Medical review (Berlin, Germany)最新文献

Spatio-temporal processes in autophagosome-lysosome fusion. 自噬体-溶酶体融合的时空过程。

Medical review (Berlin, Germany) Pub Date : 2025-06-19 eCollection Date: 2025-08-01 DOI: 10.1515/mr-2024-0095

Shizuo Liu, Huan Yan, Jiajie Diao, Shen Zhang, Qing Zhong

{"title":"Spatio-temporal processes in autophagosome-lysosome fusion.","authors":"Shizuo Liu, Huan Yan, Jiajie Diao, Shen Zhang, Qing Zhong","doi":"10.1515/mr-2024-0095","DOIUrl":"10.1515/mr-2024-0095","url":null,"abstract":"Macroautophagy/autophagy is a lysosome-dependent degradation process involved in cellular energy metabolism, recycling and quality control. Autophagy is a highly dynamic and precisely regulated process, which contains four major steps: autophagic membrane initiation and cargo recognition, autophagosome formation, autophagosome-lysosome fusion and lysosomal degradation. During the terminal phase of autophagy, the merging of the autophagosome and lysosome membranes is critical for the effective breakdown of sequestered cargoes. However, the participated molecules and the interplay among them have not been fully uncovered. The spatiotemporal property of these molecules is crucial for maintaining the orderly fusion of autophagosomes and lysosomes, otherwise it may lead to fusion disorders. In this article, we tend to summarize the molecules mediating autophagosome-lysosome fusion into two categories: effector molecules and regulatory molecules. The effector molecules are soluble N-ethylmaleimide-sensitive factor attachment protein receptor and tethering proteins, and the latter category contains phosphatidylinositol, Rab GTPases and ATG8-family proteins. The spatio-temporal properties of these autophagosome-lysosome fusion mediating molecules will be featured in this review.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 4","pages":"297-317"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can chimeric antigen receptors - based therapy bring a gleam of hope for thyroid-associated ophthalmopathy and other autoimmune diseases? 以嵌合抗原受体为基础的治疗能给甲状腺相关眼病和其他自身免疫性疾病带来一线希望吗？

Medical review (Berlin, Germany) Pub Date : 2025-04-14 eCollection Date: 2025-08-01 DOI: 10.1515/mr-2024-0099

Weiyi Zhou, Xinyu Zhu, Yongquan Shi

{"title":"Can chimeric antigen receptors - based therapy bring a gleam of hope for thyroid-associated ophthalmopathy and other autoimmune diseases?","authors":"Weiyi Zhou, Xinyu Zhu, Yongquan Shi","doi":"10.1515/mr-2024-0099","DOIUrl":"10.1515/mr-2024-0099","url":null,"abstract":"Thyroid-associated ophthalmopathy (TAO), also known as Graves' ophthalmopathy (GO) is an autoimmune disease (AD) with abnormal thyroid function typically. Currently, intravenous glucocorticoid therapy remains the first-line treatment for moderate-to-severe active TAO. Second-line treatments, including immunosuppressants and biological agents, are being explored in depth. However, like other ADs, the adverse effects of these therapies, little impact on long-term sequelae, and the irreversible progression of the disease remain significant limitations. As a result, the development of new therapeutic strategies for TAO is essential. Chimeric antigen receptors (CAR)-based adoptive cell therapy has emerged as an innovative approach for ADs treatment, capitalizing on its principles of genetically modifying immune cells to specifically target pathogenic cells. This approach aims to reduce autoimmune response or eliminate effective cells, CAR-based therapies of both T-cell-mediated and B-cell-mediated ADs have shown promising results in wide clinical trial. CAR-based therapy obviously become a rising star on refractory and relapsed ADs. TAO is no exception in terms of the potential for improvement through CAR-based therapy. However, the success of CAR-based therapy in TAO depends critically on identifying appropriate targets. Selected targets need to be coverage to ensure the therapeutic efficiency while specificity to preserve safety. Furthermore, the target cells must be relevant to the pathogenesis of TAO. Except target selection, adopting advanced and effective strategies for CAR design is also crucial. For example, dual-target approaches involving thyroid-stimulating hormone receptor (TSHR) or insulin-like growth factor-1 receptor (lGF-1R), off-the-shelf CAR-based cells, or leveraging artificial intelligence (Al) to predict optimal targets could enhance the specificity and effectiveness of CAR-based, therapies in TAO treatment.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 4","pages":"339-347"},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Target discovery-directed pharmacological mechanism elucidation of bioactive natural products. 靶点发现导向的生物活性天然产物的药理学机制阐明。

Medical review (Berlin, Germany) Pub Date : 2025-03-06 eCollection Date: 2025-08-01 DOI: 10.1515/mr-2024-0076

Zixuan Zhen, Lina Yin, Tingting Niu, Asma Rehman, Yang Liu, Kewu Zeng

{"title":"Target discovery-directed pharmacological mechanism elucidation of bioactive natural products.","authors":"Zixuan Zhen, Lina Yin, Tingting Niu, Asma Rehman, Yang Liu, Kewu Zeng","doi":"10.1515/mr-2024-0076","DOIUrl":"10.1515/mr-2024-0076","url":null,"abstract":"Natural products, the most important chemical library with magical structures and unique functions, have long been playing significant roles in contributing to the discovery of novel drugs. The complexity and diversity of natural products present great challenges regarding the exploration of their potential targets. Identifying the targets of natural products not only enhances our understanding of biological functions and molecular mechanisms, but also paves the way for discovering novel lead compounds for disease treatment. Recent advances in technologies like chemical biology, structural biology, and artificial intelligence have provided powerful tools for pinpointing natural product target and unraveling molecular mechanisms. This review aims to comprehensively summarize the innovative strategies employed in recent years to identify natural product targets, and evaluate their impact on biological pathways by modulating target functions for pharmacological effects. Moreover, we also discuss the challenges encountered in this field and outline future research prospects, aiming to offer guidance for researchers in natural product chemical biology.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 4","pages":"277-296"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From tumor immunity to precision medicine: the next step in B7-H3/CD276 research. 从肿瘤免疫到精准医疗：B7-H3/CD276研究的下一步

Medical review (Berlin, Germany) Pub Date : 2025-03-03 eCollection Date: 2025-06-01 DOI: 10.1515/mr-2025-0003

Haolie Fang, Yuqian Liu, Gege Wang, Heng-Jia Liu

引用次数: 0

Ventricular ion channels and arrhythmias: an overview of physiology, pathophysiology and pharmacology. 心室离子通道与心律失常：生理学、病理生理学和药理学综述。

Medical review (Berlin, Germany) Pub Date : 2025-03-03 eCollection Date: 2025-06-01 DOI: 10.1515/mr-2024-0085

Shiqi Liu, Wei Wang, Yang Yang, Zhuo Huang

{"title":"Ventricular ion channels and arrhythmias: an overview of physiology, pathophysiology and pharmacology.","authors":"Shiqi Liu, Wei Wang, Yang Yang, Zhuo Huang","doi":"10.1515/mr-2024-0085","DOIUrl":"10.1515/mr-2024-0085","url":null,"abstract":"Cardiac ion channels are critical transmembrane proteins that mediate almost all aspects of cardiac function including generation and propagation of cardiac action potential (AP) as well as maintenance of normal heart excitability and contraction. In addition, the pivotal role of cardiac ion channels in cardiac health and disease is underscored by the profound effects of their dysfunctional mutations on various arrhythmias. Hence, ion channels are vital targets for antiarrhythmic drugs. In this review, we first summarize the characteristics, structure of the various cardiac ion channels and their specific roles in cardiac electrophysiology. Subsequently, we highlight the implications of genetic mutations that disrupt ion channel function, which are associated with inherited cardiac arrhythmias. Finally, we address antiarrhythmic drugs acting on cardiac ion channels respectively, according to their therapeutic targets. In conclusion, this manuscript aims to review the physiology, pathophysiology and pharmacology of the most prominent ventricular NaV, CaV, KV, and Kir ion channels.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 3","pages":"231-243"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence-powered innovations in radiotherapy: boosting efficiency and efficacy. 人工智能驱动的放射治疗创新：提高效率和疗效。

Medical review (Berlin, Germany) Pub Date : 2025-02-28 eCollection Date: 2025-08-01 DOI: 10.1515/mr-2025-0007

Junyi Chen, Xinlin Zhu, Jian-Yue Jin, Feng-Ming Spring Kong, Gen Yang

引用次数: 0

The potential of generative AI with prostate-specific membrane antigen (PSMA) PET/CT: challenges and future directions. 前列腺特异性膜抗原（PSMA） PET/CT生成人工智能的潜力：挑战和未来方向。

Medical review (Berlin, Germany) Pub Date : 2025-01-24 eCollection Date: 2025-08-01 DOI: 10.1515/mr-2024-0086

Md Zobaer Islam, Ergi Spiro, Pew-Thian Yap, Michael A Gorin, Steven P Rowe

{"title":"The potential of generative AI with prostate-specific membrane antigen (PSMA) PET/CT: challenges and future directions.","authors":"Md Zobaer Islam, Ergi Spiro, Pew-Thian Yap, Michael A Gorin, Steven P Rowe","doi":"10.1515/mr-2024-0086","DOIUrl":"10.1515/mr-2024-0086","url":null,"abstract":"The diagnosis and prognosis of Prostate cancer (PCa) have undergone a significant transformation with the advent of prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) imaging. PSMA-PET imaging has demonstrated superior performance compared to conventional imaging methods by detecting PCa, its biochemical recurrence, and sites of metastasis with higher sensitivity and specificity. That transformation now intersects with rapid advances in artificial intelligence (AI) - including the emergence of generative AI. However, there are unique clinical challenges associated with PSMA-PET imaging that still need to be addressed to ensure its continued widespread integration into clinical care and research trials. Some of those challenges are the very wide dynamic range of lesion uptake, benign uptake in organs that may be adjacent to sites of disease, insufficient large datasets for training AI models, as well as artifacts in the images. Generative AI models, e.g., generative adversarial networks, variational autoencoders, diffusion models, and large language models have played crucial roles in overcoming many such challenges across various imaging modalities, including PET, computed tomography, magnetic resonance imaging, ultrasound, etc. In this review article, we delve into the potential role of generative AI in enhancing the robustness and widespread utilization of PSMA-PET imaging and image analysis, drawing insights from existing literature while also exploring current limitations and future directions in this domain.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 4","pages":"265-276"},"PeriodicalIF":0.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of 3D bioprinting for organoids. 类器官3D生物打印研究进展。

Medical review (Berlin, Germany) Pub Date : 2025-01-14 eCollection Date: 2025-08-01 DOI: 10.1515/mr-2024-0089

Zeqing Li, Long Chen, Jialin Wu, Yikang Chen, Yizhun Zhu, Gang Li, Guoxi Xie, Guosheng Tang, Maobin Xie

{"title":"A review of 3D bioprinting for organoids.","authors":"Zeqing Li, Long Chen, Jialin Wu, Yikang Chen, Yizhun Zhu, Gang Li, Guoxi Xie, Guosheng Tang, Maobin Xie","doi":"10.1515/mr-2024-0089","DOIUrl":"10.1515/mr-2024-0089","url":null,"abstract":"Current two-dimensional (2D) cell models for effective drug screening suffer from significant limitations imposed by the lack of realism in the physiological environment. Three-dimensional (3D) organoids models hold immense potential in mimicking the key functions of human organs by overcoming the limitations of traditional 2D cell models. However, current techniques for preparation of 3D organoids models had limitations in reproducibility, scalability, and the ability to closely replicate the complex microenvironment found in vivo. Additionally, traditional 3D cell culture systems often involve lengthy and labor-intensive processes that hinder high-throughput applications necessary for a large-scale drug screening. Advancements in 3D bioprinting technologies offer promising solutions to these challenges by enabling precise spatial control over cell placement and material composition, thereby facilitating the creation of more physiologically relevant organoids than current techniques. This review provides a comprehensive summary of recent advances in 3D bioprinting technologies for creating organoids models, which begins with an introduction to different types of 3D bioprinting techniques (especially focus on volumetric bioprinting (VBP) technique), followed by an overview of bioinks utilized for organoids bioprinting. Moreover, we also introduce the applications of 3D bioprinting organoids in disease models, drug efficiency evaluation and regenerative medicine. Finally, the challenges and possible strategies for the development and clinical translation of 3D bioprinting organoids are concluded.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 4","pages":"318-338"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Embracing a new era of echocardiography-guided percutaneous and non-fluoroscopical procedure for structure heart disease. 拥抱超声心动图引导下的经皮和非透视治疗结构性心脏病的新时代。

Medical review (Berlin, Germany) Pub Date : 2025-01-14 eCollection Date: 2025-04-01 DOI: 10.1515/mr-2024-0101

Jie Dong, Zeye Liu, Jing Dong, Fang Fang, Fengwen Zhang, Xiangbin Pan

{"title":"Embracing a new era of echocardiography-guided percutaneous and non-fluoroscopical procedure for structure heart disease.","authors":"Jie Dong, Zeye Liu, Jing Dong, Fang Fang, Fengwen Zhang, Xiangbin Pan","doi":"10.1515/mr-2024-0101","DOIUrl":"https://doi.org/10.1515/mr-2024-0101","url":null,"abstract":"The advancement of catheter-based interventional techniques represents a significant evolution in cardiovascular medicine. However, traditional methods that rely on fluoroscopic guidance present considerable limitations including radiation exposure and contrast agent-related risks and the heavy load-caused lead suits. In response, zero or low X-ray emerge, including percutaneous and non-fluoroscopical (PAN) procedure coming as a transformative solution, particularly in treating congenital heart disease, valvular disease, and arrhythmias. These methods minimize the risk of iatrogenic injuries associated with radiative procedures. Innovative PAN procedures and methodologies have been developed to enhance imaging, transcatheter interventions, safety, and accuracy, overcoming previous limitations. By eliminating radiation and expanding accessibility, PAN procedures offer a safe, effective, and economically viable alternative to traditional methods, ushering in a new era of minimally invasive cardiovascular treatment.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 2","pages":"174-176"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Yoga and chronic diseases: an umbrella review of systematic reviews and meta-analyses. 瑜伽和慢性疾病：系统综述和荟萃分析的总括性综述。

Medical review (Berlin, Germany) Pub Date : 2025-01-06 eCollection Date: 2025-06-01 DOI: 10.1515/mr-2024-0078

Feifei Wang, Wenchang Yang, Chen Wang, Kaiyue Wang, Zhongyi Yu, Dandan Ke, Liang Sun, Xiang Gao

{"title":"Yoga and chronic diseases: an umbrella review of systematic reviews and meta-analyses.","authors":"Feifei Wang, Wenchang Yang, Chen Wang, Kaiyue Wang, Zhongyi Yu, Dandan Ke, Liang Sun, Xiang Gao","doi":"10.1515/mr-2024-0078","DOIUrl":"10.1515/mr-2024-0078","url":null,"abstract":"Introduction: With the popularity of yoga increasing as a means to improve overall well-being, this umbrella review aimed to evaluate the potential effects of yoga on chronic disease outcomes by synthesizing previously published systematic reviews, including meta-analyses, of randomized controlled trials in adult populations.Content: PubMed, Scopus, Cochrane, Web of Science, and CINAHL for systematic reviews published up to 31st March 2023. Systematic reviews examining the effectiveness of yoga interventions compared with controllable groups on chronic disease outcomes were searched from adults aged above 18 years old. Fifty-one systematic reviews, of which 34 were with meta-analyses, were eligible. The included reviews yielded 579 individual studies with 28403 reported participants. Most studies (n=45, 86.5 %) were conducted with general adult participants, other six studies were with women diagnosed with breast cancer. Yoga interventions had strong effects on depression, blood pressure, blood glucose, and fatigue management, while weak evidence was found for pain management and arthritis.Summary: Yoga intervention may have an effect on improvements on depression, hypertension, type 2 diabetes, and fatigue management but not beneficial for physically disordered chronic diseases.Outlook: Future studies with larger sample sizes and longer durations are necessary to validate the effect of yoga on chornic diseases. Further exploration on yoga implementation are expected.Primary funding source: JIF201036Y and JIF201018Y (PROSPERO: CRD42023417841).","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 3","pages":"244-255"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0