Medical review (Berlin, Germany)最新文献

From tumor immunity to precision medicine: the next step in B7-H3/CD276 research. 从肿瘤免疫到精准医疗：B7-H3/CD276研究的下一步

Medical review (Berlin, Germany) Pub Date : 2025-03-03 eCollection Date: 2025-06-01 DOI: 10.1515/mr-2025-0003

Haolie Fang, Yuqian Liu, Gege Wang, Heng-Jia Liu

引用次数: 0

Ventricular ion channels and arrhythmias: an overview of physiology, pathophysiology and pharmacology. 心室离子通道与心律失常：生理学、病理生理学和药理学综述。

Medical review (Berlin, Germany) Pub Date : 2025-03-03 eCollection Date: 2025-06-01 DOI: 10.1515/mr-2024-0085

Shiqi Liu, Wei Wang, Yang Yang, Zhuo Huang

{"title":"Ventricular ion channels and arrhythmias: an overview of physiology, pathophysiology and pharmacology.","authors":"Shiqi Liu, Wei Wang, Yang Yang, Zhuo Huang","doi":"10.1515/mr-2024-0085","DOIUrl":"10.1515/mr-2024-0085","url":null,"abstract":"Cardiac ion channels are critical transmembrane proteins that mediate almost all aspects of cardiac function including generation and propagation of cardiac action potential (AP) as well as maintenance of normal heart excitability and contraction. In addition, the pivotal role of cardiac ion channels in cardiac health and disease is underscored by the profound effects of their dysfunctional mutations on various arrhythmias. Hence, ion channels are vital targets for antiarrhythmic drugs. In this review, we first summarize the characteristics, structure of the various cardiac ion channels and their specific roles in cardiac electrophysiology. Subsequently, we highlight the implications of genetic mutations that disrupt ion channel function, which are associated with inherited cardiac arrhythmias. Finally, we address antiarrhythmic drugs acting on cardiac ion channels respectively, according to their therapeutic targets. In conclusion, this manuscript aims to review the physiology, pathophysiology and pharmacology of the most prominent ventricular NaV, CaV, KV, and Kir ion channels.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 3","pages":"231-243"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Embracing a new era of echocardiography-guided percutaneous and non-fluoroscopical procedure for structure heart disease. 拥抱超声心动图引导下的经皮和非透视治疗结构性心脏病的新时代。

Medical review (Berlin, Germany) Pub Date : 2025-01-14 eCollection Date: 2025-04-01 DOI: 10.1515/mr-2024-0101

Jie Dong, Zeye Liu, Jing Dong, Fang Fang, Fengwen Zhang, Xiangbin Pan

{"title":"Embracing a new era of echocardiography-guided percutaneous and non-fluoroscopical procedure for structure heart disease.","authors":"Jie Dong, Zeye Liu, Jing Dong, Fang Fang, Fengwen Zhang, Xiangbin Pan","doi":"10.1515/mr-2024-0101","DOIUrl":"https://doi.org/10.1515/mr-2024-0101","url":null,"abstract":"The advancement of catheter-based interventional techniques represents a significant evolution in cardiovascular medicine. However, traditional methods that rely on fluoroscopic guidance present considerable limitations including radiation exposure and contrast agent-related risks and the heavy load-caused lead suits. In response, zero or low X-ray emerge, including percutaneous and non-fluoroscopical (PAN) procedure coming as a transformative solution, particularly in treating congenital heart disease, valvular disease, and arrhythmias. These methods minimize the risk of iatrogenic injuries associated with radiative procedures. Innovative PAN procedures and methodologies have been developed to enhance imaging, transcatheter interventions, safety, and accuracy, overcoming previous limitations. By eliminating radiation and expanding accessibility, PAN procedures offer a safe, effective, and economically viable alternative to traditional methods, ushering in a new era of minimally invasive cardiovascular treatment.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 2","pages":"174-176"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Yoga and chronic diseases: an umbrella review of systematic reviews and meta-analyses. 瑜伽和慢性疾病：系统综述和荟萃分析的总括性综述。

Medical review (Berlin, Germany) Pub Date : 2025-01-06 eCollection Date: 2025-06-01 DOI: 10.1515/mr-2024-0078

Feifei Wang, Wenchang Yang, Chen Wang, Kaiyue Wang, Zhongyi Yu, Dandan Ke, Liang Sun, Xiang Gao

{"title":"Yoga and chronic diseases: an umbrella review of systematic reviews and meta-analyses.","authors":"Feifei Wang, Wenchang Yang, Chen Wang, Kaiyue Wang, Zhongyi Yu, Dandan Ke, Liang Sun, Xiang Gao","doi":"10.1515/mr-2024-0078","DOIUrl":"10.1515/mr-2024-0078","url":null,"abstract":"Introduction: With the popularity of yoga increasing as a means to improve overall well-being, this umbrella review aimed to evaluate the potential effects of yoga on chronic disease outcomes by synthesizing previously published systematic reviews, including meta-analyses, of randomized controlled trials in adult populations.Content: PubMed, Scopus, Cochrane, Web of Science, and CINAHL for systematic reviews published up to 31st March 2023. Systematic reviews examining the effectiveness of yoga interventions compared with controllable groups on chronic disease outcomes were searched from adults aged above 18 years old. Fifty-one systematic reviews, of which 34 were with meta-analyses, were eligible. The included reviews yielded 579 individual studies with 28403 reported participants. Most studies (n=45, 86.5 %) were conducted with general adult participants, other six studies were with women diagnosed with breast cancer. Yoga interventions had strong effects on depression, blood pressure, blood glucose, and fatigue management, while weak evidence was found for pain management and arthritis.Summary: Yoga intervention may have an effect on improvements on depression, hypertension, type 2 diabetes, and fatigue management but not beneficial for physically disordered chronic diseases.Outlook: Future studies with larger sample sizes and longer durations are necessary to validate the effect of yoga on chornic diseases. Further exploration on yoga implementation are expected.Primary funding source: JIF201036Y and JIF201018Y (PROSPERO: CRD42023417841).","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 3","pages":"244-255"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selenium compounds for cancer prevention and therapy - human clinical trial considerations. 硒化合物对癌症的预防和治疗——人体临床试验的考虑。

Medical review (Berlin, Germany) Pub Date : 2025-01-06 eCollection Date: 2025-06-01 DOI: 10.1515/mr-2024-0065

Junxuan Lü, Cheng Jiang, Hongbo Hu

{"title":"Selenium compounds for cancer prevention and therapy - human clinical trial considerations.","authors":"Junxuan Lü, Cheng Jiang, Hongbo Hu","doi":"10.1515/mr-2024-0065","DOIUrl":"10.1515/mr-2024-0065","url":null,"abstract":"Selenium (Se) is an essential trace mineral crucial for human health. Nearly a dozen human clinical trials with seleno-methionine (SeMet) and selenized-yeast (contains mostly SeMet) for the prevention of non-cutaneous solid organ cancers in North America and European countries conclusively refuted their utility. We have articulated two lessons from these trials: (1) the anti-oxidant hypothesis was tested in inappropriate Se-adequate populations, and (2) the selection of these Se forms was not supported by cell culture and animal efficacy data. Nevertheless, preclinical studies of proximal methylselenol precursors (\"methyl Se\") have shown many desirable attributes, involving crucial molecules and pathways in cancer epithelial cells, vascular endothelial, immune and inflammatory cells in the tumor microenvironment, for potential use as chemopreventive and therapy agents. Methylseleninic acid and Se-methylselenocysteine are prototypical methyl-Se, yet not equal in their targets. Selenate, selenite and selenious acid had been recently studied in human clinical trials, providing novel safety data, but, missing critical genotoxicity assessments. Given the popularity of Se-enriched foods in China and a continued presence of nutritional Se deficiency in many localities, we discuss recommendations for clinical studies of Se forms for cancer therapy or chemoprevention in China and other countries with similar Se nutrition predicament.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 3","pages":"203-230"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When biomarkers for major depressive disorder remain elusive. 当重度抑郁症的生物标志物仍然难以捉摸时。

Medical review (Berlin, Germany) Pub Date : 2024-12-24 eCollection Date: 2025-04-01 DOI: 10.1515/mr-2024-0082

Yao Xiao, Fei Wang, Xizhe Zhang

引用次数: 0

Biomedical applications of organoids in genetic diseases. 类器官在遗传疾病中的生物医学应用。

Medical review (Berlin, Germany) Pub Date : 2024-12-24 eCollection Date: 2025-04-01 DOI: 10.1515/mr-2024-0077

Wenhua Huang, Seogsong Jeong, Won Kim, Lei Chen

{"title":"Biomedical applications of organoids in genetic diseases.","authors":"Wenhua Huang, Seogsong Jeong, Won Kim, Lei Chen","doi":"10.1515/mr-2024-0077","DOIUrl":"https://doi.org/10.1515/mr-2024-0077","url":null,"abstract":"Organoid technology has significantly transformed biomedical research by providing exceptional prospects for modeling human tissues and disorders in a laboratory setting. It has significant potential for understanding the intricate relationship between genetic mutations, cellular phenotypes, and disease pathology, especially in the field of genetic diseases. The intersection of organoid technology and genetic research offers great promise for comprehending the pathophysiology of genetic diseases and creating innovative treatment approaches customized for specific patients. This review aimed to present a thorough analysis of the current advancements in organoid technology and its biomedical applications for genetic diseases. We examined techniques for modeling genetic disorders using organoid platforms, analyze the approaches for incorporating genetic disease organoids into clinical practice, and showcase current breakthroughs in preclinical application, individualized healthcare, and transplantation. Through the integration of knowledge from several disciplines, such as genetics, regenerative medicine, and biological engineering, our aim is to enhance our comprehension of the complex connection between genetic variations and organoid models in relation to human health and disease.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 2","pages":"152-163"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune cells in Alzheimer's disease: insights into pathogenesis and potential therapeutic targets. 阿尔茨海默病的免疫细胞：对发病机制和潜在治疗靶点的见解。

Medical review (Berlin, Germany) Pub Date : 2024-12-23 eCollection Date: 2025-06-01 DOI: 10.1515/mr-2024-0064

Xiaofeng Fu, Huimin Cai, Shuiyue Quan, Ziye Ren, Yinghao Xu, Longfei Jia

{"title":"Immune cells in Alzheimer's disease: insights into pathogenesis and potential therapeutic targets.","authors":"Xiaofeng Fu, Huimin Cai, Shuiyue Quan, Ziye Ren, Yinghao Xu, Longfei Jia","doi":"10.1515/mr-2024-0064","DOIUrl":"10.1515/mr-2024-0064","url":null,"abstract":"Alzheimer's disease (AD) is a chronic neurodegenerative disorder for which there are currently no effective treatment options. Increasing evidence suggests that AD is a systemic disease closely associated with the immune system, not merely a central nervous system (CNS) disorder. Immune cells play crucial roles in the onset and progression of AD. Microglia and astrocytes are the primary inflammatory cells in the brain that can sensitively detect changes in the internal environment and transform into different phenotypes to exert differing effects at various stages of AD. Peripheral immune cells, such as T cells, B cells, monocytes/macrophages, and neutrophils can also be recruited to the CNS to mediate the inflammatory response in AD. As such, investigating the role of immune cells in AD is particularly important for elucidating its specific pathogenesis. This review primarily discusses the roles of central innate immune cells, peripheral immune cells, and the interactions between central and peripheral immune cells in the development of neuroinflammation in AD. Furthermore, we listed clinical trials targeting AD-associated neuroinflammation, which may represent a promising direction for developing effective treatments for AD in the future.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 3","pages":"179-202"},"PeriodicalIF":0.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histone lactylation as a driver of metabolic reprogramming and immune evasion. 组蛋白乳酸化是代谢重编程和免疫逃避的驱动因素。

Medical review (Berlin, Germany) Pub Date : 2024-12-17 eCollection Date: 2025-06-01 DOI: 10.1515/mr-2024-0091

Qiaoting Cai, Wei Deng, Yutian Zou, Zhe-Sheng Chen, Hailin Tang

{"title":"Histone lactylation as a driver of metabolic reprogramming and immune evasion.","authors":"Qiaoting Cai, Wei Deng, Yutian Zou, Zhe-Sheng Chen, Hailin Tang","doi":"10.1515/mr-2024-0091","DOIUrl":"10.1515/mr-2024-0091","url":null,"abstract":"Lactate is the end product of glycolysis, and extensive research has shown that lactate participates in various pathophysiological processes. Along with associated hydrogen ions, lactate typically functions as an immunosuppressive negative factor and plays a crucial role in tumor metabolic reprogramming. The recently discovered lactylation is a novel epigenetic modification that, similar to other epigenetic modifications, modifies histones to alter chromatin spatial configuration, thereby affecting DNA accessibility and regulating gene expression. More importantly, the degree of lactylation is closely related to local lactate concentrations, establishing a link between epigenetics and metabolic reprogramming. During cellular metabolism, lactate accumulation promotes histone lysine lactylation in cancer cells and immune cells such as macrophages and T cells, playing an essential role in tumor immune evasion and resistance to immunotherapy. This paper details the role of lactylation modifications in cancer immune evasion and resistance to immunotherapy, providing novel therapeutic directions and targets for cancer treatment.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 3","pages":"256-259"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of fragile X syndrome in South Asia, and importance of diagnosis. 脆性X染色体综合征在南亚的患病率和诊断的重要性。

Medical review (Berlin, Germany) Pub Date : 2024-11-29 eCollection Date: 2025-04-01 DOI: 10.1515/mr-2024-0060

Aminath Fazna, Randi Jenssen Hagerman

{"title":"Prevalence of fragile X syndrome in South Asia, and importance of diagnosis.","authors":"Aminath Fazna, Randi Jenssen Hagerman","doi":"10.1515/mr-2024-0060","DOIUrl":"https://doi.org/10.1515/mr-2024-0060","url":null,"abstract":"Fragile X syndrome (FXS) is a genetic disorder caused by a mutation in the FMR1 gene on the X chromosome, leading to a range of developmental and intellectual disabilities. FXS is characterized by intellectual disability, behavior challenges, and distinct physical features such as an elongated face, large ears, and hyperflexible joints; FXS remains the most common inherited cause of intellectual disability. Behavioral manifestations often include attention deficits, hyperactivity, anxiety, and features of autism spectrum disorder. The prevalence of FXS in the South Asian population is not well-documented, but existing studies suggest it may be comparable to global prevalence rates, which are approximately 1 in 4,000 males and 1 in 8,000 females. Accurate diagnosis of FXS in South Asians is crucial due to the implications for early intervention and treatment, which can significantly improve the quality of life and developmental outcomes for affected individuals. Early diagnosis also facilitates genetic counselling and family planning, helping to reduce the risk of recurrence in families. Increased awareness and screening in South Asian communities are essential to address the diagnostic gap and ensure timely support for individuals with FXS or disorders associated with the premutation of FMR1.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 2","pages":"164-173"},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0