectively eliminate cancer cells. However, because of difficulties of proliferation and easy to be induced dysfunction in the setting of cancer post NK cell therapy, the curative effect of NK cell infusion has been constrained and not been widely applicable in clinical practice. The rapid development of biotechnology has promoted the development of NK cell therapy for cancer treatment. In this review, we will provide a comprehensive analysis of the current status and future prospects of NK cell therapy for cancer, focusing on the biological characteristics of NK cells, as well as strategies to enhance their targeting capabilities and overcome tumor immune suppression within the microenvironment.
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