Medical review (Berlin, Germany)最新文献_第3页

Emerging magic bullet: subcellular organelle-targeted cancer therapy. 新兴的灵丹妙药：亚细胞细胞器靶向癌症治疗。

Medical review (Berlin, Germany) Pub Date : 2024-09-12 eCollection Date: 2025-04-01 DOI: 10.1515/mr-2024-0044

Yue Yan, Yimeng Zhang, Jianxiong Liu, Binlong Chen, Yiguang Wang

{"title":"Emerging magic bullet: subcellular organelle-targeted cancer therapy.","authors":"Yue Yan, Yimeng Zhang, Jianxiong Liu, Binlong Chen, Yiguang Wang","doi":"10.1515/mr-2024-0044","DOIUrl":"https://doi.org/10.1515/mr-2024-0044","url":null,"abstract":"The therapeutic efficacy of anticancer drugs heavily relies on their concentration and retention at the corresponding target site. Hence, merely increasing the cellular concentration of drugs is insufficient to achieve satisfactory therapeutic outcomes, especially for the drugs that target specific intracellular sites. This necessitates the implementation of more precise targeting strategies to overcome the limitations posed by diffusion distribution and nonspecific interactions within cells. Consequently, subcellular organelle-targeted cancer therapy, characterized by its exceptional precision, have emerged as a promising approach to eradicate cancer cells through the specific disruption of subcellular organelles. Owing to several advantages including minimized dosage and side effect, optimized efficacy, and reversal of multidrug resistance, subcellular organelle-targeted therapies have garnered significant research interest in recent years. In this review, we comprehensively summarize the distribution of drug targets, targeted delivery strategies at various levels, and sophisticated strategies for targeting specific subcellular organelles. Additionally, we highlight the significance of subcellular targeting in cancer therapy and present essential considerations for its clinical translation.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 2","pages":"117-138"},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic advances in neurodevelopmental disorders. 神经发育障碍的遗传研究进展。

Medical review (Berlin, Germany) Pub Date : 2024-09-03 eCollection Date: 2025-04-01 DOI: 10.1515/mr-2024-0040

Shilin Gao, Chaoyi Shan, Rong Zhang, Tianyun Wang

{"title":"Genetic advances in neurodevelopmental disorders.","authors":"Shilin Gao, Chaoyi Shan, Rong Zhang, Tianyun Wang","doi":"10.1515/mr-2024-0040","DOIUrl":"https://doi.org/10.1515/mr-2024-0040","url":null,"abstract":"Neurodevelopmental disorders (NDDs) are a group of highly heterogeneous diseases that affect children's social, cognitive, and emotional functioning. The etiology is complicated with genetic factors playing an important role. During the past decade, large-scale whole exome sequencing (WES) and whole genome sequencing (WGS) have vastly advanced the genetic findings of NDDs. Various forms of variants have been reported to contribute to NDDs, such as de novo mutations (DNMs), copy number variations (CNVs), rare inherited variants (RIVs), and common variation. By far, over 200 high-risk NDD genes have been identified, which are involved in biological processes including synaptic function, transcriptional and epigenetic regulation. In addition, monogenic, oligogenic, polygenetic, and omnigenic models have been proposed to explain the genetic architecture of NDDs. However, the majority of NDD patients still do not have a definitive genetic diagnosis. In the future, more types of risk factors, as well as noncoding variants, are await to be identified, and including their interplay mechanisms are key to resolving the etiology and heterogeneity of NDDs.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 2","pages":"139-151"},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combining transcriptomic and metabolomic insights to guide the clinical application of adipose- and bone marrow-derived mesenchymal stem cells. 结合转录组学和代谢组学的见解来指导脂肪和骨髓来源的间充质干细胞的临床应用。

Medical review (Berlin, Germany) Pub Date : 2024-08-29 eCollection Date: 2025-02-01 DOI: 10.1515/mr-2024-0056

Wenyan Zhou, Junxin Lin, David C Hay, Xudong Yao, Hongwei Ouyang

{"title":"Combining transcriptomic and metabolomic insights to guide the clinical application of adipose- and bone marrow-derived mesenchymal stem cells.","authors":"Wenyan Zhou, Junxin Lin, David C Hay, Xudong Yao, Hongwei Ouyang","doi":"10.1515/mr-2024-0056","DOIUrl":"10.1515/mr-2024-0056","url":null,"abstract":"Adipose-derived mesenchymal stem cells (ADSCs) and bone marrow-derived mesenchymal stem cells (BMSCs) have shown great potential in clinical applications. However, the similarities and differences between these two cell types have not been fully elucidated. Recent advances in transcriptomic and metabolomic research have provided valuable insight into the characteristics and functions of ADSCs and BMSCs. In this perspective article, we review the key findings from these studies, including cellular heterogeneity as well as differences in metabolic and secretory properties. We discuss how these insights can help guide the selection of the most suitable cell source for the clinic, and the optimization of preconditioning strategies prior to clinical deployment. Furthermore, we analyze the current landscape of products and clinical trials involving ADSCs and BMSCs, highlighting their therapeutic potential. We propose that the integration of multi-omics datasets will be crucial for establishing a comprehensive understanding of ADSC and BMSC identity and potency, and the provision of quality-assured stem cell-derived products for the clinic.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 1","pages":"76-82"},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redefining chronic mountain sickness: insights from high-altitude research and clinical experience. 重新定义慢性高原病：来自高海拔研究和临床经验的见解。

Medical review (Berlin, Germany) Pub Date : 2024-08-27 eCollection Date: 2025-02-01 DOI: 10.1515/mr-2024-0036

Gustavo Zubieta-Calleja

引用次数: 0

Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries. 抗菌、再矿化和渗透：阻断龋齿的先进策略。

Medical review (Berlin, Germany) Pub Date : 2024-08-23 eCollection Date: 2025-04-01 DOI: 10.1515/mr-2024-0035

Qingyi Yang, Fan Li, Yangyang Ye, Xu Zhang

{"title":"Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries.","authors":"Qingyi Yang, Fan Li, Yangyang Ye, Xu Zhang","doi":"10.1515/mr-2024-0035","DOIUrl":"https://doi.org/10.1515/mr-2024-0035","url":null,"abstract":"Dental caries, driven by plaque biofilm, poses a major oral health challenge due to imbalance in mineralization and demineralization. The primary objective in caries management is to maintain biofilm homeostasis while facilitating the repair and regeneration of dental hard tissues, thus restoring both structural integrity and functionality of affected teeth. Though antimicrobial and remineralization approaches haven shown promise, their standalone utilization without concurrent bacterial control or rebalancing lacks an integrated strategy to effectively arrest caries progression. Furthermore, according to the principles of minimally invasive dentistry, treatment materials should exhibit high permeability to ensure optimal sealing of demineralized tooth surfaces. The concept of interrupting dental caries (IDC) has emerged as a holistic approach, drawing upon extensive research encompassing three pivotal techniques: antibacterial strategies, remineralization therapies, and infiltration mechanisms, all of which are indispensable components in combating the progression of dental caries. In this review, we provide a comprehensive overview of the mechanisms and applications of antibacterial, remineralization, and infiltration technologies within the context of caries management. Additionally, we summarize advanced materials that align with the IDC concept, aiming to offer valuable insights for designing next-generation materials adept at preventing or halting caries progression efficiently.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"5 2","pages":"87-116"},"PeriodicalIF":0.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical force modulates inflammation and immunomodulation in periodontal ligament cells. 机械力调节牙周韧带细胞的炎症和免疫调节。

Medical review (Berlin, Germany) Pub Date : 2024-08-13 eCollection Date: 2024-12-01 DOI: 10.1515/mr-2024-0034

Jira Chansaenroj, Ravipha Suwittayarak, Hiroshi Egusa, Lakshman P Samaranayake, Thanaphum Osathanon

{"title":"Mechanical force modulates inflammation and immunomodulation in periodontal ligament cells.","authors":"Jira Chansaenroj, Ravipha Suwittayarak, Hiroshi Egusa, Lakshman P Samaranayake, Thanaphum Osathanon","doi":"10.1515/mr-2024-0034","DOIUrl":"10.1515/mr-2024-0034","url":null,"abstract":"Mechanical forces control a multitude of biological responses in various cells and tissues. The periodontal ligament, located between the tooth's root and alveolar bone, is a major tissue compartment that is incessantly subjected to such mechanical stimulation through either normal or abnormal oral functionality. It is now known that mechanical stimulation activates periodontal ligament stem cells (PDLSCs) to modulate periodontal immunity and regulate inflammation - a basic feature of periodontal disease that affects virtually every human during their lifetime. For instance, shear stress induces the expression of immunomodulatory-related gene, indoleamine 2,3-dioxygenase (IDO). IDO cleaves l-tryptophan, resulting in increased l-kynurenine levels that, in turn, further promote regulatory T-cell differentiation and inhibit T cell proliferation. These and other related data reinforce the notion that mechanical stimulation plays a crucial role in controlling inflammation and immunomodulation of periodontal tissues. Further investigations, however, are warranted to evaluate the immunomodulatory features of PDLSCs so as to understand the pathological basis of periodontal disease and translate these into clinical interventions.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"4 6","pages":"544-548"},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new year, a renewed dedication: greetings from Medical Review. 新的一年，新的奉献：来自《医学评论》的问候。

Medical review (Berlin, Germany) Pub Date : 2024-03-11 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2024-0015

Qimin Zhan, Zhengwei Xie

引用次数: 0

The complex interplay between aging and cancer: unraveling the clues. 衰老与癌症之间复杂的相互作用：揭开谜底。

Medical review (Berlin, Germany) Pub Date : 2024-03-08 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2024-0014

Zhengwei Xie, Qimin Zhan

引用次数: 0

Therapeutic robots for post-stroke rehabilitation. 用于中风后康复的治疗机器人。

Medical review (Berlin, Germany) Pub Date : 2024-02-27 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2023-0054

Ronghua Hong, Bingyu Li, Yunjun Bao, Lingyu Liu, Lingjing Jin

引用次数: 0

The new era of cardiovascular research: revolutionizing cardiovascular research with 3D models in a dish. 心血管研究的新时代：利用碟中三维模型彻底改变心血管研究。

Medical review (Berlin, Germany) Pub Date : 2024-02-20 eCollection Date: 2024-02-01 DOI: 10.1515/mr-2023-0059

Yuan Yang, Hao Yang, Fedir N Kiskin, Joe Z Zhang

{"title":"The new era of cardiovascular research: revolutionizing cardiovascular research with 3D models in a dish.","authors":"Yuan Yang, Hao Yang, Fedir N Kiskin, Joe Z Zhang","doi":"10.1515/mr-2023-0059","DOIUrl":"10.1515/mr-2023-0059","url":null,"abstract":"Cardiovascular research has heavily relied on studies using patient samples and animal models. However, patient studies often miss the data from the crucial early stage of cardiovascular diseases, as obtaining primary tissues at this stage is impracticable. Transgenic animal models can offer some insights into disease mechanisms, although they usually do not fully recapitulate the phenotype of cardiovascular diseases and their progression. In recent years, a promising breakthrough has emerged in the form of in vitro three-dimensional (3D) cardiovascular models utilizing human pluripotent stem cells. These innovative models recreate the intricate 3D structure of the human heart and vessels within a controlled environment. This advancement is pivotal as it addresses the existing gaps in cardiovascular research, allowing scientists to study different stages of cardiovascular diseases and specific drug responses using human-origin models. In this review, we first outline various approaches employed to generate these models. We then comprehensively discuss their applications in studying cardiovascular diseases by providing insights into molecular and cellular changes associated with cardiovascular conditions. Moreover, we highlight the potential of these 3D models serving as a platform for drug testing to assess drug efficacy and safety. Despite their immense potential, challenges persist, particularly in maintaining the complex structure of 3D heart and vessel models and ensuring their function is comparable to real organs. However, overcoming these challenges could revolutionize cardiovascular research. It has the potential to offer comprehensive mechanistic insights into human-specific disease processes, ultimately expediting the development of personalized therapies.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"4 1","pages":"68-85"},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10954298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0