Medical review (Berlin, Germany)最新文献

The Huchang-Barrier framework: an integrative perspective on the spatial features of the tumor invasive front. 湖昌屏障框架：肿瘤侵袭前沿空间特征的综合视角。

Medical review (Berlin, Germany) Pub Date : 2026-07-27 eCollection Date: 2026-08-01 DOI: 10.1515/mr-2026-0037

Dan Xie, Zexing Li, Jinghua Li, Kaiwen Hu

{"title":"The Huchang-Barrier framework: an integrative perspective on the spatial features of the tumor invasive front.","authors":"Dan Xie, Zexing Li, Jinghua Li, Kaiwen Hu","doi":"10.1515/mr-2026-0037","DOIUrl":"10.1515/mr-2026-0037","url":null,"abstract":"The tumor invasive front is a critical interface for tumor-host interactions that impacts patient prognosis. Although the tumor-node-metastasis (TNM) staging system and single-parameter assessments such as tumor budding, T-cell density, tertiary lymphoid structures (TLS), and stromal features provide important prognostic information, they capture only partial aspects of this spatially organized tumor-host interface. Inspired by the traditional Chinese medicine concept of \"Huchang\", used here as a metaphorical descriptor of host-protective organization at the tumor boundary, and informed by recent advances in spatial immunology, we propose the Huchang-Barrier (HB) framework. HB conceptualizes the invasive front as a dynamic tumor-host interface whose biological state is determined by the balance between tumor invasive burden and host physical/tissue and spatial immune barriers. Unlike fixed single-marker scores or tumor-type-specific microenvironmental indices, HB integrates three conserved functional elements while allowing cancer-adapted readouts, thereby providing a modular framework for evaluating the invasion-barrier balance at the invasive front. To improve operability, we outline a two-tier assessment strategy and provide a minimal executable HB-Standard example in resected non-small cell lung cancer (NSCLC). The HB framework is proposed as a hypothesis-generating spatial pathology model that requires retrospective calibration, independent validation, and prospective testing before clinical implementation.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"6 4","pages":"354-358"},"PeriodicalIF":0.0,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolution of malignant tumors as neoorgan and predictions of future scenarios resulting from inappropriate treatment. 恶性肿瘤作为新器官的演变和不适当治疗导致的未来情景的预测。

Medical review (Berlin, Germany) Pub Date : 2026-07-16 eCollection Date: 2026-08-01 DOI: 10.1515/mr-2026-0026

Qianqian Chen, Shuai Tian, Enqiang Linghu

{"title":"Evolution of malignant tumors as neoorgan and predictions of future scenarios resulting from inappropriate treatment.","authors":"Qianqian Chen, Shuai Tian, Enqiang Linghu","doi":"10.1515/mr-2026-0026","DOIUrl":"10.1515/mr-2026-0026","url":null,"abstract":"Malignant tumors have long been viewed as uncontrolled cell proliferation driven by somatic mutations. However, emerging multi-omics and microenvironment evidence challenges this paradigm. Advanced tumors transcend cellular abnormality to form a \"neoorgan\" - a complex tissue ecosystem with multicellular coordination, functional autonomy, metabolic symbiosis, neural integration, and evolutionary potential. Genomic instability generates lineage-specific karyotypes; tumors reactivate ancient gene modules from primitive multicellular organisms; they actively remodel immune function via mitochondrial transfer; and they establish functional connections with the nervous system. Based on this evolutionary trajectory, we propose testable predictions: tumors may progress from a parasitic neoorgan toward an independent species, as exemplified by naturally occurring transmissible tumors and the \"tumor-derived animal\" hypothesis. Recognizing cancer as an evolutionary entity striving for independence - rather than a mere genetic malfunction - demands a fundamental shift in therapeutic strategy. Instead of solely cytotoxic \"killing\", rational approaches may aim to reintegrate the tumor into host regulatory networks or guide its evolution toward self-destruction. This framework expands tumor biology and challenges conventional boundaries between disease, life, and species.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"6 4","pages":"347-350"},"PeriodicalIF":0.0,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gaseous biomarkers speak medical conditions. 气体生物标志物能说明医疗状况。

Medical review (Berlin, Germany) Pub Date : 2026-07-06 eCollection Date: 2026-08-01 DOI: 10.1515/mr-2026-0033

Chenyu Zhu, Huaying Liu, Maosheng Yao

引用次数: 0

Immune reset: what do we learn from bone marrow transplantation. 免疫重置：我们从骨髓移植中学到了什么？

Medical review (Berlin, Germany) Pub Date : 2026-06-16 eCollection Date: 2026-08-01 DOI: 10.1515/mr-2026-0021

Huidong Guo, Xiao-Jun Huang

{"title":"Immune reset: what do we learn from bone marrow transplantation.","authors":"Huidong Guo, Xiao-Jun Huang","doi":"10.1515/mr-2026-0021","DOIUrl":"10.1515/mr-2026-0021","url":null,"abstract":"Bone marrow transplantation (BMT) has traditionally been viewed as a curative strategy for hematologic malignancies through replacement of the diseased hematopoietic system. However, accumulating evidence indicates that BMT represents a far more profound biological process: an enforced collapse and subsequent reconstruction of the hematopoietic and immune system. This process provides a unique human model to investigate how immune homeostasis can be reprogrammed beyond physiological conditions. Importantly, post-transplant immunity does not revert to a pre-existing state but instead converges on a newly defined equilibrium shaped by conditioning-induced injury, donor-recipient immune interactions, stromal regeneration, and therapeutic interventions. In this review, we conceptualize BMT as an immune reset and synthesize emerging insights into the mechanisms that govern tolerance reinstallation and immune stability after transplantation. By reframing BMT as a model of immune reset rather than simple immune reconstitution, we highlight general principles of immune homeostasis restoration that extend beyond transplantation and may inform therapeutic strategies for autoimmunity, immune aging, and immune-mediated diseases.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"6 4","pages":"273-286"},"PeriodicalIF":0.0,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut mucosal barrier: the frontline of bidirectional regulation of the gut-X axis. 肠黏膜屏障：肠- x轴双向调节的前线。

Medical review (Berlin, Germany) Pub Date : 2026-06-08 eCollection Date: 2026-08-01 DOI: 10.1515/mr-2026-0009

Xiang Xu, Yaowen Hu, Shuaizhi Ruan, Cheng Peng, Taotao Han, Pengguang Yan, Francis Ka Leung Chan, Jingnan Li

{"title":"Gut mucosal barrier: the frontline of bidirectional regulation of the gut-X axis.","authors":"Xiang Xu, Yaowen Hu, Shuaizhi Ruan, Cheng Peng, Taotao Han, Pengguang Yan, Francis Ka Leung Chan, Jingnan Li","doi":"10.1515/mr-2026-0009","DOIUrl":"10.1515/mr-2026-0009","url":null,"abstract":"While maintaining absorption and physiological exchange, the gut mucosal barrier prevents microorganisms and their products from freely entering tissues and blood vessels. Therefore, its functional state can affect signals transmitted to distal organs. This review defines the gut-X axis as bidirectional communication between the intestine and extraintestinal systems, and points the intestinal barrier as a selective gatekeeper that regulates thresholds and amplifies gut-derived information flow. We summarize barrier organization, the renewal and repair mechanism to maintain the epithelial integrity under persistent exposure. We then integrate factors shaping barrier steady state, including diet, microbial metabolites, host factors and drugs. Next, we explained how barrier-regulated signal outputs disseminate through immune inflammatory mediators, neural pathways and endocrine metabolic signals, and analyzed how reverse regulation by the brain, liver, lungs and systemic metabolic state reshapes barrier responses. In neuropsychiatric, hepatic, pulmonary, and endocrine metabolic diseases, we focus on the positive feedback cycle, heterogeneity, and the ambiguity in causal direction, and evaluate treatment strategies, covering dietary intervention, microbiota-directed therapies including fecal microbiota transplantation (FMT), and pharmacologic or immunologic methods. Progress will rely on standardized intestinal barrier indicators longitudinal research design to clarify temporal relationship, and hierarchical intervention tests to verify barrier-centered causal hypotheses.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"6 4","pages":"287-324"},"PeriodicalIF":0.0,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current status, development and challenges in the treatment of chronic graft-versus-host disease. 慢性移植物抗宿主病治疗的现状、发展和挑战。

Medical review (Berlin, Germany) Pub Date : 2026-06-03 eCollection Date: 2026-06-01 DOI: 10.1515/mr-2026-0030

Hongru Chen, Xiaodong Mo

引用次数: 0

Endogenous jaw bone regeneration: past, present, and future. 内源性颌骨再生：过去、现在和未来。

Medical review (Berlin, Germany) Pub Date : 2026-06-01 DOI: 10.1515/mr-2026-0016

Zhuoran Xu, Wenjie Zhang

引用次数: 0

Proactive personalized early warning systems: the next frontier in climate-health preparedness. 主动个性化预警系统：气候卫生防范的下一个前沿领域。

Medical review (Berlin, Germany) Pub Date : 2026-05-28 eCollection Date: 2026-06-01 DOI: 10.1515/mr-2026-0028

Tao Liu, Hejie Wang, Cunrui Huang, Tiantian Li

引用次数: 0

Advances in pharmacotherapy for fibrotic interstitial lung disease. 纤维化间质性肺疾病的药物治疗进展。

Medical review (Berlin, Germany) Pub Date : 2026-05-11 eCollection Date: 2026-08-01 DOI: 10.1515/mr-2025-0086

Xiaoguo Feng, Mingming Deng, Jinrui Miao, Ziwen Zheng, Gang Hou

引用次数: 0

Mother-to-offspring microbial vertical transmission: timing, determinants, and impact on offspring susceptibility to gastrointestinal diseases. 母婴微生物垂直传播：时间、决定因素和对后代胃肠道疾病易感性的影响。

Medical review (Berlin, Germany) Pub Date : 2026-05-04 eCollection Date: 2026-06-01 DOI: 10.1515/mr-2026-0008

Ruqiao Duan, Kun Wang, Liping Duan

{"title":"Mother-to-offspring microbial vertical transmission: timing, determinants, and impact on offspring susceptibility to gastrointestinal diseases.","authors":"Ruqiao Duan, Kun Wang, Liping Duan","doi":"10.1515/mr-2026-0008","DOIUrl":"10.1515/mr-2026-0008","url":null,"abstract":"The establishment of the early-life microbiota is profoundly shaped by microbial vertical transmission from mother to offspring. This review synthesized the current understanding of the timing, determinants, and health implications of mother-to-offspring microbial vertical transmission. We detailed the contentious evidence regarding prenatal microbial transmission and highlighted the well-established roles of intrapartum and postnatal transmission via birth and breastfeeding, respectively. Multiple factors, including delivery mode, gestational age, feeding patterns and antibiotic exposure, are critical modulators of microbial transmission, shaping the initial microbial community. Emerging intervention strategies, such as breastfeeding, probiotic supplementation, vaginal microbiota transplantation, and fecal microbiota transplantation, offer promising avenues for restoring a healthy microbial trajectory when natural transmission is disrupted. This review underscores that vertical transmission is the cornerstone of intergenerational microbiome inheritance and a potential therapeutic target for preventing early-life dysbiosis and associated diseases.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"6 3","pages":"243-261"},"PeriodicalIF":0.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0