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Journal of ocular biology, diseases, and informatics最新文献

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Epigenetics rules. 表观遗传学的规则。
Journal of ocular biology, diseases, and informatics Pub Date : 2012-06-14 Print Date: 2011-09-01 DOI: 10.1007/s12177-012-9088-8
Evgenya Popova, Colin J Barnstable
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引用次数: 1
Significance of G-X-W motif in the myocilin olfactomedin domain. G-X-W基序在心肌olfactomedin区域中的意义。
Journal of ocular biology, diseases, and informatics Pub Date : 2012-06-05 Print Date: 2011-12-01 DOI: 10.1007/s12177-012-9089-7
K Rangachari, J Jeyalaxmi, P J Eswari Pandaranayaka, N Prasanthi, P Sundaresan, S R Krishnadas, S Krishnaswamy
{"title":"Significance of G-X-W motif in the myocilin olfactomedin domain.","authors":"K Rangachari, J Jeyalaxmi, P J Eswari Pandaranayaka, N Prasanthi, P Sundaresan, S R Krishnadas, S Krishnaswamy","doi":"10.1007/s12177-012-9089-7","DOIUrl":"https://doi.org/10.1007/s12177-012-9089-7","url":null,"abstract":"","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"4 4","pages":"154-8"},"PeriodicalIF":0.0,"publicationDate":"2012-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-012-9089-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31575582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Three-dimensional imaging by spectral domain optical coherence tomography in central serous chorioretinopathy with fibrin. 伴有纤维蛋白的中枢性浆液性脉络膜视网膜病变的光谱域光学相干断层成像。
Journal of ocular biology, diseases, and informatics Pub Date : 2012-05-22 Print Date: 2011-12-01 DOI: 10.1007/s12177-012-9087-9
Sandeep Saxena, Neha Sinha, Shashi Sharma
{"title":"Three-dimensional imaging by spectral domain optical coherence tomography in central serous chorioretinopathy with fibrin.","authors":"Sandeep Saxena, Neha Sinha, Shashi Sharma","doi":"10.1007/s12177-012-9087-9","DOIUrl":"https://doi.org/10.1007/s12177-012-9087-9","url":null,"abstract":"","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"4 4","pages":"149-53"},"PeriodicalIF":0.0,"publicationDate":"2012-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-012-9087-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31450541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Neural inflammation and the microglial response in diabetic retinopathy. 糖尿病视网膜病变的神经炎症和小胶质细胞反应。
Journal of ocular biology, diseases, and informatics Pub Date : 2012-04-24 Print Date: 2011-06-01 DOI: 10.1007/s12177-012-9086-x
Steven F Abcouwer
{"title":"Neural inflammation and the microglial response in diabetic retinopathy.","authors":"Steven F Abcouwer","doi":"10.1007/s12177-012-9086-x","DOIUrl":"https://doi.org/10.1007/s12177-012-9086-x","url":null,"abstract":"<p><p>This chapter reviews the function of microglia and their potential roles in neural inflammation and pathological changes during diabetic retinopathy.</p>","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"4 1-2","pages":"25-33"},"PeriodicalIF":0.0,"publicationDate":"2012-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-012-9086-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31474632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Alterations in "in vivo" histology of retina in bilateral chronic central serous chorioretinopathy after intravitreal bevacizumab. 玻璃体内贝伐单抗治疗双侧慢性中枢性浆液性脉络膜视网膜病变后视网膜“体内”组织学的改变
Journal of ocular biology, diseases, and informatics Pub Date : 2011-12-01 Epub Date: 2012-03-08 DOI: 10.1007/s12177-012-9077-y
Sandeep Saxena, Astha Jain
{"title":"Alterations in \"in vivo\" histology of retina in bilateral chronic central serous chorioretinopathy after intravitreal bevacizumab.","authors":"Sandeep Saxena,&nbsp;Astha Jain","doi":"10.1007/s12177-012-9077-y","DOIUrl":"https://doi.org/10.1007/s12177-012-9077-y","url":null,"abstract":"","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"4 4","pages":"137-40"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-012-9077-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31293876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
A case of suture-related bacterial keratitis and its treatment with topical imipenem. 缝合线相关性细菌性角膜炎1例及局部亚胺培南治疗。
Journal of ocular biology, diseases, and informatics Pub Date : 2011-12-01 Epub Date: 2012-03-17 DOI: 10.1007/s12177-012-9081-2
Kemal Turkyilmaz, Ali Kurt, Aziz R Dilek, Berrak Sekeryapan, Ayse Erturk
{"title":"A case of suture-related bacterial keratitis and its treatment with topical imipenem.","authors":"Kemal Turkyilmaz,&nbsp;Ali Kurt,&nbsp;Aziz R Dilek,&nbsp;Berrak Sekeryapan,&nbsp;Ayse Erturk","doi":"10.1007/s12177-012-9081-2","DOIUrl":"https://doi.org/10.1007/s12177-012-9081-2","url":null,"abstract":"","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"4 4","pages":"141-4"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-012-9081-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31317188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Three-dimensional optical coherence tomography of the optic nerve head with myelinated nerve fibers. 有髓神经纤维视神经头的三维光学相干断层扫描。
Journal of ocular biology, diseases, and informatics Pub Date : 2011-12-01 Epub Date: 2012-03-28 DOI: 10.1007/s12177-012-9082-1
Sandeep Saxena, Astha Jain
{"title":"Three-dimensional optical coherence tomography of the optic nerve head with myelinated nerve fibers.","authors":"Sandeep Saxena,&nbsp;Astha Jain","doi":"10.1007/s12177-012-9082-1","DOIUrl":"https://doi.org/10.1007/s12177-012-9082-1","url":null,"abstract":"","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":" ","pages":"145-8"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-012-9082-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40231713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Epigenetic regulation of retinal development and disease. 视网膜发育和疾病的表观遗传调控。
Journal of ocular biology, diseases, and informatics Pub Date : 2011-09-01 Epub Date: 2012-03-29 DOI: 10.1007/s12177-012-9083-0
Rajesh C Rao, Anne K Hennig, Muhammad T A Malik, Dong Feng Chen, Shiming Chen
{"title":"Epigenetic regulation of retinal development and disease.","authors":"Rajesh C Rao,&nbsp;Anne K Hennig,&nbsp;Muhammad T A Malik,&nbsp;Dong Feng Chen,&nbsp;Shiming Chen","doi":"10.1007/s12177-012-9083-0","DOIUrl":"https://doi.org/10.1007/s12177-012-9083-0","url":null,"abstract":"<p><p>Epigenetic regulation, including DNA methylation, histone modifications, and chromosomal organization, is emerging as a new layer of transcriptional regulation in retinal development and maintenance. Guided by intrinsic transcription factors and extrinsic signaling molecules, epigenetic regulation can activate and/or repress the expression of specific sets of genes, therefore playing an important role in retinal cell fate specification and terminal differentiation during development as well as maintaining cell function and survival in adults. Here, we review the major findings that have linked these mechanisms to the development and maintenance of retinal structure and function, with a focus on ganglion cells and photoreceptors. The mechanisms of epigenetic regulation are highly complex and vary among different cell types. Understanding the basic principles of these mechanisms and their regulatory pathways may provide new insight into the pathogenesis of retinal diseases associated with transcription dysregulation, and new therapeutic strategies for treatment.</p>","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":" ","pages":"121-36"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-012-9083-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40233241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Eyes on DNA methylation: current evidence for DNA methylation in ocular development and disease. 眼睛上的DNA甲基化:眼部发育和疾病中DNA甲基化的最新证据。
Journal of ocular biology, diseases, and informatics Pub Date : 2011-09-01 Epub Date: 2012-03-29 DOI: 10.1007/s12177-012-9078-x
Deborah C Otteson
{"title":"Eyes on DNA methylation: current evidence for DNA methylation in ocular development and disease.","authors":"Deborah C Otteson","doi":"10.1007/s12177-012-9078-x","DOIUrl":"https://doi.org/10.1007/s12177-012-9078-x","url":null,"abstract":"<p><p>Epigenetic modulation of chromatin states constitutes a vital component of the cellular repertoire of transcriptional regulatory mechanisms. The development of new technologies capable of generating genome-wide maps of chromatin modifications has re-energized the field. We are now poised to determine how species- and tissue-specific patterns of DNA methylation, in concert with other chromatin modifications, function to establish and maintain cell- and tissue-specific patterns of gene expression during normal development, cellular differentiation, and disease. This review addresses our current understanding of the major mechanisms and function of DNA methylation in vertebrates with a historical perspective and an emphasis on what is known about DNA methylation in eye development and disease.</p>","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":" ","pages":"95-103"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-012-9078-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40232823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Matters of life and death: the role of chromatin remodeling proteins in retinal neuron survival. 生死攸关:染色质重塑蛋白在视网膜神经元存活中的作用。
Journal of ocular biology, diseases, and informatics Pub Date : 2011-09-01 Epub Date: 2012-03-17 DOI: 10.1007/s12177-012-9080-3
Pamela S Lagali, David J Picketts
{"title":"Matters of life and death: the role of chromatin remodeling proteins in retinal neuron survival.","authors":"Pamela S Lagali,&nbsp;David J Picketts","doi":"10.1007/s12177-012-9080-3","DOIUrl":"https://doi.org/10.1007/s12177-012-9080-3","url":null,"abstract":"<p><p>Retinal neurons are highly vulnerable to a diverse array of neurotoxic stimuli that leads to their degeneration, which is a major contributor to blindness. This review summarizes the role of epigenetic factors in mediating neuronal homeostasis and survival to protect against cell death and neurodegenerative conditions. Studies in human patients and mouse models implicate numerous chromatin modifications in neuroprotective processes including histone protein acetylation and methylation, DNA methylation, and ATP-dependent nucleosome remodeling. Recent research has begun to uncover specific epigenetic mechanisms invoked by neurotoxic stimuli. Continued investigation in this area will be the key to the generation of therapeutic strategies for the intervention of retinal neurodegenerative diseases.</p>","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":" ","pages":"111-20"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-012-9080-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40211447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
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