发布求助
文献互助 智能选刊 最新文献

Medical review (Berlin, Germany)最新文献

筛选
英文 中文
Oral microbiome: a doubtful predictor but potential target of cardiovascular diseases. 口腔微生物组：一个值得怀疑的预测因素，但可能成为心血管疾病的靶点。
Medical review (Berlin, Germany) Pub Date : 2023-06-22 eCollection Date: 2023-06-01 DOI: 10.1515/mr-2023-0015
Chak Kwong Cheng, Yu Huang
{"title":"Oral microbiome: a doubtful predictor but potential target of cardiovascular diseases.","authors":"Chak Kwong Cheng, Yu Huang","doi":"10.1515/mr-2023-0015","DOIUrl":"10.1515/mr-2023-0015","url":null,"abstract":"<p><p>Our oral cavity houses various types of microbes including bacteria, protozoa, fungi and viruses, harboring over 700 bacterial species. Oral dysbiosis refers to the imbalance between symbionts and pathobionts in the oral cavity, posing potential threats to host cardiovascular health. Importantly, oral dysbiosis promotes cardiovascular pathophysiology through different mechanisms. Although overgrowth of certain pathogenic bacteria have been indicated in some cardiometabolic diseases, it is still premature to consider oral microbiome as a suitable predictor for non-invasive diagnostic purpose. However, targeting oral microbiome might still provide preventive and therapeutic insights on cardiovascular diseases. Further extensive efforts are needed to deepen our understanding on oral-cardiovascular connection in the context of diagnostic and therapeutic perspectives.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 3","pages":"209-213"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/bd/mr-3-3-mr-2023-0015.PMC10542880.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41164461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two-dimensional layered nanomaterials for tumor diagnosis and treatment. 用于肿瘤诊断和治疗的二维层状纳米材料。
Medical review (Berlin, Germany) Pub Date : 2023-06-14 eCollection Date: 2023-06-01 DOI: 10.1515/mr-2023-0006
Chengyuan Hong, Zhusheng Liu, Tianxiang Chen, Aiguo Wu
{"title":"Two-dimensional layered nanomaterials for tumor diagnosis and treatment.","authors":"Chengyuan Hong, Zhusheng Liu, Tianxiang Chen, Aiguo Wu","doi":"10.1515/mr-2023-0006","DOIUrl":"10.1515/mr-2023-0006","url":null,"abstract":"<p><p>With the evolution of nanomedicine, the past decades witnessed diversified nanomaterials as marvelous anti-tumor tools ushering in a new era of tumor diagnosis and treatment. Among them, two-dimensional layered nanomaterial as an emerging class of nanomaterials has one dimension less than 100 nm, showing a high specific area and the thinnest sheet-like structure (Liu S, Pan X, Liu H. Twodimensional nanomaterials for photothermal therapy. Angew Chem Int Ed 2020;59:5890-900). The discovery of graphene drove the exploration of various new two-dimensional layered nanomaterials for tumor diagnosis and treatment including graphene-based nanomaterials, black phosphorus (BP), transition metal dichalcogenides (TMDs), layered double hydroxides (LDHs), and bismuth oxyhalides (BiOX, X=F, Cl, Br, I) (Ma H, Xue MQ. Recent advances in the photothermal applications of two-dimensional nanomaterial: photothermal therapy and beyond. J Mater Chem 2021;9:17569). On the one hand, they exhibit strong near-infrared (NIR) absorption and the capacity of optimizing corresponding properties by adjusting the crystal structure. On the other hand, they own unique strengths such as fantastic physicochemical properties (graphene-based nanomaterials), high loading capacity (BP), distinct phase-dependent optical properties (TMDs), a specific chemical response to the tumor microenvironment (LDHs), and large X-ray attenuation coefficient (BiOX). Herein, we briefly introduce three typical two-dimensional layered nanomaterials, their prospects and future research priorities in tumor diagnosis and treatment are concluded.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 3","pages":"205-208"},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/06/6a/mr-3-3-mr-2023-0006.PMC10542879.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frontmatter 头版头条
Medical review (Berlin, Germany) Pub Date : 2023-06-01 DOI: 10.1515/mr-2023-frontmatter3
{"title":"Frontmatter","authors":"","doi":"10.1515/mr-2023-frontmatter3","DOIUrl":"https://doi.org/10.1515/mr-2023-frontmatter3","url":null,"abstract":"","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monkeypox scenario in India: a review study. 印度猴痘情况：一项综述研究。
Medical review (Berlin, Germany) Pub Date : 2023-05-26 eCollection Date: 2023-06-01 DOI: 10.1515/mr-2023-0004
Ashish William, Molly Madan
{"title":"Monkeypox scenario in India: a review study.","authors":"Ashish William, Molly Madan","doi":"10.1515/mr-2023-0004","DOIUrl":"10.1515/mr-2023-0004","url":null,"abstract":"<p><p>The monkeypox virus, which causes the viral zoonotic disease, is known as the most significant orthopoxvirus infection following the elimination of smallpox. The monkeypox virus, which was previously exclusive to West and Central African nations and caused endemic diseases in monkeys and people, has recently been linked to human infections in non-endemic areas including the United States of America (USA) and more than 30 additional countries. Guidelines for the diagnosis and treatment of monkeypox have also recently been made available by the Ministry of Health and Family Welfare of India and the Indian Government. The monkeypox outbreak continues to be a worldwide health emergency, the highest degree of alert recognised by the World Health Organization. The Centers for Disease Control and Prevention (CDC) advises vaccination for those who have been exposed to the disease as well as those who may be at higher risk of contracting it, such as those who have been identified by public health officials as a contact of someone who has the disease.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 3","pages":"270-276"},"PeriodicalIF":0.0,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/82/9b/mr-3-3-mr-2023-0004.PMC10542878.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"One-for-All" approach: a black technology for nanomedicine development? “一个为所有人”的方法：纳米医学发展的黑技术？
Medical review (Berlin, Germany) Pub Date : 2023-04-26 eCollection Date: 2023-04-01 DOI: 10.1515/mr-2023-0003
Jiajia Xiang, Shiqun Shao, Zhuxian Zhou, Youqing Shen
{"title":"\"One-for-All\" approach: a black technology for nanomedicine development?","authors":"Jiajia Xiang, Shiqun Shao, Zhuxian Zhou, Youqing Shen","doi":"10.1515/mr-2023-0003","DOIUrl":"10.1515/mr-2023-0003","url":null,"abstract":"<p><p>Cancer nanomedicines require different, even opposite, properties to voyage the cascade drug delivery process involving a series of biological barriers. Currently-approved nanomedicines can only alleviate adverse effects but cannot improve patient survival because they fail to meet all the requirements. Therefore, nanocarriers with synchronized functions are highly requisite to capacitate efficient drug delivery and enhanced therapeutic efficacies. This perspective article summarizes recent advances in the two main strategies for nanomedicine design, the All-in-One approach (integration of all the functions in one system) and the One-for-All approach (one functional group with proper affinity enables all the functions), and presents our views on future nanomedicine development.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 2","pages":"184-187"},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/6e/mr-3-2-mr-2023-0003.PMC10471114.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10311379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of macrophage polarization by iron-based nanoparticles. 铁基纳米颗粒对巨噬细胞极化的调节。
Medical review (Berlin, Germany) Pub Date : 2023-04-18 eCollection Date: 2023-04-01 DOI: 10.1515/mr-2023-0002
He Ding, Yuxin Zhang, Yu Mao, Yan Li, Yan Shen, Jingyi Sheng, Ning Gu
{"title":"Modulation of macrophage polarization by iron-based nanoparticles.","authors":"He Ding, Yuxin Zhang, Yu Mao, Yan Li, Yan Shen, Jingyi Sheng, Ning Gu","doi":"10.1515/mr-2023-0002","DOIUrl":"10.1515/mr-2023-0002","url":null,"abstract":"<p><p>Macrophage polarization is an essential process involved in immune regulation. In response to different microenvironmental stimulation, macrophages polarize into cells with different phenotypes and functions, most typically M1 (pro-inflammatory) and M2 (anti-inflammatory) macrophages. Iron-based nanoparticles have been widely explored and reported to regulate macrophage polarization for various biomedical applications. However, the influence factors and modulation mechanisms behind are complicated and not clear. In this review, we systemically summarized different iron-based nanoparticles that regulate macrophage polarization and function and discussed the influence factors and mechanisms underlying the modulation process. This review aims to deepen the understanding of the modulation of macrophage polarization by iron-based nanoparticles and expects to provide evidence and guidance for subsequent design and application of iron-based nanoparticles with specific macrophage modulation functions.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 2","pages":"105-122"},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/d2/mr-3-2-mr-2023-0002.PMC10471121.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10311382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Nanomedicine sheds new light on cancer immunotherapy. 纳米医学为癌症免疫疗法提供了新的思路。
Medical review (Berlin, Germany) Pub Date : 2023-04-17 eCollection Date: 2023-04-01 DOI: 10.1515/mr-2023-0005
Yingying Yu, Liangzhu Feng, Zhuang Liu
{"title":"Nanomedicine sheds new light on cancer immunotherapy.","authors":"Yingying Yu, Liangzhu Feng, Zhuang Liu","doi":"10.1515/mr-2023-0005","DOIUrl":"10.1515/mr-2023-0005","url":null,"abstract":"<p><p>Cancer immunotherapy comprising of immune checkpoint blockade (ICB) therapy, immune cell therapies, cancer vaccines and many others represents a profound arsenal in the fight against different types of cancers. However, their overall clinical objective response rates, particularly against most solid tumors, are still not sufficient owing to a variety of reasons including the heterogenous expression of tumor antigens, limited tumor infiltration of effector immune cells, acquired tumor immunosuppression and some other factors. In recent years, various nanomedicine strategies have been proposed to assist cancer immunotherapy via distinct mechanisms, presenting new promises in many published studies. This perspective will thus provide a brief overview regarding the development of nanomedicine platforms for improving cancer immunotherapy.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 2","pages":"188-192"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/78/44/mr-3-2-mr-2023-0005.PMC10471084.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10674620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
mRNA lipid nanoparticles induce immune tolerance to treat human diseases. 信使核糖核酸脂质纳米粒子诱导免疫耐受以治疗人类疾病。
Medical review (Berlin, Germany) Pub Date : 2023-04-14 eCollection Date: 2023-04-01 DOI: 10.1515/mr-2023-0008
Wei Cao, Tian Xia
{"title":"mRNA lipid nanoparticles induce immune tolerance to treat human diseases.","authors":"Wei Cao,&nbsp;Tian Xia","doi":"10.1515/mr-2023-0008","DOIUrl":"10.1515/mr-2023-0008","url":null,"abstract":"<p><p>Rapid developments in the coronavirus disease 2019 (COVID-19) mRNA vaccine showcased the power of lipid nanoparticle (LNP) delivery systems in fighting infectious diseases. In addition, mRNA therapeutics are also in development for cancer immunotherapy. Recently, mRNA therapy has been expanded to induce immune tolerance, the opposite of immune-boosting effects, to treat diseases involving enhanced immune responses including allergies and autoimmune diseases. mRNA LNPs have been used to treat peanut allergy by us and autoimmune experimental autoimmune encephalomyelitis by Ugur Sahin. It is expected that more and more research is going to delve into the immune tolerance field for allergies and autoimmune diseases, where effective therapies are in short supply.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 2","pages":"180-183"},"PeriodicalIF":0.0,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/e9/mr-3-2-mr-2023-0008.PMC10471105.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10311384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in nanoparticle-based regulation of immune cells. 基于纳米粒子的免疫细胞调控研究进展。
Medical review (Berlin, Germany) Pub Date : 2023-04-12 eCollection Date: 2023-04-01 DOI: 10.1515/mr-2022-0047
Ya-Nan Fan, Gui Zhao, Yue Zhang, Qian-Ni Ye, Yi-Qun Sun, Song Shen, Yang Liu, Cong-Fei Xu, Jun Wang
{"title":"Progress in nanoparticle-based regulation of immune cells.","authors":"Ya-Nan Fan, Gui Zhao, Yue Zhang, Qian-Ni Ye, Yi-Qun Sun, Song Shen, Yang Liu, Cong-Fei Xu, Jun Wang","doi":"10.1515/mr-2022-0047","DOIUrl":"10.1515/mr-2022-0047","url":null,"abstract":"<p><p>Immune cells are indispensable defenders of the human body, clearing exogenous pathogens and toxicities or endogenous malignant and aging cells. Immune cell dysfunction can cause an inability to recognize, react, and remove these hazards, resulting in cancers, inflammatory diseases, autoimmune diseases, and infections. Immune cells regulation has shown great promise in treating disease, and immune agonists are usually used to treat cancers and infections caused by immune suppression. In contrast, immunosuppressants are used to treat inflammatory and autoimmune diseases. However, the key to maintaining health is to restore balance to the immune system, as excessive activation or inhibition of immune cells is a common complication of immunotherapy. Nanoparticles are efficient drug delivery systems widely used to deliver small molecule inhibitors, nucleic acid, and proteins. Using nanoparticles for the targeted delivery of drugs to immune cells provides opportunities to regulate immune cell function. In this review, we summarize the current progress of nanoparticle-based strategies for regulating immune function and discuss the prospects of future nanoparticle design to improve immunotherapy.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 2","pages":"152-179"},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/be/ae/mr-3-2-mr-2022-0047.PMC10471115.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10311383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Versatile biomimetic nanomedicine for treating cancer and inflammation disease. 用于治疗癌症和炎症疾病的多功能仿生纳米药物。
Medical review (Berlin, Germany) Pub Date : 2023-04-07 eCollection Date: 2023-04-01 DOI: 10.1515/mr-2022-0046
Zhiwen Zhao, Dangge Wang, Yaping Li
{"title":"Versatile biomimetic nanomedicine for treating cancer and inflammation disease.","authors":"Zhiwen Zhao, Dangge Wang, Yaping Li","doi":"10.1515/mr-2022-0046","DOIUrl":"10.1515/mr-2022-0046","url":null,"abstract":"<p><p>Nanosized drug delivery systems (NDDSs) have emerged as a powerful tool to optimize drug delivery in complex diseases, including cancer and inflammation. However, the therapeutic effect of NDDSs is still far from satisfactory due to their poor circulation time, low delivery efficiency, and innate toxicity. Fortunately, biomimetic approaches offer new opportunities to develop nanomedicine, which is derived from a variety of native biomolecules including cells, exosomes, bacteria, and so on. Since inheriting the superior biocompatibility and versatile functions of natural materials, biomimetic nanomedicine can mimic biological processes, prolong blood circulation, and lower immunogenicity, serving as a desired platform for precise drug delivery for treating cancer and inflammatory disease. In this review, we outline recent advances in biomimetic NDDSs, which consist of two concepts: biomimetic exterior camouflage and bioidentical molecule construction. We summarize engineering strategies that further functionalized current biomimetic NDDSs. A series of functional biomimetic NDDSs created by our group are introduced. We conclude with an outlook on remaining challenges and possible directions for biomimetic NDDSs. We hope that better technologies can be inspired and invented to advance drug delivery systems for cancer and inflammation therapy.</p>","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 2","pages":"123-151"},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/12/mr-3-2-mr-2022-0046.PMC10471090.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10311381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信