Journal of ocular biology, diseases, and informatics最新文献

Post-trabeculectomy topical bevacizumab preventing bleb failure: a preliminary study. 小梁切除术后局部贝伐单抗预防水泡衰竭:初步研究。

Journal of ocular biology, diseases, and informatics Pub Date : 2013-06-27 eCollection Date: 2012-12-01 DOI: 10.1007/s12177-013-9108-3

Shashi Kumar Bhasker, Sandeep Saxena, Kamlesh Singh

{"title":"Post-trabeculectomy topical bevacizumab preventing bleb failure: a preliminary study.","authors":"Shashi Kumar Bhasker, Sandeep Saxena, Kamlesh Singh","doi":"10.1007/s12177-013-9108-3","DOIUrl":"https://doi.org/10.1007/s12177-013-9108-3","url":null,"abstract":"This study aims to evaluate the efficacy and safety of post-trabeculectomy topical bevacizumab, in preventing bleb failure. A total of 11 females and 12 males were enrolled for the study. After a complete ophthalmic evaluation, the patients underwent trabeculectomy. Full ophthalmic examination was done the next day, which included visual acuity, intraocular pressure (IOP), and bleb morphology. Next, two drops of bevacizumab [0.25 mg (0.01 ml)] were instilled over the wound area with a tuberculin (1 ml) syringe. Pressure was applied at the medial canthus to prevent it from going into the lacrimal passage. Similar postoperative procedures were repeated at 1, 2, 3, and 4 weeks. So in all, five instillations of bevacizumab were completed. Later, the patients were followed at 1-month interval for 6 months. Target IOP was achieved in all eyes and was maintained during the study period of 6 months without any anti-glaucoma medication. Average IOP before trabeculectomy was 27.27 ± 8.92 mmHg, which decreased postoperatively to 8.77 ± 0.97 mmHg at 3 months and 9.27 ± 1.16 mmHg at 6 months. This drop in IOP was statistically significant on both occasions (p = 0.00). A nice low filtering bleb was formed after the surgery, and it remained the same during the study period. The other parameters like cup-to-disc ratio and visual field did not change during the 6 months of study as expected because glaucoma is a slow progressive disease. Modulating the wound at multiple sites by bevacizumab (inflammation, proliferative, and remodeling stages) can lead to success of trabeculectomy. ","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"5 3-4","pages":"89-95"},"PeriodicalIF":0.0,"publicationDate":"2013-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-013-9108-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40283829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Two separate methods of stem cell transplantation in both eyes of a single patient presented with bilateral stem cell deficiency following exposure to Euphorbia latex. 两种不同的干细胞移植方法在一个单一的病人的双眼呈现双侧干细胞缺乏后，暴露于大大麻乳胶。

Journal of ocular biology, diseases, and informatics Pub Date : 2013-06-12 eCollection Date: 2012-12-01 DOI: 10.1007/s12177-013-9109-2

Jayanta Dutta, Somnath Mukhopadhyay, Kapil D Lahiri, Himadri Datta

引用次数: 0

A case of pseudoxantoma elasticum. 弹性假性黄瘤1例。

Journal of ocular biology, diseases, and informatics Pub Date : 2013-05-05 eCollection Date: 2012-12-01 DOI: 10.1007/s12177-013-9107-4

Duriye Deniz Demirseren, Nagihan Ugurlu, Aysegul Arman, Selma Emre, Sibel Orhun Yavuz, Ahmet Metin

引用次数: 1

Effect of cord blood serum on ex vivo human limbal epithelial cell culture. 脐带血血清对体外培养人角膜缘上皮细胞的影响。

Journal of ocular biology, diseases, and informatics Pub Date : 2013-05-04 eCollection Date: 2012-12-01 DOI: 10.1007/s12177-013-9106-5

Anindita Chakraborty, Jayanta Dutta, Sumantra Das, Himadri Datta

{"title":"Effect of cord blood serum on ex vivo human limbal epithelial cell culture.","authors":"Anindita Chakraborty, Jayanta Dutta, Sumantra Das, Himadri Datta","doi":"10.1007/s12177-013-9106-5","DOIUrl":"https://doi.org/10.1007/s12177-013-9106-5","url":null,"abstract":"Limbal cell transplantation is an efficacious procedure for rehabilitation of visual acuity in patients with severe ocular surface disorders. Cultivation of limbal epithelial stem cell with fetal bovine serum for transplantation has been a promising treatment for reconstructing the ocular surface in severe limbal stem cell deficiency caused by Steven Johnson syndrome, chemical or thermal injury. This technique of \"cell therapy\" has been accepted worldwide but the cost of cultivating the cells for transplantation is high. The objective of this study was to investigate the effect of cord blood serum in place of fetal bovine serum on the growth of human limbal epithelial cell culture. Our group has experimented with human cord blood serum which was obtained free of cost from willing donors. The use of human cord blood serum in place of fetal bovine serum for ex vivo culture of limbal stem cell has helped us in reducing the cost of culture. Fresh human limbal tissues from donor cadavers were cultured on intact and denuded amniotic membrane. Cells were proliferated in vitro with cell culture media containing human cord blood serum. Reverse transcription-polymerase chain reaction and immunofluorescence cytochemistry of cultured human limbal epithelial stem cell was done for characterization of the cells. ","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"5 3-4","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"2013-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-013-9106-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40283826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

3D spectral domain OCT in spontaneous retinal pigment epithelial tear. 自发性视网膜色素上皮撕裂的三维光谱域OCT。

Journal of ocular biology, diseases, and informatics Pub Date : 2013-04-25 eCollection Date: 2012-12-01 DOI: 10.1007/s12177-013-9105-6

Sandeep Saxena, Nibha Mishra, Carsten H Meyer

引用次数: 2

Advanced glycation end products and diabetic retinopathy. 晚期糖基化终产物与糖尿病视网膜病变。

Journal of ocular biology, diseases, and informatics Pub Date : 2013-04-19 eCollection Date: 2012-12-01 DOI: 10.1007/s12177-013-9104-7

Yashodhara Sharma, Sandeep Saxena, Arvind Mishra, Anita Saxena, Shankar Madhav Natu

{"title":"Advanced glycation end products and diabetic retinopathy.","authors":"Yashodhara Sharma, Sandeep Saxena, Arvind Mishra, Anita Saxena, Shankar Madhav Natu","doi":"10.1007/s12177-013-9104-7","DOIUrl":"https://doi.org/10.1007/s12177-013-9104-7","url":null,"abstract":"Studies have established hyperglycemia as the most important factor in the progress of vascular complications. Formation of advanced glycation end products (AGEs) correlates with glycemic control. The AGE hypothesis proposes that hyperglycemia contributes to the pathogenesis of diabetic complications including retinopathy. However, their role in diabetic retinopathy remains largely unknown. This review discusses the chemistry of AGEs formation and their patho-biochemistry particularly in relation to diabetic retinopathy. AGEs exert deleterious effects by acting directly to induce cross-linking of long-lived proteins to promote vascular stiffness, altering vascular structure and function and interacting with receptor for AGE, to induce intracellular signaling leading to enhanced oxidative stress and elaboration of key proinflammatory and prosclerotic cytokines. Novel anti-AGE strategies are being developed hoping that in next few years, some of these promising therapies will be successfully evaluated in clinical context aiming to reduce the major economical and medical burden caused by diabetic retinopathy. ","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"5 3-4","pages":"63-9"},"PeriodicalIF":0.0,"publicationDate":"2013-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-013-9104-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40283825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

An unusual case of branch retinal venous occlusion in a patient of uncomplicated pregnancy. 无并发症妊娠患者视网膜分支静脉闭塞的罕见病例。

Journal of ocular biology, diseases, and informatics Pub Date : 2013-04-05 eCollection Date: 2012-12-01 DOI: 10.1007/s12177-013-9103-8

Jayanta Dutta, Rupam Roy, Somnath Mukhopadhyay, Suhrita De Roy

引用次数: 0

Structural studies on AIPL1 and its functional interactions with NUB1 to identify key interacting residues in LCA4. AIPL1的结构研究及其与NUB1的功能相互作用，以确定LCA4中关键的相互作用残基。

Journal of ocular biology, diseases, and informatics Pub Date : 2013-04-04 eCollection Date: 2012-12-01 DOI: 10.1007/s12177-013-9102-9

S Muthukumaran, V Umashankar, Meena Revathi Valliappan

{"title":"Structural studies on AIPL1 and its functional interactions with NUB1 to identify key interacting residues in LCA4.","authors":"S Muthukumaran, V Umashankar, Meena Revathi Valliappan","doi":"10.1007/s12177-013-9102-9","DOIUrl":"https://doi.org/10.1007/s12177-013-9102-9","url":null,"abstract":"Leber congenital amaurosis (LCA) is an autosomal recessive disorder that causes visual impairment in children due to fifteen different gene mutations. Of these, mutations in Aryl-Hydrocarbon Receptor Interacting Protein-like 1 (AIPL1) cause the most severe form of LCA (LCA4) leading to the degeneration of photoreceptor cells. NEDD8 Ultimate Buster 1 (NUB1), a protein that regulates cell cycle progression, interacts with AIPL1 to prevent the over expression of NUB1. In the case of over expression, cell cycle progression is disrupted and may lead to LCA. The studies on interactions between these two proteins will aid in identifying potential modulators for this condition. Since no three-dimensional structure is currently available for these two proteins, in this study we predicted the structures of these two proteins by molecular modelling methods. Moreover, we also modelled the three proven significant mutant forms of AIPL1 spanning the tetratricopeptide domain. Finally, both the modelled wild and mutant structures of AIPL1 (A197P, C239R and G262S) were computationally docked to NUB1, so as to map the potential molecular interactions. This is the first study on modelling the structure-function relationship of AIPL1-NUB1 interactions which shall aid in discovery of novel therapeutic agents. ","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"5 3-4","pages":"54-60"},"PeriodicalIF":0.0,"publicationDate":"2013-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-013-9102-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40283822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A rare case of visual loss due to serous detachment associated with retinal "mulberry" hamartoma in a case of tuberous sclerosis. 结节性硬化症少见的因浆液脱离合并视网膜“桑树”错构瘤而导致视力丧失的病例。

Journal of ocular biology, diseases, and informatics Pub Date : 2013-03-03 eCollection Date: 2012-12-01 DOI: 10.1007/s12177-013-9101-x

Jayanta Dutta

引用次数: 2

Topographic assessment of retinal pigment epithelium detachment in central serous chorioretinopathy by three-dimensional optical coherence tomography single-layer retinal pigment epithelium map. 三维光学相干断层扫描单层视网膜色素上皮图对中枢性浆液性脉络膜视网膜病变视网膜色素上皮脱离的地形学评价。

Journal of ocular biology, diseases, and informatics Pub Date : 2013-01-31 eCollection Date: 2012-06-01 DOI: 10.1007/s12177-013-9099-0

Sandeep Saxena, Carsten H Meyer, Shashi R Sharma

{"title":"Topographic assessment of retinal pigment epithelium detachment in central serous chorioretinopathy by three-dimensional optical coherence tomography single-layer retinal pigment epithelium map.","authors":"Sandeep Saxena, Carsten H Meyer, Shashi R Sharma","doi":"10.1007/s12177-013-9099-0","DOIUrl":"https://doi.org/10.1007/s12177-013-9099-0","url":null,"abstract":"Purpose: This study aims to compare the topographic distribution of retinal pigment epithelium detachment (PED) in central serous chorioretinopathy (CSC) on spectral domain optical coherence tomography (SD-OCT) single-layer retinal pigment epithelium (SL-RPE) map and fluorescein angiography for the first time.Methods: Twenty-seven eyes of CSC with PEDs were studied retrospectively. Topographic distribution of PEDs was documented on 50° fluorescein angiography and SD-OCT SL-RPE map on macular cube 512 × 128.Results: Quantity of PEDs ranged from 1 to 5 on SD-OCT SL-RPE map macular cube 512 × 128 and corresponding macular cube area on 50° fluorescein angiography. Topographic distribution of PEDs on SL-RPE map matched with PEDs on fluorescein angiography in the corresponding macular cube area, in all the cases (interobserver correlation = 0.9).Conclusion: SD-OCT SL-RPE map is a noninvasive, three-dimensional advanced tool for documentation of topographic assessment of PEDs and obviates the need of fluorescein angiography for monitoring CSC.","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":" ","pages":"44-7"},"PeriodicalIF":0.0,"publicationDate":"2013-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-013-9099-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40284491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0