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Medical review (Berlin, Germany)最新文献

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A new year, a renewed dedication: greetings from Medical Review. 新的一年，新的奉献：来自《医学评论》的问候。
Medical review (Berlin, Germany) Pub Date : 2024-03-11 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2024-0015
Qimin Zhan, Zhengwei Xie
{"title":"A new year, a renewed dedication: greetings from Medical Review.","authors":"Qimin Zhan, Zhengwei Xie","doi":"10.1515/mr-2024-0015","DOIUrl":"https://doi.org/10.1515/mr-2024-0015","url":null,"abstract":"","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"4 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10954293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The complex interplay between aging and cancer: unraveling the clues. 衰老与癌症之间复杂的相互作用：揭开谜底。
Medical review (Berlin, Germany) Pub Date : 2024-03-08 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2024-0014
Zhengwei Xie, Qimin Zhan
{"title":"The complex interplay between aging and cancer: unraveling the clues.","authors":"Zhengwei Xie, Qimin Zhan","doi":"10.1515/mr-2024-0014","DOIUrl":"10.1515/mr-2024-0014","url":null,"abstract":"","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"4 1","pages":"2-4"},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10954294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic robots for post-stroke rehabilitation. 用于中风后康复的治疗机器人。
Medical review (Berlin, Germany) Pub Date : 2024-02-27 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2023-0054
Ronghua Hong, Bingyu Li, Yunjun Bao, Lingyu Liu, Lingjing Jin
{"title":"Therapeutic robots for post-stroke rehabilitation.","authors":"Ronghua Hong, Bingyu Li, Yunjun Bao, Lingyu Liu, Lingjing Jin","doi":"10.1515/mr-2023-0054","DOIUrl":"10.1515/mr-2023-0054","url":null,"abstract":"<p><p>Stroke is a prevalent, severe, and disabling health-care issue on a global scale, inevitably leading to motor and cognitive deficits. It has become one of the most significant challenges in China, resulting in substantial social and economic burdens. In addition to the medication and surgical interventions during the acute phase, rehabilitation treatment plays a crucial role in stroke care. Robotic technology takes distinct advantages over traditional physical therapy, occupational therapy, and speech therapy, and is increasingly gaining popularity in post-stroke rehabilitation. The use of rehabilitation robots not only alleviates the workload of healthcare professionals but also enhances the prognosis for specific stroke patients. This review presents a concise overview of the application of therapeutic robots in post-stroke rehabilitation, with particular emphasis on the recovery of motor and cognitive function.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"4 1","pages":"55-67"},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10954296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The new era of cardiovascular research: revolutionizing cardiovascular research with 3D models in a dish. 心血管研究的新时代：利用碟中三维模型彻底改变心血管研究。
Medical review (Berlin, Germany) Pub Date : 2024-02-20 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2023-0059
Yuan Yang, Hao Yang, Fedir N Kiskin, Joe Z Zhang
{"title":"The new era of cardiovascular research: revolutionizing cardiovascular research with 3D models in a dish.","authors":"Yuan Yang, Hao Yang, Fedir N Kiskin, Joe Z Zhang","doi":"10.1515/mr-2023-0059","DOIUrl":"10.1515/mr-2023-0059","url":null,"abstract":"<p><p>Cardiovascular research has heavily relied on studies using patient samples and animal models. However, patient studies often miss the data from the crucial early stage of cardiovascular diseases, as obtaining primary tissues at this stage is impracticable. Transgenic animal models can offer some insights into disease mechanisms, although they usually do not fully recapitulate the phenotype of cardiovascular diseases and their progression. In recent years, a promising breakthrough has emerged in the form of <i>in vitro</i> three-dimensional (3D) cardiovascular models utilizing human pluripotent stem cells. These innovative models recreate the intricate 3D structure of the human heart and vessels within a controlled environment. This advancement is pivotal as it addresses the existing gaps in cardiovascular research, allowing scientists to study different stages of cardiovascular diseases and specific drug responses using human-origin models. In this review, we first outline various approaches employed to generate these models. We then comprehensively discuss their applications in studying cardiovascular diseases by providing insights into molecular and cellular changes associated with cardiovascular conditions. Moreover, we highlight the potential of these 3D models serving as a platform for drug testing to assess drug efficacy and safety. Despite their immense potential, challenges persist, particularly in maintaining the complex structure of 3D heart and vessel models and ensuring their function is comparable to real organs. However, overcoming these challenges could revolutionize cardiovascular research. It has the potential to offer comprehensive mechanistic insights into human-specific disease processes, ultimately expediting the development of personalized therapies.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"4 1","pages":"68-85"},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10954298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanotechnology-based delivery systems to overcome drug resistance in cancer. 基于纳米技术的给药系统，克服癌症耐药性。
Medical review (Berlin, Germany) Pub Date : 2024-02-20 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2023-0058
Harsh Patel, Jiaxin Li, Letao Bo, Riddhi Mehta, Charles R Ashby, Shanzhi Wang, Wei Cai, Zhe-Sheng Chen
{"title":"Nanotechnology-based delivery systems to overcome drug resistance in cancer.","authors":"Harsh Patel, Jiaxin Li, Letao Bo, Riddhi Mehta, Charles R Ashby, Shanzhi Wang, Wei Cai, Zhe-Sheng Chen","doi":"10.1515/mr-2023-0058","DOIUrl":"10.1515/mr-2023-0058","url":null,"abstract":"<p><p>Cancer nanomedicine is defined as the application of nanotechnology and nanomaterials for the formulation of cancer therapeutics that can overcome the impediments and restrictions of traditional chemotherapeutics. Multidrug resistance (MDR) in cancer cells can be defined as a decrease or abrogation in the efficacy of anticancer drugs that have different molecular structures and mechanisms of action and is one of the primary causes of therapeutic failure. There have been successes in the development of cancer nanomedicine to overcome MDR; however, relatively few of these formulations have been approved by the United States Food and Drug Administration for the treatment of cancer. This is primarily due to the paucity of knowledge about nanotechnology and the fundamental biology of cancer cells. Here, we discuss the advances, types of nanomedicines, and the challenges regarding the translation of <i>in vitro</i> to <i>in vivo</i> results and their relevance to effective therapies.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"4 1","pages":"5-30"},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10954245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of clinical trials in advancing reproductive medicine: a comprehensive overview. 临床试验在生殖医学发展中的作用：全面概述。
Medical review (Berlin, Germany) Pub Date : 2023-12-05 eCollection Date: 2023-10-01 DOI: 10.1515/mr-2023-0053
Tian Tian, Jie Qiao
{"title":"The role of clinical trials in advancing reproductive medicine: a comprehensive overview.","authors":"Tian Tian, Jie Qiao","doi":"10.1515/mr-2023-0053","DOIUrl":"10.1515/mr-2023-0053","url":null,"abstract":"","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 5","pages":"363-365"},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10811349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139572258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In silico protein function prediction: the rise of machine learning-based approaches. 硅学蛋白质功能预测：基于机器学习方法的兴起。
Medical review (Berlin, Germany) Pub Date : 2023-11-29 eCollection Date: 2023-12-01 DOI: 10.1515/mr-2023-0038
Jiaxiao Chen, Zhonghui Gu, Luhua Lai, Jianfeng Pei
{"title":"In silico protein function prediction: the rise of machine learning-based approaches.","authors":"Jiaxiao Chen, Zhonghui Gu, Luhua Lai, Jianfeng Pei","doi":"10.1515/mr-2023-0038","DOIUrl":"10.1515/mr-2023-0038","url":null,"abstract":"<p><p>Proteins function as integral actors in essential life processes, rendering the realm of protein research a fundamental domain that possesses the potential to propel advancements in pharmaceuticals and disease investigation. Within the context of protein research, an imperious demand arises to uncover protein functionalities and untangle intricate mechanistic underpinnings. Due to the exorbitant costs and limited throughput inherent in experimental investigations, computational models offer a promising alternative to accelerate protein function annotation. In recent years, protein pre-training models have exhibited noteworthy advancement across multiple prediction tasks. This advancement highlights a notable prospect for effectively tackling the intricate downstream task associated with protein function prediction. In this review, we elucidate the historical evolution and research paradigms of computational methods for predicting protein function. Subsequently, we summarize the progress in protein and molecule representation as well as feature extraction techniques. Furthermore, we assess the performance of machine learning-based algorithms across various objectives in protein function prediction, thereby offering a comprehensive perspective on the progress within this field.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 6","pages":"487-510"},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139572259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The application of artificial intelligence in the management of sepsis. 人工智能在败血症管理中的应用。
Medical review (Berlin, Germany) Pub Date : 2023-11-28 eCollection Date: 2023-10-01 DOI: 10.1515/mr-2023-0039
Jie Yang, Sicheng Hao, Jiajie Huang, Tianqi Chen, Ruoqi Liu, Ping Zhang, Mengling Feng, Yang He, Wei Xiao, Yucai Hong, Zhongheng Zhang
{"title":"The application of artificial intelligence in the management of sepsis.","authors":"Jie Yang, Sicheng Hao, Jiajie Huang, Tianqi Chen, Ruoqi Liu, Ping Zhang, Mengling Feng, Yang He, Wei Xiao, Yucai Hong, Zhongheng Zhang","doi":"10.1515/mr-2023-0039","DOIUrl":"10.1515/mr-2023-0039","url":null,"abstract":"<p><p>Sepsis is a complex and heterogeneous syndrome that remains a serious challenge to healthcare worldwide. Patients afflicted by severe sepsis or septic shock are customarily placed under intensive care unit (ICU) supervision, where a multitude of apparatus is poised to produce high-granularity data. This reservoir of high-quality data forms the cornerstone for the integration of AI into clinical practice. However, existing reviews currently lack the inclusion of the latest advancements. This review examines the evolving integration of artificial intelligence (AI) in sepsis management. Applications of artificial intelligence include early detection, subtyping analysis, precise treatment and prognosis assessment. AI-driven early warning systems provide enhanced recognition and intervention capabilities, while profiling analyzes elucidate distinct sepsis manifestations for targeted therapy. Precision medicine harnesses the potential of artificial intelligence for pathogen identification, antibiotic selection, and fluid optimization. In conclusion, the seamless amalgamation of artificial intelligence into the domain of sepsis management heralds a transformative shift, ushering in novel prospects to elevate diagnostic precision, therapeutic efficacy, and prognostic acumen. As AI technologies develop, their impact on shaping the future of sepsis care warrants ongoing research and thoughtful implementation.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 5","pages":"369-380"},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10811352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139572195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insights into non-invasive screening of esophageal squamous cell carcinoma. 食管鳞状细胞癌无创筛查的新见解。
Medical review (Berlin, Germany) Pub Date : 2023-11-17 eCollection Date: 2023-10-01 DOI: 10.1515/mr-2023-0045
Ye Gao, Luowei Wang, Zhaoshen Li
{"title":"New insights into non-invasive screening of esophageal squamous cell carcinoma.","authors":"Ye Gao, Luowei Wang, Zhaoshen Li","doi":"10.1515/mr-2023-0045","DOIUrl":"10.1515/mr-2023-0045","url":null,"abstract":"","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 5","pages":"366-368"},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10811350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139572245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current state of stem cell research in non-human primates: an overview 非人类灵长类动物干细胞研究现状综述
Medical review (Berlin, Germany) Pub Date : 2023-11-06 DOI: 10.1515/mr-2023-0035
Junmo Wu, Yuxi Shi, Shanshan Yang, Zengli Tang, Zifan Li, Zhuoyao Li, Jiawei Zuo, Weizhi Ji, Yuyu Niu
{"title":"Current state of stem cell research in non-human primates: an overview","authors":"Junmo Wu, Yuxi Shi, Shanshan Yang, Zengli Tang, Zifan Li, Zhuoyao Li, Jiawei Zuo, Weizhi Ji, Yuyu Niu","doi":"10.1515/mr-2023-0035","DOIUrl":"https://doi.org/10.1515/mr-2023-0035","url":null,"abstract":"Abstract The remarkable similarity between non-human primates (NHPs) and humans establishes them as essential models for understanding human biology and diseases, as well as for developing novel therapeutic strategies, thereby providing more comprehensive reference data for clinical treatment. Pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells provide unprecedented opportunities for cell therapies against intractable diseases and injuries. As continue to harness the potential of these biotechnological therapies, NHPs are increasingly being employed in preclinical trials, serving as a pivotal tool to evaluate the safety and efficacy of these interventions. Here, we review the recent advancements in the fundamental research of stem cells and the progress made in studies involving NHPs.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"80 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135584888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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