Medical review (Berlin, Germany)最新文献

Biofluid biomarkers for Alzheimer's disease: past, present, and future. 阿尔茨海默病的生物流体生物标志物：过去、现在和未来。

Medical review (Berlin, Germany) Pub Date : 2024-10-17 eCollection Date: 2024-12-01 DOI: 10.1515/mr-2023-0071

Chengyu An, Huimin Cai, Ziye Ren, Xiaofeng Fu, Shuiyue Quan, Longfei Jia

{"title":"Biofluid biomarkers for Alzheimer's disease: past, present, and future.","authors":"Chengyu An, Huimin Cai, Ziye Ren, Xiaofeng Fu, Shuiyue Quan, Longfei Jia","doi":"10.1515/mr-2023-0071","DOIUrl":"10.1515/mr-2023-0071","url":null,"abstract":"Alzheimer's disease (AD) is a gradually progressive neurodegenerative disease with tremendous social and economic burden. Therefore, early and accurate diagnosis is imperative for effective treatment or prevention of the disease. Cerebrospinal fluid and blood biomarkers emerge as favorable diagnostic tools due to their relative accessibility and potential for widespread clinical use. This review focuses on the AT(N) biomarker system, which includes biomarkers reflecting AD core pathologies, amyloid deposition, and pathological tau, as well as neurodegeneration. Novel biomarkers associated with inflammation/immunity, synaptic dysfunction, vascular pathology, and α-synucleinopathy, which might contribute to either the pathogenesis or the clinical progression of AD, have also been discussed. Other emerging candidates including non-coding RNAs, metabolites, and extracellular vesicle-based markers have also enriched the biofluid biomarker landscape for AD. Moreover, the review discusses the current challenges of biofluid biomarkers in AD diagnosis and offers insights into the prospective future development.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"4 6","pages":"467-491"},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microplastic exposure is associated with male reproductive health. 接触微塑料与男性生殖健康有关。

Medical review (Berlin, Germany) Pub Date : 2024-10-17 eCollection Date: 2024-12-01 DOI: 10.1515/mr-2024-0069

Weijia Liu, Zhi Qu, Xuemei Wang, Huailiang Feng, Shaohua Ma, Yichao Zheng, Guimiao Lin, Suli Huang, Qiming Yang, Xihua Feng, Tianling Shen, Nan Liu

引用次数: 0

A stepwise approach to deriving functional β-cells from human embryonic or induced pluripotent stem cells.

Medical review (Berlin, Germany) Pub Date : 2024-10-16 eCollection Date: 2025-02-01 DOI: 10.1515/mr-2024-0039

Clara Farhat, Viktoria Xega, Jun-Li Liu

{"title":"A stepwise approach to deriving functional β-cells from human embryonic or induced pluripotent stem cells.","authors":"Clara Farhat, Viktoria Xega, Jun-Li Liu","doi":"10.1515/mr-2024-0039","DOIUrl":"10.1515/mr-2024-0039","url":null,"abstract":"Our understanding of β-cell differentiation from pluripotent stem cells (PSCs) is rapidly evolving. Although progress has been made, challenges remain, particularly in achieving glucose-stimulated insulin secretion (GSIS). Human embryonic stem cells (hESCs) are valuable due to their pluripotent ability. A fixed protocol targeting master regulatory genes initiates stem cells into pancreatic lineage commitment. Due to the observations that a single stem cell can differentiate into multiple cell types depending on various factors and conditions, non-linear differentiation pathways exist. Co-expression of key factors remains essential for successful β-cell differentiation. The mature β-cell marker MAFA plays a critical role in maintaining the differentiation state and preventing dedifferentiation. Recapitulating pancreatic islet clustering enhances physiological responses, offering potential avenues for diabetes treatment. On the other hand, several enhanced differentiation protocols from induced pluripotent stem cells (iPSCs) have improved the functional insulin producing β-cells generated. These findings, with their potential to revolutionize diabetes treatment, highlight the complexity of β-cell differentiation and guide further advancements in regenerative medicine.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 1","pages":"23-34"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision phototherapy and imaging with aggregation-induced emission-based nanoparticles cloaked in macrophage membrane.

Medical review (Berlin, Germany) Pub Date : 2024-09-26 eCollection Date: 2025-02-01 DOI: 10.1515/mr-2024-0041

Quazi T H Shubhra, Laiping Fang, A K M Moshiul Alam

引用次数: 0

Combining transcriptomic and metabolomic insights to guide the clinical application of adipose- and bone marrow-derived mesenchymal stem cells.

Medical review (Berlin, Germany) Pub Date : 2024-08-29 eCollection Date: 2025-02-01 DOI: 10.1515/mr-2024-0056

Wenyan Zhou, Junxin Lin, David C Hay, Xudong Yao, Hongwei Ouyang

{"title":"Combining transcriptomic and metabolomic insights to guide the clinical application of adipose- and bone marrow-derived mesenchymal stem cells.","authors":"Wenyan Zhou, Junxin Lin, David C Hay, Xudong Yao, Hongwei Ouyang","doi":"10.1515/mr-2024-0056","DOIUrl":"10.1515/mr-2024-0056","url":null,"abstract":"Adipose-derived mesenchymal stem cells (ADSCs) and bone marrow-derived mesenchymal stem cells (BMSCs) have shown great potential in clinical applications. However, the similarities and differences between these two cell types have not been fully elucidated. Recent advances in transcriptomic and metabolomic research have provided valuable insight into the characteristics and functions of ADSCs and BMSCs. In this perspective article, we review the key findings from these studies, including cellular heterogeneity as well as differences in metabolic and secretory properties. We discuss how these insights can help guide the selection of the most suitable cell source for the clinic, and the optimization of preconditioning strategies prior to clinical deployment. Furthermore, we analyze the current landscape of products and clinical trials involving ADSCs and BMSCs, highlighting their therapeutic potential. We propose that the integration of multi-omics datasets will be crucial for establishing a comprehensive understanding of ADSC and BMSC identity and potency, and the provision of quality-assured stem cell-derived products for the clinic.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 1","pages":"76-82"},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redefining chronic mountain sickness: insights from high-altitude research and clinical experience.

Medical review (Berlin, Germany) Pub Date : 2024-08-27 eCollection Date: 2025-02-01 DOI: 10.1515/mr-2024-0036

Gustavo Zubieta-Calleja

引用次数: 0

Mechanical force modulates inflammation and immunomodulation in periodontal ligament cells. 机械力调节牙周韧带细胞的炎症和免疫调节。

Medical review (Berlin, Germany) Pub Date : 2024-08-13 eCollection Date: 2024-12-01 DOI: 10.1515/mr-2024-0034

Jira Chansaenroj, Ravipha Suwittayarak, Hiroshi Egusa, Lakshman P Samaranayake, Thanaphum Osathanon

{"title":"Mechanical force modulates inflammation and immunomodulation in periodontal ligament cells.","authors":"Jira Chansaenroj, Ravipha Suwittayarak, Hiroshi Egusa, Lakshman P Samaranayake, Thanaphum Osathanon","doi":"10.1515/mr-2024-0034","DOIUrl":"10.1515/mr-2024-0034","url":null,"abstract":"Mechanical forces control a multitude of biological responses in various cells and tissues. The periodontal ligament, located between the tooth's root and alveolar bone, is a major tissue compartment that is incessantly subjected to such mechanical stimulation through either normal or abnormal oral functionality. It is now known that mechanical stimulation activates periodontal ligament stem cells (PDLSCs) to modulate periodontal immunity and regulate inflammation - a basic feature of periodontal disease that affects virtually every human during their lifetime. For instance, shear stress induces the expression of immunomodulatory-related gene, indoleamine 2,3-dioxygenase (IDO). IDO cleaves l-tryptophan, resulting in increased l-kynurenine levels that, in turn, further promote regulatory T-cell differentiation and inhibit T cell proliferation. These and other related data reinforce the notion that mechanical stimulation plays a crucial role in controlling inflammation and immunomodulation of periodontal tissues. Further investigations, however, are warranted to evaluate the immunomodulatory features of PDLSCs so as to understand the pathological basis of periodontal disease and translate these into clinical interventions.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"4 6","pages":"544-548"},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new year, a renewed dedication: greetings from Medical Review. 新的一年，新的奉献：来自《医学评论》的问候。

Medical review (Berlin, Germany) Pub Date : 2024-03-11 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2024-0015

Qimin Zhan, Zhengwei Xie

引用次数: 0

The complex interplay between aging and cancer: unraveling the clues. 衰老与癌症之间复杂的相互作用：揭开谜底。

Medical review (Berlin, Germany) Pub Date : 2024-03-08 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2024-0014

Zhengwei Xie, Qimin Zhan

引用次数: 0

Therapeutic robots for post-stroke rehabilitation. 用于中风后康复的治疗机器人。

Medical review (Berlin, Germany) Pub Date : 2024-02-27 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2023-0054

Ronghua Hong, Bingyu Li, Yunjun Bao, Lingyu Liu, Lingjing Jin

引用次数: 0