Journal of neuro-AIDS最新文献_第2页

Kinetics of HIV-1 in cerebrospinal fluid and serum after zidovudine treatment. 齐多夫定治疗后脑脊液和血清中HIV-1的动力学。

Journal of neuro-AIDS Pub Date : 1999-01-01 DOI: 10.1300/J128v02n02_03

L Hagberg, M Gisslen, G Norkrans, B Svennerholm

引用次数: 3

Clinical evolution of tropical spastic paraparesis: The Tumaco experience. 热带痉挛性麻痹的临床演变:图马科经验。

Journal of neuro-AIDS Pub Date : 1999-01-01 DOI: 10.1300/J128v02n02_04

N Bernal, E Bernal, R Patarca, M Concha, J M Trujillo, R D Bonilla, C Arango

引用次数: 0

Reduction in phosphorylated heavy neurofilament in the cerebellum in HIV disease. HIV疾病中小脑磷酸化重神经丝的减少。

Journal of neuro-AIDS Pub Date : 1999-01-01 DOI: 10.1300/J128v02n02_05

I P Everall, H Barnes

引用次数: 2

Human immunodeficiency virus type 1 envelope glycoprotein gp120 induces tumor necrosis factor-alpha in astrocytes. 人类免疫缺陷病毒1型包膜糖蛋白gp120诱导星形胶质细胞肿瘤坏死因子α。

Journal of neuro-AIDS Pub Date : 1999-01-01 DOI: 10.1300/J128v02n02_01

A Buriani, L Petrelli, L Facci, P G Romano, R Dal Tosso, A Leon, S D Skaper

{"title":"Human immunodeficiency virus type 1 envelope glycoprotein gp120 induces tumor necrosis factor-alpha in astrocytes.","authors":"A Buriani, L Petrelli, L Facci, P G Romano, R Dal Tosso, A Leon, S D Skaper","doi":"10.1300/J128v02n02_01","DOIUrl":"https://doi.org/10.1300/J128v02n02_01","url":null,"abstract":"gp120 induction of the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) was studied in cultures of purified astrocytes. Incubation of pure mouse cortical astrocytes with gp120 IIIB induced the expression of TNF-alpha mRNA, assessed by in situ hybridization. Anti- TNF-alpha immunocytochemical staining of gp120 IIIB stimulated astrocytes indicated the presence of TNF-alpha. gp120 IIIB treatment also stimulated secretion of bioactive TNF-alpha from astrocytes, which was prevented by inhibitors of transcription and translation. Hippocampal and cerebellar astrocytes displayed similar behaviors. Further, gp120 displayed cytotoxicity for astrocytes that depended on macromolecular synthesis. The data are the first to show gp120 IIIB induction of de novo TNF-alpha production by pure astrocytes. Because TNF-alpha exerts a wide array of effects in the brain of infected individuals and has HIV-1 inducing activity as well, induction of this cytokine by gp120 IIIB in astrocytes may contribute importantly to the pathogenesis of AIDS dementia complex. Since TNF-alpha can stimulate astrocyte reactivity and proliferation by an autocrine mechanism, the extent of the gp120 effect could conceivably increase with HIV-1 disease progression in a self-amplifying loop, involving other cell types, thus favoring both virus persistence and a chronic disease state.","PeriodicalId":73854,"journal":{"name":"Journal of neuro-AIDS","volume":"2 2","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26169434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Cerebrovascular disease in patients with HIV-1 associated pulmonary hypertension. HIV-1相关肺动脉高压患者的脑血管疾病

Journal of neuro-AIDS Pub Date : 1999-01-01 DOI: 10.1300/J128v02n02_06

G Schifitto, R Holloway

引用次数: 3

Reduction of glutamate levels in HIV-infected subjects treated with acetylcarnitine. 乙酰肉碱治疗降低hiv感染者谷氨酸水平

Journal of neuro-AIDS Pub Date : 1999-01-01 DOI: 10.1300/J128v02n02_07

G Famularo, S Moretti, E Alesse, V Trinchieri, A Angelucci, G Santini, G Cifone, C De Simone

引用次数: 5

Genetic markers on HIV-1 gp120 C2-V3 region associated with the expression or absence of cognitive motor complex in HIV/AIDS. HIV-1 gp120 C2-V3区域的遗传标记与HIV/AIDS患者认知运动复合体的表达或缺失相关

Journal of neuro-AIDS Pub Date : 1999-01-01 DOI: 10.1300/J128v02n02_02

A Jurado, P Rahimi-Moghaddam, S Bar-Jurado, J S Richardson, M Jurado, A Shuaib

引用次数: 6

MR and TL-210 spect imaging with pathologic correlation for the assessment of CNS lymphoma vs. toxoplasmosis in AIDS patients. mri和TL-210 spect显像与病理相关性评价艾滋病患者中枢神经系统淋巴瘤与弓形虫病。

Journal of neuro-AIDS Pub Date : 1998-01-01 DOI: 10.1300/J128v02n01_02

L Ketonen, R C De la Peña, J Villanueva-Meyer

引用次数: 0

Gradient of microglial activation in the brain of SIV infected macaques. SIV感染猕猴脑内小胶质细胞的激活梯度。

Journal of neuro-AIDS Pub Date : 1998-01-01 DOI: 10.1300/J128v02n01_03

N E Berman, L G Sheffield, J Purcell, S V Joag, O Narayan, P Cheney

{"title":"Gradient of microglial activation in the brain of SIV infected macaques.","authors":"N E Berman, L G Sheffield, J Purcell, S V Joag, O Narayan, P Cheney","doi":"10.1300/J128v02n01_03","DOIUrl":"https://doi.org/10.1300/J128v02n01_03","url":null,"abstract":"Brains of macaques inoculated with macrophage-tropic, neurovirulent virus 7F, with lymphocyte-tropic SIV mac239, or with dual-tropic SIVmac239/1yE, were examined for microglial activation, astrocyte activation, apoptosis and neuron loss. The brain one animal inoculated with neurovirulent virus 7f showed massive microglial activation as assessed by expression of the major histo-compatibility complex class II (MHC-II). In this animal very numerous, large microglial nodules expressing MHC-II were concentrated in the basal pons and internal capsule. These microglial nodules contained cells undergoing apoptosis detected by in situ end labeling of fragmented DNA. In this animal, neuron loss was apparent near the microglial nodules. In the animals inoculated with SIVmac239 or SIVmac239/17E, pathologic changes such as perivascular cuffing and formation of microglial nodules were absent. However, increased expression of MHC-11 by microglial cells was also concentrated in white matter of the basal pons, midbrain and internal capsule. These results indicate the microglial activation in SIV-infected macaques follows a ventral to dorsal gradient regardless of viral tropism. These results also show that the type and severity of neuropathological changes in SIV-infected macaques is highly dependent on the tropism of the inoculated virus.","PeriodicalId":73854,"journal":{"name":"Journal of neuro-AIDS","volume":"2 1","pages":"43-54"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26169429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Short echo-time proton magnetic resonance spectroscopy in regions of severe HIV-related diffuse white matter abnormality on MRI. 短回声时间质子磁共振波谱在严重hiv相关弥漫性白质异常MRI上的应用。

Journal of neuro-AIDS Pub Date : 1998-01-01 DOI: 10.1300/J128v02n01_04

I D Wilkinson, R F Miller, M A Hall-Craggs, M N Paley, M J Harrison

{"title":"Short echo-time proton magnetic resonance spectroscopy in regions of severe HIV-related diffuse white matter abnormality on MRI.","authors":"I D Wilkinson, R F Miller, M A Hall-Craggs, M N Paley, M J Harrison","doi":"10.1300/J128v02n01_04","DOIUrl":"https://doi.org/10.1300/J128v02n01_04","url":null,"abstract":"The purpose of this study was to determine whether short echo-time proton magnetic resonance spectroscopy (H-MRS) could detect mobile lipid resonances attributable to myelin breakdown products in the deep cerebral white matter of patients with AIDS who have severe diffuse/patchy white matter hyperintensity on T2-weighted magnetic resonance imaging (MRI). Seven patients with AIDS and clinical HIV-associated dementia complex (HADC) and 12 male controls were studied at 1.5T using a single 8 ml voxel, gradient localised, stimulated echo acquisition mode (STEAM) spectroscopy sequence. Spectra were acquired at an echo time of 20 ms with a repetition time of 5000 ms. No spectroscopic peaks were identified at 0.9 ppm and 1.3 ppm (corresponding to lipid resonances) in 6 of the 7 patients with AIDS or in any of the controls. Lipid resonances were identified in 1 patient who had been taking anti-retroviral therapy for 8 weeks. Follow up MRI/H-MRS, performed after a further 14 weeks of anti-retroviral therapy, showed partial resolution of white matter hyperintensity and lipid resonances were not detectable. These data suggest that mobile lipids are only rarely detected by H-MRS in patients with HADC and abnormalities on MRI and that their presence may be transitory.","PeriodicalId":73854,"journal":{"name":"Journal of neuro-AIDS","volume":"2 1","pages":"55-67"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26169430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2