Medical review (Berlin, Germany)最新文献_第2页

Combining transcriptomic and metabolomic insights to guide the clinical application of adipose- and bone marrow-derived mesenchymal stem cells. 结合转录组学和代谢组学的见解来指导脂肪和骨髓来源的间充质干细胞的临床应用。

Medical review (Berlin, Germany) Pub Date : 2024-08-29 eCollection Date: 2025-02-01 DOI: 10.1515/mr-2024-0056

Wenyan Zhou, Junxin Lin, David C Hay, Xudong Yao, Hongwei Ouyang

{"title":"Combining transcriptomic and metabolomic insights to guide the clinical application of adipose- and bone marrow-derived mesenchymal stem cells.","authors":"Wenyan Zhou, Junxin Lin, David C Hay, Xudong Yao, Hongwei Ouyang","doi":"10.1515/mr-2024-0056","DOIUrl":"10.1515/mr-2024-0056","url":null,"abstract":"Adipose-derived mesenchymal stem cells (ADSCs) and bone marrow-derived mesenchymal stem cells (BMSCs) have shown great potential in clinical applications. However, the similarities and differences between these two cell types have not been fully elucidated. Recent advances in transcriptomic and metabolomic research have provided valuable insight into the characteristics and functions of ADSCs and BMSCs. In this perspective article, we review the key findings from these studies, including cellular heterogeneity as well as differences in metabolic and secretory properties. We discuss how these insights can help guide the selection of the most suitable cell source for the clinic, and the optimization of preconditioning strategies prior to clinical deployment. Furthermore, we analyze the current landscape of products and clinical trials involving ADSCs and BMSCs, highlighting their therapeutic potential. We propose that the integration of multi-omics datasets will be crucial for establishing a comprehensive understanding of ADSC and BMSC identity and potency, and the provision of quality-assured stem cell-derived products for the clinic.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 1","pages":"76-82"},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redefining chronic mountain sickness: insights from high-altitude research and clinical experience. 重新定义慢性高原病：来自高海拔研究和临床经验的见解。

Medical review (Berlin, Germany) Pub Date : 2024-08-27 eCollection Date: 2025-02-01 DOI: 10.1515/mr-2024-0036

Gustavo Zubieta-Calleja

引用次数: 0

Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries. 抗菌、再矿化和渗透：阻断龋齿的先进策略。

Medical review (Berlin, Germany) Pub Date : 2024-08-23 eCollection Date: 2025-04-01 DOI: 10.1515/mr-2024-0035

Qingyi Yang, Fan Li, Yangyang Ye, Xu Zhang

{"title":"Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries.","authors":"Qingyi Yang, Fan Li, Yangyang Ye, Xu Zhang","doi":"10.1515/mr-2024-0035","DOIUrl":"https://doi.org/10.1515/mr-2024-0035","url":null,"abstract":"Dental caries, driven by plaque biofilm, poses a major oral health challenge due to imbalance in mineralization and demineralization. The primary objective in caries management is to maintain biofilm homeostasis while facilitating the repair and regeneration of dental hard tissues, thus restoring both structural integrity and functionality of affected teeth. Though antimicrobial and remineralization approaches haven shown promise, their standalone utilization without concurrent bacterial control or rebalancing lacks an integrated strategy to effectively arrest caries progression. Furthermore, according to the principles of minimally invasive dentistry, treatment materials should exhibit high permeability to ensure optimal sealing of demineralized tooth surfaces. The concept of interrupting dental caries (IDC) has emerged as a holistic approach, drawing upon extensive research encompassing three pivotal techniques: antibacterial strategies, remineralization therapies, and infiltration mechanisms, all of which are indispensable components in combating the progression of dental caries. In this review, we provide a comprehensive overview of the mechanisms and applications of antibacterial, remineralization, and infiltration technologies within the context of caries management. Additionally, we summarize advanced materials that align with the IDC concept, aiming to offer valuable insights for designing next-generation materials adept at preventing or halting caries progression efficiently.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 2","pages":"87-116"},"PeriodicalIF":0.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical force modulates inflammation and immunomodulation in periodontal ligament cells. 机械力调节牙周韧带细胞的炎症和免疫调节。

Medical review (Berlin, Germany) Pub Date : 2024-08-13 eCollection Date: 2024-12-01 DOI: 10.1515/mr-2024-0034

Jira Chansaenroj, Ravipha Suwittayarak, Hiroshi Egusa, Lakshman P Samaranayake, Thanaphum Osathanon

{"title":"Mechanical force modulates inflammation and immunomodulation in periodontal ligament cells.","authors":"Jira Chansaenroj, Ravipha Suwittayarak, Hiroshi Egusa, Lakshman P Samaranayake, Thanaphum Osathanon","doi":"10.1515/mr-2024-0034","DOIUrl":"10.1515/mr-2024-0034","url":null,"abstract":"Mechanical forces control a multitude of biological responses in various cells and tissues. The periodontal ligament, located between the tooth's root and alveolar bone, is a major tissue compartment that is incessantly subjected to such mechanical stimulation through either normal or abnormal oral functionality. It is now known that mechanical stimulation activates periodontal ligament stem cells (PDLSCs) to modulate periodontal immunity and regulate inflammation - a basic feature of periodontal disease that affects virtually every human during their lifetime. For instance, shear stress induces the expression of immunomodulatory-related gene, indoleamine 2,3-dioxygenase (IDO). IDO cleaves l-tryptophan, resulting in increased l-kynurenine levels that, in turn, further promote regulatory T-cell differentiation and inhibit T cell proliferation. These and other related data reinforce the notion that mechanical stimulation plays a crucial role in controlling inflammation and immunomodulation of periodontal tissues. Further investigations, however, are warranted to evaluate the immunomodulatory features of PDLSCs so as to understand the pathological basis of periodontal disease and translate these into clinical interventions.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"4 6","pages":"544-548"},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new year, a renewed dedication: greetings from Medical Review. 新的一年，新的奉献：来自《医学评论》的问候。

Medical review (Berlin, Germany) Pub Date : 2024-03-11 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2024-0015

Qimin Zhan, Zhengwei Xie

引用次数: 0

The complex interplay between aging and cancer: unraveling the clues. 衰老与癌症之间复杂的相互作用：揭开谜底。

Medical review (Berlin, Germany) Pub Date : 2024-03-08 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2024-0014

Zhengwei Xie, Qimin Zhan

引用次数: 0

Therapeutic robots for post-stroke rehabilitation. 用于中风后康复的治疗机器人。

Medical review (Berlin, Germany) Pub Date : 2024-02-27 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2023-0054

Ronghua Hong, Bingyu Li, Yunjun Bao, Lingyu Liu, Lingjing Jin

引用次数: 0

The new era of cardiovascular research: revolutionizing cardiovascular research with 3D models in a dish. 心血管研究的新时代：利用碟中三维模型彻底改变心血管研究。

Medical review (Berlin, Germany) Pub Date : 2024-02-20 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2023-0059

Yuan Yang, Hao Yang, Fedir N Kiskin, Joe Z Zhang

{"title":"The new era of cardiovascular research: revolutionizing cardiovascular research with 3D models in a dish.","authors":"Yuan Yang, Hao Yang, Fedir N Kiskin, Joe Z Zhang","doi":"10.1515/mr-2023-0059","DOIUrl":"10.1515/mr-2023-0059","url":null,"abstract":"Cardiovascular research has heavily relied on studies using patient samples and animal models. However, patient studies often miss the data from the crucial early stage of cardiovascular diseases, as obtaining primary tissues at this stage is impracticable. Transgenic animal models can offer some insights into disease mechanisms, although they usually do not fully recapitulate the phenotype of cardiovascular diseases and their progression. In recent years, a promising breakthrough has emerged in the form of in vitro three-dimensional (3D) cardiovascular models utilizing human pluripotent stem cells. These innovative models recreate the intricate 3D structure of the human heart and vessels within a controlled environment. This advancement is pivotal as it addresses the existing gaps in cardiovascular research, allowing scientists to study different stages of cardiovascular diseases and specific drug responses using human-origin models. In this review, we first outline various approaches employed to generate these models. We then comprehensively discuss their applications in studying cardiovascular diseases by providing insights into molecular and cellular changes associated with cardiovascular conditions. Moreover, we highlight the potential of these 3D models serving as a platform for drug testing to assess drug efficacy and safety. Despite their immense potential, challenges persist, particularly in maintaining the complex structure of 3D heart and vessel models and ensuring their function is comparable to real organs. However, overcoming these challenges could revolutionize cardiovascular research. It has the potential to offer comprehensive mechanistic insights into human-specific disease processes, ultimately expediting the development of personalized therapies.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"4 1","pages":"68-85"},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10954298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotechnology-based delivery systems to overcome drug resistance in cancer. 基于纳米技术的给药系统，克服癌症耐药性。

Medical review (Berlin, Germany) Pub Date : 2024-02-20 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2023-0058

Harsh Patel, Jiaxin Li, Letao Bo, Riddhi Mehta, Charles R Ashby, Shanzhi Wang, Wei Cai, Zhe-Sheng Chen

引用次数: 0

The role of clinical trials in advancing reproductive medicine: a comprehensive overview. 临床试验在生殖医学发展中的作用：全面概述。

Medical review (Berlin, Germany) Pub Date : 2023-12-05 eCollection Date: 2023-10-01 DOI: 10.1515/mr-2023-0053

Tian Tian, Jie Qiao

引用次数: 0