Journal of ocular biology, diseases, and informatics最新文献_第2页

Hereditary hemorrhagic telangiectasia with multiple fusiform retinal aneurysms. 遗传性出血性毛细血管扩张伴多发梭状视网膜动脉瘤。

Journal of ocular biology, diseases, and informatics Pub Date : 2013-01-29 eCollection Date: 2012-06-01 DOI: 10.1007/s12177-013-9100-y

Nagihan Uğurlu, Selma Emre, Fatma Yülek, Emine Kalkan Akcay, Ahmet Sengun

引用次数: 2

Panuveitis complicated by an inflammatory retinal mass. 全葡萄膜炎并发炎性视网膜肿块。

Journal of ocular biology, diseases, and informatics Pub Date : 2013-01-10 eCollection Date: 2012-06-01 DOI: 10.1007/s12177-012-9097-7

Weiqiang Qiu, Huirong Zhang, Ziyuan Liu, Xuran Dong, Xuemin Li, Wei Wang

引用次数: 0

Protein-ligand interaction studies of retinol-binding protein 3 with herbal molecules using AutoDock for the management of Eales' disease. 利用AutoDock研究视黄醇结合蛋白3与草药分子的蛋白质-配体相互作用，用于Eales病的治疗。

Journal of ocular biology, diseases, and informatics Pub Date : 2012-12-30 eCollection Date: 2012-01-01 DOI: 10.1007/s12177-012-9098-6

Anshul Tiwari, Sandeep Saxena, A B Pant, Prachi Srivastava

{"title":"Protein-ligand interaction studies of retinol-binding protein 3 with herbal molecules using AutoDock for the management of Eales' disease.","authors":"Anshul Tiwari, Sandeep Saxena, A B Pant, Prachi Srivastava","doi":"10.1007/s12177-012-9098-6","DOIUrl":"https://doi.org/10.1007/s12177-012-9098-6","url":null,"abstract":"Eales' disease is an idiopathic retinal vasculitis of the eye. The disease is predominantly characterized by recurrent vitreous hemorrhage. Interphotoreceptor retinol-binding protein 3 plays a significant role in the etiopathogenesis of this condition. It transports retinoids between the retinal pigment epithelium and the photoreceptors; hence, this protein is a potential target for docking studies. In silico data reveal that herbal molecules interact with regulatory domains of interphotoreceptor retinol-binding protein 3 (IRBP-3), resulting into significant docking score and also forms H-bond and several hydrophobic interactions between active residues of IRBP-3. These interactions between the active residues may lead to significant conformational change in that particular portion of the protein. This efficacy and suitability of ligand was determined on the basis of binding energy calculations. Ginkgolide showed minimum binding energy calculations among selected 10 other natural ligands. This fact of virtual screening for potential ligand can give new insights toward the therapeutic intonations and alterations toward the advances in treatment for Eales' disease. ","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"5 2","pages":"40-3"},"PeriodicalIF":0.0,"publicationDate":"2012-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-012-9098-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31987238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Matrix metalloproteinases (MMP-2 and MMP-9) activity in corneal ulcer and ocular surface disorders determined by gelatin zymography. 明胶酶谱法测定角膜溃疡和眼表疾病中基质金属蛋白酶(MMP-2和MMP-9)活性。

Journal of ocular biology, diseases, and informatics Pub Date : 2012-12-29 eCollection Date: 2012-01-01 DOI: 10.1007/s12177-012-9096-8

Arti Singh, O P S Maurya, M V Jagannadhan, Ashok Patel

引用次数: 17

Three-dimensional spectral domain optical coherence tomography in Stargardt disease and fundus flavimaculatus. 斯塔加特病和黄斑眼底的三维光谱域光学相干断层扫描。

Journal of ocular biology, diseases, and informatics Pub Date : 2012-12-07 eCollection Date: 2012-01-01 DOI: 10.1007/s12177-012-9093-y

Sandeep Saxena, Nibha Mishra, Carsten H Meyer

引用次数: 0

Diazinon-induced ulcerative keratitis in C57bl/6 mice. 二嗪农致C57bl/6小鼠溃疡性角膜炎。

Journal of ocular biology, diseases, and informatics Pub Date : 2012-12-06 eCollection Date: 2012-01-01 DOI: 10.1007/s12177-012-9095-9

Ebrahim Zabihi, Abbas Soleymani, Leila Ghassemi

引用次数: 2

Punctal plugs versus artificial tears for treating dry eye: a comparative observation of their effects on contrast sensitivity. 点塞与人工泪液治疗干眼症:对比敏感度的比较观察。

Journal of ocular biology, diseases, and informatics Pub Date : 2012-11-29 eCollection Date: 2012-01-01 DOI: 10.1007/s12177-012-9094-x

Weiqiang Qiu, Ziyuan Liu, Zhihong Zhang, Mingxin Ao, Xuemin Li, Wei Wang

{"title":"Punctal plugs versus artificial tears for treating dry eye: a comparative observation of their effects on contrast sensitivity.","authors":"Weiqiang Qiu, Ziyuan Liu, Zhihong Zhang, Mingxin Ao, Xuemin Li, Wei Wang","doi":"10.1007/s12177-012-9094-x","DOIUrl":"https://doi.org/10.1007/s12177-012-9094-x","url":null,"abstract":"This study aimed to compare the effects of treatment with punctal plugs versus artificial tears on visual function and tear film stability for dry eye. A total of 56 consecutive eyes of 28 dry eye patients observed at our clinic from May to October in 2009 were divided into two groups. One group (32 eyes of 16 patients) was treated with artificial tears, and punctal plugs were used in the other group (24 eyes of 12 patients). A questionnaire was used in these patients before treatment and was repeated 2 weeks after treatment. Fluorescent staining for tear film break-up time (BUT), the Schirmer test I (STI), and contrast sensitivity was performed at the same time. The questionnaire indicated that all patients complained about the uncomfortable symptoms associated with dry eye. These symptoms were relieved after the application of artificial tears or punctal plugs, and there was no significant difference between these two groups. We found that the corneal fluorescent staining disappeared after treatment. The BUT was improved significantly after treatment in both groups, but the improvement was greater in patients who received punctal plugs than those that received artificial tears. There was no remarkable change in the STI in the artificial tears group, but a significant change was observed in the punctal plugs group. The contrast sensitivities were greatly improved in simulated daylight, night, and glare disability conditions after treatment with artificial tears and punctal plugs. However, the changes in contrast sensitivity did not significantly differ between groups. Both artificial tears and punctal plugs relieved dry eye symptoms, repaired corneal lesions, enhanced tear film stability, and improved contrast sensitivity. Punctal plugs could improve tear film stability and elongate the BUT better than artificial tears. ","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"5 1","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"2012-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-012-9094-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31913430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Three-dimensional spectral domain optical coherence tomography of retina in choroidal metastasis due to breast and lung carcinoma. 三维光谱域光学相干断层扫描在乳腺癌和肺癌脉络膜转移中的应用。

Journal of ocular biology, diseases, and informatics Pub Date : 2012-10-19 eCollection Date: 2012-01-01 DOI: 10.1007/s12177-012-9092-z

Sandeep Saxena, Astha Jain, Levent Akduman

引用次数: 4

Role of matrix metalloproteinase-2 and -9 in the development of diabetic retinopathy. 基质金属蛋白酶-2和-9在糖尿病视网膜病变中的作用。

Journal of ocular biology, diseases, and informatics Pub Date : 2012-07-06 Print Date: 2012-03-01 DOI: 10.1007/s12177-012-9091-0

Ghulam Mohammad, Mohammad Mairaj Siddiquei

{"title":"Role of matrix metalloproteinase-2 and -9 in the development of diabetic retinopathy.","authors":"Ghulam Mohammad, Mohammad Mairaj Siddiquei","doi":"10.1007/s12177-012-9091-0","DOIUrl":"https://doi.org/10.1007/s12177-012-9091-0","url":null,"abstract":"Diabetic retinopathy represents the most common causes of vision loss in patients affected by diabetes mellitus. The cause of vision loss in diabetic retinopathy is complex and remains incompletely understood. One of the earliest changes in the development of retinopathy is the accelerated apoptosis of retinal microvascular cells and the formation of acellular capillaries by unknown mechanism. Results of a recent research suggest an important role of matrix metalloproteinases (MMPs) in the development of diabetic retinopathy. MMPs are a large family of proteinases that remodel extracellular matrix components, and under pathological condition, its induction is considered as a negative regulator of cell survival; and in diabetes, latent MMPs are activated in the retina and its capillary cells, and activation of MMP-2 and -9 induces apoptosis of retinal capillary cells. This review will focus on the MMP-2 and MMP-9 in the diabetic retina with special reference to oxidative stress, mitochondria dysfunction, inflammation and angiogenesis, as well as summarizing the current information linking these proteins to pathogenesis of diabetic retinopathy. ","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"5 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2012-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-012-9091-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31562637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

An unusual case of bilateral retinal haemorrhage following snakebite. 蛇咬伤后双侧视网膜出血的罕见病例。

Journal of ocular biology, diseases, and informatics Pub Date : 2012-06-19 Print Date: 2011-12-01 DOI: 10.1007/s12177-012-9090-1

Jayanta Dutta, Swarnali Sen, Sumanta Kumar Bera, Himadri Datta

引用次数: 4