Journal of ocular biology, diseases, and informatics最新文献_第9页

Erratum. 勘误表。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-06-01 Epub Date: 2009-05-28 DOI: 10.1007/s12177-009-9022-x

Narayanasamy Angayarkanni, Radhakrishnan Selvi, Pukhraj Rishi, Jyotirmoy Biswas, J Bhavesh Shah, Joyce Tombran-Tink

引用次数: 7

An experiment of the combined treatment of traditional Lei-huo-jiu therapy with Chinese medicine for the lacrimal gland of Sjögren's syndrome. 传统雷火九疗法与中药联合治疗斯约格伦综合征泪腺的实验。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-06-01 Epub Date: 2009-07-21 DOI: 10.1007/s12177-009-9027-5

Ming Jin, Haijiao Song, Lin Pan

{"title":"An experiment of the combined treatment of traditional Lei-huo-jiu therapy with Chinese medicine for the lacrimal gland of Sjögren's syndrome.","authors":"Ming Jin, Haijiao Song, Lin Pan","doi":"10.1007/s12177-009-9027-5","DOIUrl":"10.1007/s12177-009-9027-5","url":null,"abstract":"This experiment chooses nonobese diabetic (NOD) mouse as the animal model of Sjögren's syndrome and investigates the morphologic changes, the expression of inflammatory factors and growth factors of this mouse's lacrimal gland in response to a combined treatment of traditional Lei-huo-jiu therapy alone and in combination with Chinese medicine. The methods were to (1) use a morphological approach to directly observe pathological changes of the lacrimal gland in response to combined treatment and (2) to detect the level of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and nuclear factor kappa B (NF-kappaB) in lacrimal gland tissue caused by the combined treatments using a immunohistochemical approach. There is a reduction of the mast cell's degranulation and modulation of the level of cytokines in TNF-alpha, IL-1, and NF-kappaB in the combined therapy group. The combined treatment of traditional Lei-huo-jiu therapy with Chinese medicine can improve the pathological changes of the lacrimal gland tissue of the NOD mouse through modulating the level of TNF-alpha, IL-1, and NF-kappaB which results in improved tear secretion and function of the lacrimal gland.","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"2 2","pages":"65-72"},"PeriodicalIF":0.0,"publicationDate":"2009-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/15/34/12177_2009_Article_9027.PMC2723673.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40027605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychoneuroimmunology: application to ocular diseases. 心理神经免疫学在眼部疾病中的应用。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-06-01 Epub Date: 2009-08-02 DOI: 10.1007/s12177-009-9028-4

Lori M Ventura

引用次数: 6

The two sides of cytokine signaling and glaucomatous optic neuropathy. 细胞因子信号转导与青光眼视神经病变的关系。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-06-01 Epub Date: 2009-07-01 DOI: 10.1007/s12177-009-9026-6

Ping Huang, Samuel Shao-Min Zhang, Chun Zhang

{"title":"The two sides of cytokine signaling and glaucomatous optic neuropathy.","authors":"Ping Huang, Samuel Shao-Min Zhang, Chun Zhang","doi":"10.1007/s12177-009-9026-6","DOIUrl":"https://doi.org/10.1007/s12177-009-9026-6","url":null,"abstract":"The mechanistic study of glaucoma pathogenesis has shifted to seeking to understand the effects of immune responses on retinal ganglion cell damage and protection. Cytokines are the hormonal factors that mediate most of the biological effects in both the immune and nonimmune systems. CD4-expressing T helper cells are a major source of cytokine production and regulation. Type 1 helper T (Th1) cells are characterized by the production of proinflammatory cytokines such as interferon-gamma, interleukin (IL)-2, IL-12, IL-23, and tumor necrosis factor-alpha while type 2 helper T (Th2) cells are characterized by the production of IL-4, IL-5, IL-6, and IL-10. The balance of Th1/Th2 cytokine production influences many pathological processes and plays both causative and protective roles in neuron damages. Growing evidence indicates that imbalances of Th1/Th2 cytokine production are involved in neural damage or protection in many neurological diseases. In this review, we discuss the possible roles of Th1/Th2 cytokine production and imbalance of Th1/Th2 cytokines in retina, especially glaucomatous optic neuropathy.","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"2 2","pages":"78-83"},"PeriodicalIF":0.0,"publicationDate":"2009-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-009-9026-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40027604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Modulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model. 枸杞对高眼压模型大鼠视网膜神经节细胞存活的调节作用。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-06-01 Epub Date: 2009-07-01 DOI: 10.1007/s12177-009-9023-9

Kin Chiu, Hiu-Chi Chan, Sze-Chun Yeung, Wai-Hung Yuen, Sze-Yong Zee, Raymond Chuen-Chung Chang, Kwok-Fai So

{"title":"Modulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model.","authors":"Kin Chiu, Hiu-Chi Chan, Sze-Chun Yeung, Wai-Hung Yuen, Sze-Yong Zee, Raymond Chuen-Chung Chang, Kwok-Fai So","doi":"10.1007/s12177-009-9023-9","DOIUrl":"10.1007/s12177-009-9023-9","url":null,"abstract":"The active component of Wolfberry (Lycium barbarum), lycium barbarum polysaccharides (LBP), has been shown to be neuroprotective to retinal ganglion cells (RGCs) against ocular hypertension (OH). Aiming to study whether this neuroprotection is mediated via modulating immune cells in the retina, we used multiphoton confocal microscopy to investigate morphological changes of microglia in whole-mounted retinas. Retinas under OH displayed slightly activated microglia. One to 100 mg/kg LBP exerted the best neuroprotection and elicited moderately activated microglia in the inner retina with ramified appearance but thicker and focally enlarged processes. Intravitreous injection of lipopolysaccharide decreased the survival of RGCs at 4 weeks, and the activated microglia exhibited amoeboid appearance as fully activated phenotype. When activation of microglia was attenuated by intravitreous injection of macrophage/microglia inhibitory factor, protective effect of 10 mg/kg LBP was attenuated. The results implicated that neuroprotective effects of LBP were partly due to modulating the activation of microglia.","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"2 2","pages":"47-56"},"PeriodicalIF":0.0,"publicationDate":"2009-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-009-9023-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40027606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Immune maintenance in glaucoma: boosting the body's own neuroprotective potential. 青光眼的免疫维护：增强人体自身的神经保护潜能。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-06-01 Epub Date: 2009-07-21 DOI: 10.1007/s12177-009-9025-7

Michal Schwartz, Anat London

{"title":"Immune maintenance in glaucoma: boosting the body's own neuroprotective potential.","authors":"Michal Schwartz, Anat London","doi":"10.1007/s12177-009-9025-7","DOIUrl":"10.1007/s12177-009-9025-7","url":null,"abstract":"Glaucoma, a slow progressive neurodegenerative disorder associated with death of retinal ganglion cells and degeneration of their connected optic nerve fibers, has been classically linked to high intraocular pressure. Regardless of the primary risk factor, degeneration may continue, resulting in further loss of neurons and subsequent glaucomatous damage. During the past decade, scientists and clinicians began to accept that, in addition or as an alternative to fighting off the primary risk factor(s), there is a need to protect the tissue from the ongoing spread of damage-an approach collectively termed \"neuroprotection.\" We found that the immune system, the body's own defense mechanism, plays a key role in the ability of the optic nerve and the retina to withstand glaucomatous conditions. This defense involves recruitment of both innate and adaptive immune cells that together create a protective niche and thereby halt disease progression. The spontaneous immune response might not be sufficient, and therefore, we suggest boosting it by immunization (with the appropriate antigen, at specific timing and predetermined optimal dosing) which may be developed into a suitable therapeutic vaccination to treat glaucoma. This view of immune system involvement in glaucoma will raise new challenges in glaucoma research, changing the way in which clinicians perceive the disease and the approach to therapy.","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"2 2","pages":"73-77"},"PeriodicalIF":0.0,"publicationDate":"2009-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e3/2b/12177_2009_Article_9025.PMC2723675.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40028014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural protection by naturopathic compounds-an example of tetramethylpyrazine from retina to brain. 自然疗法化合物的神经保护作用——以四甲基吡嗪为例，从视网膜到大脑。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-06-01 Epub Date: 2009-07-14 DOI: 10.1007/s12177-009-9024-8

Zhiqun Tan

{"title":"Neural protection by naturopathic compounds-an example of tetramethylpyrazine from retina to brain.","authors":"Zhiqun Tan","doi":"10.1007/s12177-009-9024-8","DOIUrl":"https://doi.org/10.1007/s12177-009-9024-8","url":null,"abstract":"Given the advantages of being stable in the ambient environment, being permeable to the blood-brain and/or blood-eye barriers and being convenient for administration, naturopathic compounds have growingly become promising therapeutic candidates for neural protection. Extracted from one of the most common Chinese herbal medicines, tetramethylpyrazine (TMP), also designated as ligustrazine, has been suggested to be neuroprotective in the central nervous system as well as the peripheral nerve network. Although the detailed molecular mechanisms of its efficacy for neural protection are understood limitedly, accumulating evidence suggests that antioxidative stress, antagonism for calcium, and suppression of pro-inflammatory factors contribute significantly to its neuroprotection. In animal studies, systemic administration of TMP (subcutaneous injection, 50 mg/kg) significantly blocked neuronal degeneration in hippocampus as well as the other vulnerable regions in brains of Sprague-Dawley rats following kainate-induced prolonged seizures. Results from us and others also demonstrated potent neuroprotective efficacy of TMP for retinal cells and robust benefits for brain in Alzheimer's disease or other brain injury. These results suggest a promising prospect for TMP to be used as a treatment of specific neurodegenerative diseases. Given the assessment of the distribution, metabolism, excretion, and toxicity information that is already available on most neuroprotective naturopathic compounds such as TMP, it would not take much preclinical data to justify bringing such therapeutic compounds to clinical trials in humans.","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"2 2","pages":"57-64"},"PeriodicalIF":0.0,"publicationDate":"2009-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-009-9024-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40027603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Intracameral bevacizumab and mitomycin C Trabeculectomy for eyes with neovascular glaucoma: a case series. 眼眶内贝伐单抗和丝裂霉素C小梁切除术治疗新生血管性青光眼:一个病例系列。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-03-31 DOI: 10.1007/s12177-009-9020-z

Carlos Gustavo Vasconcelos de Moraes, Antonio Carlos Facio, José Humberto Costa, Roberto Freire Santiago Malta

{"title":"Intracameral bevacizumab and mitomycin C Trabeculectomy for eyes with neovascular glaucoma: a case series.","authors":"Carlos Gustavo Vasconcelos de Moraes, Antonio Carlos Facio, José Humberto Costa, Roberto Freire Santiago Malta","doi":"10.1007/s12177-009-9020-z","DOIUrl":"https://doi.org/10.1007/s12177-009-9020-z","url":null,"abstract":"The purpose of this study was to describe the surgical outcomes and safety of intracameral bevacizumab during trabeculectomy in eyes with neovascular glaucoma. Pilot study included four eyes (four patients) with refractory neovascular glaucoma submitted to fornix-based trabeculectomy with adjunctive use of bevacizumab in the anterior chamber during the procedure. Patients were previously treated with panretinal photocoagulation as standard therapy. Variables evaluated were intraocular pressure, bleb appearance, iris neovascularization, intraoperative/postoperative complications, and visual outcomes. No intraoperative complication was observed. The mean follow-up period was 12.75 (range, 12-15 months). All eyes showed significant intraocular pressure control postoperatively. Iris neovascularization reduced significantly within 1 month after surgery. Mild anterior chamber inflammation was observed during follow-up in all eyes. No significant postoperative complication was observed, and no patient presented visual acuity deterioration. Intracameral bevacizumab may be used as an adjunctive therapy during trabeculectomy in eyes with neovascular glaucoma.","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"2 1","pages":"40-6"},"PeriodicalIF":0.0,"publicationDate":"2009-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-009-9020-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28644711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Biocompatibility of subretinal parylene-based Ti/Pt microelectrode array in rabbit for further artificial vision studies. 视网膜下聚苯二烯基Ti/Pt微电极阵列在兔体内的生物相容性研究。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-03-27 DOI: 10.1007/s12177-009-9018-6

Weihong Yu, Xuqian Wang, Chan Zhao, Zhikun Yang, Rongping Dai, Fangtian Dong

引用次数: 12

A case of amniotic membrane transplantation in non-healing Nocardia asteroides keratitis. 羊膜移植治疗未愈合的小行星诺卡菌角膜炎1例。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-03-10 DOI: 10.1007/s12177-009-9019-5

Firoozeh Rahimi, Masood Aghsaie Fard, Reza Soltani Mogaddam

引用次数: 3