Journal of neuro-AIDS最新文献_第3页

Neuronal loss in FIV-MD infected cats. FIV-MD感染猫的神经元丧失。

Journal of neuro-AIDS Pub Date : 1998-01-01 DOI: 10.1300/J128v02n01_05

W R Buck, M Podell

引用次数: 6

Detection of varicella-zoster virus DNA by nested PCR in CSF from HIV-infected patients: A prospective evaluation. 用巢式PCR检测hiv感染者脑脊液中水痘-带状疱疹病毒DNA:一项前瞻性评价

Journal of neuro-AIDS Pub Date : 1998-01-01 DOI: 10.1300/J128v02n01_07

N S Brink, J D Fox, J C Waite, Y Sharvell, R F Miller

引用次数: 3

Potential relationships between the presence of HIV, macrophages, and astrogliosis in SCID mice with HIV encephalitis. HIV脑炎SCID小鼠中存在的HIV、巨噬细胞和星形胶质细胞之间的潜在关系

Journal of neuro-AIDS Pub Date : 1998-01-01 DOI: 10.1300/J128v02n01_01

N G Avgeropoulos, G W Burris, G W Ohlandt, S L Wesselingh, R B Markham, W R Tyor

{"title":"Potential relationships between the presence of HIV, macrophages, and astrogliosis in SCID mice with HIV encephalitis.","authors":"N G Avgeropoulos, G W Burris, G W Ohlandt, S L Wesselingh, R B Markham, W R Tyor","doi":"10.1300/J128v02n01_01","DOIUrl":"https://doi.org/10.1300/J128v02n01_01","url":null,"abstract":"The pathogenesis of HIV encephalitis (HIVE) has not been determined although increased numbers of mononuclear phagocytes (macrophages and microglia), some of which are HIV-infected, and reactive astrogliosis are important pathological findings in this condition. For this experiment, fifty-one SCID mice were inoculated intracerebrally either with human cells and HIV-1, human cells only or HIV only and then sacrificed at various time points. HIV gag mRNA was detected by reverse transcriptase polymerase chain reaction (PCR) distant from the site of inoculation in 73% of mouse brains inoculated with HIV and human cells attesting to the pervasiveness of HIV infection in SCID brain. HIV mRNA was detected as long as 91 days after inoculation of human cells and virus and the presence of HIV gag, nef, and tat/rev mRNA in HIV-infected SCID brains indicates ongoing HIV mRNA synthesis. Brain tissue sections were immunostained for HIV, human macrophages, and astrocytes from a subset of mice (n = 29) from the above groups and qualitatively assessed. PCR data for HIV mRNA was correlated with staining results and these data suggested that the greatest astrogliosis was present in mice inoculated with HIV and human cells, consistent with previously reported data. The data further suggest that astrogliosis is greater when HIV is detected. Taken together the data are consistent with a synergistic effect between macrophages and HIV in the development of astrogliosis.","PeriodicalId":73854,"journal":{"name":"Journal of neuro-AIDS","volume":"2 1","pages":"1-20"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26169479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Heterogeneity of macrophage and T cell subpopulations in peripheral nerves from HIV infected individuals: A preliminary study. HIV感染者周围神经中巨噬细胞和T细胞亚群的异质性:初步研究

Journal of neuro-AIDS Pub Date : 1998-01-01 DOI: 10.1300/J128v02n01_06

S Delgado, P Shapshak, R Stewart, P R de la Vega, N C Sun, S Benjamin, C Petito, W Bradley

{"title":"Heterogeneity of macrophage and T cell subpopulations in peripheral nerves from HIV infected individuals: A preliminary study.","authors":"S Delgado, P Shapshak, R Stewart, P R de la Vega, N C Sun, S Benjamin, C Petito, W Bradley","doi":"10.1300/J128v02n01_06","DOIUrl":"https://doi.org/10.1300/J128v02n01_06","url":null,"abstract":"Goal: To determine the heterogeneity of surface marker expression of macrophages in peripheral nerve of patients who died with AIDS.Background: Peripheral neuropathy occurs in 20%-40% of AIDS patients. There is evidence that activated macrophages may be involved in the neural damage associated with HIV-1 infection. We studied the expression of macrophage surface markers CD14, CD11c, CD68, and HLA-DR and also T cell surface markers CD3, CD4, and CD8 in peripheral nerves of AIDS patients.Methods: Three levels of peripheral nerves (sciatic, tibial, or sural) were examined from a limited number of subjects consisting of 4 HIV-seropositive and 5 HIV-seronegative individuals. Standard immunohistochemical technique utilized alkaline phosphatase conjugate and fuchsin substrate.Results: Surface antigen expression was significantly (p < .0025 increased in HIV-positive tissues compared with HIV-negative controls for CD14 and CD4 in sciatic nerves, CD68 and CD4 in tibial nerves, and CD68 in sural nerves. There were trends for increased expression of HLA-DR, CD3, and CD8 in sciatic nerves, CD11c and CD14 in tibial nerves, and CD14, HLA-DR, and CD4 in sural nerves in HIV-positive tissues compared with HIV-negative controls.Conclusion: During the course of AIDS there may be an involvement of all three levels of peripheral nerves suggesting that HIV-related neuropathy is a multifocal process.","PeriodicalId":73854,"journal":{"name":"Journal of neuro-AIDS","volume":"2 1","pages":"79-97"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26169432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Enhanced Excitotoxicity in Primary Feline Neural Cultures Exposed to Feline Immunodeficiency Virus (FIV). 暴露于猫免疫缺陷病毒(FIV)的原代猫神经培养物的兴奋毒性增强。

Journal of neuro-AIDS Pub Date : 1997-01-01 DOI: 10.1300/j128v01n03_01

R Meeker, R English, M Tompkins

{"title":"Enhanced Excitotoxicity in Primary Feline Neural Cultures Exposed to Feline Immunodeficiency Virus (FIV).","authors":"R Meeker, R English, M Tompkins","doi":"10.1300/j128v01n03_01","DOIUrl":"https://doi.org/10.1300/j128v01n03_01","url":null,"abstract":"The ability of feline immunodeficiency virus (FIV) to induce neurodegenerative changes in vitro similar to those due to HIV was examined as a potential model to examine the mechanisms underlying AIDS dementia. Primary cultures of feline neural tissue (neurons, astrocytes and microglia) were established from E40-E57 fetal cat cortex and challenged by inoculation with the NCSU1 strain of FIV. Proviral FIV was detected in the cultures and correlated with the presence of microglia. No direct toxicity of FIV was seen. Stimulation of FIV-inoculated cortical cultures with 20 uM glutamate resulted in a greatly enhanced acute swelling response in approximately 14-24% of the neurons and an increase in the number of dead cells after 24 h relative to control cultures. The enhanced responses were due to an increase in the sensitivity of the cells to glutamate and were dependent on the presence of a soluble factor in the medium. The similarity of the indirect excitoxic effects of FIV to current models of HIV-gp120 neurotoxicity and the versatility of the in vitro cultures, indicate that FIV should provide a valuable model for the investigation of the mechanisms of neurodegeneration in AIDS dementia.","PeriodicalId":73854,"journal":{"name":"Journal of neuro-AIDS","volume":"1 3","pages":"1-27"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10401120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

HIV-1 gp120 Effects on Signal Transduction Processes and Cytokines: Increased src-Family Protein Tyrosine Kinase Activity. HIV-1 gp120对信号转导过程和细胞因子的影响:src家族蛋白酪氨酸激酶活性增加。

Journal of neuro-AIDS Pub Date : 1997-01-01 DOI: 10.1300/j128v01n03_04

R J Ziegler

{"title":"HIV-1 gp120 Effects on Signal Transduction Processes and Cytokines: Increased src-Family Protein Tyrosine Kinase Activity.","authors":"R J Ziegler","doi":"10.1300/j128v01n03_04","DOIUrl":"https://doi.org/10.1300/j128v01n03_04","url":null,"abstract":"Varying degrees of neurological dysfunction are observed in AIDS patients who develop AIDS dementia complex (ADC). Data from a large number of in vivo and in vitro rodent studies have suggested a role for the HIV envelope glycoprotein gp 120 in this process. These studies were initiated to clarify possible effects of recombinant gp120 on signal transduction systems and the synthesis of specific ADC-related cytokines in human neuroblastoma cells. Out results indicate that gp120 on signal transduction systems and the synthesis of specific ADC-related cytokines in human neuroblastoma cells. Our results indicate that gp120 did not induce the synthesis of cAMP, IPs or NO, nor did it alter agonist-induced synthesis of these molecules. In addition, it did not induce the synthesis of IL-6 and TNFα. However, it did activate a src-family protein tyrosine kinase which phosphorylates several substrates, including prominent proteins in the 115 and 60 kDa range. This gp120-induced tyrosine phosphorylation may contribute to neurological dysfunction since protein tyrosine kinases are known to be involved in processes important for pre- and post-synaptic neuronal function.","PeriodicalId":73854,"journal":{"name":"Journal of neuro-AIDS","volume":" ","pages":"51-71"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26170641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Quantitative MRI Study of the Basal Ganglia in Depression in HIV Seropositive Men. HIV血清阳性男性抑郁症基底神经节的定量MRI研究。

Journal of neuro-AIDS Pub Date : 1997-01-01 DOI: 10.1300/j128v01n03_02

S E Davison, E H Aylward, J C McArthur, O A Selnes, C Lyketsos, P E Barta, G D Pearlson

{"title":"A Quantitative MRI Study of the Basal Ganglia in Depression in HIV Seropositive Men.","authors":"S E Davison, E H Aylward, J C McArthur, O A Selnes, C Lyketsos, P E Barta, G D Pearlson","doi":"10.1300/j128v01n03_02","DOIUrl":"https://doi.org/10.1300/j128v01n03_02","url":null,"abstract":"Unlabelled: HIV (Human Immunodeficiency Virus) infection is associated with high rates of depressive symptomatology. There is evidence that such infection is associated with damage to the basal ganglia. It has also been suggested that the basal ganglia are implicated in the aetiology of affective disorders.Objective: This study examined the association between basal ganglia atrophy and depression in HIV seropositive men. We hypothesized that depressed HIV seropositive patients would have smaller basal ganglia compared with nondepressed HIV positive comparison subjects.Method: Using quantitative magnetic resonance imaging (MRI) techniques we compared for the basal ganglia volumes of sixteen depressed, and sixteen group-matched nondepressed HIV seropositive homosexual men.Results: We found no significant difference in basal ganglia volumes between the two groups.Conclusions: We suggest that depression, at least in the early stages of HIV infection, is not associated with basal ganglia atrophy.","PeriodicalId":73854,"journal":{"name":"Journal of neuro-AIDS","volume":" ","pages":"29-41"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26170639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Neuropsychological Dysfunction in HIV Infection:A Review. HIV感染中的神经心理障碍:综述。

Journal of neuro-AIDS Pub Date : 1997-01-01 DOI: 10.1300/j128v01n03_05

N Dunbar, B Brew

{"title":"Neuropsychological Dysfunction in HIV Infection:A Review.","authors":"N Dunbar, B Brew","doi":"10.1300/j128v01n03_05","DOIUrl":"https://doi.org/10.1300/j128v01n03_05","url":null,"abstract":"FIfty-six studies which used neuropsychological tests to investigate areas of function affected by central nervous system dysfunction in HIV were reviewed. Only studies which compared the performance of HIV + subjects to HIV - controls using analysis of variance techniques were included. The results are examined in terms of broad neuropsychological function domains, and are examined separately for asymptomatic and symptomatic subjects. Studies which did and did not find significant differences between HIV + and HIV - subjects were compared in terms of various confounding factors such as risk groups, number of tests, sample size and subject characteristics. There was evidence for some dysfunction among subjects who are otherwise asymptomatic in the areas of verbal memory (27% of studies), executive function (43%), motor performance (20%) and information processing (44%). Studies of subjects with more advanced HIV infection showed consistent evidence of abnormal functioning in the areas of verbal (48% of studies) and visual memory (43%), executive functioning (71%), complex attention (62%), motor performance (37%) and information processing (69%). These deficits occurred prior to the onset of clinically apparent dementia. There were no consistent significant differences between studies which did and did not find significant differences between HIV + and HIV - subjects in terms of most of the confounding variables investigated, although studies of ASX subjects were more likely to find differences between HIV + subjects and controls with larger neuropsychological test battereies. However, much of the variation in results due to the neuropsychological tests used. In many cases, tests which relied on functions with a frontal lobe component were more likely to find significant results.","PeriodicalId":73854,"journal":{"name":"Journal of neuro-AIDS","volume":" ","pages":"73-102"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26170642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Proton Spectroscopy in a Cross-Section of HIV-Positive Asymptomatic Patients Receiving Immediate Compared with Deferred Zidovudine (Concorde Study). 质子光谱在hiv阳性无症状患者的横截面接受立即与延迟齐多夫定的比较(协和研究)。

Journal of neuro-AIDS Pub Date : 1997-01-01 DOI: 10.1300/j128v01n03_06

M A Hall-Craggs, I G Williams, I D Wilkinson, M Paley, R J Chinn, W K Chong, B E Kendall, M J Harrison, T Baldeweg, K Pugh, M Riccio, J Catalan, I V Weller

引用次数: 6

CNS lymphoma in an AIDS patient involving the posterior fornix case report. 爱滋病患者中枢神经系统淋巴瘤累及后穹窿1例报告。

Journal of neuro-AIDS Pub Date : 1997-01-01 DOI: 10.1300/j128v01n03_03

L Ketonen, K D Kieburtz, M J Tuite, T Eskin, J Simon

引用次数: 0