Medical review (Berlin, Germany)最新文献_第5页

mRNA lipid nanoparticles induce immune tolerance to treat human diseases. 信使核糖核酸脂质纳米粒子诱导免疫耐受以治疗人类疾病。

Medical review (Berlin, Germany) Pub Date : 2023-04-14 eCollection Date: 2023-04-01 DOI: 10.1515/mr-2023-0008

Wei Cao, Tian Xia

引用次数: 0

Progress in nanoparticle-based regulation of immune cells. 基于纳米粒子的免疫细胞调控研究进展。

Medical review (Berlin, Germany) Pub Date : 2023-04-12 eCollection Date: 2023-04-01 DOI: 10.1515/mr-2022-0047

Ya-Nan Fan, Gui Zhao, Yue Zhang, Qian-Ni Ye, Yi-Qun Sun, Song Shen, Yang Liu, Cong-Fei Xu, Jun Wang

{"title":"Progress in nanoparticle-based regulation of immune cells.","authors":"Ya-Nan Fan, Gui Zhao, Yue Zhang, Qian-Ni Ye, Yi-Qun Sun, Song Shen, Yang Liu, Cong-Fei Xu, Jun Wang","doi":"10.1515/mr-2022-0047","DOIUrl":"10.1515/mr-2022-0047","url":null,"abstract":"Immune cells are indispensable defenders of the human body, clearing exogenous pathogens and toxicities or endogenous malignant and aging cells. Immune cell dysfunction can cause an inability to recognize, react, and remove these hazards, resulting in cancers, inflammatory diseases, autoimmune diseases, and infections. Immune cells regulation has shown great promise in treating disease, and immune agonists are usually used to treat cancers and infections caused by immune suppression. In contrast, immunosuppressants are used to treat inflammatory and autoimmune diseases. However, the key to maintaining health is to restore balance to the immune system, as excessive activation or inhibition of immune cells is a common complication of immunotherapy. Nanoparticles are efficient drug delivery systems widely used to deliver small molecule inhibitors, nucleic acid, and proteins. Using nanoparticles for the targeted delivery of drugs to immune cells provides opportunities to regulate immune cell function. In this review, we summarize the current progress of nanoparticle-based strategies for regulating immune function and discuss the prospects of future nanoparticle design to improve immunotherapy.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 2","pages":"152-179"},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/be/ae/mr-3-2-mr-2022-0047.PMC10471115.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10311383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Versatile biomimetic nanomedicine for treating cancer and inflammation disease. 用于治疗癌症和炎症疾病的多功能仿生纳米药物。

Medical review (Berlin, Germany) Pub Date : 2023-04-07 eCollection Date: 2023-04-01 DOI: 10.1515/mr-2022-0046

Zhiwen Zhao, Dangge Wang, Yaping Li

{"title":"Versatile biomimetic nanomedicine for treating cancer and inflammation disease.","authors":"Zhiwen Zhao, Dangge Wang, Yaping Li","doi":"10.1515/mr-2022-0046","DOIUrl":"10.1515/mr-2022-0046","url":null,"abstract":"Nanosized drug delivery systems (NDDSs) have emerged as a powerful tool to optimize drug delivery in complex diseases, including cancer and inflammation. However, the therapeutic effect of NDDSs is still far from satisfactory due to their poor circulation time, low delivery efficiency, and innate toxicity. Fortunately, biomimetic approaches offer new opportunities to develop nanomedicine, which is derived from a variety of native biomolecules including cells, exosomes, bacteria, and so on. Since inheriting the superior biocompatibility and versatile functions of natural materials, biomimetic nanomedicine can mimic biological processes, prolong blood circulation, and lower immunogenicity, serving as a desired platform for precise drug delivery for treating cancer and inflammatory disease. In this review, we outline recent advances in biomimetic NDDSs, which consist of two concepts: biomimetic exterior camouflage and bioidentical molecule construction. We summarize engineering strategies that further functionalized current biomimetic NDDSs. A series of functional biomimetic NDDSs created by our group are introduced. We conclude with an outlook on remaining challenges and possible directions for biomimetic NDDSs. We hope that better technologies can be inspired and invented to advance drug delivery systems for cancer and inflammation therapy.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 2","pages":"123-151"},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/12/mr-3-2-mr-2022-0046.PMC10471090.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10311381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frontmatter 头版头条

Medical review (Berlin, Germany) Pub Date : 2023-04-01 DOI: 10.1515/mr-2023-frontmatter2

引用次数: 0

Promoting the bench-to-bedside translation of nanomedicines. 推广纳米药物的台式到床边的翻译。

Medical review (Berlin, Germany) Pub Date : 2023-03-17 eCollection Date: 2023-02-01 DOI: 10.1515/mr-2023-0007

Ning Zhang

引用次数: 0

Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy. 开发刺激响应性聚合物纳米药物，调节肿瘤微环境，改善癌症治疗。

Medical review (Berlin, Germany) Pub Date : 2023-03-17 eCollection Date: 2023-02-01 DOI: 10.1515/mr-2022-0048

Yuanzhen Su, Guanyu Jin, Huicong Zhou, Zhaofan Yang, Lanqing Wang, Zi Mei, Qionghua Jin, Shixian Lv, Xuesi Chen

引用次数: 1

Ferritin-based nanomedicine for disease treatment. 用于疾病治疗的基于铁蛋白的纳米药物。

Medical review (Berlin, Germany) Pub Date : 2023-03-10 eCollection Date: 2023-02-01 DOI: 10.1515/mr-2023-0001

Yuanjun Zhu, Yuefeng Zhu, Tianmiao Cao, Xiaoyu Liu, Xiaoyan Liu, Yi Yan, Yujie Shi, Jian-Cheng Wang

{"title":"Ferritin-based nanomedicine for disease treatment.","authors":"Yuanjun Zhu, Yuefeng Zhu, Tianmiao Cao, Xiaoyu Liu, Xiaoyan Liu, Yi Yan, Yujie Shi, Jian-Cheng Wang","doi":"10.1515/mr-2023-0001","DOIUrl":"10.1515/mr-2023-0001","url":null,"abstract":"Ferritin is an endogenous protein which is self-assembled by 24 subunits into a highly uniform nanocage structure. Due to the drug-encapsulating ability in the hollow inner cavity and abundant modification sites on the outer surface, ferritin nanocage has been demonstrated great potential to become a multi-functional nanomedicine platform. Its good biocompatibility, low toxicity and immunogenicity, intrinsic tumor-targeting ability, high stability, low cost and massive production, together make ferritin nanocage stand out from other nanocarriers. In this review, we summarized ferritin-based nanomedicine in field of disease diagnosis, treatment and prevention. The different types of drugs to be loaded in ferritin, as well as drug-loading methods were classified. The strategies for site-specific and non-specific functional modification of ferritin were investigated, then the application of ferritin for disease imaging, drug delivery and vaccine development were discussed. Finally, the challenges restricting the clinical translation of ferritin-based nanomedicines were analyzed.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 1","pages":"49-74"},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fb/af/mr-3-1-mr-2023-0001.PMC10471093.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10313079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Precise genome editing with base editors. 使用基础编辑器进行精确的基因组编辑。

Medical review (Berlin, Germany) Pub Date : 2023-02-22 eCollection Date: 2023-02-01 DOI: 10.1515/mr-2022-0044

Hongcai Liu, Yao Zhu, Minjie Li, Zhimin Gu

引用次数: 1

Application and prospect of artificial intellingence in diabetes care. 人工智能在糖尿病护理中的应用与展望。

Medical review (Berlin, Germany) Pub Date : 2023-02-17 eCollection Date: 2023-02-01 DOI: 10.1515/mr-2022-0039

Weiping Jia, Edwin B Fisher

{"title":"Application and prospect of artificial intellingence in diabetes care.","authors":"Weiping Jia, Edwin B Fisher","doi":"10.1515/mr-2022-0039","DOIUrl":"10.1515/mr-2022-0039","url":null,"abstract":"Diabetes is one of the fastest-growing non-communicable diseases, becoming an important public health concern worldwide as well as in China. Currently, China has the largest population living with diabetes. Artificial intelligence (AI) is a fast-growing field and its applications to diabetes could enable the delivery of better management services for people with diabetes. This perspective summarized the latest findings of digital technologies and AI use in the following areas of diabetes care, mainly including screening and risk predictions of diabetes and diabetic complications, precise monitoring and intervention combined with new technologies, and mobile health application in self-management support for people with diabetes. Challenges to promote further use of AI in diabetes care included data standardization and integration, performance of AI-based medical devices, motivation of patients, and sensitivity to privacy. In summary, although the AI applications in clinical practice is still at an early stage, we are moving toward a new paradigm for diabetes care with the rapid development and emerging application of AI.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 1","pages":"102-104"},"PeriodicalIF":0.0,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/90/81/mr-3-1-mr-2022-0039.PMC10471118.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10657918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frontmatter 头版头条

Medical review (Berlin, Germany) Pub Date : 2023-02-01 DOI: 10.1515/mr-2023-frontmatter1

引用次数: 0