Medical review (Berlin, Germany)最新文献_第2页

Biofluid biomarkers for Alzheimer's disease: past, present, and future. 阿尔茨海默病的生物流体生物标志物：过去、现在和未来。

Medical review (Berlin, Germany) Pub Date : 2024-10-17 eCollection Date: 2024-12-01 DOI: 10.1515/mr-2023-0071

Chengyu An, Huimin Cai, Ziye Ren, Xiaofeng Fu, Shuiyue Quan, Longfei Jia

{"title":"Biofluid biomarkers for Alzheimer's disease: past, present, and future.","authors":"Chengyu An, Huimin Cai, Ziye Ren, Xiaofeng Fu, Shuiyue Quan, Longfei Jia","doi":"10.1515/mr-2023-0071","DOIUrl":"10.1515/mr-2023-0071","url":null,"abstract":"Alzheimer's disease (AD) is a gradually progressive neurodegenerative disease with tremendous social and economic burden. Therefore, early and accurate diagnosis is imperative for effective treatment or prevention of the disease. Cerebrospinal fluid and blood biomarkers emerge as favorable diagnostic tools due to their relative accessibility and potential for widespread clinical use. This review focuses on the AT(N) biomarker system, which includes biomarkers reflecting AD core pathologies, amyloid deposition, and pathological tau, as well as neurodegeneration. Novel biomarkers associated with inflammation/immunity, synaptic dysfunction, vascular pathology, and α-synucleinopathy, which might contribute to either the pathogenesis or the clinical progression of AD, have also been discussed. Other emerging candidates including non-coding RNAs, metabolites, and extracellular vesicle-based markers have also enriched the biofluid biomarker landscape for AD. Moreover, the review discusses the current challenges of biofluid biomarkers in AD diagnosis and offers insights into the prospective future development.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"4 6","pages":"467-491"},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microplastic exposure is associated with male reproductive health. 接触微塑料与男性生殖健康有关。

Medical review (Berlin, Germany) Pub Date : 2024-10-17 eCollection Date: 2024-12-01 DOI: 10.1515/mr-2024-0069

Weijia Liu, Zhi Qu, Xuemei Wang, Huailiang Feng, Shaohua Ma, Yichao Zheng, Guimiao Lin, Suli Huang, Qiming Yang, Xihua Feng, Tianling Shen, Nan Liu

引用次数: 0

A stepwise approach to deriving functional β-cells from human embryonic or induced pluripotent stem cells. 从人胚胎或诱导多能干细胞中逐步获得功能性β细胞的方法。

Medical review (Berlin, Germany) Pub Date : 2024-10-16 eCollection Date: 2025-02-01 DOI: 10.1515/mr-2024-0039

Clara Farhat, Viktoria Xega, Jun-Li Liu

{"title":"A stepwise approach to deriving functional β-cells from human embryonic or induced pluripotent stem cells.","authors":"Clara Farhat, Viktoria Xega, Jun-Li Liu","doi":"10.1515/mr-2024-0039","DOIUrl":"10.1515/mr-2024-0039","url":null,"abstract":"Our understanding of β-cell differentiation from pluripotent stem cells (PSCs) is rapidly evolving. Although progress has been made, challenges remain, particularly in achieving glucose-stimulated insulin secretion (GSIS). Human embryonic stem cells (hESCs) are valuable due to their pluripotent ability. A fixed protocol targeting master regulatory genes initiates stem cells into pancreatic lineage commitment. Due to the observations that a single stem cell can differentiate into multiple cell types depending on various factors and conditions, non-linear differentiation pathways exist. Co-expression of key factors remains essential for successful β-cell differentiation. The mature β-cell marker MAFA plays a critical role in maintaining the differentiation state and preventing dedifferentiation. Recapitulating pancreatic islet clustering enhances physiological responses, offering potential avenues for diabetes treatment. On the other hand, several enhanced differentiation protocols from induced pluripotent stem cells (iPSCs) have improved the functional insulin producing β-cells generated. These findings, with their potential to revolutionize diabetes treatment, highlight the complexity of β-cell differentiation and guide further advancements in regenerative medicine.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 1","pages":"23-34"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision phototherapy and imaging with aggregation-induced emission-based nanoparticles cloaked in macrophage membrane. 巨噬细胞膜中聚集诱导发射纳米粒子的精密光疗和成像。

Medical review (Berlin, Germany) Pub Date : 2024-09-26 eCollection Date: 2025-02-01 DOI: 10.1515/mr-2024-0041

Quazi T H Shubhra, Laiping Fang, A K M Moshiul Alam

引用次数: 0

Emerging magic bullet: subcellular organelle-targeted cancer therapy. 新兴的灵丹妙药：亚细胞细胞器靶向癌症治疗。

Medical review (Berlin, Germany) Pub Date : 2024-09-12 eCollection Date: 2025-04-01 DOI: 10.1515/mr-2024-0044

Yue Yan, Yimeng Zhang, Jianxiong Liu, Binlong Chen, Yiguang Wang

{"title":"Emerging magic bullet: subcellular organelle-targeted cancer therapy.","authors":"Yue Yan, Yimeng Zhang, Jianxiong Liu, Binlong Chen, Yiguang Wang","doi":"10.1515/mr-2024-0044","DOIUrl":"https://doi.org/10.1515/mr-2024-0044","url":null,"abstract":"The therapeutic efficacy of anticancer drugs heavily relies on their concentration and retention at the corresponding target site. Hence, merely increasing the cellular concentration of drugs is insufficient to achieve satisfactory therapeutic outcomes, especially for the drugs that target specific intracellular sites. This necessitates the implementation of more precise targeting strategies to overcome the limitations posed by diffusion distribution and nonspecific interactions within cells. Consequently, subcellular organelle-targeted cancer therapy, characterized by its exceptional precision, have emerged as a promising approach to eradicate cancer cells through the specific disruption of subcellular organelles. Owing to several advantages including minimized dosage and side effect, optimized efficacy, and reversal of multidrug resistance, subcellular organelle-targeted therapies have garnered significant research interest in recent years. In this review, we comprehensively summarize the distribution of drug targets, targeted delivery strategies at various levels, and sophisticated strategies for targeting specific subcellular organelles. Additionally, we highlight the significance of subcellular targeting in cancer therapy and present essential considerations for its clinical translation.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 2","pages":"117-138"},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic advances in neurodevelopmental disorders. 神经发育障碍的遗传研究进展。

Medical review (Berlin, Germany) Pub Date : 2024-09-03 eCollection Date: 2025-04-01 DOI: 10.1515/mr-2024-0040

Shilin Gao, Chaoyi Shan, Rong Zhang, Tianyun Wang

{"title":"Genetic advances in neurodevelopmental disorders.","authors":"Shilin Gao, Chaoyi Shan, Rong Zhang, Tianyun Wang","doi":"10.1515/mr-2024-0040","DOIUrl":"https://doi.org/10.1515/mr-2024-0040","url":null,"abstract":"Neurodevelopmental disorders (NDDs) are a group of highly heterogeneous diseases that affect children's social, cognitive, and emotional functioning. The etiology is complicated with genetic factors playing an important role. During the past decade, large-scale whole exome sequencing (WES) and whole genome sequencing (WGS) have vastly advanced the genetic findings of NDDs. Various forms of variants have been reported to contribute to NDDs, such as de novo mutations (DNMs), copy number variations (CNVs), rare inherited variants (RIVs), and common variation. By far, over 200 high-risk NDD genes have been identified, which are involved in biological processes including synaptic function, transcriptional and epigenetic regulation. In addition, monogenic, oligogenic, polygenetic, and omnigenic models have been proposed to explain the genetic architecture of NDDs. However, the majority of NDD patients still do not have a definitive genetic diagnosis. In the future, more types of risk factors, as well as noncoding variants, are await to be identified, and including their interplay mechanisms are key to resolving the etiology and heterogeneity of NDDs.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 2","pages":"139-151"},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combining transcriptomic and metabolomic insights to guide the clinical application of adipose- and bone marrow-derived mesenchymal stem cells. 结合转录组学和代谢组学的见解来指导脂肪和骨髓来源的间充质干细胞的临床应用。

Medical review (Berlin, Germany) Pub Date : 2024-08-29 eCollection Date: 2025-02-01 DOI: 10.1515/mr-2024-0056

Wenyan Zhou, Junxin Lin, David C Hay, Xudong Yao, Hongwei Ouyang

{"title":"Combining transcriptomic and metabolomic insights to guide the clinical application of adipose- and bone marrow-derived mesenchymal stem cells.","authors":"Wenyan Zhou, Junxin Lin, David C Hay, Xudong Yao, Hongwei Ouyang","doi":"10.1515/mr-2024-0056","DOIUrl":"10.1515/mr-2024-0056","url":null,"abstract":"Adipose-derived mesenchymal stem cells (ADSCs) and bone marrow-derived mesenchymal stem cells (BMSCs) have shown great potential in clinical applications. However, the similarities and differences between these two cell types have not been fully elucidated. Recent advances in transcriptomic and metabolomic research have provided valuable insight into the characteristics and functions of ADSCs and BMSCs. In this perspective article, we review the key findings from these studies, including cellular heterogeneity as well as differences in metabolic and secretory properties. We discuss how these insights can help guide the selection of the most suitable cell source for the clinic, and the optimization of preconditioning strategies prior to clinical deployment. Furthermore, we analyze the current landscape of products and clinical trials involving ADSCs and BMSCs, highlighting their therapeutic potential. We propose that the integration of multi-omics datasets will be crucial for establishing a comprehensive understanding of ADSC and BMSC identity and potency, and the provision of quality-assured stem cell-derived products for the clinic.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 1","pages":"76-82"},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redefining chronic mountain sickness: insights from high-altitude research and clinical experience. 重新定义慢性高原病：来自高海拔研究和临床经验的见解。

Medical review (Berlin, Germany) Pub Date : 2024-08-27 eCollection Date: 2025-02-01 DOI: 10.1515/mr-2024-0036

Gustavo Zubieta-Calleja

引用次数: 0

Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries. 抗菌、再矿化和渗透：阻断龋齿的先进策略。

Medical review (Berlin, Germany) Pub Date : 2024-08-23 eCollection Date: 2025-04-01 DOI: 10.1515/mr-2024-0035

Qingyi Yang, Fan Li, Yangyang Ye, Xu Zhang

{"title":"Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries.","authors":"Qingyi Yang, Fan Li, Yangyang Ye, Xu Zhang","doi":"10.1515/mr-2024-0035","DOIUrl":"https://doi.org/10.1515/mr-2024-0035","url":null,"abstract":"Dental caries, driven by plaque biofilm, poses a major oral health challenge due to imbalance in mineralization and demineralization. The primary objective in caries management is to maintain biofilm homeostasis while facilitating the repair and regeneration of dental hard tissues, thus restoring both structural integrity and functionality of affected teeth. Though antimicrobial and remineralization approaches haven shown promise, their standalone utilization without concurrent bacterial control or rebalancing lacks an integrated strategy to effectively arrest caries progression. Furthermore, according to the principles of minimally invasive dentistry, treatment materials should exhibit high permeability to ensure optimal sealing of demineralized tooth surfaces. The concept of interrupting dental caries (IDC) has emerged as a holistic approach, drawing upon extensive research encompassing three pivotal techniques: antibacterial strategies, remineralization therapies, and infiltration mechanisms, all of which are indispensable components in combating the progression of dental caries. In this review, we provide a comprehensive overview of the mechanisms and applications of antibacterial, remineralization, and infiltration technologies within the context of caries management. Additionally, we summarize advanced materials that align with the IDC concept, aiming to offer valuable insights for designing next-generation materials adept at preventing or halting caries progression efficiently.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 2","pages":"87-116"},"PeriodicalIF":0.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical force modulates inflammation and immunomodulation in periodontal ligament cells. 机械力调节牙周韧带细胞的炎症和免疫调节。

Medical review (Berlin, Germany) Pub Date : 2024-08-13 eCollection Date: 2024-12-01 DOI: 10.1515/mr-2024-0034

Jira Chansaenroj, Ravipha Suwittayarak, Hiroshi Egusa, Lakshman P Samaranayake, Thanaphum Osathanon

{"title":"Mechanical force modulates inflammation and immunomodulation in periodontal ligament cells.","authors":"Jira Chansaenroj, Ravipha Suwittayarak, Hiroshi Egusa, Lakshman P Samaranayake, Thanaphum Osathanon","doi":"10.1515/mr-2024-0034","DOIUrl":"10.1515/mr-2024-0034","url":null,"abstract":"Mechanical forces control a multitude of biological responses in various cells and tissues. The periodontal ligament, located between the tooth's root and alveolar bone, is a major tissue compartment that is incessantly subjected to such mechanical stimulation through either normal or abnormal oral functionality. It is now known that mechanical stimulation activates periodontal ligament stem cells (PDLSCs) to modulate periodontal immunity and regulate inflammation - a basic feature of periodontal disease that affects virtually every human during their lifetime. For instance, shear stress induces the expression of immunomodulatory-related gene, indoleamine 2,3-dioxygenase (IDO). IDO cleaves l-tryptophan, resulting in increased l-kynurenine levels that, in turn, further promote regulatory T-cell differentiation and inhibit T cell proliferation. These and other related data reinforce the notion that mechanical stimulation plays a crucial role in controlling inflammation and immunomodulation of periodontal tissues. Further investigations, however, are warranted to evaluate the immunomodulatory features of PDLSCs so as to understand the pathological basis of periodontal disease and translate these into clinical interventions.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"4 6","pages":"544-548"},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0