Journal of ocular biology, diseases, and informatics最新文献_第8页

Radiotherapy in the treatment of Graves ophthalmopathy-to do it or not? 放疗治疗Graves眼病——该不该?

Journal of ocular biology, diseases, and informatics Pub Date : 2009-10-06 DOI: 10.1007/s12177-009-9021-y

Aneta Zygulska

{"title":"Radiotherapy in the treatment of Graves ophthalmopathy-to do it or not?","authors":"Aneta Zygulska","doi":"10.1007/s12177-009-9021-y","DOIUrl":"https://doi.org/10.1007/s12177-009-9021-y","url":null,"abstract":"To the objective of this study is to evaluate the role and toxicity of radiotherapy in the treatment of Graves ophthalmopathy. In the years 2000-2003, 121 patients with malignant exophthalmos were treated with radiotherapy of the retrobulbar area to the total dose of 20 Gy in ten fractions with a 6 MeV photon beam. The treatment was performed by the team of the Clinic of Oncology of the Jagiellonian University Medical College in Cracow. The radiotherapy was preceded by intravenous steroid therapy: methylprednisolone acetate administered at the dose of 2 g/week for four consecutive weeks. The highest efficacy, expressed as improvement of all ocular symptoms, was observed for the combined treatment. Female and non-diabetic patients responded positively to the combined treatment. Radiotherapy combined with steroid therapy in the treatment of Graves ophthalmopathy seems to be an effective treatment for strictly defined indications. In the treatment of Graves-Basedow disease, radiotherapy is a well-tolerated treatment modality. Diabetes is a factor that worsens prognosis in Graves ophthalmopathy and female sex is a favourable factor for this condition.","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"3 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2009-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-009-9021-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40063398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Erratum: Psychoneuroimmunology: application to ocular diseases. 勘误:心理神经免疫学:在眼部疾病中的应用。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-09-01 Epub Date: 2009-09-19 DOI: 10.1007/s12177-009-9032-8

Lori M Ventura

{"title":"Erratum: Psychoneuroimmunology: application to ocular diseases.","authors":"Lori M Ventura","doi":"10.1007/s12177-009-9032-8","DOIUrl":"https://doi.org/10.1007/s12177-009-9032-8","url":null,"abstract":"Psychoneuroimmunology (PNI) is a relatively new discipline within the field of neuroscience which researches the relationship between emotional states, the central and peripheral nervous systems, and the endocrine and immune systems. Negative psychological states, such as stress, anxiety, and depression, may alter immune system regulation and modulation of peripheral cytokines. A plethora of PNI studies have shown that increased psychological stress and depression are associated with an alteration of immune functioning and worsened health outcomes for many conditions. To date, application of PNI methodology has not been reported for ocular diseases. This article provides an historical perspective on the origins of the rift between the emotional and spiritual from physical aspects of disease. A review of how stress is mediated through sympathetic adrenomedullary and hypothalamic pituitary axis activation with shifts in immunity is provided. The literature which supports spirituality in healing is presented. Finally, ocular diseases which would be most amenable to a PNI approach are discussed.[This corrects the article on p. in vol. .].","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"2 3","pages":"109-118"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-009-9032-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28624620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Erratum: An experiment of the combined treatment of traditional Lei-huo-jiu therapy with Chinese medicine for the lacrimal gland of Sjögren's syndrome. 转载：传统雷火九疗法与中药联合治疗斯约格伦综合征泪腺的实验。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-09-01 Epub Date: 2009-09-03 DOI: 10.1007/s12177-009-9031-9

Ming Jin, Haijiao Song, Lin Pan

{"title":"Erratum: An experiment of the combined treatment of traditional Lei-huo-jiu therapy with Chinese medicine for the lacrimal gland of Sjögren's syndrome.","authors":"Ming Jin, Haijiao Song, Lin Pan","doi":"10.1007/s12177-009-9031-9","DOIUrl":"10.1007/s12177-009-9031-9","url":null,"abstract":"This experiment chooses nonobese diabetic (NOD) mouse as the animal model of Sjögren's syndrome and investigates the morphologic changes, the expression of inflammatory factors and growth factors of this mouse's lacrimal gland in response to a combined treatment of traditional Lei-huo-jiu therapy alone and in combination with Chinese medicine. The methods were to (1) use a morphological approach to directly observe pathological changes of the lacrimal gland in response to combined treatment and (2) to detect the level of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and nuclear factor kappa B (NF-kappaB) in lacrimal gland tissue caused by the combined treatments using a immunohistochemical approach. There is a reduction of the mast cell's degranulation and modulation of the level of cytokines in TNF-alpha, IL-1, and NF-kappaB in the combined therapy group. The combined treatment of traditional Lei-huo-jiu therapy with Chinese medicine can improve the pathological changes of the lacrimal gland tissue of the NOD mouse through modulating the level of TNF-alpha, IL-1, and NF-kappaB which results in improved tear secretion and function of the lacrimal gland.[This corrects the article on p. in vol. .].","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"2 3","pages":"119-126"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/37/12177_2009_Article_9031.PMC2798982.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28624003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bile acids in treatment of ocular disease. 胆汁酸治疗眼疾。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-09-01 Epub Date: 2009-08-27 DOI: 10.1007/s12177-009-9030-x

Jeffrey H Boatright, John M Nickerson, Anisha G Moring, Machelle T Pardue

引用次数: 0

Erratum: Neural protection by naturopathic compounds-an example of tetramethylpyrazine from retina to brain. 勘误:自然疗法化合物的神经保护作用——以四甲基吡嗪为例，从视网膜到大脑。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-09-01 DOI: 10.1007/s12177-009-9033-7

Zhiqun Tan

{"title":"Erratum: Neural protection by naturopathic compounds-an example of tetramethylpyrazine from retina to brain.","authors":"Zhiqun Tan","doi":"10.1007/s12177-009-9033-7","DOIUrl":"https://doi.org/10.1007/s12177-009-9033-7","url":null,"abstract":"Given the advantages of being stable in the ambient environment, being permeable to the blood-brain and/or blood-eye barriers and being convenient for administration, naturopathic compounds have growingly become promising therapeutic candidates for neural protection. Extracted from one of the most common Chinese herbal medicines, tetramethylpyrazine (TMP), also designated as ligustrazine, has been suggested to be neuroprotective in the central nervous system as well as the peripheral nerve network. Although the detailed molecular mechanisms of its efficacy for neural protection are understood limitedly, accumulating evidence suggests that antioxidative stress, antagonism for calcium, and suppression of pro-inflammatory factors contribute significantly to its neuroprotection. In animal studies, systemic administration of TMP (subcutaneous injection, 50 mg/kg) significantly blocked neuronal degeneration in hippocampus as well as the other vulnerable regions in brains of Sprague-Dawley rats following kainate-induced prolonged seizures. Results from us and others also demonstrated potent neuroprotective efficacy of TMP for retinal cells and robust benefits for brain in Alzheimer's disease or other brain injury. These results suggest a promising prospect for TMP to be used as a treatment of specific neurodegenerative diseases. Given the assessment of the distribution, metabolism, excretion, and toxicity information that is already available on most neuroprotective naturopathic compounds such as TMP, preclinical data to justify bringing such therapeutic compounds to clinical trials in humans is feasible.[This corrects the article on p. in vol. .].","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"2 3","pages":"137-144"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-009-9033-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28624008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Erratum: Modulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model. 更正:枸杞调节小胶质细胞对高眼压模型大鼠视网膜神经节细胞存活的影响。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-09-01 Epub Date: 2009-09-16 DOI: 10.1007/s12177-009-9035-5

Kin Chiu, Hiu-Chi Chan, Sze-Chun Yeung, Wai-Hung Yuen, Sze-Yong Zee, Raymond Chuen-Chung Chang, Kwok-Fai So

{"title":"Erratum: Modulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model.","authors":"Kin Chiu, Hiu-Chi Chan, Sze-Chun Yeung, Wai-Hung Yuen, Sze-Yong Zee, Raymond Chuen-Chung Chang, Kwok-Fai So","doi":"10.1007/s12177-009-9035-5","DOIUrl":"10.1007/s12177-009-9035-5","url":null,"abstract":"The active component of Wolfberry (Lycium barbarum), lycium barbarum polysaccharides (LBP), has been shown to be neuroprotective to retinal ganglion cells (RGCs) against ocular hypertension (OH). Aiming to study whether this neuroprotection is mediated via modulating immune cells in the retina, we used multiphoton confocal microscopy to investigate morphological changes of microglia in whole-mounted retinas. Retinas under OH displayed slightly activated microglia. One to 100 mg/kg LBP exerted the best neuroprotection and elicited moderately activated microglia in the inner retina with ramified appearance but thicker and focally enlarged processes. Intravitreous injection of bacterial endotoxin lipopolysaccharide (LPS) decreased the survival of RGCs at 4 weeks, and the activated microglia exhibited amoeboid appearance as fully activated phenotype. When activation of microglia was attenuated by intravitreous injection of macrophage/microglia inhibitory factor, protective effect of 10 mg/kg LBP was attenuated. The results implicated that neuroprotective effects of LBP were partly due to modulating the activation of microglia.[This corrects the article on p. in vol. .].","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"2 3","pages":"127-136"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-009-9035-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28624004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Introduction: complementary medicine in ophthalmology. 介绍:眼科的补充医学。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-09-01 Epub Date: 2009-08-05 DOI: 10.1007/s12177-009-9029-3

Lori Ventura

引用次数: 1

Erratum: The two sides of cytokine signaling and glaucomatous optic neuropathy. 勘误:细胞因子信号传导与青光眼视神经病变的两面。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-09-01 Epub Date: 2009-09-09 DOI: 10.1007/s12177-009-9034-6

Ping Huang, Samuel Shao-Min Zhang, Chun Zhang

{"title":"Erratum: The two sides of cytokine signaling and glaucomatous optic neuropathy.","authors":"Ping Huang, Samuel Shao-Min Zhang, Chun Zhang","doi":"10.1007/s12177-009-9034-6","DOIUrl":"https://doi.org/10.1007/s12177-009-9034-6","url":null,"abstract":"The mechanistic study of glaucoma pathogenesis has shifted to seeking to understand the effects of immune responses on retinal ganglion cell damage and protection. Cytokines are the hormonal factors that mediate most of the biological effects in both the immune and nonimmune systems. CD4-expressing T helper cells are a major source of cytokine production and regulation. Type 1 helper T (Th1) cells are characterized by the production of proinflammatory cytokines such as interferon-gamma, interleukin (IL)-2, IL-12, IL-23, and tumor necrosis factor-alpha while type 2 helper T (Th2) cells are characterized by the production of IL-4, IL-5, IL-6, and IL-10. The balance of Th1/Th2 cytokine production influences many pathological processes and plays both causative and protective roles in neuronal damage. Growing evidence indicates that imbalances of Th1/Th2 cytokine production are involved in neural damage or protection in many neurological diseases. In this review, we discuss the possible roles of Th1/Th2 cytokine production and imbalance of Th1/Th2 cytokines in retina, especially glaucomatous optic neuropathy.[This corrects the article on p. in vol. .].","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"2 3","pages":"98-103"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-009-9034-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28624005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Erratum to: Immune maintenance in glaucoma: boosting the body's own neuroprotective potential. 勘误：青光眼的免疫维护：增强人体自身的神经保护潜能。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-09-01 Epub Date: 2009-09-23 DOI: 10.1007/s12177-009-9037-3

Michal Schwartz, Anat London

{"title":"Erratum to: Immune maintenance in glaucoma: boosting the body's own neuroprotective potential.","authors":"Michal Schwartz, Anat London","doi":"10.1007/s12177-009-9037-3","DOIUrl":"10.1007/s12177-009-9037-3","url":null,"abstract":"Glaucoma, a slow progressive neurodegenerative disorder associated with death of retinal ganglion cells and degeneration of their connected optic nerve fibers, has been classically linked to high intraocular pressure. Regardless of the primary risk factor, degeneration may continue, resulting in further loss of neurons and subsequent glaucomatous damage. During the past decade, scientists and clinicians began to accept that, in addition or as an alternative to fighting off the primary risk factor(s), there is a need to protect the tissue from the ongoing spread of damage-an approach collectively termed \"neuroprotection.\" We found that the immune system, the body's own defense mechanism, plays a key role in the ability of the optic nerve and the retina to withstand glaucomatous conditions. This defense involves recruitment of both innate and adaptive immune cells that together create a protective niche and thereby halt disease progression. The spontaneous immune response might not be sufficient, and therefore, we suggest boosting it by immunization (with the appropriate antigen, at specific timing and predetermined optimal dosing) which may be developed into a suitable therapeutic vaccination to treat glaucoma. This view of immune system involvement in glaucoma will raise new challenges in glaucoma research, changing the way in which clinicians perceive the disease and the approach to therapy.[This corrects the article on p. in vol. .].","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"2 3","pages":"104-108"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ec/a4/12177_2009_Article_9037.PMC2798980.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28624619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria and the regulation of free radical damage in the eye. 线粒体与眼睛自由基损伤的调节。

Journal of ocular biology, diseases, and informatics Pub Date : 2009-09-01 Epub Date: 2009-09-18 DOI: 10.1007/s12177-009-9036-4

Colin J Barnstable

引用次数: 0