Medical review (Berlin, Germany)最新文献_第3页

Advances in the pathogenesis and clinical management of pulmonary hypertension. 肺动脉高压的发病机制及临床治疗进展。

Medical review (Berlin, Germany) Pub Date : 2026-03-20 eCollection Date: 2026-04-01 DOI: 10.1515/mr-2026-0002

Yi Yan, Zhuoyuan Xu, Yanghanyue Zhou, Xike Wang, Hao Zhang

{"title":"Advances in the pathogenesis and clinical management of pulmonary hypertension.","authors":"Yi Yan, Zhuoyuan Xu, Yanghanyue Zhou, Xike Wang, Hao Zhang","doi":"10.1515/mr-2026-0002","DOIUrl":"10.1515/mr-2026-0002","url":null,"abstract":"Pulmonary hypertension (PH) is a severe cardiopulmonary disorder characterized by pulmonary vascular remodeling, which leads to increased pulmonary vascular resistance (PVR), right ventricular (RV) hypertrophy, and ultimately heart failure and death. This review explores the dual landscape of PH, integrating recent insights into its complex pathogenesis with evolving clinical management strategies. The pathogenesis of PH involves a complex interplay of genetics, metabolism, immune dysfunction, biomechanical force and other factors, all contributing to vascular remodeling and presenting opportunities for novel therapies and biomarkers. Among these, certain pathogenic mechanisms are of particular relevance and may hold distinct importance in the pediatric population. Concurrently, notable progress has been made in clinical front including diagnosis, risk stratification, drug development, interventional or surgical procedures, and imaging technologies. Hence, this review integrates current evidence in both PH pathogenesis and clinical management to guide future research toward novel therapies and precision medicine.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"6 2","pages":"120-141"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic reprogramming in aortic diseases: insights from metabolomics and therapeutic opportunities. 主动脉疾病的代谢重编程：来自代谢组学和治疗机会的见解。

Medical review (Berlin, Germany) Pub Date : 2026-03-20 eCollection Date: 2026-04-01 DOI: 10.1515/mr-2026-0010

Yingjie Liu, Linlu Zhao, Chi Zhang, Xiao Ruan, Hualong Yu, Yangpo Cao, Wenhao Ju, Haocheng Lu

{"title":"Metabolic reprogramming in aortic diseases: insights from metabolomics and therapeutic opportunities.","authors":"Yingjie Liu, Linlu Zhao, Chi Zhang, Xiao Ruan, Hualong Yu, Yangpo Cao, Wenhao Ju, Haocheng Lu","doi":"10.1515/mr-2026-0010","DOIUrl":"10.1515/mr-2026-0010","url":null,"abstract":"Aortic diseases (aortic aneurysm, aortic dissection, atherosclerosis) represent a substantial clinical and economic burden due to the lack of effective early diagnostic tools and mechanism-based therapies. Metabolomics, the systematic study of low-molecular-weight metabolites, has emerged as a powerful approach for elucidating pathogenesis, screening candidate biomarkers, and discovering novel drug targets. Rather than merely cataloging metabolic perturbations, this review highlights how metabolic reprogramming, particularly involving amino acid pathways, mitochondrial dysfunction, and gut microbiota-derived metabolites, actively drives aortic pathology. While specific metabolites (e.g., succinate and trimethylamine N-oxide) show promises as prognostic biomarkers, their greatest value lies in revealing actionable therapeutic nodes. Although challenges remain regarding metabolite identification, biological heterogeneity, and clinical translation, continued technological advances and integrative multi-omics approaches offer clear pathways to overcome these barriers. Ultimately, we posit that prioritizing these convergent metabolic axes, especially the gut-vascular interface, could unlock next-generation precision therapies that transcend the limitations of conventional hemodynamic management.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"6 2","pages":"142-161"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiotherapy meets anticancer metallodrugs. 放疗遇上抗癌金属药物。

Medical review (Berlin, Germany) Pub Date : 2026-03-18 eCollection Date: 2026-04-01 DOI: 10.1515/mr-2026-0013

Shuren Zhang, Siyong Shen, Jiangsheng Li, Qunfeng Fu, Zijian Guo, Zhibo Liu

{"title":"Radiotherapy meets anticancer metallodrugs.","authors":"Shuren Zhang, Siyong Shen, Jiangsheng Li, Qunfeng Fu, Zijian Guo, Zhibo Liu","doi":"10.1515/mr-2026-0013","DOIUrl":"10.1515/mr-2026-0013","url":null,"abstract":"Combined radiotherapy and chemotherapy remain central to cancer treatment, with metallodrugs - most notably platinum agents - playing indispensable roles in clinical regimens. However, systemic toxicity and limited tumor selectivity continue to constrain their optimal integration with radiotherapy. Recent advances in radiation precision and metal chemistry are reshaping this landscape, giving rise to strategies in which radiotherapy and anticancer metallodrugs no longer act merely in combination, but intersect at the molecular level. Ionizing radiation generates highly reactive chemical species that can be harnessed to activate, modulate, or amplify the function of metallodrugs within irradiated tissues. Across platinum prodrugs, non-platinum metal complexes, and high-Z metal materials, radiation energy is increasingly exploited to achieve spatially confined cytotoxicity, immune modulation, and synergistic tumor control. Notably, radiometal-based drugs integrate radiochemistry with metal coordination chemistry, positioning themselves at the intersection of radiotherapy and metallodrug therapy, where they are already playing an increasingly important role in clinical oncology.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"6 2","pages":"166-169"},"PeriodicalIF":0.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The nitrate-Sialin axis: a new target for regulation of macrophage metabolic reprogramming and metabolic homeostasis. 硝酸盐- sialin轴：巨噬细胞代谢重编程和代谢稳态调控的新靶点。

Medical review (Berlin, Germany) Pub Date : 2026-03-16 eCollection Date: 2026-04-01 DOI: 10.1515/mr-2026-0011

Yao Feng, Yijia Shi, Wudi Zhai, Yibing Huang, Shaorong Li, Songlin Wang, Mo Chen

引用次数: 0

How to efficiently establish animal models of cholangiocarcinoma: challenges and inspiration. 如何高效建立胆管癌动物模型：挑战与启示。

Medical review (Berlin, Germany) Pub Date : 2026-03-02 eCollection Date: 2026-04-01 DOI: 10.1515/mr-2025-0081

Ruiqiang Gou, Ping Yue, Peng Liu, Jinyu Zhao, Chunfei Huang, Kiyohito Tanaka, Peng F Wong, Rungsun Rerknimitr, Jong H Moon, Tan T Cheung, Christian Waydhas, Azumi Suzuki, Yanyan Lin, Emmanuel Melloul, Hans Schlitt, John Fung, Joseph W Leung, Wenbo Meng

{"title":"How to efficiently establish animal models of cholangiocarcinoma: challenges and inspiration.","authors":"Ruiqiang Gou, Ping Yue, Peng Liu, Jinyu Zhao, Chunfei Huang, Kiyohito Tanaka, Peng F Wong, Rungsun Rerknimitr, Jong H Moon, Tan T Cheung, Christian Waydhas, Azumi Suzuki, Yanyan Lin, Emmanuel Melloul, Hans Schlitt, John Fung, Joseph W Leung, Wenbo Meng","doi":"10.1515/mr-2025-0081","DOIUrl":"10.1515/mr-2025-0081","url":null,"abstract":"Cholangiocarcinoma (CCA) consists of a class of malignant tumors of the biliary system, with a rising incidence and carries a poor prognosis. Developing reliable animal models of CCA is crucial to elucidate the pathogenesis, identify novel therapeutic targets, and assess treatment efficacy. Among these models, the in situ primary cholangiocarcinoma model which closely mimics clinical reality, serves as a robust tool for evaluating drug efficacy, simulating tumor progression characteristics, and facilitates immunotherapy strategies. Although in situ primary CCA models have been utilized in preclinical research, they have inherent limitations that warrant attention and further refinement. This review article highlights the status of the most relevant experimental animal models in preclinical CCA studies. It further delineates the differences in the development of intrahepatic and extrahepatic bile ducts that influence CCA model construction. In addition, we review the advancements, strengths and weaknesses of CCA organoids, primary intrahepatic and extrahepatic CCA models, and examine the pivotal role of bile duct inflammation and biliary fibrosis in creating the invasive cancer models. We emphasize the innovative application and immense potential of single-cell sequencing technology in studying cancer models. Additionally, this article summarizes the progress of CCA-targeted therapies and associated clinical trials which offered relevant insights. With a comprehensive review of in situ primary CCA models, we aim to provide suggestions and recommendation for future development of more advanced and clinically relevant research in constructing CCA models.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"6 2","pages":"91-119"},"PeriodicalIF":0.0,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress on immune tolerance mechanisms in liver metastatic tumors and the "Liver-metastasis-oriented shared-mechanism therapeutic strategy" approach. 肝转移瘤免疫耐受机制研究进展及“以肝转移为导向的共享机制治疗策略”

Medical review (Berlin, Germany) Pub Date : 2026-02-26 eCollection Date: 2026-02-01 DOI: 10.1515/mr-2025-0077

Qing Zhang, Wenjing Wang, Hongli Yu, Fuchuan Wang, Xiong Chen, Zhipeng Liang, Yinying Lu

{"title":"Research progress on immune tolerance mechanisms in liver metastatic tumors and the \"Liver-metastasis-oriented shared-mechanism therapeutic strategy\" approach.","authors":"Qing Zhang, Wenjing Wang, Hongli Yu, Fuchuan Wang, Xiong Chen, Zhipeng Liang, Yinying Lu","doi":"10.1515/mr-2025-0077","DOIUrl":"10.1515/mr-2025-0077","url":null,"abstract":"Liver metastases pose a serious challenge in the field of systemic cancer treatment, as this organ has a particular microenvironment that favours malignant cells disseminating to settle there. We outline major steps of liver immune tolerance in metastasis including pre-metastatic niche formation, immune evasion during circulation, establishment of an intrahepatic immune desert and metabolism, myeloid cell networks and gut microbiome-mediated coordinated tolerance. We then combine new combination and integrative therapies that are intended to break this tolerance; these include immunochemotherapy regimens, synergistic antiangiogenics and immunotherapies, dual immune checkpoint blockade and myeloid-cell reprogramming, combined locoregional and systemic therapies and new microenvironmental targeting. Each strategy is assessed with regard to its potential disruption of hepatic immune quiescence, improved clinical translation and durable antitumour activity. We suggest a proposed solution termed Liver-metastasis-oriented shared-mechanism therapeutic strategy, which may target multiple metastatic bottlenecks due to similarities. This framework provides a basis for personalizing combination therapies and designing future clinical trials for treating liver metastases, with organ-specific considerations and will be the subject of a commentary.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"6 1","pages":"57-74"},"PeriodicalIF":0.0,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12955356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147356707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory roles of bioactive lipids in vascular homeostasis and remodeling. 生物活性脂类在血管稳态和重塑中的调节作用。

Medical review (Berlin, Germany) Pub Date : 2026-02-09 eCollection Date: 2026-02-01 DOI: 10.1515/mr-2025-0073

Jie Yang, Haiyan Xiao, Zhongze Zhang, Liuyang Zhang, Xu Zhang

引用次数: 0

Strengthening clinical research and practice in China's healthcare system: a decade of action via the NEJM pilot initiative. 加强中国医疗保健系统的临床研究和实践：通过NEJM试点倡议的十年行动。

Medical review (Berlin, Germany) Pub Date : 2026-01-29 eCollection Date: 2026-02-01 DOI: 10.1515/mr-2025-0069

Pei Li, Jianfei Zhao, Shengjie Zhu, Rui-Ping Xiao

{"title":"Strengthening clinical research and practice in China's healthcare system: a decade of action via the NEJM pilot initiative.","authors":"Pei Li, Jianfei Zhao, Shengjie Zhu, Rui-Ping Xiao","doi":"10.1515/mr-2025-0069","DOIUrl":"10.1515/mr-2025-0069","url":null,"abstract":"China's healthcare system has made significant progress in the past 20 years, but disparities between urban and rural areas persist. The New England Journal of Medicine (NEJM) launched a pilot initiative to address these gaps through four core approaches: translation and dissemination of medical evidence, digital continuing medical education (CME), building research capacity, and fostering global health collaboration. Over the past decade, NEJM's Chinese-language platform has translated 1,709 high-impact articles, making them accessible to clinicians nationwide. Digital CME initiatives, accelerated by the COVID-19 pandemic, have enabled real-time knowledge sharing, reaching 450,000 physicians. Collaborative training programs have equipped clinicians with essential research skills. These efforts have shown measurable impact, with a sharp increase in original research submissions and publications from China-based authors since 2014. While progress has been made, further focus on knowledge dissemination, equitable access to CME, research capacity building, and global engagement is crucial for advancing China's healthcare system.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"6 1","pages":"75-78"},"PeriodicalIF":0.0,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12955350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the hype: navigating the real-world applications of artificial intelligence (AI) in healthcare. 在炒作之外：引导人工智能（AI）在医疗保健领域的实际应用。

Medical review (Berlin, Germany) Pub Date : 2026-01-29 eCollection Date: 2026-02-01 DOI: 10.1515/mr-2025-0074

Man-Cheong Fung

{"title":"Beyond the hype: navigating the real-world applications of artificial intelligence (AI) in healthcare.","authors":"Man-Cheong Fung","doi":"10.1515/mr-2025-0074","DOIUrl":"10.1515/mr-2025-0074","url":null,"abstract":"The integration of Artificial Intelligence (AI) into healthcare signifies one of the most formidable and multifaceted advancements in contemporary medicine. The relentless pace of innovation necessitates a timely synthesis of the field's trajectory, critically evaluating both the promises and complexities of this ongoing transformation. This report aims to map the expansive terrain of AI's deployment across critical healthcare sectors, encompassing clinical decision support, diagnostic imaging, pharmaceutical innovation, biomedical research, and regulatory review. It begins with an analysis of the opportunities and challenges inherent in the real-world implementation of AI technologies, systematically categorizing their adoption and utilities into three core domains: (1) clinical informatics and healthcare delivery, (2) clinical sciences and therapeutic interventions, and (3) drug development and biomedical investigation. Thereafter, the discussion turns to AI's role within the regulatory landscape for drug and medical product reviews and approvals. Adopting a progressive outlook, the author formulates strategic recommendations aimed at surmounting potential barriers, thus facilitating the judicious, efficacious, and equitable integration of AI. Collectively, these analyses provide a narrative that highlights both the transformative potential and the pragmatic imperatives of deploying AI to improve human health.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"6 1","pages":"14-34"},"PeriodicalIF":0.0,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12955354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transfer RNA-derived small RNAs (tsRNAs) in Alzheimer's disease: emerging mechanisms and diagnostic potential. 阿尔茨海默病中的转移rna衍生小rna (tsRNAs)：新出现的机制和诊断潜力

Medical review (Berlin, Germany) Pub Date : 2026-01-26 eCollection Date: 2026-02-01 DOI: 10.1515/mr-2025-0078

Juan Zhang, Jialuo Han, Qiang Liu

引用次数: 0